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DK0855397T3 - (R)-5-brom-N-(ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridincarboxamid, fremgangsmåde til dets fremstilling og medicinsk præparat indeholdende denne forbindelse - Google Patents

(R)-5-brom-N-(ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridincarboxamid, fremgangsmåde til dets fremstilling og medicinsk præparat indeholdende denne forbindelse

Info

Publication number
DK0855397T3
DK0855397T3 DK96924189T DK96924189T DK0855397T3 DK 0855397 T3 DK0855397 T3 DK 0855397T3 DK 96924189 T DK96924189 T DK 96924189T DK 96924189 T DK96924189 T DK 96924189T DK 0855397 T3 DK0855397 T3 DK 0855397T3
Authority
DK
Denmark
Prior art keywords
methylhexahydro
pyridinecarboxamide
diazepin
methylamino
bromo
Prior art date
Application number
DK96924189T
Other languages
Danish (da)
English (en)
Inventor
Shiro Kato
Toshiya Morie
Hiroshi Harada
Naoyuki Yoshida
Yoshimi Hirokawa
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Application granted granted Critical
Publication of DK0855397T3 publication Critical patent/DK0855397T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK96924189T 1995-07-28 1996-07-23 (R)-5-brom-N-(ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridincarboxamid, fremgangsmåde til dets fremstilling og medicinsk præparat indeholdende denne forbindelse DK0855397T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP07212495 1995-07-28
PCT/JP1996/002053 WO1997005129A1 (fr) 1995-07-28 1996-07-23 (r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridine-carboxamide, son procede d'obtention et medicament le contenant

Publications (1)

Publication Number Publication Date
DK0855397T3 true DK0855397T3 (da) 2001-06-25

Family

ID=16623612

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96924189T DK0855397T3 (da) 1995-07-28 1996-07-23 (R)-5-brom-N-(ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridincarboxamid, fremgangsmåde til dets fremstilling og medicinsk præparat indeholdende denne forbindelse

Country Status (24)

Country Link
US (1) US5945415A (fr)
EP (1) EP0855397B1 (fr)
KR (1) KR19990028395A (fr)
CN (1) CN1096459C (fr)
AT (1) ATE201021T1 (fr)
AU (1) AU700635B2 (fr)
BR (1) BR9609691A (fr)
CA (1) CA2228056A1 (fr)
CZ (1) CZ290442B6 (fr)
DE (1) DE69612753T2 (fr)
DK (1) DK0855397T3 (fr)
ES (1) ES2156616T3 (fr)
GR (1) GR3036089T3 (fr)
HU (1) HUP9901208A3 (fr)
IL (1) IL122753A (fr)
MX (1) MX9800620A (fr)
NO (1) NO312964B1 (fr)
NZ (1) NZ312799A (fr)
PL (1) PL184073B1 (fr)
PT (1) PT855397E (fr)
RU (1) RU2156248C2 (fr)
SK (1) SK282044B6 (fr)
TR (1) TR199800165T1 (fr)
WO (1) WO1997005129A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
GB0216027D0 (en) * 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
US20040048874A1 (en) * 2001-05-22 2004-03-11 Bardsley Hazel Judith New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
ITBO20020198A1 (it) * 2002-04-12 2003-10-13 Univ Bologna Derivati 2 , 5 bis diammino 1 , 4 benzochenionici utili per il trattamento della malattia di alzheimer , metodo per la loro preparazione ed
KR20050094843A (ko) * 2003-01-13 2005-09-28 다이노젠 파마세우티컬스, 인코포레이티드 욕지기, 구토, 구역질 또는 이들의 조합을 치료하는 방법
EP2286817A3 (fr) * 2003-01-13 2011-06-15 Edusa Pharmaceuticals, Inc Méthode de traitement des troubles intestinaux fonctionnels
ES2290741T3 (es) * 2003-04-04 2008-02-16 Dynogen Pharmaceuticals Inc. Metodo de tratamiento de trastornos del tracto urinario inferior.
US20060293309A1 (en) * 2005-03-28 2006-12-28 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
CN102333763A (zh) 2009-03-31 2012-01-25 善利亚新药工业股份有限公司 1,5-苯二氮䓬衍生物的制备方法
EP2610252A4 (fr) 2010-08-26 2013-09-04 Kowa Co Nouveau procédé de production de dérivés isoquinoline et de leurs sels
RU2438669C1 (ru) * 2010-10-29 2012-01-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" Средство, проявляющее свойства антагониста серотониновых 5-ht3-рецепторов
PT3102565T (pt) * 2014-02-03 2019-04-01 Mylan Laboratories Ltd Processos para a preparação de intermediários de raltegravir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017573A (en) * 1988-07-29 1991-05-21 Dainippon Pharmaceutical Co., Ltd. Indazole-3-carboxylic acid derivatives
US5166341A (en) * 1988-07-29 1992-11-24 Dainippon Pharmaceutical Co., Ltd. 6-amino-1,4-hexahydro-1H-diazepine derivatives
JPH04210970A (ja) * 1990-01-26 1992-08-03 Dainippon Pharmaceut Co Ltd ベンズアミド誘導体及びその中間体
JPH03223265A (ja) * 1990-01-26 1991-10-02 Dainippon Pharmaceut Co Ltd 環状ジアミン誘導体
SU1825501A3 (ru) * 1990-10-29 1995-12-10 И.В. Комиссаров Dl-3-[(4-[4- (2-пиридил)-1- пиперазинил]бутил)] -1,8,8-триметил -3-азабицикло[3,2,1] октан-2,4-диона дигидрохлорид, проявляющий противотревожную, нейролептическую и противорвотную активность
PT100990A (pt) * 1991-10-24 1994-01-31 Smithkline Beecham Plc Derivados de piridina e sua utilizacao como substancia terapeutica

Also Published As

Publication number Publication date
TR199800165T1 (xx) 1998-06-22
EP0855397A4 (fr) 1998-12-02
NO980333D0 (no) 1998-01-26
KR19990028395A (ko) 1999-04-15
EP0855397A1 (fr) 1998-07-29
HK1018049A1 (en) 1999-12-10
GR3036089T3 (en) 2001-09-28
IL122753A0 (en) 1998-08-16
CZ23098A3 (cs) 1998-06-17
NO312964B1 (no) 2002-07-22
DE69612753D1 (de) 2001-06-13
CN1096459C (zh) 2002-12-18
RU2156248C2 (ru) 2000-09-20
PT855397E (pt) 2001-08-30
IL122753A (en) 2000-10-31
CZ290442B6 (cs) 2002-07-17
CA2228056A1 (fr) 1997-02-13
BR9609691A (pt) 1999-03-23
DE69612753T2 (de) 2005-07-07
US5945415A (en) 1999-08-31
AU6471796A (en) 1997-02-26
NZ312799A (en) 1999-04-29
AU700635B2 (en) 1999-01-07
HUP9901208A3 (en) 2002-10-28
ATE201021T1 (de) 2001-05-15
SK282044B6 (sk) 2001-10-08
WO1997005129A1 (fr) 1997-02-13
ES2156616T3 (es) 2001-07-01
SK9398A3 (en) 1998-08-05
CN1192213A (zh) 1998-09-02
NO980333L (no) 1998-03-23
PL324749A1 (en) 1998-06-08
MX9800620A (es) 1998-04-30
EP0855397B1 (fr) 2001-05-09
HUP9901208A2 (hu) 2000-04-28
PL184073B1 (pl) 2002-08-30

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