[go: up one dir, main page]

DK0743940T3 - Nye forbindelser med analgetisk og local-anæstetisk virkning - Google Patents

Nye forbindelser med analgetisk og local-anæstetisk virkning

Info

Publication number
DK0743940T3
DK0743940T3 DK95910029T DK95910029T DK0743940T3 DK 0743940 T3 DK0743940 T3 DK 0743940T3 DK 95910029 T DK95910029 T DK 95910029T DK 95910029 T DK95910029 T DK 95910029T DK 0743940 T3 DK0743940 T3 DK 0743940T3
Authority
DK
Denmark
Prior art keywords
new compounds
analgesic
local anesthetic
anesthetic effect
effect
Prior art date
Application number
DK95910029T
Other languages
English (en)
Inventor
Anna-Lena Ask
Lars-Inge Olsson
Rune Sandberg
Original Assignee
Astrazeneca Ab
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astra Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0743940T3 publication Critical patent/DK0743940T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Finger-Pressure Massage (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK95910029T 1994-02-11 1995-02-03 Nye forbindelser med analgetisk og local-anæstetisk virkning DK0743940T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9400447A SE9400447D0 (sv) 1994-02-11 1994-02-11 New compounds
PCT/SE1995/000106 WO1995021821A1 (en) 1994-02-11 1995-02-03 New compounds with analgesic and local anaesthetic effect

Publications (1)

Publication Number Publication Date
DK0743940T3 true DK0743940T3 (da) 2000-08-14

Family

ID=20392881

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95910029T DK0743940T3 (da) 1994-02-11 1995-02-03 Nye forbindelser med analgetisk og local-anæstetisk virkning

Country Status (31)

Country Link
US (2) US5756520A (da)
EP (1) EP0743940B1 (da)
JP (1) JPH09508904A (da)
CN (1) CN1067989C (da)
AT (1) ATE192435T1 (da)
AU (1) AU686760B2 (da)
BR (1) BR9506748A (da)
CA (1) CA2181068A1 (da)
CZ (1) CZ286753B6 (da)
DE (1) DE69516671T2 (da)
DK (1) DK0743940T3 (da)
EE (1) EE03252B1 (da)
ES (1) ES2148493T3 (da)
FI (1) FI963128A7 (da)
GR (1) GR3033999T3 (da)
HR (1) HRP950414B1 (da)
HU (1) HU216734B (da)
IL (1) IL112374A (da)
IS (1) IS1771B (da)
MX (1) MX9603092A (da)
MY (1) MY130166A (da)
NO (1) NO306718B1 (da)
NZ (1) NZ281355A (da)
PL (1) PL180212B1 (da)
PT (1) PT743940E (da)
RU (1) RU2145599C1 (da)
SE (1) SE9400447D0 (da)
SK (1) SK281931B6 (da)
TW (1) TW348176B (da)
WO (1) WO1995021821A1 (da)
ZA (1) ZA95709B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
DE19912889A1 (de) * 1999-03-23 2000-09-28 Daimler Chrysler Ag Verfahren zur Herstellung eines Ventilsitzes
CN1744899A (zh) * 2002-12-13 2006-03-08 史密丝克莱恩比彻姆公司 作为ccr5拮抗剂的哌啶衍生物
US6916833B2 (en) * 2003-03-13 2005-07-12 Hoffmann-La Roche Inc. Substituted piperidines
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
TW200831497A (en) * 2006-10-12 2008-08-01 Epix Delaware Inc Carboxamide compounds and their use
CN101925383A (zh) 2007-12-11 2010-12-22 赛特帕斯凡德株式会社 甲酰胺化合物及其作为趋化因子受体激动剂的应用
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US20100185249A1 (en) * 2009-01-22 2010-07-22 Wingeier Brett M Method and Devices for Adrenal Stimulation
US20220096452A1 (en) 2019-01-22 2022-03-31 Icm (Institut Du Cerveau Et De La Moelle Épinière) Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951080A (en) * 1957-08-05 1960-08-30 Lilly Co Eli Novel phenyl-substituted piperidines
NL130088C (da) * 1960-03-14
US3850935A (en) * 1971-10-16 1974-11-26 Sumitomo Chemical Co Process for producing piperidine derivatives by degrading quaternary piperidinium salts
US4369184A (en) * 1980-01-24 1983-01-18 Janssen Pharmaceutica N.V. 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives
SE8904298D0 (sv) * 1989-12-21 1989-12-21 Astra Ab New compounds
JPH08504435A (ja) * 1992-12-14 1996-05-14 メルク シヤープ エンド ドーム リミテツド タキキニン受容体拮抗剤としての４−アミノメチル／チオメチル／スルホニルメチル−４−フェニルピペリジン

Also Published As

Publication number Publication date
FI963128A0 (fi) 1996-08-09
HUT75641A (en) 1997-05-28
PL315777A1 (en) 1996-12-09
DE69516671D1 (de) 2000-06-08
EP0743940A1 (en) 1996-11-27
FI963128L (fi) 1996-08-09
GR3033999T3 (en) 2000-11-30
ZA95709B (en) 1995-08-11
CZ286753B6 (en) 2000-06-14
HRP950414A2 (en) 1997-10-31
AU1826995A (en) 1995-08-29
CZ203296A3 (en) 1996-12-11
DE69516671T2 (de) 2001-02-01
EP0743940B1 (en) 2000-05-03
CN1140448A (zh) 1997-01-15
JPH09508904A (ja) 1997-09-09
AU686760B2 (en) 1998-02-12
BR9506748A (pt) 1997-09-16
US5756520A (en) 1998-05-26
HRP950414B1 (en) 2001-02-28
ATE192435T1 (de) 2000-05-15
HU216734B (hu) 1999-08-30
SK281931B6 (sk) 2001-09-11
MX9603092A (es) 1997-03-29
SE9400447D0 (sv) 1994-02-11
EE03252B1 (et) 2000-02-15
TW348176B (en) 1998-12-21
NO963292L (no) 1996-08-07
RU2145599C1 (ru) 2000-02-20
PT743940E (pt) 2000-08-31
MY130166A (en) 2007-06-29
IL112374A (en) 1999-12-31
FI963128A7 (fi) 1996-08-09
IL112374A0 (en) 1995-03-30
ES2148493T3 (es) 2000-10-16
PL180212B1 (pl) 2001-01-31
NZ281355A (en) 1998-02-26
WO1995021821A1 (en) 1995-08-17
US5968953A (en) 1999-10-19
CA2181068A1 (en) 1995-08-17
NO306718B1 (no) 1999-12-13
CN1067989C (zh) 2001-07-04
IS1771B (is) 2001-05-28
NO963292D0 (no) 1996-08-07
HU9602206D0 (en) 1996-10-28
IS4251A (is) 1995-08-12
SK92896A3 (en) 1997-07-09

Similar Documents

Publication Publication Date Title
TR199801180T2 (xx) Aneljestik etkiye sahip yeni bile�ikler.
NO178858C (no) Analogifremgangsmåte for fremstilling av substituerte 4-fenyl-4-piperidinkarboksamider med både lokal anestetisk og analgetisk effekt
DK0743940T3 (da) Nye forbindelser med analgetisk og local-anæstetisk virkning
SE9401728D0 (sv) New compounds II
KR100239168B1 (en) Heterocyclic amines useful in the therapy of athma and inflammation of the respiratory tracts
MA23170A1 (fr) Procede de preparation d'un nouveau compose .
MY130773A (en) Stable extended release oral dosage composition
ES2102475T3 (es) Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
MY108146A (en) Medicaments for treating inflammatory conditions or for analgesia
TR199801184T2 (xx) Analjezik tesirli yeni bile�ikler.
NO993921L (no) Medikament mot infertilitet og for ökt fertilitet
NO903291L (no) Renin-hemmende aminooligohydroksyderivater.
JO1652B1 (en) New compounds for local anesthesia and a way to prepare them
GR900100108A (el) Νεες ενωσεις τοπικης αναισθησιας και μεθοδος για την παρασκευη τους.