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DE69933686D1 - Zusammensetzung zur verwendung in der chemonukleolyse - Google Patents

Zusammensetzung zur verwendung in der chemonukleolyse

Info

Publication number
DE69933686D1
DE69933686D1 DE69933686T DE69933686T DE69933686D1 DE 69933686 D1 DE69933686 D1 DE 69933686D1 DE 69933686 T DE69933686 T DE 69933686T DE 69933686 T DE69933686 T DE 69933686T DE 69933686 D1 DE69933686 D1 DE 69933686D1
Authority
DE
Germany
Prior art keywords
tissues
methods
devices
chemonucleolysis
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69933686T
Other languages
English (en)
Other versions
DE69933686T2 (de
Inventor
Koichi Masuda
J-M Thonar
Howard An
T Sampath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rush University Medical Center
Original Assignee
Rush University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rush University Medical Center filed Critical Rush University Medical Center
Application granted granted Critical
Publication of DE69933686D1 publication Critical patent/DE69933686D1/de
Publication of DE69933686T2 publication Critical patent/DE69933686T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Prostheses (AREA)
DE69933686T 1998-10-06 1999-07-30 Zusammensetzung zur verwendung in der chemonukleolyse Expired - Lifetime DE69933686T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10316198P 1998-10-06 1998-10-06
US103161P 1998-10-06
PCT/US1999/017392 WO2000020559A1 (en) 1998-10-06 1999-07-30 Method for the treatment of chemonucleolysis

Publications (2)

Publication Number Publication Date
DE69933686D1 true DE69933686D1 (de) 2006-11-30
DE69933686T2 DE69933686T2 (de) 2007-08-23

Family

ID=22293705

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69933686T Expired - Lifetime DE69933686T2 (de) 1998-10-06 1999-07-30 Zusammensetzung zur verwendung in der chemonukleolyse
DE69927512T Expired - Lifetime DE69927512T2 (de) 1998-10-06 1999-07-30 Verwendung von op-1 zur herstellung einer pharmazeutischen zusammensetzung zur reparatur von nicht-gelenksknorpeldefekten eines säugers

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69927512T Expired - Lifetime DE69927512T2 (de) 1998-10-06 1999-07-30 Verwendung von op-1 zur herstellung einer pharmazeutischen zusammensetzung zur reparatur von nicht-gelenksknorpeldefekten eines säugers

Country Status (10)

Country Link
US (2) US20020106362A1 (de)
EP (3) EP2374870B1 (de)
JP (5) JP4768125B2 (de)
AT (2) ATE342961T1 (de)
AU (3) AU772479B2 (de)
CA (2) CA2346375C (de)
DE (2) DE69933686T2 (de)
ES (2) ES2478257T3 (de)
MX (1) MXPA01003538A (de)
WO (2) WO2000020021A1 (de)

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US20030153976A1 (en) 1999-10-20 2003-08-14 Cauthen Joseph C. Spinal disc annulus reconstruction method and spinal disc annulus stent
US7052516B2 (en) 1999-10-20 2006-05-30 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and deformable spinal disc annulus stent
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JPWO2003000287A1 (ja) * 2001-06-26 2004-10-07 小森 博達 ヘルニア治療剤
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GB0205022D0 (en) * 2002-03-04 2002-04-17 Univ Cambridge Tech Materials and methods for the treatment of cns damage
US6812211B2 (en) 2002-03-19 2004-11-02 Michael Andrew Slivka Method for nonsurgical treatment of the intervertebral disc and kit therefor
ATE500842T1 (de) * 2002-05-04 2011-03-15 Acorda Therapeutics Inc Zusammensetzungen und verfahren zur förderung des neuronalen wachstums
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CA2525804C (en) * 2003-05-16 2017-04-25 Acorda Therapeutics, Inc. Use of chondroitinase abc enzyme for the treatment of cns injuries
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US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US8226941B2 (en) * 2004-05-18 2012-07-24 Acorda Therapeutics, Inc. Methods of purifying chondroitinase and stable formulations thereof
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AU2011265308B2 (en) * 2004-05-25 2014-06-26 Stryker Corporation Use of Morphogenic Proteins for Treating Cartilage Defects
US20060194726A1 (en) * 2004-05-25 2006-08-31 Rueger David C Methods of treating cartilage defects
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
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JP4907908B2 (ja) * 2005-06-29 2012-04-04 ルネサスエレクトロニクス株式会社 駆動回路及び表示装置
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US20070213717A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Biological fusion in the vertebral column
US20070213822A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
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US20070258941A1 (en) * 2006-05-02 2007-11-08 Pfister Brian E Methods and compositions for remediation of disc herniation by modifying structure
US20080027554A1 (en) * 2006-07-31 2008-01-31 Talmadge Karen D Kit and methods of treatment of an intervertebral disc
CA3009034C (en) * 2006-10-10 2020-08-18 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
EP2310533A4 (de) * 2008-07-04 2012-03-14 Axial Biotech Inc Genetische marker in zusammenhang mit degenerativen bandscheibenschäden und verwendungen davon
US8163022B2 (en) 2008-10-14 2012-04-24 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US12377189B2 (en) 2008-12-13 2025-08-05 Bioventus Llc Osteoinductive bone implant including harvested demineralized bone and bone morphogenetic proteins bound thereto obtained from the same donor
US20120122791A1 (en) * 2009-05-01 2012-05-17 Jnc Corporation Substrate for cartilage cultivation using artificial collagen, and method for cartilage regeneration treatment using the substrate
CN107412864A (zh) 2009-12-13 2017-12-01 阿米特·普拉卡什·戈维 生物活性移植物和复合物
US8652153B2 (en) 2010-01-11 2014-02-18 Anulex Technologies, Inc. Intervertebral disc annulus repair system and bone anchor delivery tool
US8740982B2 (en) * 2010-10-26 2014-06-03 Kyphon Sarl Devices containing a chemonucleolysis agent and methods for treating an intervertebral disc or spinal arachnoiditis
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US9414930B2 (en) 2010-10-26 2016-08-16 Kyphon SÀRL Activatable devices containing a chemonucleolysis agent
US8404268B2 (en) 2010-10-26 2013-03-26 Kyphon Sarl Locally targeted anti-fibrotic agents and methods of use
KR20170004032A (ko) * 2010-12-13 2017-01-10 세이가가쿠 고교 가부시키가이샤 추간판 헤르니아 치료제
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Also Published As

Publication number Publication date
EP1119611A4 (de) 2004-12-01
ATE342961T1 (de) 2006-11-15
JP4768125B2 (ja) 2011-09-07
CA2346375A1 (en) 2000-04-13
JP2015126921A (ja) 2015-07-09
DE69933686T2 (de) 2007-08-23
AU772479B2 (en) 2004-04-29
JP4620868B2 (ja) 2011-01-26
AU5330199A (en) 2000-04-26
WO2000020021A1 (en) 2000-04-13
JP2002526553A (ja) 2002-08-20
JP5623764B2 (ja) 2014-11-12
AU2004202345B2 (en) 2007-12-13
JP2013075173A (ja) 2013-04-25
CA2343698A1 (en) 2000-04-13
US20040033221A1 (en) 2004-02-19
EP1119611A1 (de) 2001-08-01
US7132098B2 (en) 2006-11-07
EP2374870A2 (de) 2011-10-12
US20020106362A1 (en) 2002-08-08
DE69927512T2 (de) 2006-07-06
EP1117422A1 (de) 2001-07-25
CA2343698C (en) 2014-05-20
JP2002526167A (ja) 2002-08-20
EP1117422B1 (de) 2005-09-28
ES2389555T3 (es) 2012-10-29
AU770725B2 (en) 2004-02-26
JP2010137085A (ja) 2010-06-24
EP1119611B1 (de) 2006-10-18
ES2478257T3 (es) 2014-07-21
EP2374870A3 (de) 2012-03-14
EP2374870B1 (de) 2014-04-23
AU2004202345A1 (en) 2004-06-24
ATE305310T1 (de) 2005-10-15
CA2346375C (en) 2013-04-23
AU5241799A (en) 2000-04-26
MXPA01003538A (es) 2005-09-08
WO2000020559A1 (en) 2000-04-13
DE69927512D1 (de) 2006-02-09

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