SG11201911256UA - Transdifferentiated cell populations and methods of use thereof - Google Patents
Transdifferentiated cell populations and methods of use thereofInfo
- Publication number
- SG11201911256UA SG11201911256UA SG11201911256UA SG11201911256UA SG11201911256UA SG 11201911256U A SG11201911256U A SG 11201911256UA SG 11201911256U A SG11201911256U A SG 11201911256UA SG 11201911256U A SG11201911256U A SG 11201911256UA SG 11201911256U A SG11201911256U A SG 11201911256UA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- cell populations
- transdifferentiated cell
- transdifferentiated
- populations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/14—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762502796P | 2017-05-08 | 2017-05-08 | |
| US201762610300P | 2017-12-26 | 2017-12-26 | |
| PCT/IL2018/050496 WO2018207179A1 (en) | 2017-05-08 | 2018-05-08 | Transdifferentiated cell populations and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201911256UA true SG11201911256UA (en) | 2020-01-30 |
Family
ID=64105188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201911256UA SG11201911256UA (en) | 2017-05-08 | 2018-05-08 | Transdifferentiated cell populations and methods of use thereof |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10975354B2 (en) |
| EP (1) | EP3635106A4 (en) |
| IL (1) | IL270492B (en) |
| SG (1) | SG11201911256UA (en) |
| WO (1) | WO2018207179A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015031253B1 (en) | 2013-06-13 | 2021-09-28 | Orgenesis Ltd. | METHOD FOR PRODUCING A TRANSDIFFERENTIATED CELL POPULATION |
| EP3049020B1 (en) | 2013-09-24 | 2022-06-15 | Giner Life Sciences, Inc. | System for gas treatment of a cell implant |
| MA41296A (en) | 2014-12-30 | 2017-11-07 | Orgenesis Ltd | TRANSDIFFERENTIATION PROCESSES AND METHODS FOR USING THE SAME |
| BR112019009712A2 (en) | 2016-11-15 | 2019-08-13 | Giner Life Sciences Inc | percutaneous gas diffusion device suitable for use with a subcutaneous implant |
| EP3618916A4 (en) | 2017-05-04 | 2021-04-14 | Giner Life Sciences, Inc. | Robust, implantable gas delivery device and methods, systems and devices including same |
| SG11201911256UA (en) | 2017-05-08 | 2020-01-30 | Orgenesis Ltd | Transdifferentiated cell populations and methods of use thereof |
| EP3816276A1 (en) * | 2019-10-31 | 2021-05-05 | Unicyte Islet AG | Viable pancreatic islet-like cell structures and a method of preparing thereof |
| EP4525933A2 (en) * | 2022-05-20 | 2025-03-26 | University of Pittsburgh - of the Commonwealth System of Higher Education | Insulin promoter for gene therapy for type 2 diabetes mellitus |
| WO2025099413A1 (en) * | 2023-11-06 | 2025-05-15 | Bit Bio Limited | Method of generating pancreatic beta cells |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| DE122007000007I1 (en) | 1986-04-09 | 2007-05-16 | Genzyme Corp | Genetically transformed animals secreting a desired protein in milk |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US4992417A (en) | 1987-07-17 | 1991-02-12 | Mount Sinai School Of Medicine | Superactive human insulin analogues |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5427940A (en) | 1991-06-03 | 1995-06-27 | Board Of Regents, The University Of Texas System | Engineered cells producing insulin in response to glucose |
| ATE200625T1 (en) | 1992-10-09 | 2001-05-15 | Advanced Tissue Sciences Inc | LIVER RESERVE CELLS |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| WO1995005463A1 (en) | 1993-08-16 | 1995-02-23 | Research Development Foundation | A novel homeobox factor which stimulates insulin expression in pancreatic islet cells |
| US5858973A (en) | 1994-02-23 | 1999-01-12 | The General Hospital Corporation | Transcription factor and uses therefor |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| US5849989A (en) | 1994-10-07 | 1998-12-15 | Ontogeny, Inc. | Insulin promoter factor, and uses related thereto |
| JP2000501290A (en) | 1995-11-30 | 2000-02-08 | リサーチ ディベロップメント ファンデーション | Screening assays for compounds that stimulate somatostatin and insulin production |
| IL118376A0 (en) | 1996-05-22 | 1996-09-12 | Univ Ben Gurion | Polysaccharide sponges for cell culture and transplantation |
| AU724745B2 (en) | 1996-06-24 | 2000-09-28 | Vivorx Pharmaceuticals, Inc. | Methods for the isolation and proliferation of insulin-secreting cells |
| EP0996736A1 (en) | 1997-08-11 | 2000-05-03 | Chiron Corporation | Methods for genetically modifying t cells |
| CA2221195A1 (en) | 1997-11-14 | 1999-05-14 | Chantal E. Holy | Biodegradable polymer matrix |
| US6143293A (en) | 1998-03-26 | 2000-11-07 | Carnegie Mellon | Assembled scaffolds for three dimensional cell culturing and tissue generation |
| IL124957A0 (en) | 1998-06-16 | 1999-01-26 | Univ Ben Gurion | Active ingredient delivery systems and devices based on porous matrices |
| US6242666B1 (en) | 1998-12-16 | 2001-06-05 | The Scripps Research Institute | Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells |
| US8778899B2 (en) | 1999-06-01 | 2014-07-15 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US6774120B1 (en) | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US6716824B1 (en) | 1999-10-22 | 2004-04-06 | F. Charles Brunicardi | Treatment of pancreatic adenocarcinoma by cytotoxic gene therapy |
| US6759039B2 (en) | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
| US7214371B1 (en) | 2000-09-01 | 2007-05-08 | Ben-Gurion University Of The Negev Research & Development Authority | Tissue engineered biografts for repair of damaged myocardium |
| AU2002323484A1 (en) | 2001-08-31 | 2003-03-18 | Joslin Diabetes Center, Inc. | Insulin related transcription factor and uses thereof |
| WO2003033697A1 (en) | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| US7722894B2 (en) | 2001-10-22 | 2010-05-25 | Massachusetts Institute Of Technology | Biodegradable polymer |
| JP4666567B2 (en) | 2001-12-07 | 2011-04-06 | ジェロン・コーポレーション | Islet cells derived from human embryonic stem cells |
| AU2003217658A1 (en) | 2002-02-22 | 2003-09-09 | University Of Florida | Cellular trans-differentiation |
| GB0206357D0 (en) | 2002-03-18 | 2002-05-01 | Univ Bath | Cells |
| JP4136434B2 (en) | 2002-04-17 | 2008-08-20 | 進 清野 | Induction of insulin-producing cells |
| US20060122104A1 (en) | 2002-05-28 | 2006-06-08 | Presnell Sharon C | Methods for in vitro expansion and transdifferentiation of human pancreatic acinar cells into insulin-producing cells |
| CN100393367C (en) | 2003-05-05 | 2008-06-11 | 宾-古里安尼格夫大学研究及发展部 | Injectable cross-linked polymer formulation and its application |
| AU2004236573B2 (en) | 2003-05-12 | 2009-10-22 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| EP1670900A4 (en) | 2003-08-27 | 2008-06-11 | Stemcells California Inc | Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| US7608447B2 (en) | 2003-12-09 | 2009-10-27 | Ben Gurion University Of The Negev Research And Development Authority | Pulse-medium perfusion bioreactor with improved mass transport for multiple-3-D cell constructs |
| CA2574802A1 (en) | 2004-07-20 | 2006-02-02 | Isogenis, Inc. | Specific inhibition of autoimmunity and diseases associated with autoantigens |
| EP1784481A1 (en) | 2004-08-25 | 2007-05-16 | Technion Research And Development Foundation, Ltd. | Methods of generating embryoid bodies using three dimensional scaffolds |
| US8679484B2 (en) | 2005-03-02 | 2014-03-25 | Polyrizon Ltd. | Method for removal of toxins from mucosal membranes |
| WO2006095342A2 (en) | 2005-03-07 | 2006-09-14 | Technion Research & Development Foundation Ltd. | Natural tissue-derived decellularized matrix and methods of generating and using same |
| US7517856B2 (en) | 2005-10-11 | 2009-04-14 | Ben-Gurion University Of The Negev Research And Development Authority | Bioconjugates comprising sulfated polysaccharides and their uses |
| JP2009543580A (en) | 2006-07-19 | 2009-12-10 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド | Composition for cell reprogramming and use thereof |
| US8735154B2 (en) | 2006-10-30 | 2014-05-27 | The University Of Kansas | Templated islet cells and small islet cell clusters for diabetes treatment |
| WO2008075339A2 (en) | 2006-12-18 | 2008-06-26 | Ben Gurion University Of The Negev | Scaffolding for tissue regeneration or repair |
| US20100226976A1 (en) | 2007-07-11 | 2010-09-09 | Marcelle Machluf | Encapsulated mesenchymal stem cells and uses thereof |
| IL187707A0 (en) | 2007-11-27 | 2008-11-03 | Univ Ben Gurion | Alginate scaffold in hepatectomy |
| WO2009126927A2 (en) | 2008-04-11 | 2009-10-15 | Joslin Diabetes Center, Inc. | Methods of generating insulin-producing cells |
| US9683215B2 (en) | 2008-08-22 | 2017-06-20 | President And Fellows Of Harvard College | Methods of reprogramming cells |
| JP5717253B2 (en) | 2009-08-02 | 2015-05-13 | 学校法人東京女子医科大学 | Islet cell sheet, production method and use thereof |
| JP2011223993A (en) | 2010-03-30 | 2011-11-10 | Kumamoto Univ | Method for inducing differentiation of stem cell |
| US9376664B2 (en) | 2010-06-14 | 2016-06-28 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| EP2741753A2 (en) | 2011-08-09 | 2014-06-18 | Yeda Research and Development Co. Ltd. | Downregulation of mir-7 for promotion of beta cell differentiation and insulin production |
| EP2816964B1 (en) | 2012-02-21 | 2023-12-27 | Ben-Gurion University of The Negev Research and Development Authority | Hydrogel system comprising spatially separated bioactive polypeptides |
| WO2014102801A1 (en) | 2012-12-30 | 2014-07-03 | Hadasit Medical Research Services And Development Ltd. | Use of alginate compositions in preventing or reducing liver damage caused by a hepatotoxic agent |
| EP4299721A3 (en) | 2013-05-08 | 2024-04-24 | ProKidney | Organoids comprising isolated renal cells and uses thereof |
| BR112015031253B1 (en) * | 2013-06-13 | 2021-09-28 | Orgenesis Ltd. | METHOD FOR PRODUCING A TRANSDIFFERENTIATED CELL POPULATION |
| WO2015125147A1 (en) | 2014-02-20 | 2015-08-27 | B. G. Negev Technologies And Applications Ltd | Anionic polyplexes for use in the delivery of nucleic acids |
| JP2017521089A (en) * | 2014-05-14 | 2017-08-03 | ザ ユニバーシティー コート オブ ザ ユニバーシティー オブ アバーディーンＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｃｏｕｒｔ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ａｂｅｒｄｅｅｎ | Obtaining pancreatic endocrine cells |
| JP6538087B2 (en) | 2014-05-30 | 2019-07-03 | ザ・セカント・グループ・エルエルシー | Waterborne manufacture of polymeric materials |
| WO2015186127A1 (en) | 2014-06-02 | 2015-12-10 | B. G. Negev Technologies And Applications Ltd | Site-selective modification of polysaccharides and applications thereof |
| MA41296A (en) | 2014-12-30 | 2017-11-07 | Orgenesis Ltd | TRANSDIFFERENTIATION PROCESSES AND METHODS FOR USING THE SAME |
| KR20180104646A (en) | 2016-01-07 | 2018-09-21 | 비.지. 네게브 테크놀로지즈 앤드 애플리케이션스 리미티드, 엣 벤-구리온 유니버시티 | Compositions and methods for establishing immune tolerance |
| WO2017175229A1 (en) | 2016-04-07 | 2017-10-12 | B.G. Negev Technologies And Applications Ltd. | Polysaccharide compositions and uses thereof |
| US20170290954A1 (en) | 2016-04-07 | 2017-10-12 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Compositions and methods for treating spinal cord injury |
| SG11201911256UA (en) | 2017-05-08 | 2020-01-30 | Orgenesis Ltd | Transdifferentiated cell populations and methods of use thereof |
-
2018
- 2018-05-08 SG SG11201911256UA patent/SG11201911256UA/en unknown
- 2018-05-08 EP EP18798077.6A patent/EP3635106A4/en active Pending
- 2018-05-08 WO PCT/IL2018/050496 patent/WO2018207179A1/en not_active Ceased
-
2019
- 2019-11-07 US US16/676,481 patent/US10975354B2/en not_active Expired - Fee Related
- 2019-11-07 IL IL270492A patent/IL270492B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL270492B (en) | 2022-02-01 |
| US10975354B2 (en) | 2021-04-13 |
| WO2018207179A1 (en) | 2018-11-15 |
| EP3635106A4 (en) | 2021-01-06 |
| EP3635106A1 (en) | 2020-04-15 |
| US20200140825A1 (en) | 2020-05-07 |
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