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DK0915864T3 - Gastrobeskyttende flavon/flavanonforbindelser med terapeutisk virkning på inflammatoriske tarmsygdomme - Google Patents

Gastrobeskyttende flavon/flavanonforbindelser med terapeutisk virkning på inflammatoriske tarmsygdomme

Info

Publication number
DK0915864T3
DK0915864T3 DK97932032T DK97932032T DK0915864T3 DK 0915864 T3 DK0915864 T3 DK 0915864T3 DK 97932032 T DK97932032 T DK 97932032T DK 97932032 T DK97932032 T DK 97932032T DK 0915864 T3 DK0915864 T3 DK 0915864T3
Authority
DK
Denmark
Prior art keywords
gastroprotective
flavone
therapeutic effect
inflammatory bowel
bowel diseases
Prior art date
Application number
DK97932032T
Other languages
Danish (da)
English (en)
Inventor
Moohi Yoo
Mi Won Imkwang Apt - Son
Ik Yon - Naeyou-Dong Deoky Kim
Won Bae Hyundai Apt - Kaep Kim
Soon Hoe Jookong Apt - Kim
Sang Deuk Eunma Apt - Daec Lee
Geun Jho Myoungsodae Hyund Lim
Joong In Lim
Byoung Ok Ahn
Nam Gi Baik
Dong Sung Kim
Tae Young Oh
Byung Kwon Ryu
Jae Sung Yang
Hee Chan Shin
Original Assignee
Dong A Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong A Pharm Co Ltd filed Critical Dong A Pharm Co Ltd
Application granted granted Critical
Publication of DK0915864T3 publication Critical patent/DK0915864T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
DK97932032T 1996-07-25 1997-07-25 Gastrobeskyttende flavon/flavanonforbindelser med terapeutisk virkning på inflammatoriske tarmsygdomme DK0915864T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019960030494A KR100447918B1 (ko) 1996-07-25 1996-07-25 대장을포함한위장관보호작용을갖는플라본및플라바논화합물
PCT/KR1997/000144 WO1998004541A1 (fr) 1996-07-25 1997-07-25 Composes de flavone/flavonone de protection contre la gastrite et leur effet therapeutique sur l'affection intestinale inflammatoire

Publications (1)

Publication Number Publication Date
DK0915864T3 true DK0915864T3 (da) 2002-12-30

Family

ID=19467593

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97932032T DK0915864T3 (da) 1996-07-25 1997-07-25 Gastrobeskyttende flavon/flavanonforbindelser med terapeutisk virkning på inflammatoriske tarmsygdomme

Country Status (8)

Country Link
US (1) US6025387A (fr)
EP (1) EP0915864B1 (fr)
JP (1) JP3377214B2 (fr)
KR (1) KR100447918B1 (fr)
CA (1) CA2261267C (fr)
DE (1) DE69715216T2 (fr)
DK (1) DK0915864T3 (fr)
WO (1) WO1998004541A1 (fr)

