DK0698111T3 - Fremgangsmåde til syntese af HMG-CoA-reduktaseinhibitorer - Google Patents
Fremgangsmåde til syntese af HMG-CoA-reduktaseinhibitorerInfo
- Publication number
- DK0698111T3 DK0698111T3 DK94917312T DK94917312T DK0698111T3 DK 0698111 T3 DK0698111 T3 DK 0698111T3 DK 94917312 T DK94917312 T DK 94917312T DK 94917312 T DK94917312 T DK 94917312T DK 0698111 T3 DK0698111 T3 DK 0698111T3
- Authority
- DK
- Denmark
- Prior art keywords
- hmg
- coa reductase
- reductase inhibitors
- synthesis
- image
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 4
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 4
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- -1 diol lactone derivatives of HMG-CoA Chemical class 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/060,847 US5420024A (en) | 1993-05-11 | 1993-05-11 | Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea |
| PCT/US1994/005019 WO1994026920A1 (en) | 1993-05-11 | 1994-05-06 | PROCESS FOR SYNTHESIS OF HMG-CoA REDUCTASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0698111T3 true DK0698111T3 (da) | 2003-03-31 |
Family
ID=22032112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94917312T DK0698111T3 (da) | 1993-05-11 | 1994-05-06 | Fremgangsmåde til syntese af HMG-CoA-reduktaseinhibitorer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5420024A (da) |
| EP (1) | EP0698111B1 (da) |
| JP (1) | JPH08510128A (da) |
| AT (1) | ATE232910T1 (da) |
| AU (1) | AU673268B2 (da) |
| CA (1) | CA2161788C (da) |
| DE (1) | DE69432144T2 (da) |
| DK (1) | DK0698111T3 (da) |
| ES (1) | ES2190441T3 (da) |
| WO (1) | WO1994026920A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
| US7141602B2 (en) * | 1998-09-18 | 2006-11-28 | Lek Pharmaceuticals D.D. | Process for obtaining HMG-CoA reductase inhibitors of high purity |
| CA2388182A1 (en) | 1999-10-27 | 2001-05-03 | Merck & Co., Inc. | Lactonization process |
| US7700329B2 (en) * | 2003-10-21 | 2010-04-20 | Brian Morgan | Methods for making simvastatin and intermediates |
| US20110059493A1 (en) * | 2007-08-27 | 2011-03-10 | Brian Morgan | Methods for Making Simvastatin and Intermediates |
| US8383382B2 (en) | 2009-09-30 | 2013-02-26 | Codexis, Inc. | Variant LovD polypeptides and their uses |
| EP2486129B1 (en) | 2009-10-08 | 2016-04-13 | The Regents of The University of California | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS |
| KR102051508B1 (ko) * | 2018-07-23 | 2019-12-03 | 중앙대학교 산학협력단 | 프로피오닐 에스테르 유도체를 유효성분으로 함유하는 x-연관 부신백질이영양증 예방 또는 치료용 약학조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60176595A (ja) * | 1984-02-21 | 1985-09-10 | Akira Endo | 生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法 |
| US5223415A (en) * | 1990-10-15 | 1993-06-29 | Merck & Co., Inc. | Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid) |
| GB2255974A (en) * | 1991-05-24 | 1992-11-25 | Merck & Co Inc | Enzymatic deacylation of simvastatin |
-
1993
- 1993-05-11 US US08/060,847 patent/US5420024A/en not_active Expired - Fee Related
-
1994
- 1994-05-06 ES ES94917312T patent/ES2190441T3/es not_active Expired - Lifetime
- 1994-05-06 AU AU69072/94A patent/AU673268B2/en not_active Ceased
- 1994-05-06 DK DK94917312T patent/DK0698111T3/da active
- 1994-05-06 JP JP6525564A patent/JPH08510128A/ja active Pending
- 1994-05-06 AT AT94917312T patent/ATE232910T1/de not_active IP Right Cessation
- 1994-05-06 DE DE69432144T patent/DE69432144T2/de not_active Expired - Fee Related
- 1994-05-06 CA CA002161788A patent/CA2161788C/en not_active Expired - Fee Related
- 1994-05-06 EP EP94917312A patent/EP0698111B1/en not_active Expired - Lifetime
