DK1027437T3 - Anvendelse af det WNT-1 inducerede udskilte polypeptid WISP-1 - Google Patents
Anvendelse af det WNT-1 inducerede udskilte polypeptid WISP-1Info
- Publication number
- DK1027437T3 DK1027437T3 DK98956340T DK98956340T DK1027437T3 DK 1027437 T3 DK1027437 T3 DK 1027437T3 DK 98956340 T DK98956340 T DK 98956340T DK 98956340 T DK98956340 T DK 98956340T DK 1027437 T3 DK1027437 T3 DK 1027437T3
- Authority
- DK
- Denmark
- Prior art keywords
- wnt
- polypeptides
- induced
- secreted polypeptide
- induced secreted
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000052547 Wnt-1 Human genes 0.000 title abstract 2
- 102100031173 CCN family member 4 Human genes 0.000 title 1
- 101710137353 CCN family member 4 Proteins 0.000 title 1
- 101150077398 WNT-1 gene Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101100156752 Caenorhabditis elegans cwn-1 gene Proteins 0.000 abstract 1
- 108700020987 Wnt-1 Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6370497P | 1997-10-29 | 1997-10-29 | |
| US7361298P | 1998-02-04 | 1998-02-04 | |
| US8169598P | 1998-04-14 | 1998-04-14 | |
| PCT/US1998/022991 WO1999021998A1 (en) | 1997-10-29 | 1998-10-29 | Wnt-1 induced secreted polypeptides: wisp-1, -2 and -3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1027437T3 true DK1027437T3 (da) | 2008-11-24 |
Family
ID=27370521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98956340T DK1027437T3 (da) | 1997-10-29 | 1998-10-29 | Anvendelse af det WNT-1 inducerede udskilte polypeptid WISP-1 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US6387657B1 (da) |
| EP (2) | EP1027437B8 (da) |
| JP (3) | JP2003533164A (da) |
| AT (1) | ATE406441T1 (da) |
| AU (2) | AU1288399A (da) |
| CA (1) | CA2306183A1 (da) |
| DE (1) | DE69839942D1 (da) |
| DK (1) | DK1027437T3 (da) |
| ES (1) | ES2313756T3 (da) |
| IL (2) | IL135704A (da) |
| WO (1) | WO1999021998A1 (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040132987A1 (en) * | 1996-11-08 | 2004-07-08 | Human Genome Sciences, Inc. | Connective tissue growth factor-3 |
| DK1027437T3 (da) * | 1997-10-29 | 2008-11-24 | Genentech Inc | Anvendelse af det WNT-1 inducerede udskilte polypeptid WISP-1 |
| US6395890B1 (en) | 1998-02-20 | 2002-05-28 | Zymogenetics, Inc. | Nucleic acids encoding connective tissue growth factor homologs |
| WO1999042583A1 (en) * | 1998-02-20 | 1999-08-26 | Zymogenetics, Inc. | Connective tissue growth factor homologs |
| AU3357799A (en) * | 1998-03-19 | 1999-10-11 | Trustees Of Tufts College | Novel heparin-induced ccn-like molecules and uses therefor |
| AU4411499A (en) * | 1998-06-05 | 1999-12-20 | Human Genome Sciences, Inc. | Connective tissue growth factor-4 |
| US20030148934A1 (en) * | 1998-06-30 | 2003-08-07 | Neil C. Corley | Growth factor modulators |
| US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| AU2437702A (en) * | 2000-10-16 | 2002-04-29 | Genentech Inc | Methods of treatment using wisp polypeptides |
| US7713526B2 (en) * | 2001-05-01 | 2010-05-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| AU2002308557A1 (en) * | 2001-05-01 | 2002-11-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| CA2489515C (en) * | 2002-06-29 | 2013-01-22 | Genentech, Inc. | Methods and compositions for modulating and detecting wisp activity |
| US7455834B2 (en) * | 2002-06-29 | 2008-11-25 | Genentech, Inc. | Methods and compositions for modulating and detecting WISP activity |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| EP2812350B1 (en) | 2012-02-11 | 2019-04-03 | F.Hoffmann-La Roche Ag | R-spondin translocations and methods using the same |
| GR1008033B (el) * | 2012-03-29 | 2013-11-18 | Βασιλειος Τσιλιβακος | Μεθοδος διερευνησης της παρουσιας ενδοκυτταριων μολυσματικων παραγοντων σε κυτταρα του σπερματος |
| TWI582239B (zh) * | 2013-03-11 | 2017-05-11 | 諾華公司 | 與wnt抑制劑相關之標記 |
| JP2017513854A (ja) * | 2014-04-15 | 2017-06-01 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | Wisp1に結合する抗原結合タンパク質 |
| JP7240749B2 (ja) * | 2017-09-29 | 2023-03-16 | ベスファジェン・インコーポレイテッド | 心不全の予防または治療のための医薬組成物 |
| US10831733B2 (en) * | 2017-12-22 | 2020-11-10 | International Business Machines Corporation | Interactive adjustment of decision rules |
| JP7264382B2 (ja) * | 2018-05-17 | 2023-04-25 | オリーブス バイオセラピューティクス インコーポレイテッド | 網膜疾患を予防又は治療するための、有効成分としてccn5を含む医薬組成物 |
| US20210388073A1 (en) * | 2018-10-19 | 2021-12-16 | The General Hospital Corporation | Compositions and Methods for Treatment of Liver Disease |
| WO2023055076A1 (ko) * | 2021-09-29 | 2023-04-06 | 이화여자대학교 산학협력단 | 암 전이 억제용 조성물 |
| WO2023182792A1 (ko) * | 2022-03-24 | 2023-09-28 | 이화여자대학교 산학협력단 | 암 성장 억제용 조성물 |
| WO2025160400A1 (en) * | 2024-01-26 | 2025-07-31 | Mediar Therapeutics, Inc. | Therapeutic antibody targeting wisp1 protein |
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-
1998
- 1998-10-29 DK DK98956340T patent/DK1027437T3/da active
- 1998-10-29 CA CA002306183A patent/CA2306183A1/en not_active Abandoned
- 1998-10-29 EP EP98956340A patent/EP1027437B8/en not_active Expired - Lifetime
- 1998-10-29 AT AT98956340T patent/ATE406441T1/de active
- 1998-10-29 WO PCT/US1998/022991 patent/WO1999021998A1/en not_active Ceased
- 1998-10-29 IL IL135704A patent/IL135704A/en not_active IP Right Cessation
- 1998-10-29 US US09/182,145 patent/US6387657B1/en not_active Expired - Lifetime
- 1998-10-29 EP EP08012474A patent/EP2014770A3/en not_active Withdrawn
- 1998-10-29 ES ES98956340T patent/ES2313756T3/es not_active Expired - Lifetime
- 1998-10-29 AU AU12883/99A patent/AU1288399A/en not_active Abandoned
- 1998-10-29 JP JP2000518090A patent/JP2003533164A/ja active Pending
- 1998-10-29 DE DE69839942T patent/DE69839942D1/de not_active Expired - Lifetime
-
2002
- 2002-03-27 US US10/112,267 patent/US7101850B2/en not_active Expired - Fee Related
-
2003
- 2003-02-24 AU AU2003201315A patent/AU2003201315B8/en not_active Ceased
-
2006
- 2006-07-17 US US11/488,375 patent/US20070041964A1/en not_active Abandoned
-
2008
- 2008-12-16 JP JP2008320202A patent/JP2009165470A/ja active Pending
- 2008-12-16 JP JP2008320203A patent/JP2009159956A/ja active Pending
-
2009
- 2009-12-29 US US12/648,425 patent/US20100221249A1/en not_active Abandoned
-
2011
- 2011-03-17 IL IL211788A patent/IL211788A0/en unknown
- 2011-05-26 US US13/117,051 patent/US8350008B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030068678A1 (en) | 2003-04-10 |
| AU2003201315A1 (en) | 2003-06-12 |
| IL135704A0 (en) | 2001-05-20 |
| AU1288399A (en) | 1999-05-17 |
| IL211788A0 (en) | 2011-05-31 |
| ES2313756T3 (es) | 2009-03-01 |
| AU2003201315A8 (en) | 2010-04-08 |
| IL135704A (en) | 2008-04-13 |
| WO1999021998A1 (en) | 1999-05-06 |
| US20110311540A1 (en) | 2011-12-22 |
| CA2306183A1 (en) | 1999-05-06 |
| EP1027437A1 (en) | 2000-08-16 |
| US20100221249A1 (en) | 2010-09-02 |
| EP1027437B8 (en) | 2008-10-29 |
| US6387657B1 (en) | 2002-05-14 |
| US8350008B2 (en) | 2013-01-08 |
| US7101850B2 (en) | 2006-09-05 |
| EP1027437B1 (en) | 2008-08-27 |
| JP2003533164A (ja) | 2003-11-11 |
| US20070041964A1 (en) | 2007-02-22 |
| AU2003201315B8 (en) | 2010-04-08 |
| DE69839942D1 (de) | 2008-10-09 |
| JP2009165470A (ja) | 2009-07-30 |
| AU2003201315B2 (en) | 2006-03-23 |
| JP2009159956A (ja) | 2009-07-23 |
| AU2003201315C1 (en) | 2007-03-08 |
| EP2014770A3 (en) | 2009-02-18 |
| EP2014770A2 (en) | 2009-01-14 |
| ATE406441T1 (de) | 2008-09-15 |
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