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DK1000062T3 - Tricykliske vasopressinagonister - Google Patents

Tricykliske vasopressinagonister

Info

Publication number
DK1000062T3
DK1000062T3 DK98938017T DK98938017T DK1000062T3 DK 1000062 T3 DK1000062 T3 DK 1000062T3 DK 98938017 T DK98938017 T DK 98938017T DK 98938017 T DK98938017 T DK 98938017T DK 1000062 T3 DK1000062 T3 DK 1000062T3
Authority
DK
Denmark
Prior art keywords
vasopressin agonists
tricyclic
tricyclic vasopressin
agonists
vasopressin
Prior art date
Application number
DK98938017T
Other languages
English (en)
Inventor
John Paul Dusza
Jay Donald Albright
Jehan Framroz Bagli
Amedeo Arturo Failli
Mark Anthony Ashwell
Thomas Joseph Caggiano
Eugene John Trybulski
Peter Sinchun Chan
Albert John Molinari
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1000062T3 publication Critical patent/DK1000062T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK98938017T 1997-07-30 1998-07-24 Tricykliske vasopressinagonister DK1000062T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90336997A 1997-07-30 1997-07-30
PCT/US1998/015495 WO1999006409A1 (en) 1997-07-30 1998-07-24 Tricyclic vasopressin agonists
EP98938017A EP1000062B1 (en) 1997-07-30 1998-07-24 Tricyclic vasopressin agonists

Publications (1)

Publication Number Publication Date
DK1000062T3 true DK1000062T3 (da) 2004-11-22

Family

ID=25417392

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98938017T DK1000062T3 (da) 1997-07-30 1998-07-24 Tricykliske vasopressinagonister

Country Status (22)

Country Link
EP (1) EP1000062B1 (da)
JP (1) JP4338305B2 (da)
KR (1) KR100580805B1 (da)
CN (1) CN1183134C (da)
AR (1) AR016557A1 (da)
AT (1) ATE277050T1 (da)
AU (1) AU756959B2 (da)
BR (1) BR9811585A (da)
CA (1) CA2297406C (da)
DE (1) DE69826487T2 (da)
DK (1) DK1000062T3 (da)
ES (1) ES2229525T3 (da)
HU (1) HUP0002480A3 (da)
IL (1) IL133788A0 (da)
NO (1) NO315273B1 (da)
NZ (1) NZ502449A (da)
PT (1) PT1000062E (da)
RU (1) RU2213094C2 (da)
SI (1) SI1000062T1 (da)
TW (1) TW502035B (da)
WO (1) WO1999006409A1 (da)
ZA (1) ZA986784B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
HU229074B1 (en) * 1999-01-19 2013-07-29 Ortho Mcneil Pharm Inc Tricyclic benzodiazepines as vasopressin receptor antagonists
US6831079B1 (en) * 1999-09-27 2004-12-14 American Cyanamid Company Vasopressin agonist formulation and process
CN1391476A (zh) * 1999-09-27 2003-01-15 美国氰胺公司 血管升压素激动剂制剂和方法
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
US7326700B2 (en) 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6903087B2 (en) 2001-04-12 2005-06-07 Wyeth Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7064120B2 (en) 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7202239B2 (en) 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US6900200B2 (en) * 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US6977254B2 (en) 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
AU2002342045C1 (en) * 2001-10-12 2009-07-30 Azevan Pharmaceuticals, Inc. Beta-lactamyl vasopressin Vla antagonists
RU2338747C2 (ru) * 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
WO2004096775A1 (ja) 2003-04-28 2004-11-11 Astellas Pharma Inc. ４，４－ジフルオロ－１，２，３，４－テトラヒドロ－５ｈ－１－ベンゾアゼピン誘導体又はその塩
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
EP1627876A1 (en) * 2004-08-20 2006-02-22 Ferring B.V. Heterocyclic condensed compounds useful as antidiuretic agents
WO2006021882A1 (en) * 2004-08-25 2006-03-02 Pfizer Limited Triazolobenzodiazepines and their use as vasopressin antagonists
CA2601709C (en) 2005-03-22 2017-02-14 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids
PE20110537A1 (es) 2008-11-13 2011-08-04 Hoffmann La Roche ESPIRO-5,6-DIHIDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENOS COMO ANTAGONISTAS DE LA V1a
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
US8420633B2 (en) * 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
GB201005623D0 (en) 2010-04-01 2010-05-19 Vantia Ltd New polymorph
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) * 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
WO2012003436A1 (en) 2010-07-01 2012-01-05 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
US9828345B2 (en) 2013-02-28 2017-11-28 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
CA2944211C (en) 2014-03-28 2022-10-04 Azevan Pharmaceuticals, Inc. Compositions and methods for treating neurodegenerative diseases
EP3681871A4 (en) 2017-09-15 2021-05-26 Azevan Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF A BRAIN DAMAGE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
TW359669B (en) * 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives

Also Published As

Publication number Publication date
CN1272111A (zh) 2000-11-01
ZA986784B (en) 2000-06-22
EP1000062A1 (en) 2000-05-17
WO1999006409A1 (en) 1999-02-11
BR9811585A (pt) 2000-09-26
PT1000062E (pt) 2004-12-31
EP1000062B1 (en) 2004-09-22
NO315273B1 (no) 2003-08-11
AR016557A1 (es) 2001-07-25
IL133788A0 (en) 2001-04-30
HUP0002480A3 (en) 2002-09-30
ATE277050T1 (de) 2004-10-15
TW502035B (en) 2002-09-11
CA2297406A1 (en) 1999-02-11
SI1000062T1 (en) 2004-12-31
AU756959B2 (en) 2003-01-30
RU2213094C2 (ru) 2003-09-27
KR20010022398A (ko) 2001-03-15
AU8663398A (en) 1999-02-22
NO20000242L (no) 2000-03-06
CN1183134C (zh) 2005-01-05
CA2297406C (en) 2009-02-24
KR100580805B1 (ko) 2006-05-17
DE69826487D1 (de) 2004-10-28
HUP0002480A2 (hu) 2000-11-28
ES2229525T3 (es) 2005-04-16
NO20000242D0 (no) 2000-01-18
DE69826487T2 (de) 2005-12-01
JP2001512125A (ja) 2001-08-21
JP4338305B2 (ja) 2009-10-07
NZ502449A (en) 2002-08-28

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