- 1994-05-06 WO PCT/US1994/005019 patent/WO1994026920A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08510128A (ja) | 1996-10-29 |
| EP0698111A4 (en) | 1998-08-26 |
| DE69432144D1 (de) | 2003-03-27 |
| ES2190441T3 (es) | 2003-08-01 |
| US5420024A (en) | 1995-05-30 |
| CA2161788C (en) | 2001-10-16 |
| EP0698111B1 (en) | 2003-02-19 |
| ATE232910T1 (de) | 2003-03-15 |
| EP0698111A1 (en) | 1996-02-28 |
| CA2161788A1 (en) | 1994-11-24 |
| AU673268B2 (en) | 1996-10-31 |
| AU6907294A (en) | 1994-12-12 |
| DE69432144T2 (de) | 2003-11-13 |
| WO1994026920A1 (en) | 1994-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2073529T3 (es) | Inhibidor de fosfolipasa a2, microorganismos que producen este inhibidor y procedimiento para su produccion. | |
| DE04010770T1 (de) | Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe | |
| DK0698111T3 (da) | Fremgangsmåde til syntese af HMG-CoA-reduktaseinhibitorer | |
| ES2061451T3 (es) | Derivados de trans-6-(2-(n-heteroaril-3,5-disubstituido)pirazol-4-il)-etil)- o etenil)tetrahidro-4-hidroxipiran-2-ona, un proceso para su preparacion y uso de los mismos. | |
| ATE296357T1 (de) | Verfahren zur herstellung von hochreinen hmg-coa reductase inhibitoren | |
| Lakshmipathi et al. | Efficient conjugate addition of hydrogen azide to enoates | |
| Kawasaki et al. | Asymmetric synthesis of 2-substituted chroman-4-ones using lipase-catalyzed kinetic resolutions | |
| Liang et al. | Chemoenzymatic synthesis of isogalactofagomine | |
| DK0649907T3 (da) | Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor | |
| DK0734392T3 (da) | Omdannelse af bisnoralkohol til bisnoraldehyd | |
| EP0605033B1 (en) | Enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer | |
| CA1245226A (en) | METHOD FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATE COMPOUNDS | |
| AU3284699A (en) | Process for the preparation of simvastatin and derivatives thereof | |
| EP0927755A3 (en) | Haloaccloacetate reductase, method for producing said enzyme, and method for producing alcohols using said enzyme | |
| NO306297B1 (no) | FremgangsmÕte for fremstilling av HIV-proteaseinhibitorer | |
| MURATA et al. | Asymmetric synthesis of a chiral norbornene derivative by lipase-catalyzed transesterification of cis-endo-5-norbornene-2, 3-dimethanol and its application to the synthesis of an optically active TXA2 antagonist | |
| EP1288213A4 (en) | METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE 2- [6- (HYDROXYMETHYL) -1,3-DIOXAN-4-YL] ACETIC ACID DERIVATIVES (12/19/01) | |
| ES2176463T3 (es) | Procedimiento para producir derivados de 1-halo-3-amino-4fenil-2-butanol opticamente activos. | |
| Caro et al. | Synthesis of optically active β-benzyl-γ-butyrolactone through lipase-catalyzed kinetic resolution | |
| Kalamkar et al. | Total synthesis of natural cis-3-hydroxy-L-proline from D-glucose | |
| Rychnovsky et al. | Enantioselective reduction of esters: synthesis of optically active α-acetoxy ethers | |
| Petschen et al. | Enzyme-catalyzed synthesis and absolute configuration of (1S, 2R, 5S)-and (1R, 2S, 5R)-2-(1-hydroxyethyl)-1-(methoxymethyloxyethyl) cyclobutane-1-carbonitrile, key intermediates for the preparation of chiral cyclobutane-containing pheromones | |
| DK0955297T3 (da) | Forbedret fremgangsmåde til lactonisering i fremstillingen af statiner | |
| DK0624568T3 (da) | Forbedret fremgangsmåde til fremstilling af L-(-)-carnitin ud fra et affaldsprodukt med modsat konfiguration | |
| Shimada et al. | Efficient stereocontrol of a quaternary chiral center in the cyclohexene systems. Potential chiral synthons for vitamin D and related compounds by enzymatic approach |