DK0971930T3 - Fremgangsmåde til fremstilling af enkelt enantiomert narwedin - Google Patents
Fremgangsmåde til fremstilling af enkelt enantiomert narwedinInfo
- Publication number
- DK0971930T3 DK0971930T3 DK98915005T DK98915005T DK0971930T3 DK 0971930 T3 DK0971930 T3 DK 0971930T3 DK 98915005 T DK98915005 T DK 98915005T DK 98915005 T DK98915005 T DK 98915005T DK 0971930 T3 DK0971930 T3 DK 0971930T3
- Authority
- DK
- Denmark
- Prior art keywords
- narwedine
- preparation
- single enantiomeric
- solvent
- single enantiomer
- Prior art date
Links
- QENVUHCAYXAROT-UHFFFAOYSA-N Galanthaminon Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(=O)C=C2 QENVUHCAYXAROT-UHFFFAOYSA-N 0.000 title abstract 4
- QENVUHCAYXAROT-YOEHRIQHSA-N Narwedine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1CC(=O)C=C2 QENVUHCAYXAROT-YOEHRIQHSA-N 0.000 title abstract 4
- WCRYNEMFWLZAAZ-WMLDXEAASA-N Narwedine Natural products COc1ccc2CCCC[C@@]34C=CC(=O)C[C@@H]3Oc1c24 WCRYNEMFWLZAAZ-WMLDXEAASA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000010899 nucleation Methods 0.000 abstract 1
- VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9707413.2A GB9707413D0 (en) | 1997-04-11 | 1997-04-11 | Process |
| PCT/GB1998/001029 WO1998046610A1 (en) | 1997-04-11 | 1998-04-08 | Process for preparing single enantiomer narwedine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0971930T3 true DK0971930T3 (da) | 2004-01-26 |
Family
ID=10810680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98915005T DK0971930T3 (da) | 1997-04-11 | 1998-04-08 | Fremgangsmåde til fremstilling af enkelt enantiomert narwedin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6392038B1 (da) |
| EP (1) | EP0971930B1 (da) |
| JP (1) | JP4322317B2 (da) |
| KR (1) | KR100523125B1 (da) |
| AT (1) | ATE253579T1 (da) |
| AU (1) | AU726812B2 (da) |
| CA (1) | CA2284976C (da) |
| DE (1) | DE69819479T2 (da) |
| DK (1) | DK0971930T3 (da) |
| ES (1) | ES2209125T3 (da) |
| GB (1) | GB9707413D0 (da) |
| NO (1) | NO325949B1 (da) |
| NZ (1) | NZ337962A (da) |
| PT (1) | PT971930E (da) |
| WO (1) | WO1998046610A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1670767B2 (en) * | 2003-09-26 | 2014-10-29 | ScinoPharm Taiwan, Ltd. | Resolution of a narwedine amide derivative |
| US20050191349A1 (en) * | 2003-12-31 | 2005-09-01 | Garth Boehm | Galantamine formulations |
| WO2005065662A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Solid dosage formulations of galantamine |
| WO2006018703A2 (en) * | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Processes for preparation of narwedine and its use in the synthesis of galantamine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428159A (en) * | 1994-04-08 | 1995-06-27 | Ciba-Geigy Corporation | Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine |
| PL184590B1 (pl) * | 1994-10-21 | 2002-11-29 | Sanochemia Pharmazeutika Ag | Sposób wytwarzania pochodnych a heksahydro H benzofuro[ a ef][ ] benzoazepiny sposób odbromowania tych pochodnych sposób wytwarzania związków typu N demetylobromo i epibromo galantaminy oraz nowe związki z określonego zbioru |
-
1997
- 1997-04-11 GB GBGB9707413.2A patent/GB9707413D0/en active Pending
-
1998
- 1998-04-08 WO PCT/GB1998/001029 patent/WO1998046610A1/en not_active Ceased
- 1998-04-08 KR KR10-1999-7009195A patent/KR100523125B1/ko not_active Expired - Lifetime
- 1998-04-08 AU AU69296/98A patent/AU726812B2/en not_active Expired
- 1998-04-08 DE DE69819479T patent/DE69819479T2/de not_active Expired - Lifetime
- 1998-04-08 EP EP98915005A patent/EP0971930B1/en not_active Expired - Lifetime
- 1998-04-08 US US09/402,722 patent/US6392038B1/en not_active Expired - Lifetime
- 1998-04-08 NZ NZ337962A patent/NZ337962A/en not_active IP Right Cessation
- 1998-04-08 PT PT98915005T patent/PT971930E/pt unknown
- 1998-04-08 DK DK98915005T patent/DK0971930T3/da active
- 1998-04-08 ES ES98915005T patent/ES2209125T3/es not_active Expired - Lifetime
- 1998-04-08 JP JP54359598A patent/JP4322317B2/ja not_active Expired - Lifetime
- 1998-04-08 CA CA002284976A patent/CA2284976C/en not_active Expired - Lifetime
- 1998-04-08 AT AT98915005T patent/ATE253579T1/de active
-
1999
- 1999-10-08 NO NO19994928A patent/NO325949B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010006117A (ko) | 2001-01-26 |
| ATE253579T1 (de) | 2003-11-15 |
| CA2284976C (en) | 2006-10-17 |
| ES2209125T3 (es) | 2004-06-16 |
| WO1998046610A1 (en) | 1998-10-22 |
| KR100523125B1 (ko) | 2005-10-19 |
| GB9707413D0 (en) | 1997-05-28 |
| EP0971930B1 (en) | 2003-11-05 |
| JP2001518911A (ja) | 2001-10-16 |
| DE69819479D1 (de) | 2003-12-11 |
| AU726812B2 (en) | 2000-11-23 |
| CA2284976A1 (en) | 1998-10-22 |
| AU6929698A (en) | 1998-11-11 |
| NZ337962A (en) | 2001-05-25 |
| US6392038B1 (en) | 2002-05-21 |
| PT971930E (pt) | 2004-02-27 |
| EP0971930A1 (en) | 2000-01-19 |
| NO994928L (no) | 1999-10-08 |
| NO994928D0 (no) | 1999-10-08 |
| JP4322317B2 (ja) | 2009-08-26 |
| NO325949B1 (no) | 2008-08-25 |
| DE69819479T2 (de) | 2004-08-26 |
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