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DK0938584T3 - Fremgangsmåde til fremstilling af (S)-eller (R)-3,3,3-trifluor-2-hydroxy-2-methylpropionsyre - Google Patents

Fremgangsmåde til fremstilling af (S)-eller (R)-3,3,3-trifluor-2-hydroxy-2-methylpropionsyre

Info

Publication number
DK0938584T3
DK0938584T3 DK97938817T DK97938817T DK0938584T3 DK 0938584 T3 DK0938584 T3 DK 0938584T3 DK 97938817 T DK97938817 T DK 97938817T DK 97938817 T DK97938817 T DK 97938817T DK 0938584 T3 DK0938584 T3 DK 0938584T3
Authority
DK
Denmark
Prior art keywords
trifluoro
hydroxy
preparation
methylpropionic acid
novel
Prior art date
Application number
DK97938817T
Other languages
Danish (da)
English (en)
Inventor
Thomas Zimmermann
Walter Brieden
Andrew Naughton
Karen Robins
Nicholas Shaw
Andreas Tinschert
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of DK0938584T3 publication Critical patent/DK0938584T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK97938817T 1996-07-10 1997-07-10 Fremgangsmåde til fremstilling af (S)-eller (R)-3,3,3-trifluor-2-hydroxy-2-methylpropionsyre DK0938584T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH172396 1996-07-10
CH50097 1997-03-03
PCT/EP1997/003670 WO1998001568A2 (fr) 1996-07-10 1997-07-10 Procede de production d'acide (s)- ou (r)-3,3,3-trifluoro-2-hydroxy-2-methylpropionique

Publications (1)

Publication Number Publication Date
DK0938584T3 true DK0938584T3 (da) 2008-09-22

Family

ID=25684754

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97938817T DK0938584T3 (da) 1996-07-10 1997-07-10 Fremgangsmåde til fremstilling af (S)-eller (R)-3,3,3-trifluor-2-hydroxy-2-methylpropionsyre

Country Status (11)

Country Link
US (3) US6773910B1 (fr)
EP (1) EP0938584B1 (fr)
JP (2) JP4326595B2 (fr)
AT (1) ATE397088T1 (fr)
AU (1) AU4113797A (fr)
CA (1) CA2259954C (fr)
DE (1) DE59712943D1 (fr)
DK (1) DK0938584T3 (fr)
ES (1) ES2308788T3 (fr)
PT (1) PT938584E (fr)
WO (1) WO1998001568A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2259954C (fr) * 1996-07-10 2012-03-06 Lonza Ag Procede de preparation d'acide (s)- ou (r)-3,3,3-trifluoro-2-hydroxy-2-methylpropionique
ATE286539T1 (de) * 1999-02-23 2005-01-15 Lonza Ag Verfahren zur herstellung von optisch aktiven 3,3,3- trifluormethyl- 2- alkylpropionsäurederivaten
DE60042364D1 (de) * 1999-04-16 2009-07-23 Mitsubishi Rayon Co Neue amidasegene
AT410545B (de) * 2001-11-07 2003-05-26 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von chiralen alpha-hydroxycarbonsäuren
DE602005023466D1 (de) * 2004-07-22 2010-10-21 Mitsubishi Gas Chemical Co Asymmetrische l-aminosäureamid-hydrolase und dafür codierende dna
EP1881077A1 (fr) * 2006-07-19 2008-01-23 Solvay Organics GmbH Procédé de préparation des acides hydroxycarboxyliques contenant du fluor
JP6201120B2 (ja) * 2013-03-04 2017-09-27 公立大学法人 富山県立大学 光学活性３，３，３−トリフルオロ−２−ヒドロキシ−２−メチルプロピオン酸の製造方法
CN106085993B (zh) * 2016-06-30 2019-07-26 浙江工业大学 一种来源于葡萄藤伯克氏菌的酰胺酶、基因、菌株及其应用
CN111621541B (zh) * 2019-02-27 2025-10-31 广安摩珈生物科技有限公司 使用电渗析技术拆分光学异构体的方法
CN116083406B (zh) * 2022-12-02 2025-03-25 凯莱英生命科学技术(天津)有限公司 酰胺酶突变体及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356912A3 (fr) * 1988-08-29 1991-09-18 Idemitsu Kosan Company Limited Procédé de préparation d'une acide carbonique 2-substitué optiquement actif
FR2655660B1 (fr) 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.
GB9214120D0 (en) * 1991-07-25 1992-08-12 Ici Plc Therapeutic amides
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5773221A (en) 1995-12-15 1998-06-30 Oceanix Biosciences Corporation Method of recovering a biological molecule from a recombinant microorganism
CA2259954C (fr) 1996-07-10 2012-03-06 Lonza Ag Procede de preparation d'acide (s)- ou (r)-3,3,3-trifluoro-2-hydroxy-2-methylpropionique
AU6611498A (en) 1997-03-18 1998-10-12 Novo Nordisk A/S Method for constructing a library using dna shuffling
US6153410A (en) 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers

Also Published As

Publication number Publication date
CA2259954A1 (fr) 1998-01-15
WO1998001568A2 (fr) 1998-01-15
WO1998001568A3 (fr) 1998-02-19
US20060177919A1 (en) 2006-08-10
US7553652B2 (en) 2009-06-30
JP4705089B2 (ja) 2011-06-22
JP2000513942A (ja) 2000-10-24
US6773910B1 (en) 2004-08-10
CA2259954C (fr) 2012-03-06
JP2008148694A (ja) 2008-07-03
EP0938584B1 (fr) 2008-05-28
DE59712943D1 (de) 2008-07-10
JP4326595B2 (ja) 2009-09-09
US7074606B2 (en) 2006-07-11
ATE397088T1 (de) 2008-06-15
ES2308788T3 (es) 2008-12-01
EP0938584A2 (fr) 1999-09-01
US20030087402A1 (en) 2003-05-08
PT938584E (pt) 2008-08-29
AU4113797A (en) 1998-02-02

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