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DE69233553D1 - Dns "typing" mit kurzen tandem-repetitiven polimorphismen und identifikation von kurzen polimorphen tandem-wiederholungen - Google Patents

Dns "typing" mit kurzen tandem-repetitiven polimorphismen und identifikation von kurzen polimorphen tandem-wiederholungen

Info

Publication number
DE69233553D1
DE69233553D1 DE69233553T DE69233553T DE69233553D1 DE 69233553 D1 DE69233553 D1 DE 69233553D1 DE 69233553 T DE69233553 T DE 69233553T DE 69233553 T DE69233553 T DE 69233553T DE 69233553 D1 DE69233553 D1 DE 69233553D1
Authority
DE
Germany
Prior art keywords
short
repeats
dna
tandem
short tandem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69233553T
Other languages
English (en)
Other versions
DE69233553T2 (de
Inventor
Thomas Caskey
O Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24597796&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69233553(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of DE69233553D1 publication Critical patent/DE69233553D1/de
Application granted granted Critical
Publication of DE69233553T2 publication Critical patent/DE69233553T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00574Chemical means radioactive
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00576Chemical means fluorophore
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00578Chemical means electrophoric
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Catalysts (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Pens And Brushes (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
DE69233553T 1991-01-31 1992-01-28 Dns "typing" mit kurzen tandem-repetitiven polimorphismen und identifikation von kurzen polimorphen tandem-wiederholungen Revoked DE69233553T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US647655 1984-09-06
US07647655 US5364759B2 (en) 1991-01-31 1991-01-31 Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
PCT/US1992/000736 WO1992013969A1 (en) 1991-01-31 1992-01-28 Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats

Publications (2)

Publication Number Publication Date
DE69233553D1 true DE69233553D1 (de) 2006-02-09
DE69233553T2 DE69233553T2 (de) 2006-07-06

Family

ID=24597796

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69233553T Revoked DE69233553T2 (de) 1991-01-31 1992-01-28 Dns "typing" mit kurzen tandem-repetitiven polimorphismen und identifikation von kurzen polimorphen tandem-wiederholungen
DE69233798T Expired - Lifetime DE69233798D1 (de) 1991-01-31 1992-01-28 DNS "Typing" mit kurzen tandem-repetitiven Polimorphismen und Identifikation von kurzen polimorphen Tandem-Wiederholungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69233798T Expired - Lifetime DE69233798D1 (de) 1991-01-31 1992-01-28 DNS "Typing" mit kurzen tandem-repetitiven Polimorphismen und Identifikation von kurzen polimorphen Tandem-Wiederholungen

Country Status (9)

Country Link
US (1) US5364759B2 (de)
EP (3) EP1967593A3 (de)
AT (2) ATE486957T1 (de)
AU (1) AU670231B2 (de)
CA (1) CA2101859A1 (de)
DE (2) DE69233553T2 (de)
DK (1) DK0639228T3 (de)
ES (1) ES2255047T3 (de)
WO (1) WO1992013969A1 (de)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766847A (en) * 1988-10-11 1998-06-16 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Process for analyzing length polymorphisms in DNA regions
DE3834636A1 (de) 1988-10-11 1990-04-19 Max Planck Gesellschaft Verfahren zur analyse von laengenpolymorphismen in dna-bereichen
US5851762A (en) * 1990-07-11 1998-12-22 Gene Type Ag Genomic mapping method by direct haplotyping using intron sequence analysis
US20100267023A1 (en) * 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
US6303297B1 (en) 1992-07-17 2001-10-16 Incyte Pharmaceuticals, Inc. Database for storage and analysis of full-length sequences
US5840484A (en) * 1992-07-17 1998-11-24 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
US6114114A (en) * 1992-07-17 2000-09-05 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
JP3598123B2 (ja) * 1993-07-15 2004-12-08 浜松ホトニクス株式会社 核酸の変性検出装置
FR2711672B1 (fr) * 1993-10-29 1995-12-08 France Etat Armement Procédé de sélection et/ou d'obtention de sondes capables de détecter de nouvelles régions à nombre variable de répétitions en tandem, sondes pouvant être ainsi obtenues et leurs utilisations.
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6207373B1 (en) * 1998-02-25 2001-03-27 Nanogen, Inc. Methods for determining nature of repeat units in DNA
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
GB9326052D0 (en) * 1993-12-21 1994-02-23 Zeneca Ltd Sequences
WO1995021269A1 (en) * 1994-02-04 1995-08-10 Perlin Mark K Method and apparatus for analyzing genetic material
US5962332A (en) * 1994-03-17 1999-10-05 University Of Massachusetts Detection of trinucleotide repeats by in situ hybridization
US5599666A (en) * 1994-03-28 1997-02-04 Promega Corporation Allelic ladders for short tandem repeat loci
US6479235B1 (en) * 1994-09-30 2002-11-12 Promega Corporation Multiplex amplification of short tandem repeat loci
US7008771B1 (en) 1994-09-30 2006-03-07 Promega Corporation Multiplex amplification of short tandem repeat loci
CA2118048C (en) * 1994-09-30 2003-04-08 James W. Schumm Multiplex amplification of short tandem repeat loci
US5843660A (en) * 1994-09-30 1998-12-01 Promega Corporation Multiplex amplification of short tandem repeat loci
AU704660B2 (en) * 1994-11-28 1999-04-29 E.I. Du Pont De Nemours And Company Compound microsatellite primers for the detection of genetic polymorphisms
US5763169A (en) * 1995-01-13 1998-06-09 Chiron Diagnostics Corporation Nucleic acid probes for the detection and identification of fungi
US6180339B1 (en) 1995-01-13 2001-01-30 Bayer Corporation Nucleic acid probes for the detection and identification of fungi
EP0721987A1 (de) * 1995-01-16 1996-07-17 Keygene N.V. Amplifikation von einfachen Sequenz-Wiederholungen
NZ294720A (en) * 1995-01-27 1998-06-26 Incyte Pharma Inc Computer system storing and analyzing microbiological data
US5908749A (en) * 1995-02-17 1999-06-01 Tge Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for high resolution HLA typing
US5635351A (en) * 1995-03-14 1997-06-03 The Regents Of The University Of California Genetic gain and loss in gliomas
JP3579497B2 (ja) * 1995-05-12 2004-10-20 株式会社飼料作物改良増殖技術研究所 Miプライマーを用いたpcr反応による個体識別方法
CN1151269C (zh) * 1995-06-06 2004-05-26 扬·维吉 用于诊断性dna检测的方法
US5683880A (en) * 1995-07-07 1997-11-04 Myriad Genetics, Inc. Linkage analysis of genes with diseases using difference spectrum analysis
CA2248084A1 (en) 1996-03-04 1997-09-12 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
US5994064A (en) 1996-04-24 1999-11-30 Identigene, Inc. Simple and complex tandem repeats with DNA typing method
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
EP0910666B1 (de) * 1996-05-02 2006-08-09 Applera Corporation Quantifizierung von rna-transkripten mittels genomischer dna als internen standard der amplifizierungsreaktion
US6156512A (en) * 1996-05-23 2000-12-05 Promega Corp Allelic ladders for short tandem repeat loci
AU726045B2 (en) * 1996-08-28 2000-10-26 Johns Hopkins University School Of Medicine, The Method for detecting cell proliferative disorders
EP1007730A4 (de) * 1996-08-30 2004-04-28 Invitrogen Corp Verfahren zur identifizierung und isolierung von spezifischen nukleotidsequenzen in cdna und genomischer dna
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
CA2274587A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
US6306588B1 (en) 1997-02-07 2001-10-23 Invitrogen Corporation Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
US5866412A (en) * 1997-03-27 1999-02-02 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
US5914394A (en) * 1997-03-27 1999-06-22 Millenium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
US5939316A (en) * 1997-03-27 1999-08-17 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
US5955355A (en) * 1997-03-27 1999-09-21 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
GB9713597D0 (en) * 1997-06-28 1997-09-03 Sec Dep Of The Home Department Improvements in and relating to forensic identification
US6013444A (en) * 1997-09-18 2000-01-11 Oligotrail, Llc DNA bracketing locus compatible standards for electrophoresis
US6090558A (en) * 1997-09-19 2000-07-18 Genetrace Systems, Inc. DNA typing by mass spectrometry with polymorphic DNA repeat markers
US6764822B1 (en) 1997-09-19 2004-07-20 Sequenom, Inc. DNA typing by mass spectrometry with polymorphic DNA repeat markers
US6173525B1 (en) 1997-09-19 2001-01-16 Cantharellus Ab Chanterelle mycelium
US20020064792A1 (en) * 1997-11-13 2002-05-30 Lincoln Stephen E. Database for storage and analysis of full-length sequences
US6143951A (en) * 1997-12-23 2000-11-07 Agribio Tech., Inc. Alfalfa line called WL-C290 and method for producing same
US6238863B1 (en) 1998-02-04 2001-05-29 Promega Corporation Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers
US6635418B2 (en) * 1998-02-13 2003-10-21 Igen International, Inc. Assay methods for nucleic acid in a sample
AU2789299A (en) * 1998-02-26 1999-09-15 Genomics Collaborative, Inc. Unique identifier for biological samples
US20040176572A1 (en) * 1998-03-16 2004-09-09 Freimer Nelson B. Methods of compositions for diagnosing and treating chromosome-18p related disorders
EP1064295A4 (de) 1998-03-16 2004-06-16 Millennium Pharm Inc Verfahren und zusammensetzungen zur diagnose und behandlung von störungen die auf chromosom 18p beruhen
US6248528B1 (en) 1998-04-06 2001-06-19 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
US6104028A (en) 1998-05-29 2000-08-15 Genetrace Systems Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
CA2335378A1 (en) 1998-07-21 2000-02-03 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of body weight disorders, including obesity
US6274339B1 (en) 1999-02-05 2001-08-14 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of body weight disorders, including obesity
US20040199544A1 (en) * 2000-11-02 2004-10-07 Affymetrix, Inc. Method and apparatus for providing an expression data mining database
KR100326937B1 (ko) 1998-09-23 2002-03-13 정연보 접착성 쉬트로 사람의 표피 dna 샘플을 획득하는 방법
US20020061556A1 (en) * 2000-04-27 2002-05-23 Walke D. Wade Novel membrane proteins and polynucleotides encoding the same
US20020164784A1 (en) * 2000-10-27 2002-11-07 Walke D. Wade Novel human 7TM proteins and polynucleotides encoding the same
US20020031802A1 (en) * 2000-05-12 2002-03-14 Yi Hu Novel seven transmembrane proteins and polynucleotides encoding the same
US6579715B1 (en) 1999-01-19 2003-06-17 Lexicon Genetics Incorporated Mammalian cortexin-like proteins and polynucleotides encoding the same
JP2002536009A (ja) * 1999-02-09 2002-10-29 レキシコン・ジェネティクス・インコーポレーテッド ヒト脱共役タンパク質およびそれをコードするポリヌクレオチド
AU5008900A (en) * 1999-05-12 2000-11-21 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6359195B1 (en) 1999-07-01 2002-03-19 W-L Research, Inc. Alfalfa line called WL-W316 and method for producing same
GB9917309D0 (en) * 1999-07-23 1999-09-22 Sec Dep Of The Home Department Improvements in and relating to forensic investigations
AU6701200A (en) * 1999-08-11 2001-03-13 Universiteit Gent Isolation of cells from forensic samples for dna-typing
US6716614B1 (en) * 1999-09-02 2004-04-06 Lexicon Genetics Incorporated Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
WO2001018206A1 (en) * 1999-09-08 2001-03-15 Lexicon Genetics Incorporated Human g-protein coupled 7 transmembrane receptor and polynucleotides encoding the same
US6541252B1 (en) 2000-05-19 2003-04-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
CA2387479A1 (en) 1999-10-11 2001-04-19 Lexicon Genetics Incorporated Human ldl receptor family proteins and polynucleotides encoding the same
US20030190644A1 (en) 1999-10-13 2003-10-09 Andreas Braun Methods for generating databases and databases for identifying polymorphic genetic markers
WO2001027275A1 (en) * 1999-10-13 2001-04-19 Lexicon Genetics Incorporated Novel human membrane proteins
AU784052B2 (en) * 1999-10-18 2006-01-19 Lexicon Genetics Incorporated Novel human proteins and polynucleotides encoding the same
US7076437B1 (en) 1999-10-29 2006-07-11 Victor Levy Process for consumer-directed diagnostic and health care information
JP2003527838A (ja) * 1999-12-07 2003-09-24 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト膜タンパクおよびそれをコードするポリヌクレオチド
AU2001229318A1 (en) * 2000-01-12 2001-07-24 Lexicon Genetics Incorporated Human olfactory receptor and polynucleotides encoding the same
ATE438660T1 (de) * 2000-02-04 2009-08-15 Lexicon Pharmaceuticals Inc Neue menschliche g-protein gekoppelten rezeptoren und dafür kodierende polynucleotide
US6761877B2 (en) * 2000-02-18 2004-07-13 Biocrystal, Ltd. Functionalized encapsulated fluorescent nanocrystals
AU2001287278A1 (en) * 2000-03-24 2001-10-08 Dzgenes, Llc Diagnostic polymorphisms of tgf-beta 1 promoter
US20040234967A1 (en) * 2000-03-24 2004-11-25 Moskowitz David W. Diagnostic polymorphisms of tgf-beta-rii promoter
US6790667B1 (en) 2000-05-30 2004-09-14 Lexicon Genetics Incorporated Human mitochondrial proteins and polynucleotides encoding the same
AU2001266844A1 (en) * 2000-06-09 2001-12-17 Lexicon Genetics Incorporated Novel human seven transmembrane proteins and polynucleotides encoding the same
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
EP1311839B1 (de) 2000-06-21 2006-03-01 Bioarray Solutions Ltd Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
EP1311676A2 (de) * 2000-08-22 2003-05-21 Lexicon Genetics Incorporated Menschliche 7tm-proteine und dafür kodierende polynukleotide
EP1191036A3 (de) * 2000-08-25 2002-07-03 Pfizer Products Inc. Methoden und Verbindungen zur Diagnose und Behandlung von Krankheiten, an denen Angiogenese beteiligt ist
EP1197550A3 (de) * 2000-08-25 2002-11-20 Pfizer Products Inc. Methoden und Zusammensetzungen zur Diagnose unde Behandlung von Krankheiten an denen Angiogenese beteiligt ist
WO2002036633A2 (en) * 2000-10-30 2002-05-10 Lexicon Genetics Incorporated Human 7tm proteins and polynucleotides encoding the same
US6929911B2 (en) * 2000-11-01 2005-08-16 The Board Of Trustees Of The Leland Stanford Junior University Method for determining genetic affiliation, substructure and gene flow within human populations
KR100415726B1 (ko) * 2000-12-08 2004-01-24 (주)진 뱅크 Dna 채취용 스티커 및 이를 이용한 dna 채취방법
JP3929250B2 (ja) * 2001-03-08 2007-06-13 株式会社ルネサステクノロジ 半導体装置
US6780588B2 (en) 2001-05-07 2004-08-24 Applera Corporation Methods for the reduction of stutter in microsatellite amplification
US6841349B2 (en) * 2001-05-07 2005-01-11 Applera Corporation Applied Biosystems Group Methods for the reduction of stutter in microsatellite amplification
US6653082B2 (en) 2001-05-17 2003-11-25 Baylor College Of Medicine Substrate-bound cleavage assay for nucleic acid analysis
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
JP4377689B2 (ja) 2001-10-15 2009-12-02 バイオアレイ ソリューションズ リミテッド 同時尋問及び酵素仲介検出による多型遺伝子座の複合分析
US6783940B2 (en) 2001-10-31 2004-08-31 Applera Corporation Method of reducing non-specific amplification in PCR
AU2002347981A1 (en) * 2001-11-07 2003-05-19 Applera Corporation Universal nucleotides for nucleic acid analysis
JP2003157004A (ja) * 2001-11-21 2003-05-30 Id Technica:Kk 識別手段を付加する添加物及びその添加物を含有する識別情報保持物
WO2003049673A2 (en) 2001-12-05 2003-06-19 Baylor College Of Medicine Methods and compositions for control of bone formation via modulation of sympathetic tone
WO2003094841A2 (en) * 2002-05-06 2003-11-20 Functional Genetics, Inc. Mammalian genes involed in rapamycin resistance and tumorgenesis: annexin xiii genes
US20040018497A1 (en) * 2002-07-26 2004-01-29 Warden Craig H Human obesity LIPIN3 polynucleotide and polypeptide sequences and methods of use thereof
US20060099676A1 (en) * 2002-08-15 2006-05-11 Limin Li Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes
WO2004020581A2 (en) * 2002-08-15 2004-03-11 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr7 genes
US7157228B2 (en) * 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7820378B2 (en) 2002-11-27 2010-10-26 Sequenom, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
EP1579013A4 (de) * 2002-12-13 2007-02-28 Gene Codes Forensics Inc Verfahren zum erstellen von proilen und zur identifizierung von personen unter verwendung von probendaten
WO2004063389A2 (en) * 2003-01-10 2004-07-29 Primera Biosystems, Inc. Methods of detecting differences in genomic sequence representation
US20040157220A1 (en) * 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
WO2004087882A2 (en) * 2003-03-26 2004-10-14 Washington University Neuregulin protein regulation of synaptic proteins
US20040219537A1 (en) * 2003-05-02 2004-11-04 Fenrich Richard K. Epidermal collection method, kit, and device
WO2005024068A2 (en) 2003-09-05 2005-03-17 Sequenom, Inc. Allele-specific sequence variation analysis
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
AU2004276761B2 (en) 2003-09-22 2009-12-24 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
JP2007505634A (ja) * 2003-09-22 2007-03-15 ロゼッタ インファーマティクス エルエルシー Rna干渉を用いる合成致死スクリーニング
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
PT1694859E (pt) 2003-10-29 2015-04-13 Bioarray Solutions Ltd Análise de ácidos nucleicos multiplexada através de fragmentação de adn de cadeia dupla
US20050112591A1 (en) * 2003-11-25 2005-05-26 Applera Corporation Novel method for isolating single stranded product
US20050136417A1 (en) * 2003-12-19 2005-06-23 Affymetrix, Inc. Amplification of nucleic acids
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
CN101233240A (zh) 2004-03-26 2008-07-30 斯昆诺有限公司 与质量分析结合的甲基化特异性扩增产物的碱基特异性切割
US20050239889A1 (en) * 2004-04-26 2005-10-27 Jean Gosselin In vivo release of endogenous anti-microbial mediators by leukotriene B4 (LTB4) administration
AU2005247332A1 (en) * 2004-04-30 2005-12-08 Corthera, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US9023614B2 (en) * 2004-07-09 2015-05-05 Tofy Mussivand Method for collecting cells for macromolecular analysis
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
JP2008513022A (ja) 2004-09-15 2008-05-01 マイクロチップ バイオテクノロジーズ, インコーポレイテッド マイクロ流体デバイス
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
KR20080096567A (ko) 2006-02-03 2008-10-30 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 장치
US20080004410A1 (en) * 2006-06-30 2008-01-03 Yu-Chin Lai Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
US8163480B2 (en) * 2006-10-05 2012-04-24 Quest Diagnostics Investments Incorporated Nucleic acid size detection method
US20080206758A1 (en) * 2006-10-17 2008-08-28 Lcm Technologies, Inc. Polynucleic acid-attached particles and their use in genomic analysis
EP2109666A4 (de) 2007-02-05 2011-09-14 Integenx Inc Mikrofluidische und nanofluidische vorrichtungen, systeme und anwendungen
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
EP2245191A1 (de) 2008-01-17 2010-11-03 Sequenom, Inc. Einzelmolekül-nukleinsäuresequenzanalyseverfahren und -zusammensetzungen
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
US20100114956A1 (en) * 2008-10-14 2010-05-06 Casework Genetics System and method for inferring str allelic genotype from snps
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
GB2467704B (en) 2008-11-07 2011-08-24 Mlc Dx Inc A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
PL2387627T3 (pl) 2009-01-15 2016-10-31 Profilowanie odporności adaptacyjnej i wytwarzanie przeciwciał monoklonalnych
WO2010112033A2 (en) 2009-03-31 2010-10-07 Østjysk Innovation A/S Method for estimating the risk of having or developing multiple sclerosis using sequence polymorphisms in a specific region of chromosome x
EP2438154A1 (de) 2009-06-02 2012-04-11 Integenx Inc. Fluidische vorrichtung mit membranventilen
CN102803147B (zh) 2009-06-05 2015-11-25 尹特根埃克斯有限公司 通用样品准备系统以及在一体化分析系统中的用途
RU2539032C2 (ru) 2009-06-25 2015-01-10 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения искусственного иммунитета
US20110070590A1 (en) 2009-09-22 2011-03-24 Jan Rohozinski Primers and Methods for Determining RhD Zygosity
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
EP2606154B1 (de) 2010-08-20 2019-09-25 Integenx Inc. Integriertes analysesystem
WO2012024657A1 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Microfluidic devices with mechanically-sealed diaphragm valves
WO2012159089A1 (en) 2011-05-19 2012-11-22 Sequenom, Inc. Products and processes for multiplex nucleic acid identification
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
HK1201565A1 (en) 2011-10-21 2015-09-04 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
CA2858070C (en) 2011-12-09 2018-07-10 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
WO2013134162A2 (en) 2012-03-05 2013-09-12 Sequenta, Inc. Determining paired immune receptor chains from frequency matched subunits
KR101621643B1 (ko) 2012-05-08 2016-05-16 어댑티브 바이오테크놀로지스 코포레이션 다중 pcr 반응에서 증폭 바이어스를 측정 및 교정하기 위한 조성물 및 방법
CA2886647A1 (en) 2012-10-01 2014-04-10 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
WO2016065073A1 (en) 2014-10-22 2016-04-28 Integenx Inc. Systems and methods for sample preparation, processing and analysis
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
EP3286327B1 (de) 2015-04-24 2021-11-10 Agena Bioscience, Inc. Gemultiplexte verfahren zur identifizierung und quantifizierung von minder vorhandenen allelen und polymorphismen
AU2016250849A1 (en) 2015-04-24 2017-11-02 Agena Bioscience, Inc. Multiplex methods for detection and quantification of minor variants
US10822647B2 (en) 2016-07-12 2020-11-03 Biodynamics S.R.L. Methods for using long ssDNA polynucleotides as primers (superprimers) in PCR assays

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS1355B6 (is) * 1984-11-12 1989-04-19 Lister Institute Of Preventive Medicine Fjölkjarna kannar
US4987066A (en) * 1986-11-07 1991-01-22 Max Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Process for the detection of restriction fragment length polymorphisms in eukaryotic genomes
GB8716367D0 (en) * 1987-07-10 1987-08-19 Reeders S T Genetic identification
EP0337625A3 (de) * 1988-04-13 1991-07-24 Imperial Chemical Industries Plc Proben
WO1989010414A1 (en) * 1988-04-28 1989-11-02 Robert Bruce Wallace AMPLIFIED SEQUENCE POLYMORPHISMS (ASPs)
DE3834636A1 (de) * 1988-10-11 1990-04-19 Max Planck Gesellschaft Verfahren zur analyse von laengenpolymorphismen in dna-bereichen
GB2228086A (en) * 1988-11-25 1990-08-15 Ici Plc Characterisation of genomic DNA
AU5358990A (en) * 1989-03-21 1990-10-22 Collaborative Research Inc. Multiplex dna diagnostic test

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US5364759B2 (en) 1999-07-20
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