[go: up one dir, main page]

DK0640137T3 - Immortaliserede humane cellelinjer indeholdende eksogene cytochrom P450-gener - Google Patents

Immortaliserede humane cellelinjer indeholdende eksogene cytochrom P450-gener

Info

Publication number
DK0640137T3
DK0640137T3 DK93912165T DK93912165T DK0640137T3 DK 0640137 T3 DK0640137 T3 DK 0640137T3 DK 93912165 T DK93912165 T DK 93912165T DK 93912165 T DK93912165 T DK 93912165T DK 0640137 T3 DK0640137 T3 DK 0640137T3
Authority
DK
Denmark
Prior art keywords
cell lines
genes
human cell
lines containing
immortalized human
Prior art date
Application number
DK93912165T
Other languages
English (en)
Inventor
Curtis C Harris
Harry V Gelboin
Frank J Gonzalez
Andrea M A Pfeifer
Original Assignee
Us Gov Health & Human Serv
Nestec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Nestec Sa filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of DK0640137T3 publication Critical patent/DK0640137T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK93912165T 1992-04-13 1993-04-09 Immortaliserede humane cellelinjer indeholdende eksogene cytochrom P450-gener DK0640137T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/869,818 US5356806A (en) 1987-06-05 1992-04-13 Immortalized human cell lines containing exogenous cytochrome P450
PCT/US1993/003336 WO1993021327A1 (en) 1992-04-13 1993-04-09 Immortalized human cell lines containing exogenous cytochrome p450 genes

Publications (1)

Publication Number Publication Date
DK0640137T3 true DK0640137T3 (da) 2004-03-29

Family

ID=25354316

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912165T DK0640137T3 (da) 1992-04-13 1993-04-09 Immortaliserede humane cellelinjer indeholdende eksogene cytochrom P450-gener

Country Status (9)

Country Link
US (1) US5356806A (da)
EP (1) EP0640137B1 (da)
AT (1) ATE254661T1 (da)
AU (1) AU680416B2 (da)
CA (1) CA2118043C (da)
DE (1) DE69333303T8 (da)
DK (1) DK0640137T3 (da)
ES (1) ES2211868T3 (da)
WO (1) WO1993021327A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506131A (en) * 1987-06-05 1996-04-09 The United States Of America As Represented By The Department Of Health And Human Services Immortalized human cell lines containing exogenous cytochrome P450 genes
WO1991012317A1 (en) * 1990-02-09 1991-08-22 Genentech, Inc. Lung cell line and methods of use
CA2128399A1 (en) * 1993-07-20 1995-01-21 Koji Hayashi Method for safety evaluation of chemical compound using recombinant yeast expressing human cytochrome p450
US6531455B1 (en) * 1995-03-24 2003-03-11 The Regents Of The University Of California Delivery of polynucleotides by secretory gland expression
US5885971A (en) * 1995-03-24 1999-03-23 The Regents Of The University Of California Gene therapy by secretory gland expression
US5837693A (en) * 1995-03-24 1998-11-17 The Regents Of The University Of California Intravenous hormone polypeptide delivery by salivary gland expression
US6153429A (en) * 1996-04-05 2000-11-28 Vera Genics Ltd. Cell lines useful for in vitro assay for indentification of carcinogens
US5821049A (en) * 1996-04-05 1998-10-13 Viratest Carcinogen Monitoring, Ltd In vitro assay for identification of carcinogens
US5763180A (en) * 1996-08-14 1998-06-09 Viratest Carcinogen Monitoring Ltd. In vitro assay for carcinogens using phenotypic transformation of human cells
DE19815519A1 (de) 1998-03-31 1999-10-07 Tacke Windenergie Gmbh Rotorblatt für eine Windkraftanlage
DE10012220A1 (de) * 2000-03-14 2001-09-20 Johannes Doehmer Stabile Expression polymorpher Formen humanen Cytochroms P450 2D6 als analytisches Werkzeug in der präklinischen Arzneimittel-Entwicklung
IL161300A0 (en) * 2001-10-31 2004-09-27 Bristol Myers Squibb Co Methods of screening for toxicity of test compounds
US9545422B2 (en) * 2010-03-01 2017-01-17 The Regents Of The University Of California Methods of inducing photosensitivity by targeting channelrhodopsin-2 and halorhodopsin to subcellular regions of retinal ganglion cells
WO2022081776A1 (en) 2020-10-13 2022-04-21 Kriya Therapeutics, Inc. Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer
EP4284936A1 (en) 2021-01-26 2023-12-06 Kriya Therapeutics, Inc. Vector constructs for delivery of nucleic acids encoding therapeutic anti-tnf antibodies and methods of using the same
EP4301860A1 (en) 2021-03-04 2024-01-10 Kriya Therapeutics, Inc. Viral vector constructs incorporating dna for inhibiting toll like receptors and methods of using the same
KR20240130139A (ko) 2022-01-09 2024-08-28 크리야 테라퓨틱스, 인크. 치료 항-igf-1r 항체를 코딩하는 핵산의 전달을 위한 벡터 구축물 및 이를 사용하는 방법
WO2024054993A1 (en) 2022-09-09 2024-03-14 Kriya Therapeutics, Inc. Vector constructs for delivery of nucleic acids encoding therapeutic anti-ctla4 antibodies and methods of using the same
WO2024130007A2 (en) 2022-12-16 2024-06-20 Kriya Therapeutics, Inc. Synthetic htert promoters and uses thereof
WO2024227074A1 (en) 2023-04-28 2024-10-31 Kriya Therapeutics, Inc. Riboswitches for regulating gene expression and therapeutic methods of using the same
WO2025014832A1 (en) 2023-07-07 2025-01-16 Kriya Therapeutics, Inc. Periocular delivery of aav vectors for treating ophthalmic pathologies
WO2025015090A1 (en) 2023-07-11 2025-01-16 Kriya Therapeutics, Inc. Vector constructs for delivery of nucleic acids encoding uricase and methods of using the same
WO2025015317A2 (en) 2023-07-13 2025-01-16 Kriya Therapeutics, Inc. Complement pathway inhibitor fusions and methods of using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816395A (en) * 1985-12-19 1989-03-28 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
US4885238A (en) * 1987-10-30 1989-12-05 The United States Of America As Represented By The Department Of Health And Human Services Immortalized human bronchial epitherial mesothelial cell lines
US5164313A (en) * 1987-06-05 1992-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinant vaccinia virus encoding cytochromes P-450

Also Published As

Publication number Publication date
DE69333303T2 (de) 2004-09-09
ES2211868T3 (es) 2004-07-16
CA2118043C (en) 2001-04-03
CA2118043A1 (en) 1993-10-28
DE69333303D1 (de) 2003-12-24
EP0640137A1 (en) 1995-03-01
US5356806A (en) 1994-10-18
DE69333303T8 (de) 2005-07-28
WO1993021327A1 (en) 1993-10-28
AU680416B2 (en) 1997-07-31
ATE254661T1 (de) 2003-12-15
AU4281693A (en) 1993-11-18
EP0640137B1 (en) 2003-11-19

Similar Documents

Publication Publication Date Title
DK0640137T3 (da) Immortaliserede humane cellelinjer indeholdende eksogene cytochrom P450-gener
DK0700442T3 (da) Udödeliggjorte humane cellelinier med indhold af exogene cytokrome P450 gener
Maurizi et al. Sox2 is required for tumor development and cancer cell proliferation in osteosarcoma
AU5488501A (en) Modified es cells and es cell-specific gene
Fellous et al. A methodological approach to tracing cell lineage in human epithelial tissues
DE69433822D1 (de) Humane epithelzellinien der leber
Brüsehafer et al. The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency
Frederiksen et al. Generation of two isogenic iPSC lines with either a heterozygous or a homozygous E280A mutation in the PSEN1 gene
Wehmeyer et al. Competing regulatory modules control the transition between mammalian gastrulation modes
YU17696A (sh) Postupak za dobijanje i alkoholni solvat olanzapina
Grigorova et al. Spontaneous and X-ray-induced chromosomal aberrations in Werner syndrome cells detected by FISH using chromosome-specific painting probes
ZA941637B (en) Genes and genetic elements accociated with sensitivity to chemotherapeutic drugs
DE69636755D1 (de) Immortalisierte menschliche Epithelzell-Linie aus Kornea
ATE256120T1 (de) Reagentien für cyp2d fluoreszenztest
Ming Sun et al. A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in S. cerevisiae
Liu et al. Establishment of mouse teratocarcinomas stem cells line and screening genes responsible for malignancy
Escobar et al. Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activator
WO2002008451A3 (en) Assay for screening compounds for inducing drug metabolizing enzymes
HUP9901786A2 (hu) Eljárás helypreferált rákos áttétképződéssel kapcsolatos gének azonosítására immuno-mágneses sejtszeparáció felhasználásával
Busley et al. Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p. G12V
Mendonca et al. Previous loss of chromosome 11 containing a suppressor locus increases radiosensitivity, neoplastic transformation frequency and delayed death in HeLa× fibroblast human hybrid cells
Harris et al. Immortalized human cell lines containing exogenous cytochrome P450
WO2001046468A3 (en) Screening method for ros-induced apoptosis in a cell
Orr et al. WS6 enables scalable ex vivo expansion and gene editing of human basal epithelial cells
GB1374492A (en) Microbial modification of benzodiazepine compounds