DK0859612T3 - Farmaceutisk sammensætning indeholdende en syre-labil omeprazol og fremgangsmåde til fremstilling deraf - Google Patents
Farmaceutisk sammensætning indeholdende en syre-labil omeprazol og fremgangsmåde til fremstilling derafInfo
- Publication number
- DK0859612T3 DK0859612T3 DK96931211T DK96931211T DK0859612T3 DK 0859612 T3 DK0859612 T3 DK 0859612T3 DK 96931211 T DK96931211 T DK 96931211T DK 96931211 T DK96931211 T DK 96931211T DK 0859612 T3 DK0859612 T3 DK 0859612T3
- Authority
- DK
- Denmark
- Prior art keywords
- enteric coating
- layer
- acid
- image
- pharmaceutical composition
- Prior art date
Links
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000381 omeprazole Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002702 enteric coating Substances 0.000 abstract 4
- 238000009505 enteric coating Methods 0.000 abstract 4
- 239000010410 layer Substances 0.000 abstract 4
- 239000011162 core material Substances 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 239000012055 enteric layer Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9511094 | 1995-09-21 | ||
| FR9514492A FR2742050A1 (fr) | 1995-12-07 | 1995-12-07 | Nouvelle composition contenant un benzimidazole acido-labile et son procede de preparation |
| FR9602265A FR2745181A1 (fr) | 1996-02-23 | 1996-02-23 | Nouvelle composition contenant un benzimidazole acido-labile et son procede de preparation |
| FR9605082A FR2747573A1 (fr) | 1996-04-23 | 1996-04-23 | Nouvelle composition contenant un benzimidazole acido-labile et son procede de preparation |
| PCT/IB1996/001055 WO1997012581A2 (en) | 1995-09-21 | 1996-09-23 | Novel composition containing an acid-labile omeprazole and process for its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0859612T3 true DK0859612T3 (da) | 2003-09-22 |
Family
ID=27446956
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96931210T DK0854718T3 (da) | 1995-09-21 | 1996-09-23 | Hidtil ukendt sammensætning indeholdende en syrelabil benzimidazol og fremgangsmåde til fremstilling deraf |
| DK03001111T DK1308159T3 (da) | 1995-09-21 | 1996-09-23 | Farmaceutisk sammensætning indeholdende en syre-labil omeprazol og fremgangsmåde til fremstilling deraf |
| DK96931211T DK0859612T3 (da) | 1995-09-21 | 1996-09-23 | Farmaceutisk sammensætning indeholdende en syre-labil omeprazol og fremgangsmåde til fremstilling deraf |
| DK00127495T DK1092434T3 (da) | 1995-09-21 | 1996-09-23 | Hidtil ukendt sammensætning indeholdende lansoprazol og fremgangsmåde til fremstilling deraf |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96931210T DK0854718T3 (da) | 1995-09-21 | 1996-09-23 | Hidtil ukendt sammensætning indeholdende en syrelabil benzimidazol og fremgangsmåde til fremstilling deraf |
| DK03001111T DK1308159T3 (da) | 1995-09-21 | 1996-09-23 | Farmaceutisk sammensætning indeholdende en syre-labil omeprazol og fremgangsmåde til fremstilling deraf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00127495T DK1092434T3 (da) | 1995-09-21 | 1996-09-23 | Hidtil ukendt sammensætning indeholdende lansoprazol og fremgangsmåde til fremstilling deraf |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6207198B1 (da) |
| EP (4) | EP0859612B1 (da) |
| JP (2) | JP3463266B2 (da) |
| KR (1) | KR100350138B1 (da) |
| CN (1) | CN1093855C (da) |
| AT (4) | ATE262332T1 (da) |
| AU (2) | AU713242B2 (da) |
| CA (1) | CA2231223C (da) |
| CZ (1) | CZ293595B6 (da) |
| DE (4) | DE69631834T2 (da) |
| DK (4) | DK0854718T3 (da) |
| ES (4) | ES2236628T3 (da) |
| HU (1) | HU227566B1 (da) |
| NO (1) | NO320489B1 (da) |
| NZ (1) | NZ318501A (da) |
| PL (1) | PL186605B1 (da) |
| PT (4) | PT1308159E (da) |
| SK (1) | SK284291B6 (da) |
| WO (2) | WO1997012581A2 (da) |
Families Citing this family (68)
