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DK0998568T3 - Mutant med uracil phosphoribosyltransferaseaktivitet - Google Patents

Mutant med uracil phosphoribosyltransferaseaktivitet

Info

Publication number
DK0998568T3
DK0998568T3 DK99914603T DK99914603T DK0998568T3 DK 0998568 T3 DK0998568 T3 DK 0998568T3 DK 99914603 T DK99914603 T DK 99914603T DK 99914603 T DK99914603 T DK 99914603T DK 0998568 T3 DK0998568 T3 DK 0998568T3
Authority
DK
Denmark
Prior art keywords
mutant
uprtase
phosphoribosyl transferase
concerns
uracil phosphoribosyl
Prior art date
Application number
DK99914603T
Other languages
English (en)
Inventor
Philippe Erbs
Richard Jund
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Application granted granted Critical
Publication of DK0998568T3 publication Critical patent/DK0998568T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
DK99914603T 1998-04-17 1999-04-16 Mutant med uracil phosphoribosyltransferaseaktivitet DK0998568T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9805054A FR2777570A1 (fr) 1998-04-17 1998-04-17 Mutant ayant une activite phosphoribosyl transferase

Publications (1)

Publication Number Publication Date
DK0998568T3 true DK0998568T3 (da) 2006-04-18

Family

ID=9525555

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99914603T DK0998568T3 (da) 1998-04-17 1999-04-16 Mutant med uracil phosphoribosyltransferaseaktivitet

Country Status (11)

Country Link
US (4) US6596533B1 (da)
EP (1) EP0998568B1 (da)
JP (1) JP4349660B2 (da)
AT (1) ATE312180T1 (da)
AU (1) AU766911B2 (da)
CA (1) CA2292882C (da)
DE (1) DE69928745T2 (da)
DK (1) DK0998568T3 (da)
ES (1) ES2253883T3 (da)
FR (1) FR2777570A1 (da)
WO (1) WO1999054481A1 (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2777570A1 (fr) * 1998-04-17 1999-10-22 Transgene Sa Mutant ayant une activite phosphoribosyl transferase
CN1302872A (zh) * 1999-10-29 2001-07-11 上海博道基因技术有限公司 一种新的多肽——人尿嘧啶磷酸核糖基转移酶21和编码这种多肽的多核苷酸
US7141404B2 (en) * 2002-12-27 2006-11-28 Onyx Pharmaceuticals, Inc. Candida kefyr cytosine deaminase
EP1648931B1 (en) 2003-07-21 2011-02-09 Transgene S.A. Multifunctional cytokines
ES2311831T3 (es) 2003-07-21 2009-02-16 Transgene S.A. Polipeptido que presenta una actividad de citosina desaminasa mejorada.
ES2320157T3 (es) * 2004-11-08 2009-05-19 Transgene S.A. Kit de partes diseñado para poner en practica un tratamiento atitumoral o antivirico en un mamifero.
KR101082296B1 (ko) 2006-06-20 2011-11-09 트랜스진 에스.에이. 폭스바이러스 및 폭스바이러스 조성물 제조 방법
CA2675355C (en) 2007-01-30 2015-04-28 Transgene S.A. Papillomavirus vaccine
CA2691868C (en) 2007-07-03 2016-12-20 Transgene S.A. Immortalized avian cell lines
US8357531B2 (en) 2007-07-03 2013-01-22 Transgene S.A. Immortalized avian cell lines
US8697934B2 (en) * 2007-07-31 2014-04-15 Kimberly-Clark Worldwide, Inc. Sensor products using conductive webs
US8058194B2 (en) 2007-07-31 2011-11-15 Kimberly-Clark Worldwide, Inc. Conductive webs
US9687515B2 (en) 2007-11-19 2017-06-27 Transgene S.A. Poxviral oncolytic vectors
US8778328B2 (en) 2007-11-19 2014-07-15 Transgene S.A. Poxviral oncolytic vectors
CN102046872B (zh) * 2008-05-29 2013-07-10 金伯利-克拉克环球有限公司 含有电路径的导电纤网及其制造方法
US7944401B2 (en) * 2008-05-29 2011-05-17 Kimberly-Clark Worldwide, Inc. Radiating element for a signal emitting apparatus
US8172982B2 (en) * 2008-12-22 2012-05-08 Kimberly-Clark Worldwide, Inc. Conductive webs and process for making same
US9510764B2 (en) * 2009-04-22 2016-12-06 Cardiac Pacemakers, Inc. Methods for detecting atrial tachyarrhythmia in implantable devices without dedicated atrial sensing
US8609392B2 (en) 2009-05-12 2013-12-17 Transgene S.A. Method for orthopoxvirus production and purification
CA2768562A1 (en) 2009-07-21 2011-01-27 Transgene Sa Enzymatic composition for the digestion of chicken embryos
WO2011015656A2 (en) 2009-08-07 2011-02-10 Transgene Sa Composition for treating hbv infection
WO2013004658A1 (en) 2011-07-01 2013-01-10 Transgene Sa Formulations of 5-fluorocytosine and uses thereof.
ES2768715T3 (es) 2014-04-10 2020-06-23 Transgene Vectores oncolíticos poxvíricos
CA3190510A1 (en) 2014-07-16 2016-01-21 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators
EP3226894B1 (en) 2014-12-01 2019-08-07 Transgene SA Stable liquid vaccinia virus formulations
CN107949397A (zh) 2015-02-13 2018-04-20 特兰斯吉恩股份有限公司 免疫治疗疫苗和抗体组合治疗
WO2016131945A1 (en) 2015-02-20 2016-08-25 Transgene Sa Combination product with autophagy modulator
KR101985271B1 (ko) * 2016-02-05 2019-06-04 주식회사 에스엘바이젠 Trail 및 cd를 발현하는 중간엽줄기세포 및 이의 용도
CA3023022A1 (en) 2016-05-04 2017-11-09 Transgene Sa Combination therapy with cpg tlr9 ligand
US20190328869A1 (en) 2016-10-10 2019-10-31 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
WO2018091680A1 (en) 2016-11-18 2018-05-24 Transgene Sa Cowpox-based oncolytic vectors
WO2019020543A1 (en) 2017-07-28 2019-01-31 Transgene Sa ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS
US12377142B2 (en) 2018-03-07 2025-08-05 Transgene Recombinant pseudocowpoxvirus
WO2020011754A1 (en) 2018-07-09 2020-01-16 Transgene Chimeric vaccinia viruses
WO2021015584A1 (ko) 2019-07-24 2021-01-28 주식회사 에스엘바이젠 불사화된 줄기세포주의 제조 방법 및 이의 용도
WO2023213764A1 (en) 2022-05-02 2023-11-09 Transgene Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf
WO2023213763A1 (en) 2022-05-02 2023-11-09 Transgene Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab
EP4573113A1 (en) 2022-08-18 2025-06-25 Transgene Chimeric poxviruses
WO2024124190A1 (en) * 2022-12-09 2024-06-13 Microbial Machines, Inc. Engineered microorganisms for delivery of therapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5856153A (en) * 1994-11-17 1999-01-05 Cayla Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases
IL116816A (en) * 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
FR2777570A1 (fr) * 1998-04-17 1999-10-22 Transgene Sa Mutant ayant une activite phosphoribosyl transferase

Also Published As

Publication number Publication date
EP0998568A1 (fr) 2000-05-10
CA2292882C (fr) 2012-06-05
DE69928745T2 (de) 2006-08-10
US7049117B2 (en) 2006-05-23
CA2292882A1 (fr) 1999-10-28
US7572438B2 (en) 2009-08-11
JP2002511769A (ja) 2002-04-16
JP4349660B2 (ja) 2009-10-21
US20030186415A1 (en) 2003-10-02
ES2253883T3 (es) 2006-06-01
FR2777570A1 (fr) 1999-10-22
US20100316610A1 (en) 2010-12-16
US8211421B2 (en) 2012-07-03
EP0998568B1 (fr) 2005-12-07
US6596533B1 (en) 2003-07-22
WO1999054481A1 (fr) 1999-10-28
AU766911B2 (en) 2003-10-23
AU3335499A (en) 1999-11-08
US20060110363A1 (en) 2006-05-25
DE69928745D1 (de) 2006-01-12
ATE312180T1 (de) 2005-12-15

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