DK0912197T3 - Hæmoglobin-hydroxyethylstivelse-konjugater som oxygentransportmidler - Google Patents
Hæmoglobin-hydroxyethylstivelse-konjugater som oxygentransportmidlerInfo
- Publication number
- DK0912197T3 DK0912197T3 DK97931768T DK97931768T DK0912197T3 DK 0912197 T3 DK0912197 T3 DK 0912197T3 DK 97931768 T DK97931768 T DK 97931768T DK 97931768 T DK97931768 T DK 97931768T DK 0912197 T3 DK0912197 T3 DK 0912197T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxyethylstarch
- haemoglobin
- pct
- transfer agents
- oxygen transfer
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title abstract 6
- 229920001612 Hydroxyethyl starch Polymers 0.000 title abstract 5
- 229940050526 hydroxyethylstarch Drugs 0.000 title abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 4
- 229910052760 oxygen Inorganic materials 0.000 title abstract 4
- 239000001301 oxygen Substances 0.000 title abstract 4
- DNZMDASEFMLYBU-RNBXVSKKSA-N hydroxyethyl starch Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O.OCCOC[C@H]1O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@@H]1OCCO DNZMDASEFMLYBU-RNBXVSKKSA-N 0.000 abstract 2
- 206010059484 Haemodilution Diseases 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003633 blood substitute Substances 0.000 abstract 1
- 239000008148 cardioplegic solution Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
- 239000003058 plasma substitute Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19628705A DE19628705A1 (de) | 1996-07-08 | 1996-07-08 | Neue Sauerstoff-Transport-Mittel, diese enthaltende Hämoglobin-Hydroxyethylstärke-Konjugate, Verfahren zu deren Herstellung, sowie deren Verwendung als Blutersatzstoffe |
| PCT/EP1997/003527 WO1998001158A2 (fr) | 1996-07-08 | 1997-07-07 | Conjugues hemoglobine-amidon hydroxyethyle comme agents de transport d'oxygene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0912197T3 true DK0912197T3 (da) | 2002-03-18 |
Family
ID=7799997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97931768T DK0912197T3 (da) | 1996-07-08 | 1997-07-07 | Hæmoglobin-hydroxyethylstivelse-konjugater som oxygentransportmidler |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6083909A (fr) |
| EP (1) | EP0912197B1 (fr) |
| JP (1) | JP2000514434A (fr) |
| AT (1) | ATE209931T1 (fr) |
| AU (1) | AU710879B2 (fr) |
| BR (1) | BR9710865A (fr) |
| CA (1) | CA2258947A1 (fr) |
| DE (2) | DE19628705A1 (fr) |
| DK (1) | DK0912197T3 (fr) |
| ES (1) | ES2166551T3 (fr) |
| PT (1) | PT912197E (fr) |
| WO (1) | WO1998001158A2 (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19933275A1 (de) * | 1999-07-14 | 2001-01-18 | Fresenius Ag | Verwendung von Hämoglobin-Derivaten zur Bestimmung des Plasma- und/oder Blutvolumens |
| DE10112825A1 (de) | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylierung von Wirkstoffen in wässriger Lösung |
| DE10112640C1 (de) * | 2001-03-16 | 2002-12-19 | Diehl Ako Stiftung Gmbh & Co | Anzeigeeinrichtung |
| DE10129369C1 (de) | 2001-06-21 | 2003-03-06 | Fresenius Kabi De Gmbh | Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats |
| DE50210039D1 (de) | 2001-08-22 | 2007-06-06 | Supramol Parenteral Colloids | Hyperverzweigtes amylopektin zum einsatz in verfahren zur chirurgischen oder therapeutischen behandlung von säugern oder in diagnostizierverfahren, insbesondere zur verwendung als plasmavolumenexpander |
| DE10207072A1 (de) * | 2002-02-20 | 2003-08-28 | Supramol Parenteral Colloids | Stärkederivate, ihre Konjugate und Verfahren zur Herstellung derselben |
| DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
| DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
| EP1681303B1 (fr) | 2002-09-11 | 2013-09-04 | Fresenius Kabi Deutschland GmbH | Polypeptides HASylés, en particulier érythropoiétine HASylée |
| DE10242076A1 (de) * | 2002-09-11 | 2004-03-25 | Fresenius Kabi Deutschland Gmbh | HAS-Allergen-Konjugate |
| EP1400533A1 (fr) * | 2002-09-11 | 2004-03-24 | Fresenius Kabi Deutschland GmbH | Polypeptides hasylés, érythropoiétine hasylée en particulier |
| AU2003255406B2 (en) | 2002-09-11 | 2009-09-10 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkyl starch derivatives |
| US7538092B2 (en) | 2002-10-08 | 2009-05-26 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
| DE10256558A1 (de) * | 2002-12-04 | 2004-09-16 | Supramol Parenteral Colloids Gmbh | Ester von Polysaccharid Aldonsäuren, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe |
| DE10324710A1 (de) | 2003-05-30 | 2004-12-16 | Supramol Parenteral Colloids Gmbh | Stärkederivatkomplexe |
| WO2005014655A2 (fr) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugues d'amidon d'hydroxyalkyle et de proteine |
| PL1660134T3 (pl) | 2003-08-08 | 2011-05-31 | Fresenius Kabi Deutschland Gmbh | Koniugaty hydroksyalkiloskrobi i G-CSF |
| HRP20110056T1 (hr) * | 2003-08-08 | 2011-02-28 | Fresenius Kabi Deutschland Gmbh | Konjugati hidroksialkil škroba i g-csf |
| BRPI0412671A (pt) * | 2003-08-08 | 2006-10-03 | Fresenius Kabi De Gmbh | conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima |
| AU2005217157B2 (en) * | 2004-03-01 | 2011-05-12 | B. Braun Melsungen Ag | Hydroxyethyl starch |
| EP2279752A3 (fr) | 2004-03-11 | 2011-08-24 | Fresenius Kabi Deutschland GmbH | Conjugés d'amidon hydroxyalkylique et d'une protéine préparés par ligation chimique native |
| WO2005092369A2 (fr) * | 2004-03-11 | 2005-10-06 | Fresenius Kabi Deutschland Gmbh | Conjugues d'hydroxy-ethyl-amidon et d'erythropoietine |
| DE202005021885U1 (de) | 2004-03-11 | 2011-03-03 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt |
| EP1861124A2 (fr) * | 2005-03-11 | 2007-12-05 | Fresenius Kabi Deutschland GmbH | Production de glycoproteines bioactives a partir d'un materiau de depart inactif |
| EP1707632A1 (fr) * | 2005-04-01 | 2006-10-04 | Bayer CropScience GmbH | Amidon de pomme de terre cireux phosphorylé |
| EP1762250A1 (fr) | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugués d' amidon hydroxyalkyle et une substance active obtenue par ligation chimique via thiazolidine |
| CN101199856B (zh) * | 2006-12-15 | 2011-04-20 | 天津协和生物科技发展有限公司 | 一种携氧抗休克药物 |
| EP2070951A1 (fr) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Procédé de production d'un dérivé hydroxyalkyle de l'amidon avec deux liens |
| EP2070950A1 (fr) | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Dérivés hydroxyalkylés de l'amidon et leur procédé de préparation |
| MX2010011957A (es) | 2008-05-02 | 2011-03-04 | Novartis Ag Star | Moleculas de union basadas en fibronectina mejoradas y usos de las mismas. |
| MX2011003117A (es) * | 2008-09-19 | 2011-04-21 | Nektar Therapeutics | Conjugados polimericos de peptidos terapeuticos. |
| WO2011051327A2 (fr) | 2009-10-30 | 2011-05-05 | Novartis Ag | Petites protéines à chaîne unique de type anticorps |
| WO2011051466A1 (fr) | 2009-11-02 | 2011-05-05 | Novartis Ag | Molécules de liaison anti-idiotypiques à base de fibronectine et leurs utilisations |
| WO2011092233A1 (fr) | 2010-01-29 | 2011-08-04 | Novartis Ag | Conjugaison de levures pour produire des combinaisons de liants à base de fibronectine à haute affinité |
| WO2012004004A1 (fr) | 2010-07-09 | 2012-01-12 | Fresenius Kabi Deutschland Gmbh | Dérivés d'hydroxyalkyl-amidon délivrant de l'oxyde nitrique |
| WO2015100235A1 (fr) | 2013-12-27 | 2015-07-02 | Virginia Commonwealth University | Modificateurs allostériques de l'hémoglobine avec une partie libérant de l'oxyde nitrique |
| JP7387597B2 (ja) | 2017-07-18 | 2023-11-28 | ヴァーテック・バイオ・インコーポレイテッド | ヘモグロビンを含む代用血液及び作製方法 |
| CN114099648B (zh) * | 2021-12-27 | 2023-08-08 | 西安血氧生物技术有限公司 | 一种助溶剂、含该助溶剂的血红蛋白氧载体冻干粉、针剂及制备方法 |
| CN119367518A (zh) * | 2024-10-28 | 2025-01-28 | 广州蕊特生物科技有限公司 | 一种人造血液及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1055932A (fr) * | 1975-10-22 | 1979-06-05 | Hematech Inc. | Succedane du sang comparable a l'hemoglobine |
| DE3029307A1 (de) * | 1980-08-01 | 1982-03-04 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Haemoglobin enthaltendes blutersatzmittel |
| FR2630329B1 (fr) * | 1988-04-20 | 1991-07-05 | Merieux Inst | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
-
1996
- 1996-07-08 DE DE19628705A patent/DE19628705A1/de not_active Withdrawn
-
1997
- 1997-07-07 BR BR9710865-0A patent/BR9710865A/pt not_active IP Right Cessation
- 1997-07-07 DE DE59705678T patent/DE59705678D1/de not_active Expired - Fee Related
- 1997-07-07 PT PT97931768T patent/PT912197E/pt unknown
- 1997-07-07 DK DK97931768T patent/DK0912197T3/da active
- 1997-07-07 ES ES97931768T patent/ES2166551T3/es not_active Expired - Lifetime
- 1997-07-07 US US09/214,430 patent/US6083909A/en not_active Expired - Fee Related
- 1997-07-07 JP JP10504767A patent/JP2000514434A/ja not_active Withdrawn
- 1997-07-07 AU AU35411/97A patent/AU710879B2/en not_active Ceased
- 1997-07-07 AT AT97931768T patent/ATE209931T1/de not_active IP Right Cessation
- 1997-07-07 CA CA002258947A patent/CA2258947A1/fr not_active Abandoned
- 1997-07-07 WO PCT/EP1997/003527 patent/WO1998001158A2/fr not_active Ceased
- 1997-07-07 EP EP97931768A patent/EP0912197B1/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2166551T3 (es) | 2002-04-16 |
| WO1998001158A2 (fr) | 1998-01-15 |
| AU710879B2 (en) | 1999-09-30 |
| DE19628705A1 (de) | 1998-01-15 |
| ATE209931T1 (de) | 2001-12-15 |
| CA2258947A1 (fr) | 1998-01-15 |
| US6083909A (en) | 2000-07-04 |
| BR9710865A (pt) | 2000-01-11 |
| JP2000514434A (ja) | 2000-10-31 |
| WO1998001158A3 (fr) | 1998-03-19 |
| EP0912197B1 (fr) | 2001-12-05 |
| DE59705678D1 (de) | 2002-01-17 |
| AU3541197A (en) | 1998-02-02 |
| PT912197E (pt) | 2002-05-31 |
| EP0912197A2 (fr) | 1999-05-06 |
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