DK0661989T3 - Proteinsammensætninger med vedvarende frigivelse - Google Patents
Proteinsammensætninger med vedvarende frigivelseInfo
- Publication number
- DK0661989T3 DK0661989T3 DK93920157.0T DK93920157T DK0661989T3 DK 0661989 T3 DK0661989 T3 DK 0661989T3 DK 93920157 T DK93920157 T DK 93920157T DK 0661989 T3 DK0661989 T3 DK 0661989T3
- Authority
- DK
- Denmark
- Prior art keywords
- prolonged release
- protein compositions
- release protein
- sustained
- novel compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 230000002035 prolonged effect Effects 0.000 title abstract 2
- 230000000975 bioactive effect Effects 0.000 abstract 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 abstract 1
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 101710142969 Somatoliberin Proteins 0.000 abstract 1
- 235000013773 glyceryl triacetate Nutrition 0.000 abstract 1
- 239000001087 glyceryl triacetate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 229960002622 triacetin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94787292A | 1992-09-21 | 1992-09-21 | |
| US96336592A | 1992-10-20 | 1992-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0661989T3 true DK0661989T3 (da) | 1998-03-02 |
Family
ID=27130263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93920157.0T DK0661989T3 (da) | 1992-09-21 | 1993-08-23 | Proteinsammensætninger med vedvarende frigivelse |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6011011A (da) |
| EP (1) | EP0661989B1 (da) |
| JP (2) | JP3756512B2 (da) |
| AT (1) | ATE156361T1 (da) |
| AU (1) | AU5018693A (da) |
| DE (1) | DE69312947T2 (da) |
| DK (1) | DK0661989T3 (da) |
| ES (1) | ES2107051T3 (da) |
| GR (1) | GR3024632T3 (da) |
| MX (1) | MX9305729A (da) |
| TW (1) | TW224055B (da) |
| WO (1) | WO1994006452A1 (da) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130222C (zh) * | 1996-01-11 | 2003-12-10 | 法玛西雅厄普约翰美国公司 | 水性延长释放配剂 |
| US5932547A (en) * | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
| KR100594519B1 (ko) * | 1996-07-03 | 2007-03-02 | 앨자 코포레이션 | 비수성양성자성펩티드제제 |
| CA2259403A1 (en) * | 1996-07-03 | 1998-01-08 | Alza Corporation | Non-aqueous protic peptide formulations |
| KR100593221B1 (ko) * | 1996-07-03 | 2007-03-02 | 알자 코포레이션 | 비수성극성비양성자성펩타이드제제 |
| US5981489A (en) * | 1996-07-18 | 1999-11-09 | Alza Corporation | Non-aqueous protic peptide formulations |
| IN184589B (da) | 1996-10-16 | 2000-09-09 | Alza Corp | |
| US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| US6773711B2 (en) * | 2000-02-15 | 2004-08-10 | Allergan, Inc. | Botulinum toxin therapy for Hashimoto's thyroiditis |
| US6524580B1 (en) | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
| US6358513B1 (en) | 2000-02-15 | 2002-03-19 | Allergan Sales, Inc. | Method for treating Hashimoto's thyroiditis |
| US6328977B1 (en) | 2000-02-22 | 2001-12-11 | Allergan Sales, Inc. | Method for treating hyperparathyroidism |
| US6306423B1 (en) | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
| US20040170665A1 (en) * | 2000-06-02 | 2004-09-02 | Allergan, Inc. | Intravitreal botulinum toxin implant |
| US20040033241A1 (en) * | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
| US7226442B2 (en) * | 2000-10-10 | 2007-06-05 | Microchips, Inc. | Microchip reservoir devices using wireless transmission of power and data |
| KR100838219B1 (ko) * | 2001-07-13 | 2008-06-13 | 동아제약주식회사 | 인간성장호르몬의 지속적인 방출이 가능한 생분해성약학적 조성물 및 미립구 제형 |
| US7497855B2 (en) * | 2002-09-04 | 2009-03-03 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
| US7074425B2 (en) * | 2002-09-26 | 2006-07-11 | Bonewax, Llc | Hemostatic compositions and methods |
| KR20050083774A (ko) | 2002-10-16 | 2005-08-26 | 유로-셀티크 소시에떼 아노뉨 | 세포-연관된 ｃａ 125/ｏ772ｐ에 결합하는 항체들 및그것의 용도의 방법들 |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2007506683A (ja) * | 2003-09-25 | 2007-03-22 | カンジェーン コーポレイション | ヒト成長ホルモン剤およびその調整方法と使用方法 |
| ATE551339T1 (de) | 2003-11-05 | 2012-04-15 | Sarcode Bioscience Inc | Modulatoren der zellulären adhäsion |
| CA2595457A1 (en) * | 2005-01-25 | 2006-08-03 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
| MY139088A (en) | 2005-02-21 | 2009-08-28 | Lg Life Sciences Ltd | Sustained release composition of protein drug |
| CA2610159C (en) * | 2005-06-10 | 2015-03-31 | Altus Pharmaceuticals Inc. | Methods to reduce oxalate concentration by administration of oxalate oxidase crystals |
| US7756524B1 (en) | 2006-01-31 | 2010-07-13 | Nextel Communications Inc. | System and method for partially count-based allocation of vocoder resources |
| US20070178138A1 (en) * | 2006-02-01 | 2007-08-02 | Allergan, Inc. | Biodegradable non-opthalmic implants and related methods |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| ES2830024T3 (es) * | 2007-10-19 | 2021-06-02 | Novartis Ag | Composiciones y métodos para el tratamiento del edema macular |
| MX2010004789A (es) | 2007-11-02 | 2010-07-05 | Acrux Dds Pty Ltd | Sistema de liberacion transdermica para hormonas y esteroides. |
| US9107815B2 (en) | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
| EP2276508A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | ADMINISTRATION OF LFA-1 ANTAGONISTS TO THE GASTROINTESTINAL SYSTEM |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CN102665401A (zh) | 2009-11-16 | 2012-09-12 | 益普生制药股份有限公司 | 黑皮质素受体配体的药物组合物 |
| DE102009056745A1 (de) * | 2009-12-04 | 2011-06-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung von Peptiden |
| PE20121707A1 (es) * | 2009-12-21 | 2012-12-17 | Ambrx Inc | Polipeptidos de somatotropina bovina modificados y sus usos |
| BR112012015597A2 (pt) * | 2009-12-21 | 2017-01-31 | Ambrx Inc | peptídeos de somatotropina suínos modificados e seus usos |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| ES2810003T3 (es) | 2011-11-18 | 2021-03-08 | Regeneron Pharma | Micropartícula que contiene proteína terapéutica recubierta con polímero biodegradable para uso médico |
| TWI631948B (zh) * | 2012-07-17 | 2018-08-11 | 拜爾紐西蘭有限公司 | 可注射型抗生素配方及其使用方法 |
| EP3718557A3 (en) | 2013-02-25 | 2020-10-21 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| HK1220696A1 (zh) | 2013-03-15 | 2017-05-12 | Bausch Health Ireland Limited | 鸟苷酸环化酶激动剂及其用途 |
| EA201690732A1 (ru) | 2013-10-10 | 2016-12-30 | Синерджи Фармасьютикалз, Инк. | Агонисты гуанилатциклазы, используемые для лечения индуцированных опиоидами дисфункций |
| TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
| EP3362041A1 (en) * | 2015-10-16 | 2018-08-22 | Regeneron Pharmaceuticals, Inc. | Stable protein compositions |
| CA3009814A1 (en) | 2016-01-11 | 2017-07-20 | Synergy Pharmaceuticals, Inc. | Formulations and methods for treating ulcerative colitis |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1185340A (en) * | 1967-12-19 | 1970-03-25 | Gen Foods Corp | Water Dispersable Hydrophilic Colloid Composition. |
| US4041155A (en) * | 1974-10-29 | 1977-08-09 | American Home Products Corporation | Long acting somatostatin composition |
| US3966962A (en) * | 1975-03-27 | 1976-06-29 | The Upjohn Company | Triacetin solutions of PGE-type compounds |
