[go: up one dir, main page]

DK0671923T3 - Leverreserveceller - Google Patents

Leverreserveceller

Info

Publication number
DK0671923T3
DK0671923T3 DK93923823T DK93923823T DK0671923T3 DK 0671923 T3 DK0671923 T3 DK 0671923T3 DK 93923823 T DK93923823 T DK 93923823T DK 93923823 T DK93923823 T DK 93923823T DK 0671923 T3 DK0671923 T3 DK 0671923T3
Authority
DK
Denmark
Prior art keywords
liver
cells
reserve
liver reserve
differentiate
Prior art date
Application number
DK93923823T
Other languages
English (en)
Inventor
Brian A Naughton
Benson Sibanda
Original Assignee
Advanced Tissue Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Tissue Sciences Inc filed Critical Advanced Tissue Sciences Inc
Application granted granted Critical
Publication of DK0671923T3 publication Critical patent/DK0671923T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK93923823T 1992-10-09 1993-10-08 Leverreserveceller DK0671923T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95862192A 1992-10-09 1992-10-09
PCT/US1993/009657 WO1994008598A1 (en) 1992-10-09 1993-10-08 Liver reserve cells

Publications (1)

Publication Number Publication Date
DK0671923T3 true DK0671923T3 (da) 2001-08-13

Family

ID=25501114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93923823T DK0671923T3 (da) 1992-10-09 1993-10-08 Leverreserveceller

Country Status (13)

Country Link
US (1) US5559022A (da)
EP (1) EP0671923B1 (da)
JP (1) JP3789930B2 (da)
KR (1) KR950703640A (da)
AT (1) ATE200625T1 (da)
AU (1) AU689758B2 (da)
CA (1) CA2146747C (da)
DE (1) DE69330167T2 (da)
DK (1) DK0671923T3 (da)
ES (1) ES2157225T3 (da)
GR (1) GR3036216T3 (da)
PT (1) PT671923E (da)
WO (1) WO1994008598A1 (da)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
CA2115140A1 (en) * 1991-08-07 1993-02-18 Lola M. Reid Proliferation of hepatocyte precursors
ES2260759T3 (es) * 1993-11-19 2006-11-01 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Hepatoblastos y metodo de aislamiento de los mismos.
US7597886B2 (en) 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
WO1996020456A1 (en) * 1994-12-23 1996-07-04 International Remote Imaging Systems, Inc. Method and apparatus of analyzing particles in a fluid sample and displaying same
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US6043092A (en) 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
WO1999031222A1 (en) 1997-12-18 1999-06-24 Willem Frederik Van Eelen Industrial scale production of meat from in vitro cell cultures
ATE227338T1 (de) 1998-03-18 2002-11-15 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
WO1999050461A1 (en) 1998-03-30 1999-10-07 Northwest Biotherapeutics, Inc. Therapeutic and diagnostic applications based on the role of the cxcr-4 gene in tumorigenesis
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US6777388B1 (en) 1998-08-21 2004-08-17 Clf Medical Technology Acceleration Program, Inc. Leptin-related peptides
EP2048228B8 (en) * 1999-01-19 2016-05-11 The University Of North Carolina At Chapel Hill Human liver progenitors
EP1161451A4 (en) 1999-02-26 2006-05-17 Human Genome Sciences Inc HUMAN ALPHA ENDOKIN AND METHOD FOR ITS USE
US6759393B1 (en) 1999-04-12 2004-07-06 Pfizer Inc. Growth hormone and growth hormone releasing hormone compositions
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
US20020187133A1 (en) 1999-10-01 2002-12-12 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
US20030108539A1 (en) 2000-02-14 2003-06-12 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
IL149340A0 (en) 1999-11-18 2002-11-10 Corvas Int Inc Nucleic acids encoding endotheliases, endotheliases and uses thereof
US6737270B1 (en) 1999-12-07 2004-05-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education Long-term three dimensional tissue culture system
US20030096411A1 (en) * 1999-12-07 2003-05-22 George Michalopoulos Novel long-term three-dimensional tissue culture system
NZ539430A (en) 1999-12-10 2006-09-29 Invitrogen Corp Use of multiple recombination sites with unique specificity in recombinational cloning
US7700341B2 (en) 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
US7473555B2 (en) * 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
US7282366B2 (en) * 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
US7256042B2 (en) * 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
ATE445158T1 (de) * 2000-06-14 2009-10-15 Vistagen Inc Toxizitätstypisierung unter verwendung von leberstammzellen
EP1294949A4 (en) 2000-06-15 2004-08-25 Human Genome Sciences Inc HUMAN TUMORNESCROSE FACTOR DELTA AND EPSILON
ES2609583T3 (es) 2000-06-16 2017-04-21 Human Genome Sciences, Inc. Anticuerpos que se unen inmunoespecíficamente a BLyS
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
EP2361635A3 (en) 2000-08-30 2011-09-14 Pfizer Products Inc. Anti IgE vaccines
US20030175255A1 (en) * 2000-10-03 2003-09-18 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
WO2002031122A1 (en) * 2000-10-20 2002-04-18 Massachusetts General Hospital Plasma supplement and use in liver assist systems
US7090843B1 (en) 2000-11-28 2006-08-15 Seattle Genetics, Inc. Recombinant anti-CD30 antibodies and uses thereof
US20040018194A1 (en) 2000-11-28 2004-01-29 Francisco Joseph A. Recombinant anti-CD30 antibodies and uses thereof
EP2338512A1 (en) 2000-11-28 2011-06-29 MedImmune, LLC Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
JP4336498B2 (ja) 2000-12-12 2009-09-30 メディミューン，エルエルシー 延長した半減期を有する分子ならびにその組成物および用途
US7125703B2 (en) 2001-03-13 2006-10-24 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
AU2002254357A1 (en) 2001-03-22 2002-10-08 Dendreon Corporation Nucleic acid molecules encoding serine protease cvsp14, the encoded polypeptides and methods based thereon
JP2005506047A (ja) 2001-03-27 2005-03-03 デンドレオン・サンディエゴ・リミテッド・ライアビリティ・カンパニー 膜貫通型セリンプロテアーゼ９をコード化する核酸分子、コード化されたポリペプチドおよびそれらに基づく方法
WO2002078439A2 (en) 2001-03-30 2002-10-10 The Arizona Board Of Regents On Behalf Of The University Of Arizona Prevascularized constructs for implantation to provide blood perfusion
EP2228389B1 (en) 2001-04-13 2015-07-08 Human Genome Sciences, Inc. Antibodies against vascular endothelial growth factor 2
KR20040080940A (ko) 2001-05-14 2004-09-20 덴드레온 코포레이션 트랜스막 세린 프로테아제 10을 암호화하는 핵산 분자,암호화된 폴리펩티드 및 이에 근거한 방법
JP2003047482A (ja) 2001-05-22 2003-02-18 Pfizer Prod Inc 非アナフィラキシー誘発性ＩｇＥワクチン
WO2002097033A2 (en) 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
DK1406998T3 (da) * 2001-06-22 2007-12-27 Stemcells Inc Leverindföjede celler, assays og anvendelser deraf
JP2005500835A (ja) 2001-06-29 2005-01-13 ノバルティス アクチエンゲゼルシャフト Ｐｅｒｖスクリーニング法およびその使用
CA2453100C (fr) * 2001-07-06 2013-10-29 Institut National De La Sante Et De La Recherche Medicale (I.N.S.E.R.M.) Nouvelles lignees d'hepatomes humains, leurs obtentions et leurs applications
US7452532B2 (en) * 2001-09-30 2008-11-18 Scicotec Gmbh Transluminal application of adult stem cells for body organ tissue repair
US20040058309A1 (en) * 2001-10-12 2004-03-25 Junji Washizu Plasma supplement and use in liver assist systems
EP1499352A4 (en) 2002-04-12 2006-10-11 Medimmune Inc ANTI-INTERLEUKIN-9 RECOMBINANT ANTIBODIES
US8034351B2 (en) 2002-04-22 2011-10-11 Recopharma Ab Mucin fusion polypeptide vaccines, compositions and methods of use thereof
US20040110289A1 (en) * 2002-07-19 2004-06-10 Ludlow John W. Method for obtaining viable human cells, including hepatic stem/progenitor cells
ES2381617T5 (es) 2002-08-14 2016-02-24 Macrogenics, Inc. Anticuerpos específicos frente a FcgammaRIIB y sus procedimientos de uso
US20040151729A1 (en) * 2002-10-28 2004-08-05 George Michalopoulos Novel long-term three-dimensional culture system
EP2298874A1 (en) 2002-12-16 2011-03-23 Halozyme, Inc. Human chondroitinase glycoprotein (CHASEGP), process for preparing the same, and pharmaceutical compositions comprising thereof
WO2004063351A2 (en) 2003-01-09 2004-07-29 Macrogenics, Inc. IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
EP1585815A4 (en) 2003-01-21 2006-02-22 Bristol Myers Squibb Co A NEW ACYL-COENZYME A, MONOCLYLGLYCERIN ACYLTRANSFERASE-3 (MGAT3), CODING POLYNUCLEOTIDE, AND USES THEREOF
WO2004071462A2 (en) 2003-02-12 2004-08-26 Johns Hopkins University Methods and compositions for treatment of viral infections based on tsg101-vps28 interaction
AU2004214932B2 (en) 2003-02-24 2009-12-03 Marine Polymer Technologies, Inc. Cell-polymer fiber compositions and use thereof
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
HUE027661T2 (en) 2003-03-05 2016-10-28 Halozyme Inc Soluble Hyaluronidase Glycoprotein (sHASEGP), Processes, Applications, and Pharmaceuticals Containing It
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
KR20110094361A (ko) 2003-04-11 2011-08-23 메디뮨 엘엘씨 재조합 ｉｌ­９ 항체 및 그의 용도
AU2004259727A1 (en) 2003-07-15 2005-02-03 Barros Research Institute Compositions and methods for immunotherapy of cancer and infectious diseases.
US20050221383A1 (en) 2003-08-08 2005-10-06 Choong-Chin Liew Osteoarthritis biomarkers and uses thereof
JP4934426B2 (ja) 2003-08-18 2012-05-16 メディミューン，エルエルシー 抗体のヒト化
ATE469984T1 (de) 2003-12-01 2010-06-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
SI3718564T1 (sl) 2003-12-23 2024-01-31 Genentech, Inc. Nova protitelesa proti il 13 in uporaba le-teh
JP5009787B2 (ja) 2004-05-07 2012-08-22 ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン、インコーポレイテッド Ｅｒｇ遺伝子を単独でまたは前立腺癌中で過剰発現もしくは過少発現される他の遺伝子と組み合わせて用いる、前立腺癌を診断または治療する方法
US8318479B2 (en) * 2004-05-19 2012-11-27 Massachusetts Institute Of Technology Perfused three-dimensional cell/tissue disease models
AU2005299355A1 (en) 2004-10-27 2006-05-04 Medimmune, Llc Modulation of antibody specificity by tailoring the affinity to cognate antigens
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
WO2006086242A2 (en) 2005-02-07 2006-08-17 Genenews, Inc. Mild osteoarthritis biomarkers and uses thereof
JP5153613B2 (ja) 2005-03-18 2013-02-27 メディミューン，エルエルシー 抗体のフレームワーク・シャッフル
AU2006236439B2 (en) 2005-04-15 2012-05-03 Macrogenics, Inc. Covalent diabodies and uses thereof
ES2579602T3 (es) 2005-08-10 2016-08-12 Macrogenics, Inc. Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de uso de estos
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
JP5237817B2 (ja) 2005-10-21 2013-07-17 ジーンニュース インコーポレーティッド バイオマーカー産物レベルを疾患に相関させるための方法および装置
WO2007056227A2 (en) 2005-11-04 2007-05-18 Genentech, Inc. Use of complement pathway inhibitors to treat ocular diseases
