DK0741741T3 - Modificerede oligonucleotider - Google Patents

Modificerede oligonucleotider

Info

Publication number: DK0741741T3
Authority: DK; Denmark
Prior art keywords: pct; nucleotides; sec; modified oligonucleotides; date
Prior art date: 1994-01-26

Application number

DK95906958T

Other languages

English (en)

Inventor

Catherine Lesueur

Mesmaeker Alain De

Adrian Waldner

Jacques Lebreton

Marc-Olivier Bevierre

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-26

Filing date

1995-01-17

Publication date

2002-12-23

1994-01-26 Priority claimed from GB9401446A external-priority patent/GB9401446D0/en

1994-06-22 Priority claimed from GB9412526A external-priority patent/GB9412526D0/en

1995-01-17 Application filed by Novartis Ag filed Critical Novartis Ag

2002-12-23 Application granted granted Critical

2002-12-23 Publication of DK0741741T3 publication Critical patent/DK0741741T3/da

Links

JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
239000002777 nucleoside Substances 0.000 abstract 2
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
125000003835 nucleoside group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK95906958T 1994-01-26 1995-01-17 Modificerede oligonucleotider DK0741741T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9401446A GB9401446D0 (en)	1994-01-26	1994-01-26	Modified oligonucleotides
GB9412526A GB9412526D0 (en)	1994-06-22	1994-06-22	Modified oligonucleotides
PCT/EP1995/000156 WO1995020597A1 (en)	1994-01-26	1995-01-17	Modified oligonucleotides

Publications (1)

Publication Number	Publication Date
DK0741741T3 true DK0741741T3 (da)	2002-12-23

Family

ID=26304218

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95906958T DK0741741T3 (da)	1994-01-26	1995-01-17	Modificerede oligonucleotider

Country Status (13)

Country	Link
US (1)	US6066447A (da)
EP (1)	EP0741741B1 (da)
JP (1)	JPH09508134A (da)
AT (1)	ATE222921T1 (da)
AU (1)	AU697134B2 (da)
CA (1)	CA2180727A1 (da)
DE (1)	DE69527942T2 (da)
DK (1)	DK0741741T3 (da)
FI (1)	FI116677B (da)
HU (1)	HU220423B (da)
IL (1)	IL112424A0 (da)
NO (1)	NO316902B1 (da)
WO (1)	WO1995020597A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1161450C (zh) *	1993-12-13	2004-08-11	普罗格特-甘布尔公司	粘度稳定的浓缩液态纺织品柔软剂组合物
US6166197A (en) *	1995-03-06	2000-12-26	Isis Pharmaceuticals, Inc.	Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
ATE327244T1 (de)	1995-03-06	2006-06-15	Isis Pharmaceuticals Inc	Verfahren zur synthese von 2'-0-substituierten pyrimidinen und oligomere davon
WO1997014709A1 (en) *	1995-10-13	1997-04-24	F. Hoffmann-La Roche Ag	Antisense oligomers
US5808035A (en) *	1995-12-08	1998-09-15	Usher; David A.	Protected nucleoside and method for its synthesis
WO1998000434A1 (en) *	1996-06-28	1998-01-08	Novartis Ag	Modified oligonucleotides
SK179899A3 (en)	1997-07-03	2001-12-03	Du Pont Pharm Co	Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6878716B1 (en)	1998-06-02	2005-04-12	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptor and uses thereof
BR9911612A (pt)	1998-06-02	2001-02-06	Osi Pharm Inc	Composições de pirrolo[2,3d]pirimidina e seus usos
US6686366B1 (en)	1998-06-02	2004-02-03	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
US6365589B1 (en)	1998-07-02	2002-04-02	Bristol-Myers Squibb Pharma Company	Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US6680322B2 (en)	1999-12-02	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
US7160890B2 (en)	1999-12-02	2007-01-09	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
US6664252B2 (en)	1999-12-02	2003-12-16	Osi Pharmaceuticals, Inc.	4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6680324B2 (en)	2000-12-01	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en)	2000-12-01	2004-01-06	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
AU2002360436A1 (en)	2001-11-30	2003-06-17	Osi Pharmaceuticals, Inc.	2-aryl pyrrologpyrimidines for a1 and a3 receptors
EA011809B1 (ru)	2001-12-20	2009-06-30	Оси Фармасьютикалз, Инк.	Пиримидиновые соединения, их применение в качестве a-селективных антагонистов и способ их получения
CN101973998A (zh)	2001-12-20	2011-02-16	Osi药物公司	吡咯并嘧啶A2b选择性拮抗剂化合物
KR100649352B1 (ko) *	2005-04-30	2006-11-27	주식회사 하이닉스반도체	반도체소자의 제조 방법
US7820810B2 (en)	2007-03-19	2010-10-26	Isis Pharmaceuticals, Inc.	Process for the synthesis of 2′-O-substituted purine nulceosides
PT2411521E (pt)	2009-03-25	2015-04-21	Univ Texas	Composições para estimulação de resistência imunitária inata de mamíferos contra patogénicos
WO2016044839A2 (en)	2014-09-19	2016-03-24	The Board Of Regents Of The University Of Texas System	Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
CN107848970B (zh) *	2015-07-30	2021-07-06	地平线孤儿病有限责任公司	岩藻糖苷酶抑制剂
WO2025149479A1 (en) *	2024-01-12	2025-07-17	Roche Diagnostics Gmbh	Synthesis of modified nucleoside triphosphates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4806463A (en) *	1986-05-23	1989-02-21	Worcester Foundation For Experimental Biology	Inhibition of HTLV-III by exogenous oligonucleotides
EP0266099A3 (en) *	1986-10-28	1990-09-19	The Johns Hopkins University	Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
WO1989008146A1 (en) *	1988-02-26	1989-09-08	Worcester Foundation For Experimental Biology	Inhibition of htlv-iii by exogenous oligonucleotides
ATE190981T1 (de) *	1989-10-24	2000-04-15	Isis Pharmaceuticals Inc	2'-modifizierte nukleotide
US5378825A (en) *	1990-07-27	1995-01-03	Isis Pharmaceuticals, Inc.	Backbone modified oligonucleotide analogs
DK0541722T3 (da) *	1990-08-03	1996-04-22	Sterling Winthrop Inc	Forbindelser og fremgangsmåder til inhibering af genekspression
EP0549686A4 (en) *	1990-09-20	1995-01-18	Gilead Sciences Inc	Modified internucleoside linkages

1995
- 1995-01-17 DK DK95906958T patent/DK0741741T3/da active
- 1995-01-17 CA CA002180727A patent/CA2180727A1/en not_active Abandoned
- 1995-01-17 DE DE69527942T patent/DE69527942T2/de not_active Expired - Fee Related
- 1995-01-17 JP JP7519861A patent/JPH09508134A/ja active Pending
- 1995-01-17 AT AT95906958T patent/ATE222921T1/de not_active IP Right Cessation
- 1995-01-17 AU AU15347/95A patent/AU697134B2/en not_active Ceased
- 1995-01-17 WO PCT/EP1995/000156 patent/WO1995020597A1/en not_active Ceased
- 1995-01-17 EP EP95906958A patent/EP0741741B1/en not_active Expired - Lifetime
- 1995-01-17 US US08/687,456 patent/US6066447A/en not_active Expired - Fee Related
- 1995-01-17 HU HU9602040A patent/HU220423B/hu not_active IP Right Cessation
- 1995-01-24 IL IL11242495A patent/IL112424A0/xx unknown
1996
- 1996-07-24 NO NO19963092A patent/NO316902B1/no unknown
- 1996-07-26 FI FI962980A patent/FI116677B/fi active IP Right Grant

Also Published As

Publication number	Publication date
DE69527942T2 (de)	2003-03-27
IL112424A0 (en)	1995-03-30
HU220423B (hu)	2002-01-28
HUT75704A (en)	1997-05-28
NO963092L (no)	1996-09-16
JPH09508134A (ja)	1997-08-19
NO963092D0 (no)	1996-07-24
AU697134B2 (en)	1998-09-24
FI116677B (fi)	2006-01-31
DE69527942D1 (de)	2002-10-02
ATE222921T1 (de)	2002-09-15
US6066447A (en)	2000-05-23
WO1995020597A1 (en)	1995-08-03
AU1534795A (en)	1995-08-15
EP0741741B1 (en)	2002-08-28
EP0741741A1 (en)	1996-11-13
NO316902B1 (no)	2004-06-21
CA2180727A1 (en)	1995-08-03
HU9602040D0 (en)	1996-09-30
FI962980L (fi)	1996-07-26
FI962980A0 (fi)	1996-07-26

Publication	Publication Date	Title
ATE222921T1 (de)	2002-09-15	Modifizierte oligonukleotide
MX9703192A (es)	1997-12-31	Nucleosidos modificados en el azucar y su uso para la sintesis de oligonucleosidos.
DE69403642D1 (de)	1997-07-10	7-deazapurin modifizierte oligonukleotide
DK0712860T3 (da)	2002-03-04	Fremgangsmåde til oprensning og isolation af 2'-deoxy-2',2'-diflournukleosider
DE69838449D1 (de)	2007-10-31	Aminooxy-modifizierte oligonukleotide
DE3854297D1 (de)	1995-09-14	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
ES2061416T1 (es)	1994-12-16	Ribocimas modificadas.
FI924188A7 (fi)	1992-09-18	Yksisäikeisen DNA:n kohtaspesifinen pilkkominen
FI913236A0 (fi)	1991-07-03	9-purinylfosfonsyraderivat.
ES2125976T3 (es)	1999-03-16	Otros derivados de indol con accion antiviral.
ATE53588T1 (de)	1990-06-15	Herstellung von cytosin-nukleosiden.
FI945323L (fi)	1995-05-16	5-metyyliuridiinimenetelmä 2',3'-didehydro-3'-deoksitymidiinin (d4T) laajamittaista valmistusta varten
DK0906329T3 (da)	2004-02-09	2'-Substituerede nukleosider og oligonukleotidderivater
DK630589A (da)	1990-06-15	2',3'-dideoxypurinnucleosid/purinnucleosid-phosphorylase-inhibitor-sammensaetning
FR2738827B1 (fr)	1997-10-17	Detection des enterobacteries
BR9801143A (pt)	2000-01-18	Copolìmeros de bloco de siloxano inovativos com espaçamento rìgidos e uso dos mesmos.
DE69323191D1 (de)	1999-03-04	Wasserlösliche retinoide
AU2739797A (en)	1997-11-26	(in situ) preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
NO306409B1 (no)	1999-11-01	Monohydrat av (E)-2'-deoxy-2'-(fluormethylen)cytidin