DK1073672T3 - Antipicornavirale forbindelser, deres fremstilling og anvendelse - Google Patents

Antipicornavirale forbindelser, deres fremstilling og anvendelse

Info

Publication number: DK1073672T3
Authority: DK; Denmark
Prior art keywords: preparation; antipicornaviral compounds; antipicornaviral; compounds
Prior art date: 1998-04-30

Application number

DK99900780T

Other languages

Danish (da)

English (en)

Inventor

Peter Scott Dragovich

Joseph Timothy Marakovits

Thomas Jay Prins

Jayashree Girish Tikhe

Stephen Evan Webber

Ru Zhou

Theodore O Johnson

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-30

Filing date

1999-01-05

Publication date

2003-12-08

1999-01-05 Application filed by Agouron Pharma filed Critical Agouron Pharma

2003-12-08 Application granted granted Critical

2003-12-08 Publication of DK1073672T3 publication Critical patent/DK1073672T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Pyridine Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines Containing Plant Substances (AREA)

DK99900780T 1998-04-30 1999-01-05 Antipicornavirale forbindelser, deres fremstilling og anvendelse DK1073672T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US8382898P	1998-04-30	1998-04-30
US9835898P	1998-08-28	1998-08-28
PCT/US1999/000260 WO1999057135A1 (fr)	1998-04-30	1999-01-05	Composes antipicornaviraux, leur preparation et leur utilisation

Publications (1)

Publication Number	Publication Date
DK1073672T3 true DK1073672T3 (da)	2003-12-08

Family

ID=26769788

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99900780T DK1073672T3 (da)	1998-04-30	1999-01-05	Antipicornavirale forbindelser, deres fremstilling og anvendelse

Country Status (33)

Country	Link
US (3)	US6531452B1 (fr)
EP (1)	EP1073672B1 (fr)
JP (1)	JP2003526600A (fr)
KR (1)	KR20010043004A (fr)
CN (1)	CN1198838C (fr)
AP (1)	AP2000001934A0 (fr)
AT (2)	ATE308557T1 (fr)
AU (1)	AU768539B2 (fr)
BG (1)	BG104899A (fr)
BR (1)	BR9910573A (fr)
CA (1)	CA2326763A1 (fr)
DE (2)	DE69928140D1 (fr)
DK (1)	DK1073672T3 (fr)
EA (1)	EA003856B1 (fr)
EE (1)	EE200000621A (fr)
ES (1)	ES2205760T3 (fr)
GE (1)	GEP20022824B (fr)
HR (1)	HRP20000623A2 (fr)
HU (1)	HUP0400624A2 (fr)
IL (1)	IL138609A0 (fr)
IS (1)	IS5633A (fr)
LT (1)	LT4846B (fr)
LV (1)	LV12666B (fr)
NO (1)	NO20005411L (fr)
NZ (1)	NZ507633A (fr)
OA (1)	OA11503A (fr)
PL (1)	PL351250A1 (fr)
PT (1)	PT1073672E (fr)
SI (1)	SI20428A (fr)
SK (1)	SK284714B6 (fr)
TR (1)	TR200003159T2 (fr)
WO (1)	WO1999057135A1 (fr)
YU (1)	YU66000A (fr)