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| JP3542189B2 (ja) * | 1995-03-08 | 2004-07-14 | 株式会社ルネサステクノロジ | 半導体装置の製造方法及び半導体装置 |
| FR2758459B1 (fr) | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| GB9710800D0 (en) * | 1997-05-23 | 1997-07-23 | Cipla Limited | Pharmaceutical composition and method of preparing it |
| SI9700186B (sl) | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
| FR2774288B1 (fr) * | 1998-01-30 | 2001-09-07 | Ethypharm Sa | Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques |
| DK173431B1 (da) | 1998-03-20 | 2000-10-23 | Gea Farmaceutisk Fabrik As | Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs |
| ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. |
| WO2000009092A1 (en) | 1998-08-12 | 2000-02-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1h-benzimidazoles |
| US6174902B1 (en) | 1999-04-28 | 2001-01-16 | Sepracor Inc. | R-rabeprazole compositions and methods |
| FR2793688B1 (fr) | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
| IL130602A0 (en) | 1999-06-22 | 2000-06-01 | Dexcel Ltd | Stable benzimidazole formulation |
| ES2168043B1 (es) * | 1999-09-13 | 2003-04-01 | Esteve Labor Dr | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. |
| TWI268779B (en) * | 1999-10-20 | 2006-12-21 | Eisai Co Ltd | Method for stabilizing benzimidazole-based compounds |
| US6761901B1 (en) * | 2000-05-02 | 2004-07-13 | Enzrel Inc. | Liposome drug delivery |
| US20020064555A1 (en) * | 2000-09-29 | 2002-05-30 | Dan Cullen | Proton pump inhibitor formulation |
| ES2191521B1 (es) * | 2000-11-22 | 2005-02-16 | Laboratorios Belmac, S.A. | Nueva formulacion galenica del omeprazol en forma de comprimidos, procedimiento para su preparacion y aplicaciones en medicina humana y en veterinaria. |
| US8765176B2 (en) * | 2001-06-20 | 2014-07-01 | Takeda Pharmaceutical Campany Limited | Method of manufacturing tablet |
| US20030091634A1 (en) * | 2001-09-14 | 2003-05-15 | Pawan Seth | Delayed release tablet of venlafaxin |
| EP1438030A2 (en) | 2001-09-28 | 2004-07-21 | McNEIL-PPC, INC. | Modified release dosage forms |
| US20030118647A1 (en) * | 2001-12-04 | 2003-06-26 | Pawan Seth | Extended release tablet of metformin |
| ES2198195B1 (es) * | 2001-12-18 | 2004-10-01 | Laboratorios Del Dr. Esteve, S.A. | Forma de dosificacion farmaceutica oral comprimida, con recubrimiento enterico, que contiene un compuesto de bencimidazol labil en medio acido. |
| US6824790B2 (en) | 2002-01-09 | 2004-11-30 | Enzrel Inc. | Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds |
| ATE430213T1 (de) * | 2002-03-11 | 2009-05-15 | Dow Global Technologies Inc | Reversible thermofixierte elastische fasern, herstellungsverfahren und daraus hergestellte artikel |
| EP1485531A1 (en) * | 2002-03-11 | 2004-12-15 | Dow Global Technologies Inc. | Stretch fabric with improved chemical resistance and durability |
| US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
| US20050191353A1 (en) * | 2002-08-16 | 2005-09-01 | Amit Krishna Antarkar | Process for manufacture of stable oral multiple unit pharmaceutical composition containing benzimidazoles |
| MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| US20040086567A1 (en) * | 2002-10-30 | 2004-05-06 | Pawan Seth | Bioequivalent composition of itraconazole and a hydrophilic polymer |
| CA2511540A1 (en) * | 2002-12-23 | 2004-07-22 | Celltech Americas, Inc. | Acid labile drug compositions |
| WO2004066982A1 (en) * | 2003-01-31 | 2004-08-12 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and processes for their preparation |
| US20040162320A1 (en) * | 2003-02-14 | 2004-08-19 | Pawan Seth | Solid composition containing nisoldipine a mixture of polyethylene oxides and an antioxidant |
| ES2234393B2 (es) * | 2003-04-29 | 2006-09-01 | Laboratorios Belmac, S.A. | "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido". |
| US20050147663A1 (en) * | 2003-07-17 | 2005-07-07 | Mohan Mailatur S. | Method of treatment for improved bioavailability |
| NZ544608A (en) * | 2003-07-17 | 2008-07-31 | Reddys Lab Ltd Dr | Pharmaceutical compositions having a swellable coating comprising prolamin |
| US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| CA2536902A1 (en) * | 2003-09-03 | 2005-03-10 | Agi Therapeutics Limited | Proton pump inhibitor formulations, and methods of preparing and using such formulations |
| TWI372066B (en) * | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
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| US20050181052A1 (en) * | 2004-02-17 | 2005-08-18 | Patel Satishkumar A. | Lansoprazole microtablets |
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| US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
| TW200626185A (en) * | 2004-12-17 | 2006-08-01 | Bpsi Holdings Inc | Enteric film coating composition containing entericpolymer micronized with detackifier |
| EP1827429A4 (en) * | 2004-12-20 | 2009-08-05 | Reddys Lab Ltd Dr | PHARMACEUTICAL COMPOSITIONS COMPRISING AMORPHOUS BENZIMIDAZOLE COMPOUNDS |
| EP1830823A2 (en) | 2004-12-23 | 2007-09-12 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and process of preparation thereof |
| MX2007008141A (es) * | 2005-01-03 | 2007-12-10 | Lupin Ltd | Composicion farmaceutica de sustancias labiles en medio acido. |
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| CN100393304C (zh) * | 2005-02-28 | 2008-06-11 | 上海艾力斯医药科技有限公司 | 一种包含酸不稳定药物的微细颗粒及其制剂 |
| US8673352B2 (en) | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
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| AU2007266574A1 (en) * | 2006-06-01 | 2007-12-06 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
| US8911787B2 (en) | 2008-02-26 | 2014-12-16 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and process of preparation thereof |
| EP2535045A1 (en) * | 2011-06-15 | 2012-12-19 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical composition of lansoprazole |
| CN102846571A (zh) * | 2012-09-29 | 2013-01-02 | 南京正科制药有限公司 | 一种埃索美拉唑镁微型片剂 |
| CN103127026B (zh) * | 2013-02-05 | 2017-02-15 | 悦康药业集团有限公司 | 一种奥美拉唑肠溶胶囊及其制备方法 |
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| US10736855B2 (en) | 2016-02-25 | 2020-08-11 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
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| CN113116894A (zh) * | 2019-12-30 | 2021-07-16 | 北京康辰药业股份有限公司 | 一种抗肿瘤药物组合物以及提高化合物的溶解度的方法 |
| GB202116644D0 (en) | 2021-11-18 | 2022-01-05 | Innovate Pharmaceuticals Ltd | Liquid composition |
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| JPS6327424A (ja) * | 1986-07-17 | 1988-02-05 | Shionogi & Co Ltd | 徐放性製剤およびその製造法 |
| US4828848A (en) * | 1987-01-29 | 1989-05-09 | Owades Joseph L | Method of making salt-free pickles |
| GB8820353D0 (en) * | 1988-08-26 | 1988-09-28 | Staniforth J N | Controlled release tablet |
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| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5232706A (en) * | 1990-12-31 | 1993-08-03 | Esteve Quimica, S.A. | Oral pharmaceutical preparation containing omeprazol |
| YU48263B (sh) * | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
| ATE156707T1 (de) * | 1991-06-21 | 1997-08-15 | Ilsan Ilac Ve Hammaddeleri San | Neues galenisches verfahren für omeprazol enthaltende pellets |
| US5178867A (en) * | 1991-08-19 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug in short-time period |
| TW224049B (da) * | 1991-12-31 | 1994-05-21 | Sunkyong Ind Ltd | |
| US5167964A (en) * | 1992-02-14 | 1992-12-01 | Warner-Lambert Company | Semi-enteric drug delivery systems and methods for preparing same |
| FR2692146B1 (fr) * | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
| US5374730A (en) * | 1993-11-04 | 1994-12-20 | Torcan Chemical Ltd. | Preparation of omeprazole and lansoprazole |
| SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| JP3350054B2 (ja) | 1994-07-08 | 2002-11-25 | アストラゼネカ・アクチエボラーグ | 複数単位の錠剤化された剤形▲i▼ |
| ES2094694B1 (es) | 1995-02-01 | 1997-12-16 | Esteve Quimica Sa | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
| US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| SE9704869D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulaton II |
-
1996
- 1996-09-23 ES ES03001111T patent/ES2236628T3/es not_active Expired - Lifetime
- 1996-09-23 EP EP96931211A patent/EP0859612B1/en not_active Expired - Lifetime
- 1996-09-23 EP EP03001111A patent/EP1308159B1/en not_active Expired - Lifetime
- 1996-09-23 EP EP96931210A patent/EP0854718B1/en not_active Expired - Lifetime
- 1996-09-23 PT PT03001111T patent/PT1308159E/pt unknown
- 1996-09-23 AT AT00127495T patent/ATE262332T1/de active
- 1996-09-23 AT AT03001111T patent/ATE286394T1/de active
- 1996-09-23 DE DE69631834T patent/DE69631834T2/de not_active Expired - Lifetime
- 1996-09-23 DK DK96931210T patent/DK0854718T3/da active
- 1996-09-23 ES ES96931210T patent/ES2220989T3/es not_active Expired - Lifetime
- 1996-09-23 AU AU69988/96A patent/AU713242B2/en not_active Ceased
- 1996-09-23 DE DE69628444T patent/DE69628444T2/de not_active Expired - Lifetime
- 1996-09-23 CN CN96197132A patent/CN1093855C/zh not_active Expired - Fee Related
- 1996-09-23 DK DK03001111T patent/DK1308159T3/da active
- 1996-09-23 KR KR10-1998-0701884A patent/KR100350138B1/ko not_active Expired - Fee Related
- 1996-09-23 US US09/043,145 patent/US6207198B1/en not_active Expired - Lifetime
- 1996-09-23 DK DK96931211T patent/DK0859612T3/da active
- 1996-09-23 DK DK00127495T patent/DK1092434T3/da active
- 1996-09-23 US US09/043,663 patent/US6159499A/en not_active Expired - Lifetime
- 1996-09-23 WO PCT/IB1996/001055 patent/WO1997012581A2/en active IP Right Grant
- 1996-09-23 WO PCT/IB1996/001054 patent/WO1997012580A2/en active IP Right Grant
- 1996-09-23 ES ES96931211T patent/ES2201200T3/es not_active Expired - Lifetime
- 1996-09-23 SK SK314-98A patent/SK284291B6/sk not_active IP Right Cessation
- 1996-09-23 CZ CZ1998879A patent/CZ293595B6/cs not_active IP Right Cessation
- 1996-09-23 EP EP00127495A patent/EP1092434B1/en not_active Expired - Lifetime
- 1996-09-23 JP JP51410897A patent/JP3463266B2/ja not_active Expired - Fee Related
- 1996-09-23 JP JP51410797A patent/JP3198337B2/ja not_active Expired - Fee Related
- 1996-09-23 AT AT96931210T patent/ATE261303T1/de active
- 1996-09-23 DE DE69631981T patent/DE69631981T2/de not_active Expired - Lifetime
- 1996-09-23 AU AU69987/96A patent/AU6998796A/en not_active Abandoned
- 1996-09-23 NZ NZ318501A patent/NZ318501A/xx not_active IP Right Cessation
- 1996-09-23 PT PT96931210T patent/PT854718E/pt unknown
- 1996-09-23 PT PT00127495T patent/PT1092434E/pt unknown
- 1996-09-23 HU HU9900467A patent/HU227566B1/hu not_active IP Right Cessation
- 1996-09-23 DE DE69634160T patent/DE69634160T2/de not_active Expired - Lifetime
- 1996-09-23 ES ES00127495T patent/ES2218054T3/es not_active Expired - Lifetime
- 1996-09-23 CA CA002231223A patent/CA2231223C/en not_active Expired - Fee Related
- 1996-09-23 PT PT96931211T patent/PT859612E/pt unknown
- 1996-09-23 AT AT96931211T patent/ATE241357T1/de active
- 1996-09-23 PL PL96325838A patent/PL186605B1/pl not_active IP Right Cessation
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1998
- 1998-03-20 NO NO19981284A patent/NO320489B1/no not_active IP Right Cessation
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1999
- 1999-12-30 US US09/538,845 patent/US6248355B1/en not_active Expired - Lifetime
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