DE69902766D1 - N-aryloxyethylaminderivate zur behandlung der depression - Google Patents
N-aryloxyethylaminderivate zur behandlung der depressionInfo
- Publication number
- DE69902766D1 DE69902766D1 DE69902766T DE69902766T DE69902766D1 DE 69902766 D1 DE69902766 D1 DE 69902766D1 DE 69902766 T DE69902766 T DE 69902766T DE 69902766 T DE69902766 T DE 69902766T DE 69902766 D1 DE69902766 D1 DE 69902766D1
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen
- halogen
- lower alkyl
- alkoxy
- treating depression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5730798A | 1998-04-08 | 1998-04-08 | |
| PCT/US1999/007622 WO1999051576A1 (en) | 1998-04-08 | 1999-04-07 | N-aryloxyethylamine derivatives for the treatment of depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69902766D1 true DE69902766D1 (de) | 2002-10-10 |
| DE69902766T2 DE69902766T2 (de) | 2003-02-06 |
Family
ID=22009801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69902766T Expired - Fee Related DE69902766T2 (de) | 1998-04-08 | 1999-04-07 | N-aryloxyethylaminderivate zur behandlung der depression |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1068184B1 (de) |
| JP (1) | JP2002510676A (de) |
| CN (1) | CN1160332C (de) |
| AT (1) | ATE223379T1 (de) |
| AU (1) | AU3386299A (de) |
| CA (1) | CA2327303A1 (de) |
| DE (1) | DE69902766T2 (de) |
| DK (1) | DK1068184T3 (de) |
| ES (1) | ES2182509T3 (de) |
| PT (1) | PT1068184E (de) |
| WO (1) | WO1999051576A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02004555A (es) * | 1999-11-08 | 2004-09-10 | Wyeth Corp | Azetidinas de [(indol-??3-il)cicloalquil]-3-substituidas para el tratamiento de padecimientos del sistema nervioso central. |
| DE10006139A1 (de) * | 2000-02-11 | 2001-08-16 | Merck Patent Gmbh | Indol-3-yl-Derivate |
| CZ20032644A3 (en) | 2001-03-29 | 2004-06-16 | Bristol-Myers Squibb Company | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors |
| US7041697B2 (en) * | 2002-09-12 | 2006-05-09 | Wyeth | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan |
| DE10305739A1 (de) * | 2003-02-11 | 2004-08-19 | Merck Patent Gmbh | Benzofuranderivate |
| DE10306941A1 (de) * | 2003-02-18 | 2004-08-26 | Merck Patent Gmbh | Benzofuranoxyethylamine |
| DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| WO2009128088A2 (en) * | 2008-04-15 | 2009-10-22 | Shodhana Laboratories Limited | Preparation of 2-(2-alkoxy phenoxy) ethylamine, an intermediate of carvedilol and tamsulosin |
| CN112358450A (zh) * | 2020-11-19 | 2021-02-12 | 南京艾康生物科技有限公司 | 一种4-(苄氧基)-2-甲基-1H-苯并[d]咪唑-6-羧酸的合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3468882A (en) * | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
| US3371098A (en) * | 1966-11-29 | 1968-02-27 | Philips Corp | 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles |
| DE2827874A1 (de) * | 1978-06-24 | 1980-02-07 | Merck Patent Gmbh | Indolalkylamine und verfahren zu ihrer herstellung |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| US5124332A (en) * | 1991-01-28 | 1992-06-23 | Warner-Lambert Company | Substituted indoles as central nervous system agents |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| JPH05125024A (ja) * | 1991-11-05 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアリールオキシアルキルアミン誘導体又はその塩 |
| US5314896A (en) * | 1991-11-20 | 1994-05-24 | Warner-Lambert Company | 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents |
| JPH05255302A (ja) * | 1992-03-09 | 1993-10-05 | Yamanouchi Pharmaceut Co Ltd | 新規なクロマニルオキシアルキルアミン誘導体 |
| IT1271352B (it) * | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
| US5436264A (en) * | 1993-08-19 | 1995-07-25 | Syntex (U.S.A.) Inc. | N-aryloxyalkyl tryptamine α1 -adrenergic receptor antagonists |
| US5468767A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| JPH0940648A (ja) * | 1995-08-02 | 1997-02-10 | Yamanouchi Pharmaceut Co Ltd | 新規な８−（２−アミノアルコキシ）キノリン誘導体 |
| CA2264080A1 (en) * | 1996-08-27 | 1998-03-05 | Richard Eric Mewshaw | 4-aminoethoxy indoles as dopamin d2 agonists and as 5ht1a ligands |
| CN1234024A (zh) * | 1996-08-27 | 1999-11-03 | 美国家用产品公司 | 4－氨基乙氧基吲哚衍生物 |
-
1999
- 1999-04-07 DK DK99915318T patent/DK1068184T3/da active
- 1999-04-07 PT PT99915318T patent/PT1068184E/pt unknown
- 1999-04-07 EP EP99915318A patent/EP1068184B1/de not_active Expired - Lifetime
- 1999-04-07 AU AU33862/99A patent/AU3386299A/en not_active Abandoned
- 1999-04-07 CA CA002327303A patent/CA2327303A1/en not_active Abandoned
- 1999-04-07 ES ES99915318T patent/ES2182509T3/es not_active Expired - Lifetime
- 1999-04-07 JP JP2000542297A patent/JP2002510676A/ja active Pending
- 1999-04-07 WO PCT/US1999/007622 patent/WO1999051576A1/en not_active Ceased
- 1999-04-07 CN CNB998068934A patent/CN1160332C/zh not_active Expired - Fee Related
- 1999-04-07 AT AT99915318T patent/ATE223379T1/de not_active IP Right Cessation
- 1999-04-07 DE DE69902766T patent/DE69902766T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999051576A1 (en) | 1999-10-14 |
| CA2327303A1 (en) | 1999-10-14 |
| DK1068184T3 (da) | 2002-12-30 |
| CN1160332C (zh) | 2004-08-04 |
| PT1068184E (pt) | 2002-12-31 |
| AU3386299A (en) | 1999-10-25 |
| DE69902766T2 (de) | 2003-02-06 |
| ATE223379T1 (de) | 2002-09-15 |
| EP1068184A1 (de) | 2001-01-17 |
| ES2182509T3 (es) | 2003-03-01 |
| JP2002510676A (ja) | 2002-04-09 |
| CN1303373A (zh) | 2001-07-11 |
| EP1068184B1 (de) | 2002-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |