DK1353948T3 - Oplöselige biologiske analoge til bata-amyloidpeptid - Google Patents

Oplöselige biologiske analoge til bata-amyloidpeptid

Info

Publication number: DK1353948T3
Authority: DK; Denmark
Prior art keywords: beta; amyloid peptide; soluble biological; biological analogs; analogs
Prior art date: 2001-01-13

Application number

DK01990584T

Other languages

English (en)

Inventor

Herwig Brunner

Afroditi Kapurniotu

Juergen Bernhagen

Original Assignee

Fraunhofer Ges Forschung

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-13

Filing date

2001-12-21

Publication date

2006-02-27

2001-12-21 Application filed by Fraunhofer Ges Forschung filed Critical Fraunhofer Ges Forschung

2006-02-27 Application granted granted Critical

2006-02-27 Publication of DK1353948T3 publication Critical patent/DK1353948T3/da

Links

DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
230000003941 amyloidogenesis Effects 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Zoology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

DK01990584T 2001-01-13 2001-12-21 Oplöselige biologiske analoge til bata-amyloidpeptid DK1353948T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10101430A DE10101430B4 (de)	2001-01-13	2001-01-13	Lösliche cyclische Analoga zur Modulation der Amyloidogenese

Publications (1)

Publication Number	Publication Date
DK1353948T3 true DK1353948T3 (da)	2006-02-27

Family

ID=7670511

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01990584T DK1353948T3 (da)	2001-01-13	2001-12-21	Oplöselige biologiske analoge til bata-amyloidpeptid

Country Status (10)

Country	Link
US (2)	US7342091B2 (da)
EP (1)	EP1353948B1 (da)
JP (1)	JP4079775B2 (da)
AT (1)	ATE307143T1 (da)
AU (1)	AU2002229677A1 (da)
CA (1)	CA2433687A1 (da)
DE (2)	DE10101430B4 (da)
DK (1)	DK1353948T3 (da)
ES (1)	ES2250509T3 (da)
WO (1)	WO2002055552A2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10303974A1 (de)	2003-01-31	2004-08-05	Abbott Gmbh & Co. Kg	Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
EP1676859A1 (en) *	2004-12-30	2006-07-05	Pevion Biotech Ltd.	Immunogenic compositions of cyclic peptides derived from the beta-amyloid peptide
CN117903302A (zh)	2005-11-30	2024-04-19	Abbvie 公司	抗-Aβ球聚体抗体，其相关产品，生产所述抗体的方法，所述抗体的应用以及使用方法
PL1976877T5 (pl) *	2005-11-30	2017-09-29	Abbvie Inc	Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
US8455626B2 (en)	2006-11-30	2013-06-04	Abbott Laboratories	Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2486928A1 (en)	2007-02-27	2012-08-15	Abbott GmbH & Co. KG	Method for the treatment of amyloidoses
CN102112488A (zh) *	2008-07-01	2011-06-29	由卫生福利和体育大臣代表的荷兰王国	抗淀粉样折叠中间体的疫苗
US20110092445A1 (en) *	2008-07-25	2011-04-21	Abbott Laboratories	Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses
MX360403B (es)	2010-04-15	2018-10-31	Abbvie Inc	Proteinas de union a amiloide beta.
EP2603524A1 (en)	2010-08-14	2013-06-19	AbbVie Inc.	Amyloid-beta binding proteins
KR102786245B1 (ko)	2015-11-09	2025-03-26	더 유니버시티 오브 브리티쉬 콜롬비아	아밀로이드 베타 중간-영역 내 에피토프 및 이에 대해 구조적으로 선택성인 항체
KR20180094876A (ko)	2015-11-09	2018-08-24	더 유니버시티 오브 브리티쉬 콜롬비아	아밀로이드 베타 에피토프 및 이에 대한 항체
US20180125920A1 (en)	2016-11-09	2018-05-10	The University Of British Columbia	Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
US12286469B2 (en)	2017-07-18	2025-04-29	The University Of British Columbia	Humanized antibodies binding to amyloid-beta (A-beta)
KR20240013764A (ko)	2021-05-26	2024-01-30	리게인 테라퓨틱스 스웨덴 에이비	단백질병증의 치료 및/또는 예방을 위한 조성물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5262332A (en) *	1989-04-05	1993-11-16	Brigham And Women's Hospital	Diagnostic method for Alzheimer's disease: examination of non-neural tissue
ATE218583T1 (de) *	1995-03-14	2002-06-15	Praecis Pharm Inc	Verbindungen mit aggregations-modulierenden wirkung auf das amyloid protein
DE19725619A1 (de)	1997-06-17	1998-12-24	Fraunhofer Ges Forschung	Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
CN1636011A (zh) *	1998-12-24	2005-07-06	杜邦药品公司	作为Aβ蛋白产生抑制剂的琥珀酰氨基苯并二氮杂䓬
IL149392A0 (en) *	1999-11-05	2002-11-10	Axonyx Inc	PEPTIDE ANALOGS AND MIMETICS SUITABLE FOR IN VIVO USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL PROTEIN FOLDING INTO AMYLOID, AMYLOID-LIKE DEPOSITS OR β-SHEET RICH PATHOLOGICAL PRECURSOR THEREOF

