DK0660821T3 - Ikke-metaboliserbare clomiphen-analoge til behandling af tamoxifen-resistente tumorer - Google Patents

Ikke-metaboliserbare clomiphen-analoge til behandling af tamoxifen-resistente tumorer

Info

Publication number: DK0660821T3
Authority: DK; Denmark
Prior art keywords: metabolizable; tamoxifen; treatment; resistant tumors; clomiphene analogs
Prior art date: 1992-09-15

Application number

DK93920100T

Other languages

Danish (da)

English (en)

Inventor

Alan J Bitonti

Russell J Baumann

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-15

Filing date

1993-08-16

Publication date

1998-09-21

1993-08-16 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1998-09-21 Application granted granted Critical

1998-09-21 Publication of DK0660821T3 publication Critical patent/DK0660821T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/45—Monoamines
- C07C211/48—N-alkylated amines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK93920100T 1992-09-15 1993-08-16 Ikke-metaboliserbare clomiphen-analoge til behandling af tamoxifen-resistente tumorer DK0660821T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US94530592A	1992-09-15	1992-09-15
PCT/US1993/007697 WO1994006762A1 (fr)	1992-09-15	1993-08-16	Analogues de clomiphene non metabolisables utilises dans le traitement de tumeurs resistantes au tamoxifene

Publications (1)

Publication Number	Publication Date
DK0660821T3 true DK0660821T3 (da)	1998-09-21

Family

ID=25482938

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93920100T DK0660821T3 (da)	1992-09-15	1993-08-16	Ikke-metaboliserbare clomiphen-analoge til behandling af tamoxifen-resistente tumorer

Country Status (16)

Country	Link
US (2)	US5410080A (fr)
EP (1)	EP0660821B1 (fr)
JP (1)	JPH09500863A (fr)
KR (1)	KR100326962B1 (fr)
AT (1)	ATE162516T1 (fr)
AU (1)	AU672234B2 (fr)
CA (1)	CA2143000C (fr)
DE (1)	DE69316633T2 (fr)
DK (1)	DK0660821T3 (fr)
ES (1)	ES2112994T3 (fr)
FI (1)	FI951193L (fr)
GR (1)	GR3026236T3 (fr)
HU (1)	HUT71244A (fr)
NO (1)	NO950985L (fr)
NZ (1)	NZ255785A (fr)
WO (1)	WO1994006762A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR008155A1 (es) *	1996-09-06	1999-12-09	Smithkline Beecham Corp	Uso de un compuesto de formula i para preparar un medicamento util para tratar y prevenir la enfermedad cardiovascular post menopausica en mujeres.
RU2214236C2 (ru) *	1997-08-15	2003-10-20	Дьюк Юниверсити	Способ профилактики или лечения эстрогензависимых заболеваний и расстройств
UA113291C2 (xx) *	2011-08-04	2017-01-10		Метаболіти транскломіфену і їх застосування
WO2014070523A1 (fr)	2012-11-02	2014-05-08	Repros Therapeutics Inc.	Trans-clomiphène pour une utilisation en cancérothérapie
CN106068121A (zh) *	2014-03-11	2016-11-02	利普生物药剂公司	使用单一溶剂进行克罗米芬合成

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2750416A (en) *	1950-12-21	1956-06-12	Rohm & Haas	Aminomethylphenols and method for their preparation
US3143568A (en) *	1961-01-25	1964-08-04	Vismara Francesco Spa	Diarylamino-acetyl-aryl derivatives
US3244705A (en) *	1962-11-14	1966-04-05	Richardson Merrell Inc	Triphenylhaloethylene derivatives
CH373975A (de) *	1963-07-20	1963-12-15	Heierle Werner	Kronen-Verschluss für Flaschen
FR3575M (fr) *	1964-01-28	1965-10-04	Richardson Merrell	Triphénylhalogénoéthylenes substitués.
US3631109A (en) *	1968-12-04	1971-12-28	Uniroyal Inc	Beta beta'-bis(dialkylaminomethyl-4-hydroxy-benzylthio)dialkylethers
GB2126576B (en) *	1982-06-25	1985-06-19	Farmos Group Limited	Alkane and alkene derivatives
DE3762617D1 (de) *	1986-09-11	1990-06-13	Nat Res Dev	Tamoxifenderivate.
US5114951A (en) *	1989-04-11	1992-05-19	Burroughs Wellcome Company	Agents for combating multiple drug resistance
US5130424A (en) *	1990-08-01	1992-07-14	Merrell Dow Pharmaceuticals Inc.	4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors

1993
- 1993-08-16 WO PCT/US1993/007697 patent/WO1994006762A1/fr not_active Ceased
- 1993-08-16 CA CA002143000A patent/CA2143000C/fr not_active Expired - Fee Related
- 1993-08-16 DK DK93920100T patent/DK0660821T3/da active
- 1993-08-16 KR KR1019950700991A patent/KR100326962B1/ko not_active Expired - Fee Related
- 1993-08-16 FI FI951193A patent/FI951193L/fi not_active Application Discontinuation
- 1993-08-16 EP EP93920100A patent/EP0660821B1/fr not_active Expired - Lifetime
- 1993-08-16 HU HU9500775A patent/HUT71244A/hu unknown
- 1993-08-16 AT AT93920100T patent/ATE162516T1/de not_active IP Right Cessation
- 1993-08-16 ES ES93920100T patent/ES2112994T3/es not_active Expired - Lifetime
- 1993-08-16 DE DE69316633T patent/DE69316633T2/de not_active Expired - Fee Related
- 1993-08-16 NZ NZ255785A patent/NZ255785A/en unknown
- 1993-08-16 AU AU50150/93A patent/AU672234B2/en not_active Ceased
- 1993-08-16 JP JP6508081A patent/JPH09500863A/ja not_active Ceased
1994
- 1994-02-10 US US08/196,817 patent/US5410080A/en not_active Expired - Fee Related
- 1994-12-05 US US08/350,192 patent/US5681863A/en not_active Expired - Fee Related
1995
- 1995-03-14 NO NO950985A patent/NO950985L/no not_active Application Discontinuation
1998
- 1998-02-25 GR GR980400417T patent/GR3026236T3/el unknown

Also Published As

Publication number	Publication date
NO950985D0 (no)	1995-03-14
EP0660821A1 (fr)	1995-07-05
FI951193A7 (fi)	1995-03-14
US5410080A (en)	1995-04-25
FI951193A0 (fi)	1995-03-14
CA2143000C (fr)	2000-03-28
US5681863A (en)	1997-10-28
AU5015093A (en)	1994-04-12
CA2143000A1 (fr)	1994-03-31
AU672234B2 (en)	1996-09-26
HUT71244A (en)	1995-11-28
DE69316633T2 (de)	1998-05-20
NO950985L (no)	1995-03-14
HU9500775D0 (en)	1995-05-29
ES2112994T3 (es)	1998-04-16
FI951193L (fi)	1995-03-14
KR100326962B1 (ko)	2002-12-02
JPH09500863A (ja)	1997-01-28
GR3026236T3 (en)	1998-05-29
WO1994006762A1 (fr)	1994-03-31
NZ255785A (en)	1997-05-26
KR950703524A (ko)	1995-09-20
EP0660821B1 (fr)	1998-01-21
DE69316633D1 (de)	1998-02-26
ATE162516T1 (de)	1998-02-15

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