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EA003856B1 (ru)	1998-04-30	2003-10-30	Агурон Фармасьютикалз, Инк.	Антипикорнавирусные композиции, их получение и применение
US6774243B2 (en)	1999-08-24	2004-08-10	Agouron Pharmaceuticals, Inc.	Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
US6355807B1 (en)	1999-08-24	2002-03-12	Agouron Pharmaceuticals, Inc.	Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PE20010517A1 (es) *	1999-08-24	2001-05-16	Agouron Pharma	Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
PA8507801A1 (es)	1999-12-03	2002-08-26	Agouron Pharma	Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
PA8515201A1 (es)	2000-04-14	2002-10-24	Agouron Pharma	Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis
JP2004503533A (ja) *	2000-06-14	2004-02-05	アグロン・ファーマシュウティカルズ・インコーポレーテッド	抗ピコルナウイルス化合物及び組成物、その医薬的使用、並びにその合成のための物質
WO2004093860A1 (fr) *	2003-04-21	2004-11-04	Pfizer Inc.	Inhibiteurs de proteinase de coronavirus apparente au virus du sras
US20040235952A1 (en) *	2003-05-05	2004-11-25	Agouron Pharmaceuticals, Inc.	Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase
US7462594B2 (en)	2003-12-31	2008-12-09	Taigen Biotechnology Co., Ltd.	Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
CA2550515A1 (fr) *	2003-12-31	2005-07-21	Taigen Biotechnology	Inhibiteurs de la protease
CN100363346C (zh) *	2004-10-22	2008-01-23	清华大学	冠状病毒主蛋白酶的小分子抑制剂、制备方法及其应用
US7893657B2 (en) *	2006-12-19	2011-02-22	Anand Kumar Chavakula	Multi-power charger and battery backup system
KR100891699B1 (ko)	2007-04-10	2009-04-03	광주과학기술원	7-아미노-4-((ｓ)-3-(4-플루오로페닐)-2-((r)-3-메틸-2-(5-메틸이소옥사졸-3-카복사미도)부탄아미도)프로판아미도)-7-옥소-2-헵테노에이트 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 및 치료용 약학적 조성물
US7741327B2 (en)	2008-04-16	2010-06-22	Hoffmann-La Roche Inc.	Pyrrolidinone glucokinase activators
AU2009250295B2 (en)	2008-05-21	2014-05-01	Genesis Technologies Limited	Selective caspase inhibitors and uses thereof
US9045524B2 (en)	2009-05-21	2015-06-02	Novagenesis Foundation	Selective caspase inhibitors and uses thereof
US8178689B2 (en)	2010-06-17	2012-05-15	Hoffman-La Roche Inc.	Tricyclic compounds
ES2665301T3 (es)	2011-04-15	2018-04-25	Genesis Technologies Limited	Inhibidores selectivos de cisteína proreasa y usos de los mismos
CN102838523A (zh) *	2011-06-23	2012-12-26	南开大学	抗肠病毒71(ev71)戊内酰胺类化合物及其制备方法和用途
CN103145608B (zh) *	2011-12-07	2015-09-02	南开大学	抗肠病毒71(ev71)己内酰胺类化合物及其制备方法和用途
RU2518314C2 (ru) *	2012-08-30	2014-06-10	Общество С Ограниченной Ответственностью "Фарминтерпрайсез"	Способ и средство активации irf-3 для лечения и профилактики заболеваний, вызываемых (+) phk-содержащими вирусами
CN110105348A (zh) *	2019-03-08	2019-08-09	南开大学	新型迈克尔受体类肠病毒71型抑制剂的制备及用途
AU2020289560A1 (en) *	2019-06-05	2021-12-23	Emory University	Peptidomimetics for the treatment of coronavirus and picornavirus infections
JP2021138694A (ja)	2020-03-06	2021-09-16	ファイザー・インク	ＳＡＲＳ−ＣｏＶ−２複製を阻害し、コロナウイルス疾患２０１９を処置する方法
CN115697328A (zh) *	2020-03-23	2023-02-03	约翰·M.H.·格雷格	抗病毒化合物及其给药方法
WO2022156692A1 (fr) *	2021-01-22	2022-07-28	中国人民解放军军事科学院军事医学研究院	Inhibiteur peptidique cyclique de protéase virale, son procédé de préparation et son application dans des médicaments antiviraux

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EA003856B1 (ru)	1998-04-30	2003-10-30	Агурон Фармасьютикалз, Инк.	Антипикорнавирусные композиции, их получение и применение
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DE60014670T2 (de)	1999-08-04	2006-03-09	Agouron Pharmaceuticals, Inc., San Diego	Antipicornavirale verbindungen und zusammensetzungen, ihre pharmazeutische verwendung, und materialien für ihre synthese
IL147862A0 (en)	1999-08-24	2002-08-14	Agouron Pharma	Process and intermediates for the preparation os isoxazolecaroxamides and analogues
PE20010517A1 (es)	1999-08-24	2001-05-16	Agouron Pharma	Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
PA8507801A1 (es)	1999-12-03	2002-08-26	Agouron Pharma	Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis

1999
- 1999-01-05 EA EA200001133A patent/EA003856B1/ru not_active IP Right Cessation
- 1999-01-05 KR KR1020007011851A patent/KR20010043004A/ko not_active Ceased
- 1999-01-05 PL PL99351250A patent/PL351250A1/xx not_active Application Discontinuation
- 1999-01-05 AT AT03009409T patent/ATE308557T1/de not_active IP Right Cessation
- 1999-01-05 TR TR2000/03159T patent/TR200003159T2/xx unknown
- 1999-01-05 IL IL13860999A patent/IL138609A0/xx unknown
- 1999-01-05 GE GEAP19995606A patent/GEP20022824B/en unknown
- 1999-01-05 SI SI9920041A patent/SI20428A/sl not_active IP Right Cessation
- 1999-01-05 CA CA002326763A patent/CA2326763A1/fr not_active Abandoned
- 1999-01-05 HR HR20000623A patent/HRP20000623A2/hr not_active Application Discontinuation
- 1999-01-05 AT AT99900780T patent/ATE248186T1/de not_active IP Right Cessation
- 1999-01-05 ES ES99900780T patent/ES2205760T3/es not_active Expired - Lifetime
- 1999-01-05 DK DK99900780T patent/DK1073672T3/da active
- 1999-01-05 LT LT2000109A patent/LT4846B/lt not_active IP Right Cessation
- 1999-01-05 NZ NZ507633A patent/NZ507633A/en unknown
- 1999-01-05 DE DE69928140T patent/DE69928140D1/de not_active Expired - Lifetime
- 1999-01-05 AU AU20287/99A patent/AU768539B2/en not_active Ceased
- 1999-01-05 YU YU66000A patent/YU66000A/sh unknown
- 1999-01-05 WO PCT/US1999/000260 patent/WO1999057135A1/fr not_active Ceased
- 1999-01-05 JP JP2000547104A patent/JP2003526600A/ja not_active Withdrawn
- 1999-01-05 DE DE69910762T patent/DE69910762T2/de not_active Expired - Fee Related
- 1999-01-05 HU HU0400624A patent/HUP0400624A2/hu unknown
- 1999-01-05 CN CNB998056278A patent/CN1198838C/zh not_active Expired - Fee Related
- 1999-01-05 AP APAP/P/2000/001934A patent/AP2000001934A0/en unknown
- 1999-01-05 SK SK1604-2000A patent/SK284714B6/sk unknown
- 1999-01-05 EP EP99900780A patent/EP1073672B1/fr not_active Expired - Lifetime
- 1999-01-05 PT PT99900780T patent/PT1073672E/pt unknown
- 1999-01-05 EE EEP200000621A patent/EE200000621A/xx unknown
- 1999-01-05 BR BR9910573-0A patent/BR9910573A/pt not_active IP Right Cessation
- 1999-04-29 US US09/301,977 patent/US6531452B1/en not_active Expired - Fee Related
2000
- 2000-09-22 IS IS5633A patent/IS5633A/is unknown
- 2000-10-20 OA OA1200000288A patent/OA11503A/en unknown
- 2000-10-27 NO NO20005411A patent/NO20005411L/no not_active Application Discontinuation
- 2000-11-01 BG BG104899A patent/BG104899A/xx unknown
- 2000-12-19 LV LV000162A patent/LV12666B/xx unknown
2002
- 2002-11-06 US US10/289,982 patent/US6995142B2/en not_active Expired - Fee Related
2005
- 2005-08-24 US US11/210,717 patent/US20060046966A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO20005411D0 (no)	2000-10-27
NO20005411L (no)	2000-10-27
HK1034722A1 (en)	2001-11-02
LV12666B (lv)	2001-11-20
US20030130204A1 (en)	2003-07-10
CN1198838C (zh)	2005-04-27
WO1999057135A1 (fr)	1999-11-11
DE69910762T2 (de)	2004-03-11
TR200003159T2 (tr)	2001-09-21
HRP20000623A2 (en)	2001-04-30
PT1073672E (pt)	2004-01-30
OA11503A (en)	2004-05-10
EA200001133A1 (ru)	2001-08-27
DE69928140D1 (de)	2005-12-08
BG104899A (en)	2001-08-31
NZ507633A (en)	2003-10-31
CA2326763A1 (fr)	1999-11-11
IL138609A0 (en)	2001-10-31
GEP20022824B (en)	2002-10-25
IS5633A (is)	2000-09-22
SK284714B6 (sk)	2005-09-08
AP2000001934A0 (en)	2000-12-31
EP1073672A1 (fr)	2001-02-07
EA003856B1 (ru)	2003-10-30
CN1311793A (zh)	2001-09-05
LT4846B (lt)	2001-10-25
EP1073672B1 (fr)	2003-08-27
US6531452B1 (en)	2003-03-11
JP2003526600A (ja)	2003-09-09
LT2000109A (en)	2001-05-25
DE69910762D1 (de)	2003-10-02
US20060046966A1 (en)	2006-03-02
ATE248186T1 (de)	2003-09-15
HUP0400624A2 (hu)	2004-06-28
ES2205760T3 (es)	2004-05-01
AU768539B2 (en)	2003-12-18
SI20428A (sl)	2001-06-30
KR20010043004A (ko)	2001-05-25
AU2028799A (en)	1999-11-23
SK16042000A3 (sk)	2001-05-10
ATE308557T1 (de)	2005-11-15
BR9910573A (pt)	2001-01-16
LV12666A (en)	2001-05-20
EE200000621A (et)	2002-06-17
YU66000A (sh)	2003-12-31
PL351250A1 (en)	2003-04-07
US6995142B2 (en)	2006-02-07

Publication	Publication Date	Title
NO20015156L (no)	2001-12-18	5-pyridyl-1,3-azolforbindelser, deres fremstilling og anvendelse
NO20014603D0 (no)	2001-09-21	Tienopyrimidinforbindelser, deres fremstilling og anvendelse
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