DE69907963D1 - Heteroaromatische amide als inhibitoren von faktor xa - Google Patents
Heteroaromatische amide als inhibitoren von faktor xaInfo
- Publication number
- DE69907963D1 DE69907963D1 DE69907963T DE69907963T DE69907963D1 DE 69907963 D1 DE69907963 D1 DE 69907963D1 DE 69907963 T DE69907963 T DE 69907963T DE 69907963 T DE69907963 T DE 69907963T DE 69907963 D1 DE69907963 D1 DE 69907963D1
- Authority
- DE
- Germany
- Prior art keywords
- factor
- inhibitors
- heteroaromatic amides
- heteroaromatic
- amides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11345298P | 1998-12-23 | 1998-12-23 | |
| US113452P | 1998-12-23 | ||
| PCT/US1999/029887 WO2000039117A1 (en) | 1998-12-23 | 1999-12-15 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69907963D1 true DE69907963D1 (de) | 2003-06-18 |
| DE69907963T2 DE69907963T2 (de) | 2004-05-19 |
Family
ID=22349511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69907963T Expired - Fee Related DE69907963T2 (de) | 1998-12-23 | 1999-12-15 | Heteroaromatische amide als inhibitoren von faktor xa |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1140905B1 (de) |
| JP (1) | JP2002533453A (de) |
| AT (1) | ATE240316T1 (de) |
| AU (1) | AU2364600A (de) |
| CA (1) | CA2358095A1 (de) |
| DE (1) | DE69907963T2 (de) |
| ES (1) | ES2196917T3 (de) |
| WO (1) | WO2000039117A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0999834B1 (de) | 1997-06-26 | 2005-10-12 | Eli Lilly And Company | Antithrombosemittel |
| IL133621A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| WO1999000127A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
| ES2241151T3 (es) | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
| ATE260103T1 (de) | 1997-12-19 | 2004-03-15 | Schering Ag | Ortho-anthranilamide derivate als antikoagulantien |
| DE69931393T2 (de) | 1998-12-23 | 2007-03-29 | Eli Lilly And Co., Indianapolis | Antithrombotische amide |
| JP2002533454A (ja) | 1998-12-23 | 2002-10-08 | イーライ・リリー・アンド・カンパニー | 芳香族アミド類 |
| CA2356214A1 (en) | 1998-12-24 | 2000-07-06 | Eli Lilly And Company | Heterocyclic amides as inhibitors of factor xa |
| DE60022508T2 (de) | 1999-06-14 | 2006-06-08 | Eli Lilly And Co., Indianapolis | Inhibitoren von serin proteasen |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| DE10023492A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| KR100526487B1 (ko) * | 2000-06-21 | 2005-11-08 | 에프. 호프만-라 로슈 아게 | 벤조티아졸 유도체 |
| WO2002010154A2 (en) | 2000-07-27 | 2002-02-07 | Eli Lilly And Company | Substituted heterocyclic amides |
| AU2001282871A1 (en) | 2000-08-17 | 2002-02-25 | Eli Lilly And Company | Antithrombotic agents |
| EP1336605B1 (de) | 2000-11-22 | 2006-04-12 | Astellas Pharma Inc. | Substituierte phenolderivate und deren salze als hemmstoffe von koagulations faktor x |
| US7163938B2 (en) | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US6864255B2 (en) | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
| US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| EP1456175A1 (de) | 2001-12-07 | 2004-09-15 | Eli Lilly And Company | Substituierte heterozyklische karboxamide mit antithrombotischer aktivität |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| CA2507707C (en) | 2002-12-03 | 2011-06-21 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| MY142655A (en) * | 2003-06-12 | 2010-12-15 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| ES2327684T3 (es) | 2003-07-24 | 2009-11-02 | Euro-Celtique S.A. | Compuestos heteroaril-tetrahidropiridilo utiles para el tratamiento o la prevencion del dolor. |
| SI1942106T1 (sl) | 2003-08-01 | 2012-01-31 | Euro Celtique Sa | Terapevtska sredstva, uporabna za zdravljenje bolečine |
| PT1664016E (pt) | 2003-09-22 | 2008-12-29 | Euro Celtique Sa | Agentes terapêuticos úteis para tratamento da dor |
| PL1664041T3 (pl) | 2003-09-22 | 2008-12-31 | Euro Celtique Sa | Przydatne do leczenia bólu związki fenylowo-karboksyamidowe |
| SE0401343D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine N oxide as scaffold |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| RU2615130C2 (ru) * | 2009-10-06 | 2017-04-04 | Милленниум Фармасьютикалз, Инк | Гетероциклические соединения, используемые в качестве ингибиторов pdk1 |
| JP2019142776A (ja) * | 2016-06-24 | 2019-08-29 | 石原産業株式会社 | N−(4−ピリジル)ベンズアミド化合物又はその塩を有効成分として含有する有害生物防除剤 |
| KR20220050944A (ko) * | 2019-08-21 | 2022-04-25 | 칼비스타 파마슈티컬즈 리미티드 | 효소 저해제 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| ES2241151T3 (es) * | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
-
1999
- 1999-12-15 AU AU23646/00A patent/AU2364600A/en not_active Abandoned
- 1999-12-15 CA CA002358095A patent/CA2358095A1/en not_active Abandoned
- 1999-12-15 JP JP2000591028A patent/JP2002533453A/ja not_active Withdrawn
- 1999-12-15 AT AT99967352T patent/ATE240316T1/de not_active IP Right Cessation
- 1999-12-15 DE DE69907963T patent/DE69907963T2/de not_active Expired - Fee Related
- 1999-12-15 WO PCT/US1999/029887 patent/WO2000039117A1/en not_active Ceased
- 1999-12-15 EP EP99967352A patent/EP1140905B1/de not_active Expired - Lifetime
- 1999-12-15 ES ES99967352T patent/ES2196917T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2358095A1 (en) | 2000-07-06 |
| ES2196917T3 (es) | 2003-12-16 |
| AU2364600A (en) | 2000-07-31 |
| ATE240316T1 (de) | 2003-05-15 |
| JP2002533453A (ja) | 2002-10-08 |
| DE69907963T2 (de) | 2004-05-19 |
| WO2000039117A1 (en) | 2000-07-06 |
| EP1140905A1 (de) | 2001-10-10 |
| EP1140905B1 (de) | 2003-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8339 | Ceased/non-payment of the annual fee |