DE69830338D1 - Antioxidantien mit spezifischer wirkung auf mitochondrien - Google Patents
Antioxidantien mit spezifischer wirkung auf mitochondrienInfo
- Publication number
- DE69830338D1 DE69830338D1 DE69830338T DE69830338T DE69830338D1 DE 69830338 D1 DE69830338 D1 DE 69830338D1 DE 69830338 T DE69830338 T DE 69830338T DE 69830338 T DE69830338 T DE 69830338T DE 69830338 D1 DE69830338 D1 DE 69830338D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- mitochondria
- antioxidants
- antioxidant
- specific effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003963 antioxidant agent Substances 0.000 title abstract 5
- 210000003470 mitochondria Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000003078 antioxidant effect Effects 0.000 abstract 4
- 150000001768 cations Chemical class 0.000 abstract 2
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ32925597 | 1997-11-25 | ||
| NZ32925597 | 1997-11-25 | ||
| PCT/NZ1998/000173 WO1999026954A1 (en) | 1997-11-25 | 1998-11-25 | Mitochondrially targeted antioxidants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69830338D1 true DE69830338D1 (de) | 2005-06-30 |
| DE69830338T2 DE69830338T2 (de) | 2006-02-02 |
Family
ID=19926531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69830338T Expired - Lifetime DE69830338T2 (de) | 1997-11-25 | 1998-11-25 | Antioxidantien mit spezifischer wirkung auf mitochondrien |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1047701B1 (de) |
| JP (1) | JP4590523B2 (de) |
| CN (1) | CN1318434C (de) |
| AT (1) | ATE296305T1 (de) |
| AU (2) | AU1696499A (de) |
| CA (1) | CA2311318C (de) |
| DE (1) | DE69830338T2 (de) |
| DK (1) | DK1047701T3 (de) |
| ES (1) | ES2244104T3 (de) |
| NZ (1) | NZ505352A (de) |
| PT (1) | PT1047701E (de) |
| WO (2) | WO1999026582A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2319131A1 (en) | 1998-01-26 | 1999-07-29 | Walter H. Moos | Mitochondria protecting agents for treating mitochondria associated diseases |
| CA2354743A1 (en) * | 2001-08-07 | 2003-02-07 | University Of Otago | Mitochondrially targeted antioxidants |
| CA2397684A1 (en) * | 2002-08-12 | 2004-02-12 | Michael P. Murphy | Mitochondrially targeted antioxidants |
| ES2541769T3 (es) | 2003-08-22 | 2015-07-24 | Antipodean Pharmaceuticals, Inc. | Derivados de mitoquinona usados como antioxidantes dirigidos a las mitocondrias |
| CA2536546C (en) * | 2003-08-22 | 2012-10-02 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| NZ528966A (en) * | 2003-10-17 | 2006-11-30 | Otago Innovation Ltd | Peptide nucleic acid conjugates and uses thereof |
| WO2005097812A1 (en) | 2004-04-09 | 2005-10-20 | Valorisation-Recherche, Société en Commandite | Phosphonium salts derivatives and their use as solubility controlling auxiliaries |
| RU2318500C2 (ru) * | 2005-10-18 | 2008-03-10 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели |
| US9045505B2 (en) | 2006-09-28 | 2015-06-02 | University Of Otago | Nitric oxide donors |
| US8658624B2 (en) | 2006-10-20 | 2014-02-25 | Mitotech Sa | Pharmaceutical compositions for preventing and treating eye pathologies |
| US8557733B2 (en) | 2006-10-20 | 2013-10-15 | Mitotech S.A. | Composition for regenerating and stimulating growth of plants and for adapting plants to different stress factors |
| WO2008094062A1 (en) * | 2007-01-29 | 2008-08-07 | Limited Liability Company 'mitotechnology' | Pharmaceutical compositions useful for preventing and treating oncological diseases |
| WO2008094061A1 (en) * | 2007-01-29 | 2008-08-07 | Limited Liability Company 'mitotechnology' | Pharmaceutical and cosmetic compositions for accelerated healing of wounds and other surface damages |
| EA201000142A1 (ru) * | 2007-04-11 | 2010-04-30 | Общество С Ограниченной Ответственностью "Митотехнология" | Композиция, замедляющая старение и увеличивающая продолжительность жизни организма, и ее применение |
| WO2009005386A1 (en) * | 2007-06-29 | 2009-01-08 | Limited Liability Company 'mitotechnology' | Use of mitochondrially-addressed compounds for preventing and treating cardiovascular diseases |
| JP6227856B2 (ja) | 2008-04-01 | 2017-11-08 | アントイポデアン ファーマシューティカルズ， インコーポレイテッド | スキンケア用組成物及び方法 |
| WO2010056145A1 (ru) | 2008-11-12 | 2010-05-20 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ умеренного повышения протонной проводимости биологических мембран при помощи митохондриально- адресованных делокализованных катионов |
