DK1047701T3 - Antioxidanter målrettet mod mitokondrier - Google Patents
Antioxidanter målrettet mod mitokondrierInfo
- Publication number
- DK1047701T3 DK1047701T3 DK98961702T DK98961702T DK1047701T3 DK 1047701 T3 DK1047701 T3 DK 1047701T3 DK 98961702 T DK98961702 T DK 98961702T DK 98961702 T DK98961702 T DK 98961702T DK 1047701 T3 DK1047701 T3 DK 1047701T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- antioxidant
- compound
- mitochondria
- cation
- Prior art date
Links
- 239000003963 antioxidant agent Substances 0.000 title abstract 5
- 210000003470 mitochondria Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000003078 antioxidant effect Effects 0.000 abstract 4
- 150000001768 cations Chemical class 0.000 abstract 2
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ32925597 | 1997-11-25 | ||
| PCT/NZ1998/000173 WO1999026954A1 (fr) | 1997-11-25 | 1998-11-25 | Composes cibles vers les mitochondries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1047701T3 true DK1047701T3 (da) | 2005-08-15 |
Family
ID=19926531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98961702T DK1047701T3 (da) | 1997-11-25 | 1998-11-25 | Antioxidanter målrettet mod mitokondrier |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1047701B1 (fr) |
| JP (1) | JP4590523B2 (fr) |
| CN (1) | CN1318434C (fr) |
| AT (1) | ATE296305T1 (fr) |
| AU (2) | AU763179B2 (fr) |
| CA (1) | CA2311318C (fr) |
| DE (1) | DE69830338T2 (fr) |
| DK (1) | DK1047701T3 (fr) |
| ES (1) | ES2244104T3 (fr) |
| NZ (1) | NZ505352A (fr) |
| PT (1) | PT1047701E (fr) |
| WO (2) | WO1999026582A2 (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002501018A (ja) * | 1998-01-26 | 2002-01-15 | マイトコー | ミトコンドリア関連疾患を処置するためのミトコンドリア保護剤 |
| CA2354743A1 (fr) * | 2001-08-07 | 2003-02-07 | University Of Otago | Antioxydants cibles par des mitochondries |
| CA2397684A1 (fr) * | 2002-08-12 | 2004-02-12 | Michael P. Murphy | Antioxydants cibles par des mitochondries |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| CA2536546C (fr) * | 2003-08-22 | 2012-10-02 | Antipodean Pharmaceuticals, Inc. | Derives de la mitoquinone utilises en tant qu'antioxydants cibles de maniere mitochondriale |
| IL173807A (en) | 2003-08-22 | 2014-02-27 | Antipodean Pharmaceuticals Inc | Antioxidant amphiphilic compounds, histoquinone history and pharmaceutical preparations containing them |
| NZ528966A (en) * | 2003-10-17 | 2006-11-30 | Otago Innovation Ltd | Peptide nucleic acid conjugates and uses thereof |
| CN101018795A (zh) | 2004-04-09 | 2007-08-15 | 瓦洛里塞森－勒谢什公司 | 鏻盐衍生物及其用作溶解度控制助剂的用途 |
| RU2318500C2 (ru) * | 2005-10-18 | 2008-03-10 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели |
| US9045505B2 (en) | 2006-09-28 | 2015-06-02 | University Of Otago | Nitric oxide donors |
| EA200900583A1 (ru) | 2006-10-20 | 2009-08-28 | Общество С Ограниченной Ответственностью "Митотехнология" | Композиция для регенерации, стимуляции роста и адаптации растений к различным стрессовым факторам |
| EP2119436A4 (fr) | 2006-10-20 | 2010-03-03 | Ltd Liability Company Mitotech | Compositions pharmaceutiques pour la prévention et le traitement de pathologies oculaires |
| US8349902B2 (en) | 2007-01-29 | 2013-01-08 | Mitotech Sa | Pharmaceutical compositions useful for preventing and treating oncological diseases |
| US9427444B2 (en) | 2007-01-29 | 2016-08-30 | Mitotech Sa | Pharmaceutical and cosmetic compositions for accelerated healing of wounds and other surface damages |
| EA201000142A1 (ru) | 2007-04-11 | 2010-04-30 | Общество С Ограниченной Ответственностью "Митотехнология" | Композиция, замедляющая старение и увеличивающая продолжительность жизни организма, и ее применение |
| US8518915B2 (en) | 2007-06-29 | 2013-08-27 | Mitotech Sa | Use of mitochondrially-addressed compounds for preventing and treating cardiovascular diseases |
| WO2009145982A1 (fr) * | 2008-04-01 | 2009-12-03 | Antipodean Pharmaceuticals, Inc. | Compositions et procédés pour le soin de la peau |
| US9308214B2 (en) | 2008-11-12 | 2016-04-12 | Mitotech S.A. | Method for moderately increasing the proton conductivity of biological membranes with the aid of mitochondria-targeted delocalized cations |
| EP2823814A1 (fr) | 2009-06-10 | 2015-01-14 | Mitotech SA | Composition Pharmaceutique utilisable en ophtalmologie Médicale et Vétérinaire |
| KR20120125980A (ko) | 2009-11-13 | 2012-11-19 | 리미티드 라이어빌러티 컴퍼니 미토테크 | 미토콘드리아 표적화된 항산화제에 기초한 약학적 물질 |
| CN103764132B (zh) | 2011-06-03 | 2017-04-12 | 米托特克公司 | 线粒体靶向的抗氧化剂的口服制剂及其制备和用途 |
| EP3030267A2 (fr) * | 2013-04-11 | 2016-06-15 | Mitotech SA | Toluquinones et timoquinones à ciblage mitochondrial |
| EP3099163B1 (fr) * | 2014-01-30 | 2019-12-11 | F.Hoffmann-La Roche Ag | Stabilisation de sang entier à température ambiante |
| US9314457B2 (en) | 2014-06-19 | 2016-04-19 | The University Of Utah Research Foundation | Methods of treating and preventing vascular instability diseases |
| CN105833289B (zh) * | 2016-05-30 | 2019-04-09 | 上海交通大学 | 一种线粒体靶向的纳米药物递送系统及其制备方法与应用 |
| EP3612544B1 (fr) * | 2017-04-20 | 2022-11-23 | Rising Tide Foundation | Dérivés d'azithromycine contenant un ion phosphonium en tant qu'agents anticancéreux |
| US11161862B2 (en) | 2017-04-20 | 2021-11-02 | Oxford University Innovation Limited | Phosphonium-ion tethered tetracycline drugs for treatment of cancer |
| US11098073B2 (en) | 2017-04-20 | 2021-08-24 | Oxford University Innovation Limited | Triphenylphosphonium-tethered tetracyclines for use in treating cancer |
| EP3612543B1 (fr) | 2017-04-20 | 2022-11-23 | Rising Tide Foundation | Dérivés d'azithromycine contenant un ion phosphonium en tant qu'agents anticancéreux |
| WO2018195434A1 (fr) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Vitamine c et doxycycline : polythérapie létale synthétique pour éradiquer des cellules souches cancéreuses (csc) |
| EP3612177A4 (fr) | 2017-04-21 | 2021-01-13 | Lunella Biotech, Inc. | Ciblage de cellules souches cancéreuses hypoxiques (csc) à l'aide de doxycycline : implications pour améliorer une thérapie anti-angiogénique |
| CA3063717C (fr) | 2017-05-19 | 2021-08-24 | Lunella Biotech, Inc. | Antimitoscines : inhibiteurs cibles de biogenese mitochondriale pour eradiquer les cellules souches cancereuses |
| WO2018213764A1 (fr) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Diagnostic compagnon pour inhibiteurs mitochondriaux |
| BR112019026097A2 (pt) | 2017-06-26 | 2020-07-07 | Lunella Biotech, Inc. | mitoketoscins: terapêuticos à base de mitocôndrias com direcionamento no metabolismo da cetona em células cancerígenas |
| US20210246144A1 (en) | 2017-06-26 | 2021-08-12 | Mitotech S.A. | A set of mitochondria-targeted compounds |
| CN109293698B (zh) * | 2018-10-15 | 2021-02-02 | 山西大学 | 一种基于苯并噻唑的线粒体pH荧光探针及其制备方法 |
| CN110016048B (zh) * | 2019-04-26 | 2020-06-30 | 山东大学 | 线粒体靶向ir780碘化物的衍生物及制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3532667A (en) * | 1967-05-31 | 1970-10-06 | Du Pont | Polyamides stabilized with phosphonium halides |
| EP0535283A1 (fr) * | 1991-10-02 | 1993-04-07 | Merrell Dow Pharmaceuticals Inc. | Analogues de tocophérol cardioprotectives |
| CA2354743A1 (fr) * | 2001-08-07 | 2003-02-07 | University Of Otago | Antioxydants cibles par des mitochondries |
-
1998
- 1998-11-25 AU AU16965/99A patent/AU763179B2/en not_active Expired
- 1998-11-25 DK DK98961702T patent/DK1047701T3/da active
- 1998-11-25 AT AT98961702T patent/ATE296305T1/de active
- 1998-11-25 WO PCT/NZ1998/000172 patent/WO1999026582A2/fr not_active Ceased
- 1998-11-25 NZ NZ505352A patent/NZ505352A/xx not_active IP Right Cessation
- 1998-11-25 PT PT98961702T patent/PT1047701E/pt unknown
- 1998-11-25 JP JP2000522111A patent/JP4590523B2/ja not_active Expired - Fee Related
- 1998-11-25 EP EP98961702A patent/EP1047701B1/fr not_active Expired - Lifetime
- 1998-11-25 AU AU16964/99A patent/AU1696499A/en not_active Withdrawn
- 1998-11-25 WO PCT/NZ1998/000173 patent/WO1999026954A1/fr not_active Ceased
- 1998-11-25 ES ES98961702T patent/ES2244104T3/es not_active Expired - Lifetime
- 1998-11-25 CA CA2311318A patent/CA2311318C/fr not_active Expired - Lifetime
- 1998-11-25 DE DE69830338T patent/DE69830338T2/de not_active Expired - Lifetime
- 1998-11-25 CN CNB988123142A patent/CN1318434C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69830338T2 (de) | 2006-02-02 |
| CN1318434C (zh) | 2007-05-30 |
| EP1047701B1 (fr) | 2005-05-25 |
| AU1696499A (en) | 1999-06-15 |
| WO1999026582A2 (fr) | 1999-06-03 |
| CN1282334A (zh) | 2001-01-31 |
| ATE296305T1 (de) | 2005-06-15 |
| CA2311318C (fr) | 2011-11-01 |
| CA2311318A1 (fr) | 1999-06-03 |
| EP1047701A4 (fr) | 2002-03-27 |
| AU763179B2 (en) | 2003-07-17 |
| AU1696599A (en) | 1999-06-15 |
| DE69830338D1 (de) | 2005-06-30 |
| ES2244104T3 (es) | 2005-12-01 |
| JP4590523B2 (ja) | 2010-12-01 |
| JP2001524483A (ja) | 2001-12-04 |
| EP1047701A1 (fr) | 2000-11-02 |
| WO1999026954A1 (fr) | 1999-06-03 |
| NZ505352A (en) | 2002-12-20 |
| PT1047701E (pt) | 2005-10-31 |
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