[go: up one dir, main page]

DK0949260T3 - Syreadditionssalte af en optisk aktiv piperidinforbindelse og fremgangsmåde til fremstilling deraf - Google Patents

Syreadditionssalte af en optisk aktiv piperidinforbindelse og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0949260T3
DK0949260T3 DK97949235T DK97949235T DK0949260T3 DK 0949260 T3 DK0949260 T3 DK 0949260T3 DK 97949235 T DK97949235 T DK 97949235T DK 97949235 T DK97949235 T DK 97949235T DK 0949260 T3 DK0949260 T3 DK 0949260T3
Authority
DK
Denmark
Prior art keywords
preparation
acid addition
addition salts
optically active
piperidine compound
Prior art date
Application number
DK97949235T
Other languages
Danish (da)
English (en)
Inventor
Jun-Ichiro Kita
Hiroshi Fujiwara
Shinji Takamura
Ryuzo Yoshioka
Shin-Ichi Yamada
Yasuhiko Ozaki
Original Assignee
Ube Industries
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27341269&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0949260(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP34785396A external-priority patent/JP3157118B2/ja
Priority claimed from JP34785196A external-priority patent/JP3157117B2/ja
Application filed by Ube Industries, Tanabe Seiyaku Co filed Critical Ube Industries
Application granted granted Critical
Publication of DK0949260T3 publication Critical patent/DK0949260T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97949235T 1996-12-26 1997-12-25 Syreadditionssalte af en optisk aktiv piperidinforbindelse og fremgangsmåde til fremstilling deraf DK0949260T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP34785396A JP3157118B2 (ja) 1996-12-26 1996-12-26 アシルアミノ酸を用いるピペリジン誘導体の光学分割方法
JP34789596 1996-12-26
JP34785196A JP3157117B2 (ja) 1996-12-26 1996-12-26 ピペリジン誘導体の光学分割方法
PCT/JP1997/004826 WO1998029409A1 (fr) 1996-12-26 1997-12-25 Sels d'addition acides de compose de piperidine optiquement actif et procede de production associe

Publications (1)

Publication Number Publication Date
DK0949260T3 true DK0949260T3 (da) 2002-09-09

Family

ID=27341269

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97949235T DK0949260T3 (da) 1996-12-26 1997-12-25 Syreadditionssalte af en optisk aktiv piperidinforbindelse og fremgangsmåde til fremstilling deraf

Country Status (15)

Country Link
US (3) US6307052B1 (fr)
EP (1) EP0949260B1 (fr)
KR (1) KR100515227B1 (fr)
CN (2) CN1098262C (fr)
AT (1) ATE217872T1 (fr)
AU (1) AU7890698A (fr)
CA (1) CA2275987C (fr)
DE (1) DE69712784T2 (fr)
DK (1) DK0949260T3 (fr)
ES (1) ES2173499T3 (fr)
ID (1) ID21985A (fr)
MY (1) MY118016A (fr)
PT (1) PT949260E (fr)
TW (1) TW486475B (fr)
WO (1) WO1998029409A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2419036A1 (fr) * 2000-08-08 2002-02-14 Ortho-Mcneil Pharmaceutical, Inc. Aryloxypiperidines non-imidazole
EP1443929A4 (fr) * 2001-10-16 2008-02-06 Hypnion Inc Traitement de troubles du systeme nerveux central (snc) a l'aide de modulateurs de cible snc
US7189757B2 (en) * 2001-10-16 2007-03-13 Hypnion, Inc. Treatment of sleep disorders using CNS target modulators
US7355042B2 (en) 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
EP1457487A4 (fr) * 2001-12-21 2005-06-22 Toray Finechemicals Co Ltd Procede de production de derives de cis-piperidine optiquement actifs
ES2263962T3 (es) * 2002-01-17 2006-12-16 Arkema France Polimeros supramoleculares.
EP1525884B1 (fr) 2002-07-31 2011-10-12 Senju Pharmaceutical Co., Ltd. Preparations liquides aqueuses et preparations liquides aqueuses photostabilisees
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
CN1310885C (zh) 2002-08-29 2007-04-18 大正制药株式会社 4－氟－2－氰基吡咯烷衍生物苯磺酸盐
BRPI0713381A2 (pt) 2006-06-28 2012-03-13 Amgen Inc composto, composição farmacêutica, e, método para o tratamento de uma doença
KR100878698B1 (ko) * 2007-04-05 2009-01-13 한미약품 주식회사 결정형의 베포타스틴 금속염 수화물, 이의 제조방법 및이를 포함하는 약학 조성물
KR100879409B1 (ko) * 2007-06-11 2009-01-19 한미약품 주식회사 (ｓ)-베포타스틴의 제조방법 및 이에 사용되는 중간체
EP2222639A1 (fr) 2007-11-21 2010-09-01 Decode Genetics EHF Inhibiteurs de biaryle pde4 pour le traitement de troubles pulmonaires et cardiovasculaires
KR101307712B1 (ko) * 2008-12-02 2013-09-11 한미사이언스 주식회사 결정형의 베포타스틴 금속염 수화물, 이의 제조방법 및 이를 포함하는 약학 조성물
KR101132949B1 (ko) * 2009-09-08 2012-04-10 경희대학교 산학협력단 베포타스틴 살리실산염, 이의 제조방법 및 이를 유효성분으로 포함하는 항히스타민 또는 항알레르기용 약학적 조성물
KR101146009B1 (ko) 2009-10-01 2012-05-15 동인화학 주식회사 광학 분리에 의한 활성 피페리딘 화합물의 제조방법
JP2011195500A (ja) * 2010-03-19 2011-10-06 Tokuyama Corp （ｓ）−４−［４−［（４−クロロフェニル）（２−ピリジル）メトキシ］ピペリジノ］ブタン酸一ベンゼンスルホン酸塩の製造方法
CN101928278B (zh) * 2010-08-23 2013-06-05 浙江燎原药业有限公司 (s)-4-[(4-氯苯基)(吡啶-2-基)甲氧基]哌啶羟基苯丙酸盐及其应用
KR101546596B1 (ko) 2011-01-04 2015-08-21 이스타 파머슈티컬즈, 인크. 베포타스틴 조성물
CN102675283B (zh) * 2012-05-17 2013-08-14 上海右手医药科技开发有限公司 一种酸性条件下缩合制备贝托斯汀的新方法
TWI455933B (zh) * 2012-08-10 2014-10-11 Everlight Chem Ind Corp 貝他斯汀或其苯磺酸鹽之製法及其使用之中間體
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
JP6114841B2 (ja) 2013-02-28 2017-04-12 ダーミラ， インク．Ｄｅｒｍｉｒａ， Ｉｎｃ． グリコピロレート塩
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
CN104031029A (zh) * 2013-03-08 2014-09-10 重庆华邦制药有限公司 单一光学异构体的2-[(4-氯苯基)(哌啶-4-氧基)甲基]吡啶的合成方法
CN104119314B (zh) * 2013-04-23 2018-01-12 重庆华邦制药有限公司 一种稳定的苯磺酸贝他斯汀晶体及其制备方法
CN104003978B (zh) * 2014-06-18 2016-01-20 江苏联环药业股份有限公司 贝他斯汀或其消旋化合物的工业化制备方法
CN104151295B (zh) * 2014-08-26 2015-12-30 山东川成医药股份有限公司 一种2-[(4-氯苯基)(4-哌啶基氧基)甲基]吡啶的合成方法
CN106117183B (zh) * 2016-06-24 2019-08-02 合肥久诺医药科技有限公司 一种高纯度苯磺贝他斯汀的精制方法
CN106938995B (zh) * 2017-01-17 2019-05-28 宜昌人福药业有限责任公司 一种眼科药物苯磺酸贝他斯汀的不对称合成方法
CN106946847B (zh) * 2017-03-27 2019-06-21 福建省微生物研究所 一种贝他斯汀重要中间体的制备方法
CN108727335A (zh) * 2018-08-07 2018-11-02 福建省微生物研究所 一种苯磺贝他斯汀的纯化方法
CN111116556B (zh) * 2019-12-26 2021-11-02 北京鑫开元医药科技有限公司 一种(r)-2-[(4-氯苯基)(4-哌啶氧基)甲基]吡啶的制备方法
CN113480521B (zh) * 2021-07-12 2024-04-16 成都丽凯手性技术有限公司 一种苯磺酸贝他斯汀全合成方法
CN116381076A (zh) * 2023-02-14 2023-07-04 济南立德医药技术有限公司 一种贝托斯汀中间体与其对映异构体的检测方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5345759A (en) * 1976-10-07 1978-04-24 Takasago Thermal Eng Co Lts Formation method for spot clean zone
JPS6336480A (ja) * 1986-07-31 1988-02-17 Hitachi Seiki Co Ltd 部品図の寸法表示自動作画装置
US4730827A (en) * 1986-11-21 1988-03-15 Williams George R Hand rehabilitation device
JPS63225465A (ja) 1987-03-13 1988-09-20 Jeol Ltd 走査電子顕微鏡等の集束レンズ
JPS6413090A (en) 1987-07-07 1989-01-17 Ube Industries Xanthine derivative
JPS6413090U (fr) * 1987-07-13 1989-01-24
JPH01242574A (ja) 1988-03-25 1989-09-27 Ube Ind Ltd 含窒素縮合環を有するピペリジン及びピペラジン誘導体、その製造方法並びにそれを含む薬学的組成物
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus
CA2035147A1 (fr) * 1990-02-08 1991-08-09 Kousuke Yasuda Derives de la thiazine (ou de l'oxazine) et leur preparation
JP2624372B2 (ja) * 1990-11-15 1997-06-25 宇部興産株式会社 ジアリールメトキシピペリジン誘導体
JPH04225465A (ja) 1990-12-27 1992-08-14 Hitachi Ltd 文書作成装置
JPH05345759A (ja) 1991-08-08 1993-12-27 Kaken Pharmaceut Co Ltd ピペリジン誘導体
JPH06135958A (ja) 1992-10-28 1994-05-17 Tanabe Seiyaku Co Ltd ベンゾシクロヘプテン誘導体及びその製法
JPH06239742A (ja) 1992-12-03 1994-08-30 Tanabe Seiyaku Co Ltd 排尿障害の予防・治療剤
JP2787973B2 (ja) 1993-05-28 1998-08-20 宇部興産株式会社 ピペリジン中間体の精製法
JPH1025465A (ja) 1996-07-10 1998-01-27 Toshiba Chem Corp 耐熱性フィルム接着剤組成物
JPH10182635A (ja) * 1996-12-26 1998-07-07 Ube Ind Ltd 光学活性ピペリジン誘導体及びその製造方法
IT1293941B1 (it) 1997-02-13 1999-03-11 Orthofix Srl Attrezzo ortopedico particolarmente per la correzione chirurgica di deformazioni ossee
JP3252741B2 (ja) * 1997-02-21 2002-02-04 宇部興産株式会社 光学活性ピペリジン化合物のラセミ化方法
US6319176B1 (en) * 1999-07-28 2001-11-20 Hampton Fitness Products, Ltd. Weightlifting plate
USD474517S1 (en) * 2002-01-18 2003-05-13 Technical Knockout, Inc. Barbell weight plate