| KR101478728B1 (ko) | 2009-06-10 | 2015-01-02 | 리미티드 라이어빌러티 컴퍼니 미토테크 | 안과 및 수의 안과에서 사용하기 위한 약학적 조성물 |
| EP2500336A1 (de) | 2009-11-13 | 2012-09-19 | Obschestvo S Ogranichennoi Otvetstvennostyu "Mitotekh" | Pharmazeutische stoffe auf der basis von auf mitochondrien gerichteten antioxidantien |
| JP6448366B2 (ja) | 2011-06-03 | 2019-01-09 | ミトテック ソシエテ アノニム | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
| WO2015063553A2 (en) * | 2013-04-11 | 2015-05-07 | Mitotech S.A. | Mitochondrially-targeted timoquinones and toluquinones |
| JP6382323B2 (ja) | 2014-01-30 | 2018-08-29 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 室温での全血の安定化 |
| US9314457B2 (en) | 2014-06-19 | 2016-04-19 | The University Of Utah Research Foundation | Methods of treating and preventing vascular instability diseases |
| CN105833289B (zh) * | 2016-05-30 | 2019-04-09 | 上海交通大学 | 一种线粒体靶向的纳米药物递送系统及其制备方法与应用 |
| CA3060892A1 (en) * | 2017-04-20 | 2018-10-25 | Rising Tide Foundation | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| US11560395B2 (en) | 2017-04-20 | 2023-01-24 | Rising Tide Foundation | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| EP3612540A1 (de) * | 2017-04-20 | 2020-02-26 | Rising Tide Foundation | An triphenylphosphonium gebundene tetracycycline zur behandlung von krebs |
| EP3612539A1 (de) * | 2017-04-20 | 2020-02-26 | Rising Tide Foundation | Phosphonium-ionen-gebundene tetracyclin-arzneimittel zur behandlung von krebs |
| CA3060510A1 (en) | 2017-04-21 | 2018-10-25 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| WO2018195446A1 (en) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy |
| PH12019502594A1 (en) | 2017-05-19 | 2020-10-26 | Lunella Biotech Inc | Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| WO2018213764A1 (en) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| RU2020102908A (ru) | 2017-06-26 | 2021-07-27 | Лунелла Байотек, Инк. | Митокетосцины: митохондриальная терапия, нацеленная на кетоновый метаболизм в раковых клетках |
| US20210246144A1 (en) | 2017-06-26 | 2021-08-12 | Mitotech S.A. | A set of mitochondria-targeted compounds |
| CN109293698B (zh) * | 2018-10-15 | 2021-02-02 | 山西大学 | 一种基于苯并噻唑的线粒体pH荧光探针及其制备方法 |
| CN110016048B (zh) * | 2019-04-26 | 2020-06-30 | 山东大学 | 线粒体靶向ir780碘化物的衍生物及制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3532667A (en) * | 1967-05-31 | 1970-10-06 | Du Pont | Polyamides stabilized with phosphonium halides |
| EP0535283A1 (de) * | 1991-10-02 | 1993-04-07 | Merrell Dow Pharmaceuticals Inc. | Tocopherol Analoge mit kardioprotektiver Wirkung |
| CA2354743A1 (en) * | 2001-08-07 | 2003-02-07 | University Of Otago | Mitochondrially targeted antioxidants |
-
1998
- 1998-11-25 CN CNB988123142A patent/CN1318434C/zh not_active Expired - Lifetime
- 1998-11-25 WO PCT/NZ1998/000172 patent/WO1999026582A2/en not_active Ceased
- 1998-11-25 AU AU16964/99A patent/AU1696499A/en not_active Withdrawn
- 1998-11-25 NZ NZ505352A patent/NZ505352A/xx not_active IP Right Cessation
- 1998-11-25 JP JP2000522111A patent/JP4590523B2/ja not_active Expired - Fee Related
- 1998-11-25 ES ES98961702T patent/ES2244104T3/es not_active Expired - Lifetime
- 1998-11-25 CA CA2311318A patent/CA2311318C/en not_active Expired - Lifetime
- 1998-11-25 DK DK98961702T patent/DK1047701T3/da active
- 1998-11-25 PT PT98961702T patent/PT1047701E/pt unknown
- 1998-11-25 AT AT98961702T patent/ATE296305T1/de active
- 1998-11-25 AU AU16965/99A patent/AU763179B2/en not_active Expired
- 1998-11-25 WO PCT/NZ1998/000173 patent/WO1999026954A1/en not_active Ceased
- 1998-11-25 DE DE69830338T patent/DE69830338T2/de not_active Expired - Lifetime
- 1998-11-25 EP EP98961702A patent/EP1047701B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999026954A1 (en) | 1999-06-03 |
| ES2244104T3 (es) | 2005-12-01 |
| JP4590523B2 (ja) | 2010-12-01 |
| CA2311318A1 (en) | 1999-06-03 |
| AU763179B2 (en) | 2003-07-17 |
| AU1696499A (en) | 1999-06-15 |
| NZ505352A (en) | 2002-12-20 |
| PT1047701E (pt) | 2005-10-31 |
| CN1282334A (zh) | 2001-01-31 |
| DE69830338T2 (de) | 2006-02-02 |
| EP1047701B1 (de) | 2005-05-25 |
| ATE296305T1 (de) | 2005-06-15 |
| DK1047701T3 (da) | 2005-08-15 |
| EP1047701A4 (de) | 2002-03-27 |
| CN1318434C (zh) | 2007-05-30 |
| AU1696599A (en) | 1999-06-15 |
| EP1047701A1 (de) | 2000-11-02 |
| JP2001524483A (ja) | 2001-12-04 |
| WO1999026582A2 (en) | 1999-06-03 |
| CA2311318C (en) | 2011-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |