DK0699759T3 - Aspartokinasegenvarianter - Google Patents
AspartokinasegenvarianterInfo
- Publication number
- DK0699759T3 DK0699759T3 DK94902116T DK94902116T DK0699759T3 DK 0699759 T3 DK0699759 T3 DK 0699759T3 DK 94902116 T DK94902116 T DK 94902116T DK 94902116 T DK94902116 T DK 94902116T DK 0699759 T3 DK0699759 T3 DK 0699759T3
- Authority
- DK
- Denmark
- Prior art keywords
- corynebacterium
- lysine
- aspartokinase
- gene variants
- threonine
- Prior art date
Links
- 108010055400 Aspartate kinase Proteins 0.000 title abstract 3
- 108010064711 Homoserine dehydrogenase Proteins 0.000 title abstract 3
- 102000054767 gene variant Human genes 0.000 title 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 8
- 241000186216 Corynebacterium Species 0.000 abstract 4
- 235000019766 L-Lysine Nutrition 0.000 abstract 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 4
- 239000004472 Lysine Substances 0.000 abstract 4
- 108020004414 DNA Proteins 0.000 abstract 2
- 239000004473 Threonine Substances 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 235000018102 proteins Nutrition 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 230000002195 synergetic effect Effects 0.000 abstract 2
- 229960002898 threonine Drugs 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
- Ceramic Products (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10145093A JP3473042B2 (ja) | 1992-04-28 | 1993-04-27 | 変異型アスパルトキナーゼ遺伝子 |
| PCT/JP1993/001809 WO1994025605A1 (fr) | 1993-04-27 | 1993-12-14 | Gene d'aspartokinase variant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0699759T3 true DK0699759T3 (da) | 2003-09-15 |
Family
ID=14301034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94902116T DK0699759T3 (da) | 1993-04-27 | 1993-12-14 | Aspartokinasegenvarianter |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5688671A (ja) |
| EP (1) | EP0699759B1 (ja) |
| JP (1) | JP3473042B2 (ja) |
| AT (1) | ATE235555T1 (ja) |
| DE (1) | DE69332805T2 (ja) |
| DK (1) | DK0699759T3 (ja) |
| ES (1) | ES2191680T3 (ja) |
| WO (1) | WO1994025605A1 (ja) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696561B1 (en) | 1909-07-09 | 2004-02-24 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport |
| JP3473042B2 (ja) * | 1992-04-28 | 2003-12-02 | 味の素株式会社 | 変異型アスパルトキナーゼ遺伝子 |
| US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
| JP3106501B2 (ja) * | 1995-06-07 | 2000-11-06 | 味の素株式会社 | Ｌ−リジンの製造法 |
| JP4035855B2 (ja) | 1996-06-05 | 2008-01-23 | 味の素株式会社 | Ｌ−リジンの製造法 |
| SK285201B6 (sk) * | 1996-12-05 | 2006-08-03 | Ajinomoto Co., Inc. | Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7 |
| JP4075087B2 (ja) * | 1996-12-05 | 2008-04-16 | 味の素株式会社 | Ｌ−リジンの製造法 |
| US6376521B1 (en) | 1998-07-10 | 2002-04-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A3 adenosine receptor antagonists |
| HK1042321B (en) | 1999-04-19 | 2012-02-24 | 协和发酵工业株式会社 | Novel desensitized aspartokinase |
| CA2383865A1 (en) | 1999-06-25 | 2001-01-04 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding metabolic pathway proteins |
| US7270984B1 (en) | 1999-06-25 | 2007-09-18 | Basf Aktiengesellschaft | Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum |
| US6884614B1 (en) | 1999-07-01 | 2005-04-26 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins |
| EP1702980A1 (en) | 1999-07-01 | 2006-09-20 | Basf Aktiengesellschaft | Corynebacterium glutamicum gene encoding Hpr of phosphoenolpyruvate:sugar phosphotransferase system |
| AU781091B2 (en) | 1999-07-02 | 2005-05-05 | Ajinomoto Co., Inc. | DNA encoding sucrose PTS enzyme II |
| US6797509B1 (en) | 1999-07-09 | 2004-09-28 | Degussa-Huls Ag | Nucleotide sequences which code for the tal gene |
| IL148564A0 (en) | 1999-09-15 | 2002-09-12 | Basf Plant Science Gmbh | Plants having altered amino acid contents and method for the production thereof |
