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DE69432144D1 - SYNTHESEVERFAHREN FÜR INHIBITOREN DER HMG-CoA-REDUKTASE - Google Patents

SYNTHESEVERFAHREN FÜR INHIBITOREN DER HMG-CoA-REDUKTASE

Info

Publication number
DE69432144D1
DE69432144D1 DE69432144T DE69432144T DE69432144D1 DE 69432144 D1 DE69432144 D1 DE 69432144D1 DE 69432144 T DE69432144 T DE 69432144T DE 69432144 T DE69432144 T DE 69432144T DE 69432144 D1 DE69432144 D1 DE 69432144D1
Authority
DE
Germany
Prior art keywords
hmg
coa reductase
inhibitors
synthesis procedure
reductase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69432144T
Other languages
English (en)
Other versions
DE69432144T2 (de
Inventor
Giorgio Carta
Michael J Conder
John Lloyd Gainer
Robert W Stieberg
Victor A Vinci
Timothy Wallace Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Virginia UVA
Merck and Co Inc
Original Assignee
University of Virginia UVA
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Virginia UVA, Merck and Co Inc filed Critical University of Virginia UVA
Application granted granted Critical
Publication of DE69432144D1 publication Critical patent/DE69432144D1/de
Publication of DE69432144T2 publication Critical patent/DE69432144T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69432144T 1993-05-11 1994-05-06 SYNTHESEVERFAHREN FÜR INHIBITOREN DER HMG-CoA-REDUKTASE Expired - Fee Related DE69432144T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/060,847 US5420024A (en) 1993-05-11 1993-05-11 Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
PCT/US1994/005019 WO1994026920A1 (en) 1993-05-11 1994-05-06 PROCESS FOR SYNTHESIS OF HMG-CoA REDUCTASE INHIBITORS

Publications (2)

Publication Number Publication Date
DE69432144D1 true DE69432144D1 (de) 2003-03-27
DE69432144T2 DE69432144T2 (de) 2003-11-13

Family

ID=22032112

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432144T Expired - Fee Related DE69432144T2 (de) 1993-05-11 1994-05-06 SYNTHESEVERFAHREN FÜR INHIBITOREN DER HMG-CoA-REDUKTASE

Country Status (10)

Country Link
US (1) US5420024A (de)
EP (1) EP0698111B1 (de)
JP (1) JPH08510128A (de)
AT (1) ATE232910T1 (de)
AU (1) AU673268B2 (de)
CA (1) CA2161788C (de)
DE (1) DE69432144T2 (de)
DK (1) DK0698111T3 (de)
ES (1) ES2190441T3 (de)
WO (1) WO1994026920A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
AU8030900A (en) 1999-10-27 2001-05-08 Merck & Co., Inc. Lactonization process
EP1678131A2 (de) * 2003-10-21 2006-07-12 Diversa Corporation Verfahren zur herstellung von simvastatin und zwischenprodukten
US20110059493A1 (en) * 2007-08-27 2011-03-10 Brian Morgan Methods for Making Simvastatin and Intermediates
DK3190123T3 (da) 2009-09-30 2019-09-30 Codexis Inc Forbedret lov-d acyltransferase medieret acylering
EP2486129B1 (de) 2009-10-08 2016-04-13 The Regents of The University of California Lov-D-MUTANTEN MIT VERBESSERTEN EIGENSCHAFTEN IN BEZUG AUF SIMVASTATIN-SYNTHESE
KR102051508B1 (ko) * 2018-07-23 2019-12-03 중앙대학교 산학협력단 프로피오닐 에스테르 유도체를 유효성분으로 함유하는 x-연관 부신백질이영양증 예방 또는 치료용 약학조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60176595A (ja) * 1984-02-21 1985-09-10 Akira Endo 生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
GB2255974A (en) * 1991-05-24 1992-11-25 Merck & Co Inc Enzymatic deacylation of simvastatin

Also Published As

Publication number Publication date
AU6907294A (en) 1994-12-12
DK0698111T3 (da) 2003-03-31
AU673268B2 (en) 1996-10-31
ES2190441T3 (es) 2003-08-01
US5420024A (en) 1995-05-30
DE69432144T2 (de) 2003-11-13
EP0698111A4 (de) 1998-08-26
EP0698111A1 (de) 1996-02-28
EP0698111B1 (de) 2003-02-19
JPH08510128A (ja) 1996-10-29
CA2161788C (en) 2001-10-16
WO1994026920A1 (en) 1994-11-24
CA2161788A1 (en) 1994-11-24
ATE232910T1 (de) 2003-03-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee