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DK0643581T3 - Okulær androgenbehandling ved Sjögren's syndrom - Google Patents

Okulær androgenbehandling ved Sjögren's syndrom

Info

Publication number
DK0643581T3
DK0643581T3 DK93910732T DK93910732T DK0643581T3 DK 0643581 T3 DK0643581 T3 DK 0643581T3 DK 93910732 T DK93910732 T DK 93910732T DK 93910732 T DK93910732 T DK 93910732T DK 0643581 T3 DK0643581 T3 DK 0643581T3
Authority
DK
Denmark
Prior art keywords
syndrome
ocular
sjögren
androgen therapy
androgen
Prior art date
Application number
DK93910732T
Other languages
English (en)
Inventor
David A Sullivan
Original Assignee
Schepens Eye Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schepens Eye Res Inst filed Critical Schepens Eye Res Inst
Application granted granted Critical
Publication of DK0643581T3 publication Critical patent/DK0643581T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Eye Examination Apparatus (AREA)
DK93910732T 1992-04-21 1993-04-21 Okulær androgenbehandling ved Sjögren's syndrom DK0643581T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87165792A 1992-04-21 1992-04-21
PCT/US1993/003801 WO1993020823A1 (en) 1992-04-21 1993-04-21 Ocular androgen therapy in sjögren's syndrome

Publications (1)

Publication Number Publication Date
DK0643581T3 true DK0643581T3 (da) 2000-04-25

Family

ID=25357867

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93910732T DK0643581T3 (da) 1992-04-21 1993-04-21 Okulær androgenbehandling ved Sjögren's syndrom

Country Status (11)

Country Link
US (1) US5620921C1 (da)
EP (1) EP0643581B1 (da)
JP (1) JPH07508716A (da)
AT (1) ATE185697T1 (da)
AU (1) AU674681B2 (da)
CA (1) CA2133966C (da)
DE (1) DE69326836T2 (da)
DK (1) DK0643581T3 (da)
ES (1) ES2139005T3 (da)
GR (1) GR3032326T3 (da)
WO (1) WO1993020823A1 (da)

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JPH08507884A (ja) * 1993-03-12 1996-08-20 アラーガン、インコーポレイテッド フェロモン添加剤を含有するアイケア用品およびその使用方法
WO1997020578A1 (en) * 1995-12-04 1997-06-12 University Of Miami Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US7265150B1 (en) 1998-08-14 2007-09-04 Gpi Nil Holdings Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US7410995B1 (en) 1998-08-14 2008-08-12 Gpi Nil Holdings Inc. N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders
WO2000038663A2 (en) 1998-12-24 2000-07-06 Alcon Laboratories, Inc. Ep4 receptor agonists for treatment of dry eye
AU2183800A (en) 1998-12-24 2000-07-31 Alcon Laboratories, Inc. Prostaglandin e agonists for treatment of dry eye
BR0015404A (pt) 1999-11-09 2002-06-25 Alcon Inc Compostos relacionados com ácido 15-hidroxieicosatetraenóico e métodos de uso
DE60019322T2 (de) 1999-11-09 2005-09-08 Alcon Inc. Heteroatomunterbrochene analoge von15-hydroxyeicosatetraensäure und verfahren zu deren verwendung
US6552084B2 (en) 1999-11-09 2003-04-22 Alcon Universal Ltd. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
TR200201244T2 (tr) 1999-11-09 2002-08-21 Alcon, Inc. Göz kurumasının iyileştirilmesi için Lipoksin A4 ve analogları
US6458854B2 (en) 1999-11-09 2002-10-01 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
WO2001034553A2 (en) 1999-11-09 2001-05-17 Alcon Universal Ltd. 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use
US6353032B1 (en) 1999-11-09 2002-03-05 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
ATE257144T1 (de) 1999-11-09 2004-01-15 Alcon Inc OMEGA KETTENMODIFIZIERTE HYDROXYEICOSATETRAENSÄURE DERIVATE VERWENDBAR IN DER BEHANDLUNG DER ßTROCKENES AUGEß KRANKHEIT
US6803385B2 (en) 1999-11-09 2004-10-12 Alcon, Inc. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
ES2215740T3 (es) 1999-11-09 2004-10-16 Alcon Inc. Homologos de 15-hete con sustitucion 3-heteroatomica y dos carbonos, y metodo de uso.
CA2388030A1 (en) 1999-11-09 2001-05-17 Alcon, Inc. Benzenoid derivatives of 15-hydroxyeicosatetraenoic acid and methods of their use in treating dry eye disorders
TR200201250T2 (tr) 1999-11-09 2002-09-23 Alcon, Inc Hidroksieikosatetraenoat tuzları, bileşimleri ve bunların göz kuruması bozukluklarının iyileştirilmesinde kullanım yöntemleri.
US6320062B1 (en) 1999-11-09 2001-11-20 Alcon Universal Ltd. 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders
BR0015416A (pt) 1999-11-09 2002-07-16 Alcon Inc Composições contendo derivados do ácido hidroxieicosa tetraenóico e métodos de uso no tratamento de distúrbios de olhos secos
WO2001046134A1 (en) 1999-12-22 2001-06-28 Alcon Universal Ltd. 6-KETO PROSTAGLANDIN F1α AND ANALOGS FOR TREATING DRY EYE
EP1301210A2 (en) 2000-07-14 2003-04-16 Allergan, Inc. Compositions containing therapeutically active components having enhanced solubility
WO2002034258A1 (en) 2000-10-23 2002-05-02 Alcon, Inc. Use of hydroxyeicosatetraenoic acid derivatives in intraocular surgery
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
JP2004527578A (ja) 2001-05-21 2004-09-09 アルコン，インコーポレイテッド ドライアイ障害を処置するためのＮＦ−κＢインヒビターの使用
ES2278049T3 (es) 2001-05-21 2007-08-01 Alcon, Inc. Uso de inhibidores de proteasoma para tratar trastornos de ojo seco.
US7112588B2 (en) * 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
JP2004531560A (ja) * 2001-05-21 2004-10-14 アルコン，インコーポレイテッド ドライアイ障害を処置する方法
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
CA2462272A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye by a combination of an antiinflammatory steroid and a muc-1 secretagogue
WO2003030894A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
US6659985B2 (en) 2002-01-30 2003-12-09 Southern College Of Optometry Method to use transdermal administration of androgens to the adnexa of the eye
WO2004060274A2 (en) * 2002-12-20 2004-07-22 Alcon, Inc. Treatment of dry eye by restoring 15-lipoxygenase activity to ocular surface cells
TWI335819B (en) * 2002-12-24 2011-01-11 Alcon Inc Use of oculosurface selective glucocorticoid in the treatment of dry eye
US6984628B2 (en) * 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
FR2877574A1 (fr) * 2004-11-08 2006-05-12 Marie Claude Benattar Utilisation d'acide hyaluronique, eventuellement en association avec au moins un androgene pour le traitement de troubles sexuels ou urinaires feminins par amplification du point g et compositions.
CA2644652A1 (en) * 2005-03-02 2006-09-08 Nascent Pharmaceuticals, Inc. Combinaion therapy for topical application in the treatment of dry eye syndrome
SI1919290T1 (sl) * 2005-07-12 2014-05-30 Ampio Pharmaceuticals, Inc. Postopki in proizvodi za zdravljenje bolezni
US20080132475A1 (en) * 2006-12-05 2008-06-05 Charles Gerald Connor Treatment for dry eye
US20100016264A1 (en) * 2007-12-05 2010-01-21 Connor Charles G Treatment for dry eye using testosterone and progestagen
SI2915529T1 (sl) 2008-05-07 2017-09-29 The Regents Of The University Of California Terapevtska regeneracija in obogatitev lubrikacije okularne površine
DK2554171T3 (da) * 2009-06-22 2014-11-17 Ampio Pharmaceuticals Inc Fremgangsmåde til behandling af sygdomme
SG177302A1 (en) * 2009-06-22 2012-02-28 Dmi Acquisition Corp Methods and products for treatment of diseases
US9119772B2 (en) 2011-01-26 2015-09-01 Allergan, Inc. Androgen composition for treating an opthalmic condition
BR112015014261A8 (pt) 2012-12-19 2019-10-08 Ampio Pharmaceuticals Inc composto de danazol, seu uso e formulação farmacêutica compreendendo este
US20140274985A1 (en) * 2013-03-15 2014-09-18 Raman Malhotra Systemic administration of androgen in treating dry eye syndrome
US20150141328A1 (en) * 2013-11-18 2015-05-21 The Schepens Eye Research Institute Stimulation of human meibomian gland function
HK1246644A1 (zh) * 2015-04-03 2018-09-14 参天制药株式会社 以诺龙或其酯、美替诺龙或其酯作为有效成分的乾眼症治疗剂

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Also Published As

Publication number Publication date
DE69326836T2 (de) 2000-02-24
AU4112193A (en) 1993-11-18
GR3032326T3 (en) 2000-04-27
ATE185697T1 (de) 1999-11-15
AU674681B2 (en) 1997-01-09
US5620921C1 (en) 2001-01-09
WO1993020823A1 (en) 1993-10-28
US5620921A (en) 1997-04-15
EP0643581A1 (en) 1995-03-22
CA2133966A1 (en) 1993-10-28
DE69326836D1 (de) 1999-11-25
EP0643581A4 (en) 1995-01-11
JPH07508716A (ja) 1995-09-28
EP0643581B1 (en) 1999-10-20
CA2133966C (en) 1997-09-09
ES2139005T3 (es) 2000-02-01

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