| US4301175A (en) * | 1980-12-29 | 1981-11-17 | The Upjohn Company | E-Type prostaglandin compositions |
| ZA831186B (en) * | 1982-03-22 | 1983-11-30 | Upjohn Ltd | Gelled pge2/triacetin solutions |
| DE3484584D1 (de) * | 1983-10-14 | 1991-06-20 | Sumitomo Pharma | Injektionen mit verzoegerter abgabe. |
| JPS60224638A (ja) * | 1984-04-23 | 1985-11-09 | Kao Corp | 経皮吸収促進剤およびこれを含有する外用剤 |
| KR890002631B1 (ko) * | 1984-10-04 | 1989-07-21 | 몬산토 캄파니 | 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물 |
| US4977140A (en) * | 1985-08-23 | 1990-12-11 | Eli Lilly And Company | Injectable sustained release formulation |
| JPS62123112A (ja) * | 1985-11-22 | 1987-06-04 | Sunstar Inc | 軟膏基剤 |
| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| FR2606597B1 (fr) * | 1986-11-17 | 1989-01-27 | Rhone Poulenc Sante | Nouvelle composition pour l'alimentation des ruminants contenant une substance biologiquement active et sa preparation |
| US4795641A (en) * | 1987-08-20 | 1989-01-03 | Eastman Kodak Company | Polymer blends having reverse phase morphology for controlled delivery of bioactive agents |
| US5004728A (en) * | 1988-03-11 | 1991-04-02 | The Trustees Of The University Of Pennsylvania | Methods of increasing milk yields in ruminants |
| IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
| CN1050373A (zh) * | 1989-05-16 | 1991-04-03 | 梅迪斯化学药物工厂普特两合股份公司 | 制备旋光2-芳基链烷酸，特别是2-芳基丙酸的方法 |
| NZ234802A (en) * | 1989-08-14 | 1992-11-25 | Merck & Co Inc | Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals |
| US5179189A (en) * | 1990-01-19 | 1993-01-12 | Nova Pharmaceutical Corporation | Fatty acid terminated polyanhydrides |
| ATE164080T1 (de) * | 1990-05-10 | 1998-04-15 | Bechgaard Int Res | Pharmazeutische zubereitung enthaltend n- glykofurole und n-äthylenglykole |
| US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
| US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
-
1993
- 1993-08-23 EP EP93920157A patent/EP0661989B1/en not_active Expired - Lifetime
- 1993-08-23 ES ES93920157T patent/ES2107051T3/es not_active Expired - Lifetime
- 1993-08-23 AU AU50186/93A patent/AU5018693A/en not_active Abandoned
- 1993-08-23 AT AT93920157T patent/ATE156361T1/de not_active IP Right Cessation
- 1993-08-23 JP JP50808394A patent/JP3756512B2/ja not_active Expired - Fee Related
- 1993-08-23 DE DE69312947T patent/DE69312947T2/de not_active Expired - Fee Related
- 1993-08-23 WO PCT/US1993/007756 patent/WO1994006452A1/en not_active Ceased
- 1993-08-23 DK DK93920157.0T patent/DK0661989T3/da active
- 1993-08-31 TW TW082107064A patent/TW224055B/zh active
- 1993-09-20 MX MX9305729A patent/MX9305729A/es not_active IP Right Cessation
-
1995
- 1995-03-20 US US08/407,327 patent/US6011011A/en not_active Expired - Fee Related
-
1997
- 1997-09-04 GR GR970402270T patent/GR3024632T3/el unknown
-
2004
- 2004-07-13 JP JP2004206098A patent/JP2004285079A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0661989A1 (en) | 1995-07-12 |
| US6011011A (en) | 2000-01-04 |
| JP3756512B2 (ja) | 2006-03-15 |
| ES2107051T3 (es) | 1997-11-16 |
| DE69312947T2 (de) | 1998-01-08 |
| AU5018693A (en) | 1994-04-12 |
| ATE156361T1 (de) | 1997-08-15 |
| MX9305729A (es) | 1994-03-31 |
| DE69312947D1 (de) | 1997-09-11 |
| GR3024632T3 (en) | 1997-12-31 |
| JP2004285079A (ja) | 2004-10-14 |
| JPH08501305A (ja) | 1996-02-13 |
| WO1994006452A1 (en) | 1994-03-31 |
| TW224055B (da) | 1994-05-21 |
| EP0661989B1 (en) | 1997-08-06 |
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