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DK0748319T3 - Fremgangsmåde til fremstilling af et epoxid - Google Patents

Fremgangsmåde til fremstilling af et epoxid

Info

Publication number
DK0748319T3
DK0748319T3 DK95911105T DK95911105T DK0748319T3 DK 0748319 T3 DK0748319 T3 DK 0748319T3 DK 95911105 T DK95911105 T DK 95911105T DK 95911105 T DK95911105 T DK 95911105T DK 0748319 T3 DK0748319 T3 DK 0748319T3
Authority
DK
Denmark
Prior art keywords
epoxide
preparing
renin
proteases
synthesizing
Prior art date
Application number
DK95911105T
Other languages
English (en)
Inventor
Ralph P Volante
Kai Rossen
David Askin
Kan K Eng
Peter E Maligres
Paul J Reider
Veena Upadhyay
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0748319(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0748319T3 publication Critical patent/DK0748319T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK95911105T 1994-03-04 1995-02-27 Fremgangsmåde til fremstilling af et epoxid DK0748319T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20607494A 1994-03-04 1994-03-04
PCT/US1995/002347 WO1995023797A1 (en) 1994-03-04 1995-02-27 Process for making an epoxide

Publications (1)

Publication Number Publication Date
DK0748319T3 true DK0748319T3 (da) 2002-03-18

Family

ID=22764868

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95911105T DK0748319T3 (da) 1994-03-04 1995-02-27 Fremgangsmåde til fremstilling af et epoxid

Country Status (25)

Country Link
EP (1) EP0748319B1 (da)
JP (1) JP3871705B2 (da)
KR (1) KR100387741B1 (da)
CN (1) CN1066728C (da)
AT (1) ATE210662T1 (da)
AU (1) AU690231B2 (da)
BR (1) BR9506977A (da)
CA (1) CA2183976C (da)
CZ (1) CZ291816B6 (da)
DE (1) DE69524578T2 (da)
DK (1) DK0748319T3 (da)
ES (1) ES2167419T3 (da)
FI (1) FI120259B (da)
HR (1) HRP950096B1 (da)
HU (1) HU222750B1 (da)
MX (1) MX9603871A (da)
NZ (1) NZ281866A (da)
PT (1) PT748319E (da)
RO (1) RO117696B1 (da)
RU (1) RU2137769C1 (da)
SK (1) SK283067B6 (da)
TW (1) TW380137B (da)
UA (1) UA45968C2 (da)
WO (1) WO1995023797A1 (da)
YU (1) YU49010B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728840A (en) * 1994-03-04 1998-03-17 Merck & Co., Inc. Process for making an epoxide
TW415948B (en) * 1995-10-30 2000-12-21 Merck & Co Inc Process for synthesizing epoxide and halohydrin
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
KR101434522B1 (ko) 2005-11-09 2014-08-26 오닉스 세라퓨틱스, 인크. 효소 저해를 위한 화합물
RU2450016C2 (ru) 2006-06-19 2012-05-10 Протеоликс, Инк. Пептидные эпоксикетоны для ингибирования протеасомы
SI2207791T2 (sl) * 2007-10-04 2019-09-30 Onyx Therapeutics, Inc. Kristalinični peptidepoksiketonski proteazni inhibitorji in sinteza aminokislinskih ketoepoksidov
EP2796134B1 (en) 2008-10-21 2016-12-07 Onyx Therapeutics, Inc. Combination of the peptide epoxyketone proteasome inhibitor carfilzomib with melphalan for use in the treatment of multiple myeloma
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
EP2498793B1 (en) 2009-11-13 2019-07-10 Onyx Therapeutics, Inc. Oprozomib for use in metastasis suppression
AU2011223795B2 (en) 2010-03-01 2015-11-05 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
US9206141B2 (en) * 2010-04-30 2015-12-08 Indiana University Research And Technology Corporation Processes for preparing linezolid
US20140105921A1 (en) 2012-07-09 2014-04-17 Onyx Therapeutics, Inc. Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
CN104692987B (zh) * 2015-01-22 2017-05-17 北京大学 卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
CA2195027C (en) * 1991-11-08 2000-01-11 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids

Also Published As

Publication number Publication date
CZ254396A3 (en) 1997-01-15
FI963452L (fi) 1996-09-03
HRP950096B1 (en) 2002-06-30
DE69524578D1 (de) 2002-01-24
NZ281866A (en) 1998-05-27
HUT75611A (en) 1997-05-28
DE69524578T2 (de) 2002-07-18
SK283067B6 (sk) 2003-02-04
CZ291816B6 (cs) 2003-06-18
BR9506977A (pt) 1997-09-02
YU14595A (sh) 1997-12-05
CA2183976A1 (en) 1995-09-08
FI963452A0 (fi) 1996-09-03
ES2167419T3 (es) 2002-05-16
EP0748319B1 (en) 2001-12-12
UA45968C2 (uk) 2002-05-15
SK112296A3 (en) 1997-02-05
CN1066728C (zh) 2001-06-06
FI120259B (fi) 2009-08-31
HU9602412D0 (en) 1996-11-28
ATE210662T1 (de) 2001-12-15
YU49010B (sh) 2003-04-30
PT748319E (pt) 2002-05-31
MX9603871A (es) 1997-07-31
HRP950096A2 (en) 1997-06-30
EP0748319A1 (en) 1996-12-18
CN1146768A (zh) 1997-04-02
KR970701714A (ko) 1997-04-12
CA2183976C (en) 2005-02-01
HU222750B1 (hu) 2003-09-29
RU2137769C1 (ru) 1999-09-20
WO1995023797A1 (en) 1995-09-08
AU690231B2 (en) 1998-04-23
TW380137B (en) 2000-01-21
JP3871705B2 (ja) 2007-01-24
RO117696B1 (ro) 2002-06-28
KR100387741B1 (ko) 2003-10-04
JPH09509929A (ja) 1997-10-07
AU1882895A (en) 1995-09-18

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