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US7638554B2 (en) * 2002-04-18 2009-12-29 Sri International Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US20030229136A1 (en) * 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
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US9060959B2 (en) * 2003-01-24 2015-06-23 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Synergistic compositions and method for potentiating anti-oxidative activity
US20040176471A1 (en) * 2003-03-07 2004-09-09 Kaohsiung Medical University Novel chalcone derivatives and pharmaceutical compositions comprising the same
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EP1765313A2 (fr) 2004-06-24 2007-03-28 Novartis Vaccines and Diagnostics, Inc. Composes utilises pour l'immunopotentialisation
JP2007297283A (ja) * 2004-07-28 2007-11-15 Santen Pharmaceut Co Ltd 新規桂皮酸関連化合物
KR20080091436A (ko) * 2006-01-09 2008-10-13 카운실 오브 사이언티픽 엔드 인더스트리얼 리서치 위장관 독성, 관련 증상 및 궤양 치료용 천연물질
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) * 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
KR100930467B1 (ko) 2007-06-07 2009-12-08 동아제약주식회사 점액분비를 촉진시키는 3',4',5-트리메톡시 플라본 유도체화합물, 그의 제조방법 및 약학적 용도
US20080319051A1 (en) * 2007-06-22 2008-12-25 Bionovo, Inc. Liquiritigenin and derivatives as selective estrogen receptor beta agonists
US20090042818A1 (en) * 2007-06-22 2009-02-12 Bionovo, Inc. Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists
KR101381999B1 (ko) * 2007-07-06 2014-04-14 동아에스티 주식회사 위염 치료제의 효력을 극대화시키기 위한 가용화 위체류시스템 매트릭스 제제
KR101391494B1 (ko) 2007-11-26 2014-05-07 동아에스티 주식회사 위염 치료제의 효력을 극대화시키기 위한 나노서스펜젼
AU2008340053A1 (en) 2007-12-20 2009-07-02 Novartis Ag Thiazole derivatives used as PI 3 kinase inhibitors
WO2009110008A1 (fr) * 2008-03-05 2009-09-11 Council Of Scientific & Industrial Research Activité anti-ulcère d'analogues de la flavone
EP2112145A1 (fr) * 2008-04-24 2009-10-28 AxoGlia Therapeutics S.A. Dérivés de chroménone utilisés pour le traitement des maladies neurodégénératives
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
JP5712580B2 (ja) * 2010-11-30 2015-05-07 株式会社ツムラ ５，７‐ジヒドロキシ‐６‐メトキシフラボン類の製造方法
TW201309700A (zh) 2011-01-31 2013-03-01 Novartis Ag 新穎雜環衍生物
WO2013061305A1 (fr) 2011-10-28 2013-05-02 Novartis Ag Nouveaux dérivés de purine et utilisation de ceux-ci dans le traitement d'une maladie
EP2849756A1 (fr) 2012-05-16 2015-03-25 Novartis AG Régime posologique pour un inhibiteur de pi-3 kinase
CA2930359C (fr) 2013-12-06 2022-03-01 Novartis Ag Schema posologique d'un inhibiteur de la phosphatidylinositol 3-kinase selectif de l'isoforme alpha
US10376488B2 (en) * 2014-09-05 2019-08-13 ONENESS BIOTECH CO., Ltd Use of flavonoids in manufacturing compositions for wound healing
CN108472289A (zh) 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案
WO2018060833A1 (fr) 2016-09-27 2018-04-05 Novartis Ag Schéma posologique pour l'alpelisib, un inhibiteur de la phosphatidylinositol 3-kinase spécifique de l'isoforme alpha
CN111374971A (zh) * 2020-04-26 2020-07-07 南开大学 香叶木素在制备用于治疗炎症性肠病的药物中的应用
CN111454240B (zh) * 2020-04-30 2023-05-16 上海爱启医药技术有限公司 制备二硒醚化合物的方法
CN115197190A (zh) * 2021-04-09 2022-10-18 中国海洋大学 一种新型植物黄酮衍生物及其制备方法和应用
CN115197191A (zh) * 2021-04-09 2022-10-18 中国海洋大学 一种新型中药黄酮衍生物及其制备方法和应用
KR102356603B1 (ko) 2021-08-05 2022-02-08 지엘팜텍주식회사 안구건조증 치료를 위한 레코플라본 함유 점안 조성물
WO2023014117A1 (fr) 2021-08-05 2023-02-09 지엘팜텍주식회사 Composition de gouttes oculaires pour le traitement du syndrome de l'oeil sec contenant une nouvelle recoflavone et son procédé de préparation
CN117794515A (zh) 2021-08-05 2024-03-29 格里医药科技公司 用于治疗干眼综合征的包含瑞可黄酮的滴眼剂组合物及其制备方法

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Also Published As

Publication number Publication date
KR100447918B1 (ko) 2005-09-28
WO1998004541A1 (fr) 1998-02-05
JPH11514015A (ja) 1999-11-30
EP0915864B1 (fr) 2002-09-04
CA2261267C (fr) 2003-10-07
JP3377214B2 (ja) 2003-02-17
DE69715216T2 (de) 2003-05-08
EP0915864A1 (fr) 1999-05-19
CA2261267A1 (fr) 1998-02-05
DE69715216D1 (de) 2002-10-10
US6025387A (en) 2000-02-15

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