2001
- 2001-01-13 DE DE10101430A patent/DE10101430B4/de not_active Expired - Fee Related
- 2001-12-21 EP EP01990584A patent/EP1353948B1/de not_active Expired - Lifetime
- 2001-12-21 DK DK01990584T patent/DK1353948T3/da active
- 2001-12-21 DE DE50107777T patent/DE50107777D1/de not_active Expired - Lifetime
- 2001-12-21 AT AT01990584T patent/ATE307143T1/de not_active IP Right Cessation
- 2001-12-21 ES ES01990584T patent/ES2250509T3/es not_active Expired - Lifetime
- 2001-12-21 WO PCT/EP2001/015181 patent/WO2002055552A2/de not_active Ceased
- 2001-12-21 US US10/250,581 patent/US7342091B2/en not_active Expired - Fee Related
- 2001-12-21 JP JP2002556620A patent/JP4079775B2/ja not_active Expired - Fee Related
- 2001-12-21 AU AU2002229677A patent/AU2002229677A1/en not_active Abandoned
- 2001-12-21 CA CA002433687A patent/CA2433687A1/en not_active Abandoned
2008
- 2008-01-09 US US11/971,695 patent/US20080146508A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1353948A2 (de)	2003-10-22
US20080146508A1 (en)	2008-06-19
AU2002229677A1 (en)	2002-07-24
US7342091B2 (en)	2008-03-11
ATE307143T1 (de)	2005-11-15
WO2002055552A2 (de)	2002-07-18
DE10101430B4 (de)	2008-10-02
WO2002055552A3 (de)	2003-04-24
JP4079775B2 (ja)	2008-04-23
US20040116337A1 (en)	2004-06-17
DE50107777D1 (de)	2005-11-24
EP1353948B1 (de)	2005-10-19
CA2433687A1 (en)	2002-07-18
ES2250509T3 (es)	2006-04-16
JP2004526693A (ja)	2004-09-02
DE10101430A1 (de)	2002-08-01

Publication	Publication Date	Title
DK1353948T3 (da)	2006-02-27	Oplöselige biologiske analoge til bata-amyloidpeptid
CO5611160A2 (es)	2006-02-28	Conjugados de agentes terapeuticos o citotoxicos y peptidos biologicamente activos
CR8012A (es)	2009-01-07	Clavo endomedular destinado al tratamiento de fracturas de femur proximal
DE60233157D1 (de)	2009-09-10	Zweikammer-herzschrittmacher-system zur diagnose und behebung von arrhythmien
ATE318590T1 (de)	2006-03-15	Arzneimittelkombinationen (z.b. chlorpromazin und pentamidin) zur therapie von neoplastischen erkrankungen
DK1206474T3 (da)	2004-10-04	Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer
YU9404A (sh)	2006-08-17	Multimerna, usmerena kontrastna sredstva na bazi peptida
ECSP045520A (es)	2005-03-10	Metodos de tratamiento con inhibidores de la ptec y agentes antihipertensivos
DK1292304T3 (da)	2005-12-19	Zolpidem Hemitartrat
ATE425253T1 (de)	2009-03-15	Tribonektine
PT1147420E (pt)	2004-12-31	Inibidor de tripsina urinario para o diagnostico da sida
MXPA03006776A (es)	2003-10-24	Uso de inhibidores de interleucina-18 para el tratamiento y/o prevencion de enfermedad cardiaca.
NO20005548D0 (no)	2000-11-03	Mykobakterieinhibitorer
IL158186A0 (en)	2004-03-28	Pharmaceutically active compounds and methods of use
AP2781A (en)	2013-10-31	Oxidized proteins, their biological activity, and therapeutic and diagnostic measures, which are derived from the active mechansim, from the use of these porteins or from the inhibition thereof
DE60215219D1 (de)	2006-11-16	Verwendung von darifenacin zur behandlung des harndrangs
DE50214523D1 (de)	2010-08-19	Nukleotidträger zur diagnose und therapie oraler erkrankungen
ATE328082T1 (de)	2006-06-15	Verkürztes bard1 protein und dessen diagnostische und therapeutische anwendungen
SE0002417D0 (sv)	2000-06-27	Promoter sequences
ATE443695T1 (de)	2009-10-15	Doppelester
WO2002097119A3 (de)	2003-05-30	Verwendung des nachweises der expression von splice-varianten von gen21 für die diagnose und therapie von tumorerkrankungen
UA28113C2 (uk)	2000-10-16	Спосіб експрес-тестування ефективності реабілітації здоров'я людини
ITRM20030219A0 (it)	2003-05-06	Uso della liquerizia per la prevenzione e la cura di aids e sars.