| JP2001120269A (ja) * | 1999-10-22 | 2001-05-08 | Ajinomoto Co Inc | 発酵法によるｌ−リジンの製造法 |
| CN1230525C (zh) * | 1999-12-24 | 2005-12-07 | 味之素株式会社 | 生产l－氨基酸的方法和新型基因 |
| US6927046B1 (en) | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
| US7087589B2 (en) | 2000-01-14 | 2006-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methanocarba cycloakyl nucleoside analogues |
| DE10210527A1 (de) | 2002-03-09 | 2003-09-18 | Degussa | Allele des aceA-Gens aus coryneformen Bakterien |
| EP1976994A1 (en) * | 2006-01-26 | 2008-10-08 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of enterobacteriaceae family with attenuated expression of the aldh gene |
| EP2184348B1 (en) * | 2006-03-23 | 2013-11-27 | Ajinomoto Co., Inc. | A method for producing an L-amino acid using bacterium of the Enterobacteriaceae family with attenuated expression of a gene coding for small RNA |
| EP2386650B1 (en) * | 2006-04-07 | 2013-07-03 | Evonik Degussa GmbH | Method for producing L-amino acids using the gap promoter |
| WO2007119890A1 (en) * | 2006-04-18 | 2007-10-25 | Ajinomoto Co., Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE sfmACDFH-fimZ CLUSTER OR THE fimZ GENE |
| JP2009165355A (ja) * | 2006-04-28 | 2009-07-30 | Ajinomoto Co Inc | Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法 |
| WO2007139219A1 (en) * | 2006-06-01 | 2007-12-06 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the rcsa gene |
| RU2337961C2 (ru) * | 2006-07-04 | 2008-11-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ L-ТРЕОНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН rspAB |
| EP1881076A1 (en) * | 2006-07-17 | 2008-01-23 | Evonik Degussa GmbH | Method for producing L-amino acids |
| JP5407858B2 (ja) * | 2006-07-19 | 2014-02-05 | 味の素株式会社 | 腸内細菌科の細菌を用いたｌ−アミノ酸の製造方法 |
| JP2010017081A (ja) | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| WO2008072761A2 (en) * | 2006-12-11 | 2008-06-19 | Ajinomoto Co., Inc. | Method for producing an l-amino acid |
| RU2006143864A (ru) * | 2006-12-12 | 2008-06-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ |
| RU2006145712A (ru) * | 2006-12-22 | 2008-06-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ получения l-аминокислот методом ферментации с использованием бактерий, обладающих повышенной способностью к утилизации глицерина |
| JP2010110217A (ja) * | 2007-02-22 | 2010-05-20 | Ajinomoto Co Inc | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法 |
| JP5217780B2 (ja) * | 2008-02-08 | 2013-06-19 | 味の素株式会社 | Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法 |
| CN102089437B (zh) | 2008-07-09 | 2014-11-05 | 味之素株式会社 | 生产氨基羟基苯甲酸盐类化合物的方法 |
| JP2012029565A (ja) | 2008-11-27 | 2012-02-16 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| US8518957B2 (en) | 2009-12-02 | 2013-08-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure |
| EP2374873A1 (en) | 2010-04-08 | 2011-10-12 | Technische Universität Hamburg-Harburg | Modified aspartate kinase from corynebacterium and its application for amino acid production |
| CN104379742A (zh) | 2012-05-29 | 2015-02-25 | 味之素株式会社 | 生产3-乙酰氨基-4-羟基苯甲酸的方法 |
| DE102012016716A1 (de) | 2012-08-22 | 2014-02-27 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung von Vektoren enthaltend ein für in seiner feedback-Inhibierung gemindertes oder ausgeschaltetes Enzym kodierendes Gen und deren Verwendung für die Herstellung von Aminosäuren und Nukleotiden |
| EP2940143B1 (de) | 2014-04-30 | 2020-02-05 | Evonik Operations GmbH | Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums |
| EP2940144A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums |
| JP6415845B2 (ja) * | 2014-04-30 | 2018-10-31 | 日本テクニカ株式会社 | 展示物の展示及び収容用ケースの構造 |
| EP2940039A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems |
| DE102014208199A1 (de) | 2014-04-30 | 2015-11-05 | Evonik Degussa Gmbh | Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums |
| KR102011994B1 (ko) * | 2017-06-30 | 2019-08-20 | 씨제이제일제당 주식회사 | 신규한 아스파토키나제 변이체 및 이를 이용한 l-아미노산의 제조방법 |
| EP3456833A1 (en) | 2017-09-18 | 2019-03-20 | Evonik Degussa GmbH | Method for the fermentative production of l-amino acids |
| EP3467099A1 (en) | 2017-10-05 | 2019-04-10 | Evonik Degussa GmbH | Method for the fermentative production of l-amino acids |
| EP3498853A1 (en) | 2017-12-14 | 2019-06-19 | Evonik Degussa GmbH | Method for the fermentative production of l-lysine |
| EP3594355A1 (en) | 2018-07-12 | 2020-01-15 | Evonik Operations GmbH | Method for the fermentative production of l-lysine |
| EP3599282B1 (en) | 2018-07-24 | 2021-03-17 | Evonik Operations GmbH | Method for the fermentative production of l-lysine |
| RU2019128538A (ru) | 2018-09-26 | 2021-03-11 | Эвоник Оперейшенс ГмбХ | Способ ферментативного получения l-лизина |
| EP3660158A1 (en) | 2018-11-29 | 2020-06-03 | Evonik Operations GmbH | Method for the fermentative production of l-lysine |
| EP3670525A1 (en) | 2018-12-18 | 2020-06-24 | Evonik Operations GmbH | Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter |
| US10829746B2 (en) | 2019-01-23 | 2020-11-10 | Evonik Operations Gmbh | Method for the fermentative production of L-lysine |
| WO2021048353A1 (en) | 2019-09-11 | 2021-03-18 | Evonik Operations Gmbh | Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine |
| WO2023041425A1 (en) | 2021-09-20 | 2023-03-23 | Evonik Operations Gmbh | Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2 |
| EP4497818A1 (en) | 2023-07-25 | 2025-01-29 | Evonik Operations GmbH | Method for the fermentative production of l-lysine using c. glutamicum strains expressing heterologous nicotinamide nucleotide transhydrogenase pntab |
| CN117327677B (zh) * | 2023-09-26 | 2024-09-20 | 江南大学 | 天冬氨酸激酶突变体及其应用 |
| EP4613854A1 (en) | 2024-03-05 | 2025-09-10 | Evonik Operations GmbH | Method for the fermentative production of l-lysine using c. glutamicum strains expressing a heterologous nicotinamide nucleotide transhydrogenase pntab and having an increased activity of a myo-inositol permease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5763095A (en) * | 1980-09-30 | 1982-04-16 | Ajinomoto Co Inc | Production of l-lysine through fermentation process |
| DE3908201A1 (de) * | 1989-03-14 | 1990-09-27 | Degussa | Verfahren zur fermentativen herstellung von l-lysin |
| JP3473042B2 (ja) * | 1992-04-28 | 2003-12-02 | 味の素株式会社 | 変異型アスパルトキナーゼ遺伝子 |
| JPH06261766A (ja) * | 1993-03-16 | 1994-09-20 | Mitsubishi Petrochem Co Ltd | フィードバックインヒビションの解除されたアスパルトキナーゼをコードする遺伝子ｄｎａ及びその利用 |
-
1993
- 1993-04-27 JP JP10145093A patent/JP3473042B2/ja not_active Expired - Fee Related
- 1993-12-14 WO PCT/JP1993/001809 patent/WO1994025605A1/ja not_active Ceased
- 1993-12-14 DK DK94902116T patent/DK0699759T3/da active
- 1993-12-14 DE DE69332805T patent/DE69332805T2/de not_active Expired - Lifetime
- 1993-12-14 EP EP94902116A patent/EP0699759B1/en not_active Expired - Lifetime
- 1993-12-14 US US08/532,828 patent/US5688671A/en not_active Expired - Lifetime
- 1993-12-14 AT AT94902116T patent/ATE235555T1/de not_active IP Right Cessation
- 1993-12-14 ES ES94902116T patent/ES2191680T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3473042B2 (ja) | 2003-12-02 |
| ATE235555T1 (de) | 2003-04-15 |
| DE69332805T2 (de) | 2004-02-19 |
| DE69332805D1 (de) | 2003-04-30 |
| EP0699759B1 (en) | 2003-03-26 |
| WO1994025605A1 (fr) | 1994-11-10 |
| EP0699759A1 (en) | 1996-03-06 |
| ES2191680T3 (es) | 2003-09-16 |
| EP0699759A4 (en) | 1999-09-22 |
| US5688671A (en) | 1997-11-18 |
| JPH0662866A (ja) | 1994-03-08 |
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