CA2634510C (en) 2005-12-21 2018-01-09 Universite Catholique De Louvain Isolated liver stem cells
GB0605761D0 (en) 2006-03-22 2006-05-03 Imp Innovations Ltd Anti-inflammatory proteins and improved vaccines
SG170819A1 (en) 2006-03-30 2011-05-30 Ptc Therapeutics Inc Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
US8148151B2 (en) * 2006-06-02 2012-04-03 Geron Corporation Differentiation of primate pluripotent cells to hepatocyte-lineage cells
AU2007281876B2 (en) 2006-06-26 2013-09-05 Macrogenics, Inc. FcgammaRIIB-specific antibodies and methods of use thereof
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
SG170032A1 (en) 2006-08-28 2011-04-29 Kyowa Hakko Kirin Co Ltd Antagonistic human light-specific human monoclonal antibodies
AU2007313300A1 (en) 2006-10-16 2008-04-24 Medimmune, Llc. Molecules with reduced half-lives, compositions and uses thereof
EP2514439A1 (en) 2006-11-15 2012-10-24 Functional Genetics, Inc. Anti-TSG101antibodies and their uses for treatment of viral infections
KR20150004933A (ko) 2006-12-18 2015-01-13 제넨테크, 인크. 항-ｎｏｔｃｈ3 길항제 항체 및 ｎｏｔｃｈ3-관련 질환의 예방 및 치료에 있어서 그의 용도
KR101599735B1 (ko) 2007-06-21 2016-03-07 마크로제닉스, 인크. 공유결합형 디아바디 및 이것의 사용
HRP20180873T1 (hr) 2007-08-29 2018-07-13 Sanofi Humanizirana anti-cxcr5 protutijela, njihovi derivati i njihova upotreba
PL2247304T3 (pl) 2008-04-02 2017-01-31 Macrogenics, Inc. Przeciwciała specyficzne wobec HER2/neu oraz sposoby ich zastosowania
MX2010010387A (es) 2008-04-02 2010-10-15 Macrogenics Inc Anticuerpos especificos para el complejo de bcr y metodos para el uso de los mismos.
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
EP2282770B1 (en) 2008-06-04 2018-03-07 MacroGenics, Inc. Antibodies with altered binding to fcrn and methods of using same
AU2008361352B2 (en) 2008-09-07 2013-05-09 Glyconex Inc. Anti-extended Type I glycosphingolipid antibody, derivatives thereof and use
RU2744176C2 (ru) 2008-12-19 2021-03-03 Макродженикс, Инк. Ковалентные диантитела и их применение
WO2010072684A1 (en) 2008-12-22 2010-07-01 Universität Regensburg Norrin in the treatment of diseases associated with an increased tgf-beta activity
US20120134984A1 (en) 2009-06-01 2012-05-31 Olga Lubman Molecules with extended half-lives and uses thereof
EA023179B1 (ru) 2009-08-13 2016-05-31 Круселл Холланд Б.В. Антитела против респираторного синцитиального вируса (pcb) и способы их применения
US20110189183A1 (en) 2009-09-18 2011-08-04 Robert Anthony Williamson Antibodies against candida, collections thereof and methods of use
WO2011073521A1 (en) 2009-12-15 2011-06-23 Petri Salven Methods for enriching adult-derived endothelial progenitor cells and uses thereof
WO2011109026A1 (en) 2010-03-05 2011-09-09 Tissue Genesis, Inc. Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells
CN106188284B (zh) 2010-07-09 2020-05-08 扬森疫苗与预防公司 抗人呼吸道合胞病毒(rsv)抗体以及使用方法
WO2012012739A2 (en) 2010-07-22 2012-01-26 President And Fellows Of Harvard College Multiple input biologic classifier circuits for cells
MX339622B (es) 2010-08-02 2016-06-02 Macrogenics Inc Diacuerpos covalentes y sus usos.
CA2809606C (en) 2010-08-26 2020-12-01 University Of Louisville Research Foundation, Inc. Compositions and methods for treating bone defects
PL2902035T3 (pl) 2010-10-14 2019-04-30 Xigen Inflammation Ltd Przechodzące przez komórkę peptydowe inhibitory szlaku przekazywania sygnałów przez JNK do zastosowania w leczeniu chorób zapalnych oka
US9150618B2 (en) 2010-10-14 2015-10-06 Xigen Inflammation Ltd. Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
EP2799078A1 (en) 2010-11-12 2014-11-05 Allergan, Inc. Metabolized conditioned growth medium and methods of use
KR102030531B1 (ko) 2011-05-21 2019-10-10 마크로제닉스, 인크. 탈면역화된 혈청-결합 도메인 및 혈청 반감기를 연장하기 위한 그것의 용도
KR102000141B1 (ko) 2011-10-27 2019-07-15 웰스테이트 옵탈믹스 코퍼레이션 간상세포 유래 원추세포 생존능 인자를 인코딩하는 벡터
EA201491062A1 (ru) 2011-11-30 2014-10-30 Ксиджен Инфлэммэйшн Лтд. Применение обладающих способностью проникать в клетку пептидных ингибиторов пути трансдукции сигнала jnk для лечения синдрома сухости глаз
LT2814844T (lt) 2012-02-15 2017-10-25 Novo Nordisk A/S Antikūnai, kurie jungiasi ir blokuoja ekspresuotą ant mieloidinių ląstelių inicijuojantį receptorių 1 (trem-1)
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
WO2013120554A1 (en) 2012-02-15 2013-08-22 Novo Nordisk A/S Antibodies that bind peptidoglycan recognition protein 1
US9592289B2 (en) 2012-03-26 2017-03-14 Sanofi Stable IgG4 based binding agent formulations
WO2013155439A1 (en) 2012-04-13 2013-10-17 Massachusetts Institute Of Technology Analog and mixed-signal computation and circuits in living cells
KR20150045935A (ko) 2012-04-24 2015-04-29 더 브리검 앤드 우먼즈 하스피털, 인크. 다능성 세포를 다시 생성하는 방법
WO2014006063A2 (en) 2012-07-02 2014-01-09 Medizinische Universität Wien Complement split product c4d for the treatment of inflammatory conditions
BR112015011933A8 (pt) 2012-11-23 2022-09-20 Seres Therapeutics Inc Composições bacterianas sinérgicas e métodos de produção e uso das mesmas
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
WO2014120975A1 (en) 2013-02-01 2014-08-07 California Institute Of Technology Antibody-mediated immunocontraception
KR20230110367A (ko) 2013-02-04 2023-07-21 세레스 테라퓨틱스, 인코포레이티드 조성물 및 방법
EP2967077A4 (en) 2013-03-15 2016-09-14 Seres Therapeutics Inc NETWORK-BASED MICROBIAL COMPOSITIONS AND METHOD
US9546383B2 (en) 2013-05-13 2017-01-17 Oregon Health & Science University Human pluripotent embryonic stem cells produced by nuclear transfer using a somatic cell nucleus treated with HVJ-E extract and an oocyte from a donor cycle that produced 15 or fewer oocytes
US11085067B2 (en) 2013-06-10 2021-08-10 President And Fellows Of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
CA2915143C (en) 2013-06-13 2021-08-03 Orgenesis Ltd. Cell populations, methods of transdifferentiation and methods of use thereof
WO2015197098A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2016055160A2 (en) 2014-10-08 2016-04-14 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
EP3016665B1 (en) 2013-07-05 2019-09-18 Université Catholique de Louvain Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders
CA2926421C (en) 2013-10-08 2022-05-03 Vivorte, Inc. Processed bone particle compositions and related methods
PT3074027T (pt) 2013-11-25 2025-03-20 Nestle Sa Composições bacterianas sinérgicas e métodos de produção e utilização das mesmas
JP6870988B2 (ja) 2014-02-24 2021-05-19 セルジーン コーポレイション 神経細胞増幅及び中枢神経系障害治療のためのセレブロンの活性化因子の使用方法
IL247890B2 (en) 2014-03-19 2024-08-01 Vcell Therapeutics Inc Methods related to stem cells
EP3142700B1 (en) 2014-05-16 2021-03-03 Medimmune, LLC Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties
US20170087196A1 (en) 2014-05-19 2017-03-30 Memorial Sloan-Kettering Cancer Center Methods and compositions for reducing clostridium difficile infection
CN113214397A (zh) 2014-07-17 2021-08-06 诺和诺德股份有限公司 定点诱变trem-1抗体以降低黏度
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
US10966414B2 (en) 2015-05-26 2021-04-06 California Institute Of Technology Population control using engineered translocations
US10729790B2 (en) 2015-05-26 2020-08-04 Salk Institute For Biological Studies Motor neuron-specific expression vectors
CA3006105A1 (en) 2015-11-25 2017-06-01 Memorial Sloan-Kettering Cancer Center Methods and compositions for reducing vancomycin-resistant enterococci infection or colonization
US20190145961A1 (en) 2016-04-20 2019-05-16 Washington University Ppar agonist or lxr agonist for use in the treatment of systemic lupus erythematosus by modulation of lap activity
JP6875670B2 (ja) 2016-06-27 2021-05-26 ユニバーシティ オブ ルーイビル リサーチ ファウンデーション，インコーポレーテッド 生体関連物質を含有する球状体および関係する方法
US11577002B2 (en) 2016-12-06 2023-02-14 The Regents Of The University Of Michigan Bioengineered vascular network
KR20190140950A (ko) 2017-04-20 2019-12-20 오레곤 헬스 앤드 사이언스 유니버시티 인간 유전자 교정
SG11201911256UA (en) 2017-05-08 2020-01-30 Orgenesis Ltd Transdifferentiated cell populations and methods of use thereof
WO2019036510A1 (en) 2017-08-14 2019-02-21 Seres Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATING CHOLESTATIC DISEASE
MX2020004495A (es) 2017-10-30 2021-01-08 Seres Therapeutics Inc Composiciones y métodos para tratar la resistencia a los antibióticos.
MY206833A (en) 2018-04-02 2025-01-09 Bristol Myers Squibb Co Anti-trem-1 antibodies and uses thereof
EP3976064A4 (en) 2019-05-28 2023-05-31 Xilis, Inc. METHODS AND DEVICES FOR PATIENT-DERIVED MICROORGANOSPHERES
GB201914296D0 (en) 2019-10-03 2019-11-20 Univ Oxford Innovation Ltd Treatment
CN117157049A (zh) 2021-01-24 2023-12-01 迈克尔·大卫·福雷斯特 Atp合酶抑制剂-化妆品和治疗用途
TW202337904A (zh) 2022-01-07 2023-10-01 美商壯生和壯生企業創新公司 ＩＬ－１β結合蛋白之材料及方法
JP2025525530A (ja) 2022-07-15 2025-08-05 ヤンセン バイオテツク，インコーポレーテツド 抗原結合可変領域の改善された生物工学による対合のための材料及び方法
WO2024206928A1 (en) 2023-03-30 2024-10-03 Pharma Cinq, Llc VECTOR ENCODING ROD-DERIVED CONE VIABILITY FACTOR AND HUMAN IgK SIGNAL SEQUENCE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106368A0 (en) * 1992-07-24 1993-11-15 Univ Pennsylvania Non-native liver generation in an animal with impaired native liver function,by cell implantation

Also Published As

Publication number Publication date
DE69330167T2 (de) 2001-11-15
GR3036216T3 (en) 2001-10-31
JP3789930B2 (ja) 2006-06-28
WO1994008598A1 (en) 1994-04-28
EP0671923A4 (en) 1996-08-21
CA2146747A1 (en) 1994-04-28
ATE200625T1 (de) 2001-05-15
AU689758B2 (en) 1998-04-09
EP0671923B1 (en) 2001-04-18
KR950703640A (ko) 1995-09-20
DE69330167D1 (de) 2001-05-23
ES2157225T3 (es) 2001-08-16
US5559022A (en) 1996-09-24
JPH08502175A (ja) 1996-03-12
AU5355494A (en) 1994-05-09
PT671923E (pt) 2001-10-30
EP0671923A1 (en) 1995-09-20
CA2146747C (en) 2006-12-19

Similar Documents

Publication Publication Date Title
ATE200625T1 (de) Leberreservezellen
Csete Oxygen in the cultivation of stem cells
Grinspan et al. Bovine endothelial cells transformed in vitro by benzo (a) pyrene
US8709800B2 (en) Methods of isolating bipotent hepatic progenitor cells
CA2339182A1 (en) Improvement of cardiac function by mesenchymal stem cell transplantation
EP0363125A3 (en) Proliferated pancreatic endocrine cell product and process
ATE368103T1 (de) Isolierung, vermehrung und gezielte differenzierung von zäugetierstammzellen des zentralnervensystems
EP0953354A4 (en) HEMATOPOIETIC STEM CELLS PROLIFERING ACTIVE SUBSTANCES
Yoffe et al. Cultures of human liver cells in simulated microgravity environment
Rheinwald The role of terminal differentiation in the finite culture lifetime of the human epidermal keratinocyte
Trujillo et al. The ability of tumor cells of the lymphoreticular system to grow in vitro
Guguen-Guillouzo et al. Modulation of human fetal hepatocyte survival and differentiation by interactions with a rat liver epithelial cell line
CA2424781C (en) Methods of isolating bipotent hepatic progenitor cells
US6008004A (en) Identification of a CD34+ bone marrow precursor for dendritic cells in blood and lymphoid tissues
AU2000278582A1 (en) Methods of isolating bipotent hepatic progenitor cells
Furukawa et al. Enrichment and characterization of clonogenic epithelial cells from adult rat liver and initiation of epithelial cell strains
Cappellini et al. Long‐term haemopoiesis in human fetal liver cell cultures
Qin et al. NIH3T3 Directs memory-fated CTL programming and represses high expression of PD-1 on antitumor CTLs
EP0927043B8 (en) Compositions for gene transfer to the central nervous system
US20030175255A1 (en) Methods of isolating bipotent hepatic progenitor cells
Wabik-Sliz et al. Culture of mouse germ cells isolated from fetal gonads
Sacks et al. A multicellular tumor spheroid model of cellular immunity against head and neck cancer
Éraizer et al. Characteristics of human embryonic hepatocytes cultivated in vitro
Rice et al. Hematopoietic stem cell expansion
Islam et al. Epigenetic reprogramming of nonreplicating somatic cells for long-term proliferation by temporary cell–cell contact