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DK0724591T3 - Delta 16 umættede C17-heterocycliske steroider anvendelige som steroid C17-20 lyaseinhibitorer - Google Patents

Delta 16 umættede C17-heterocycliske steroider anvendelige som steroid C17-20 lyaseinhibitorer

Info

Publication number
DK0724591T3
DK0724591T3 DK94929935T DK94929935T DK0724591T3 DK 0724591 T3 DK0724591 T3 DK 0724591T3 DK 94929935 T DK94929935 T DK 94929935T DK 94929935 T DK94929935 T DK 94929935T DK 0724591 T3 DK0724591 T3 DK 0724591T3
Authority
DK
Denmark
Prior art keywords
steroid
delta
unsaturated
lyase inhibitors
steroids useful
Prior art date
Application number
DK94929935T
Other languages
Danish (da)
English (en)
Inventor
Joseph P Burkhart
Cynthia P Gates
Norton P Peet
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0724591T3 publication Critical patent/DK0724591T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK94929935T 1993-10-27 1994-09-29 Delta 16 umættede C17-heterocycliske steroider anvendelige som steroid C17-20 lyaseinhibitorer DK0724591T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14367993A 1993-10-27 1993-10-27
PCT/US1994/011030 WO1995011914A1 (en) 1993-10-27 1994-09-29 Δ16 unsaturated c¿17? heterocyclic steroids useful as steroid c17-20 lyase inhibitors

Publications (1)

Publication Number Publication Date
DK0724591T3 true DK0724591T3 (da) 1999-09-27

Family

ID=22505119

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94929935T DK0724591T3 (da) 1993-10-27 1994-09-29 Delta 16 umættede C17-heterocycliske steroider anvendelige som steroid C17-20 lyaseinhibitorer

Country Status (19)

Country Link
US (3) US5677293A (el)
EP (1) EP0724591B1 (el)
JP (1) JPH09511214A (el)
KR (1) KR960705838A (el)
CN (1) CN1046736C (el)
AT (1) ATE177751T1 (el)
AU (2) AU684844B2 (el)
CA (1) CA2173729C (el)
DE (1) DE69417248T2 (el)
DK (1) DK0724591T3 (el)
ES (1) ES2133582T3 (el)
FI (1) FI961792A7 (el)
GR (1) GR3030263T3 (el)
HU (1) HUT73855A (el)
IL (1) IL111364A0 (el)
NO (1) NO961693D0 (el)
NZ (1) NZ274694A (el)
WO (1) WO1995011914A1 (el)
ZA (1) ZA948310B (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
AU6087700A (en) * 1999-07-15 2001-02-05 Procter & Gamble Company, The Nitrogen-containing steroid compounds and their use to regulate hair growth
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
US6562457B1 (en) 2001-10-31 2003-05-13 E. I. Du Pont De Nemours And Company Polyether ester elastomer comprising polytrimethylene ether ester soft segment and tetramethylene ester hard segment
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
WO2011088160A2 (en) * 2010-01-15 2011-07-21 Biomarin Pharmaceutical Inc. Novel cyp17 inhibitors
KR101823275B1 (ko) 2010-08-04 2018-03-08 펠피큐어 파마슈티걸즈 아이엔씨 전립선 암종의 치료를 위한 병용 요법
CN102746358B (zh) * 2011-04-22 2016-02-10 天津金耀集团有限公司 一种合成孕甾21位溴化物的工艺
CN102898495B (zh) * 2012-11-12 2014-11-26 浙江神洲药业有限公司 醋酸阿比特龙酯的制备方法
CN103059091B (zh) * 2012-11-22 2017-04-19 常州靶点医药科技有限公司 一种避免重金属残留的醋酸阿比特龙的制备方法
US20160022606A1 (en) 2013-03-14 2016-01-28 Pellficure Pharmaceuticals Inc. Novel therapy for prostate carcinoma
EP3191087A1 (en) 2014-09-12 2017-07-19 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
HUP1500055A1 (hu) 2015-02-09 2016-08-29 Druggability Technologies Ip Holdco Ltd Abirateron acetát komplexei, eljárás elõállításukra, és az azokat tartalmazó gyógyászati készítmények
EP3528799A1 (en) 2016-10-24 2019-08-28 Pellficure Pharmaceuticals, Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
CN106866773A (zh) * 2017-02-14 2017-06-20 西北农林科技大学 一组具有抗癌活性吡唑基甾体衍生物的制备方法及应用
CN116621905B (zh) * 2023-06-06 2025-07-15 西北农林科技大学 双烯噻唑类衍生物及其合成方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081647A (en) * 1965-04-01 1967-08-31 Shionogi & Co Furan compounds
AT253975B (de) * 1965-06-15 1967-05-10 Carinthia Elektrogeraete Ges M Trockenrasierapparat
US3436390A (en) * 1966-05-24 1969-04-01 American Home Prod 4,4-dihydroxy-2-butenoic acid lactones
US3398138A (en) * 1966-05-24 1968-08-20 American Home Prod Novel cardenolides and derivatives
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
US4380624A (en) * 1981-07-31 1983-04-19 Advance Biofactures Corp. Novel isomers of bufalin and resibufogenin and their preparation
US4523917A (en) * 1983-12-27 1985-06-18 Dana Corporation Variable pitch diameter torque sensing pulley assembly
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
DE69327096T2 (de) * 1992-03-31 2000-06-21 Btg International Ltd., London 17-substituierte steroide, verwendbar bei behandlung von krebs
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Also Published As

Publication number Publication date
DE69417248T2 (de) 1999-08-19
FI961792A0 (fi) 1996-04-26
AU695341B2 (en) 1998-08-13
ZA948310B (en) 1995-06-14
EP0724591B1 (en) 1999-03-17
CN1046736C (zh) 1999-11-24
CN1133596A (zh) 1996-10-16
WO1995011914A1 (en) 1995-05-04
JPH09511214A (ja) 1997-11-11
FI961792L (fi) 1996-04-26
NO961693L (no) 1996-04-26
FI961792A7 (fi) 1996-04-26
US5965548A (en) 1999-10-12
US5977094A (en) 1999-11-02
EP0724591A1 (en) 1996-08-07
KR960705838A (ko) 1996-11-08
AU3993097A (en) 1998-01-08
IL111364A0 (en) 1994-12-29
HU9601113D0 (en) 1996-07-29
ES2133582T3 (es) 1999-09-16
HUT73855A (en) 1996-09-30
GR3030263T3 (en) 1999-08-31
CA2173729A1 (en) 1995-05-04
NO961693D0 (no) 1996-04-26
AU684844B2 (en) 1998-01-08
AU7922394A (en) 1995-05-22
CA2173729C (en) 2001-05-15
US5677293A (en) 1997-10-14
DE69417248D1 (de) 1999-04-22
ATE177751T1 (de) 1999-04-15
NZ274694A (en) 1998-01-26

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