Also Published As

Publication number Publication date
KR100515227B1 (ko) 2005-09-16
KR20000062337A (ko) 2000-10-25
US20020026054A1 (en) 2002-02-28
US6780877B2 (en) 2004-08-24
US7282589B2 (en) 2007-10-16
TW486475B (en) 2002-05-11
CN1098262C (zh) 2003-01-08
US6307052B1 (en) 2001-10-23
CN1242013A (zh) 2000-01-19
CA2275987C (fr) 2006-12-19
PT949260E (pt) 2002-09-30
WO1998029409A1 (fr) 1998-07-09
EP0949260A1 (fr) 1999-10-13
ID21985A (id) 1999-08-19
MY118016A (en) 2004-08-30
AU7890698A (en) 1998-07-31
CA2275987A1 (fr) 1998-07-09
DE69712784D1 (de) 2002-06-27
ES2173499T3 (es) 2002-10-16
EP0949260A4 (fr) 2000-03-15
US20040220226A1 (en) 2004-11-04
EP0949260B1 (fr) 2002-05-22
CN1231478C (zh) 2005-12-14
HK1022477A1 (en) 2000-08-11
ATE217872T1 (de) 2002-06-15
DE69712784T2 (de) 2002-11-21
CN1446812A (zh) 2003-10-08

Similar Documents

Publication Publication Date Title
DK0949260T3 (da) Syreadditionssalte af en optisk aktiv piperidinforbindelse og fremgangsmåde til fremstilling deraf
NO891698D0 (no) Pyridonkarboksylsyrederivater og fremgangsmaate for deres fremstilling.
DE69226822D1 (de) Diastereomeres Salz von optisch aktiver Chinolinmevalonsäure
DK1295890T3 (da) Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge
NO874549L (no) Sulfonperoxycarboxylsyrer, deres anvendelse for bleking og preparater inneholdende samme.
DE69915004D1 (de) 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate
DK616388A (da) Quinolincarboxylsyre-derivater og fysiologisk acceptable salte deraf med antibakteriel virkning
NO981658D0 (no) Kondensert piperidinforbindelse
ATE174908T1 (de) Chinazolinonderivate
BR0312586A (pt) Derivados de pirolidina como antagonistas e oxitocina
ID30435A (id) Proses-proses untuk menyiapkan perantara-perantara pestisidal
AR019197A1 (es) COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS.
DE69123757D1 (de) Epoxysuccinamidsäurederivat
NO20054418L (no) Substituert benzoylureidopyridylpiperidin- og -pyrrolidinkarboksylsyrederivater, deres fremstilling og anvendelse
DE69928610D1 (de) Verfahren zur Herstellung von 2-Carbamoyl-Pyridinen
DK0488345T3 (da) Optisk aktive 1,4-dihydropyridinderivater og fremgangsmåder til fremstilling deraf
DK1813610T3 (da) Nye pyridoncarboxylsyrederivater eller salte deraf
PT83715B (pt) Processo para a preparacao de novos derivados de piperidina
ATE242227T1 (de) Tetrahydrofuranderivate
NO972291L (no) Fremgangsmåte for fremstilling av optisk aktive forbindelser
ATE260264T1 (de) Verfahren zur herstellung von oxazol-derivaten
HU217345B (hu) Helyettesített dihidro-piridin ftálamidsav származéka, és eljárás előállítására