[go: up one dir, main page]

NO20013369L - Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon - Google Patents

Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon

Info

Publication number
NO20013369L
NO20013369L NO20013369A NO20013369A NO20013369L NO 20013369 L NO20013369 L NO 20013369L NO 20013369 A NO20013369 A NO 20013369A NO 20013369 A NO20013369 A NO 20013369A NO 20013369 L NO20013369 L NO 20013369L
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
halogen
nitrogen
arylpiperazinyl
Prior art date
Application number
NO20013369A
Other languages
English (en)
Other versions
NO20013369D0 (no
Inventor
Richard Eric Mewshaw
Ping Zhou
Dahui Zhou
Kristin Lynne Meagher
Magda Asselin
Deborah Ann Evrard
Adam Matthew Gilbert
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO20013369D0 publication Critical patent/NO20013369D0/no
Publication of NO20013369L publication Critical patent/NO20013369L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser tilveiebringes som er anvendelige for behandling av serotonin-påvirkete nevrologiske lidelser som omfatter (I) hvori: Ra, RI, RI og R3'hver uavhengig er hydrogen eller en substituent valgt fra halogen, CF3. alkyl, alkoksy, MeSOi, amino eller aminokarbonyl ( hver eventuelt substituert med en eller to grupper valgt fra alkyl og benzyl) karboksy eller alkoksykarbonyl ; eller to i nabostilling av Ra og RM sammen kan danne en 5-7-leddet karbocyklisk eller heterocyklisk ring som eventuelt er substituert med en substituent definert ovenfor; Ra er hydrogen, halogen eller alkyl; R 5 er hydrogen, alkyl, arylalkyl eller aryl; Rg er hydrogen, halogen, Cp3, CN, karbamid, alkoksy eller benzyloksy; Xi, X2 og X3 er hver karbon eller en av Xi, X2 eller X3 kan være nitrogen; Y er CH eller nitrogen; og Z er karbon eller nitrogen; eller farmasøytisk akseptable salter derav.
NO20013369A 1999-01-07 2001-07-06 Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon NO20013369L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22658399A 1999-01-07 1999-01-07
PCT/US2000/000223 WO2000040554A1 (en) 1999-01-07 2000-01-06 Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression

Publications (2)

Publication Number Publication Date
NO20013369D0 NO20013369D0 (no) 2001-07-06
NO20013369L true NO20013369L (no) 2001-09-03

Family

ID=22849500

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013369A NO20013369L (no) 1999-01-07 2001-07-06 Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon

Country Status (19)

Country Link
EP (1) EP1147083B1 (no)
JP (1) JP2002534411A (no)
KR (1) KR20010086163A (no)
CN (1) CN1166636C (no)
AR (1) AR028810A1 (no)
AT (1) ATE269303T1 (no)
AU (1) AU2490900A (no)
BR (1) BR0007424A (no)
CA (1) CA2355342A1 (no)
CZ (1) CZ20012444A3 (no)
DE (1) DE60011570T2 (no)
DK (1) DK1147083T3 (no)
ES (1) ES2219302T3 (no)
HU (1) HUP0200309A3 (no)
IL (1) IL143979A0 (no)
NO (1) NO20013369L (no)
PT (1) PT1147083E (no)
WO (1) WO2000040554A1 (no)
ZA (1) ZA200105190B (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6337326B1 (en) * 1999-11-08 2002-01-08 American Home Products Corporation N-aryl-(homopiperazinyl)-cyclohexyl amines
CA2390531A1 (en) * 1999-11-08 2001-05-17 Wyeth ¬(indol-3-yl)-cycloalkyl|-3-substituted azetidines for the treatment of central nervous system disorders
BR0206512A (pt) * 2001-01-16 2004-01-06 Astrazeneca Ab Composto, método de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de um composto, e, processo para preparar um composto.
CN1821236B (zh) * 2001-01-16 2010-06-23 阿斯特拉曾尼卡有限公司 治疗性杂环化合物
MXPA03008807A (es) 2001-03-29 2004-02-12 Bristol Myers Squibb Co Derivados de ciclopropilindol como inhibidores selectivos de recaptacion de serotonina.
EP2036547A3 (en) 2001-07-20 2009-12-23 Psychogenics Inc. Treatment for Attention-Deficit Hyperactivity Disorder
SE0103649D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinoline compounds
SE0103648D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinolone compounds
GB0227240D0 (en) * 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
KR20070027584A (ko) 2004-06-17 2007-03-09 와이어쓰 고나도트로핀 방출 호르몬 수용체 길항제
RU2007101509A (ru) 2004-06-17 2008-07-27 Уайт (Us) Способ получения антагонистов рецепторов гормона, высвобождающего гонадотропин
US7968538B2 (en) 2005-01-25 2011-06-28 Galenea Corp. Substituted arylamine compounds and methods of treatment
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
TW200808730A (en) * 2006-06-09 2008-02-16 Wyeth Corp Process for synthesizing piperazine-piperidine compounds
TW200819457A (en) 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
US20080262228A1 (en) * 2006-11-28 2008-10-23 Wyeth Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof
CL2008001002A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
DE102007028925A1 (de) * 2007-06-22 2008-12-24 Saltigo Gmbh Verfahren zur Herstellung von 2-Phenoxyacetalen und den daraus korrespondierenden 2-Phenoxycarbaldehyden
PL2245028T3 (pl) 2007-12-18 2012-07-31 Actelion Pharmaceuticals Ltd Pochodne 5-aminocyklilometyloksazolidyn-2-onu
KR100970606B1 (ko) * 2008-10-08 2010-07-20 장경분 향초 및 이를 위한 제조방법
JP5721706B2 (ja) 2009-06-17 2015-05-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルス複製の阻害剤
WO2012083117A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
KR102338461B1 (ko) 2013-11-13 2021-12-13 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제 억제제의 제조 방법
CN110156779A (zh) 2013-11-13 2019-08-23 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
CN103724276A (zh) * 2013-12-13 2014-04-16 成都丽璟科技有限公司 一种由硝基苯胺制备苯并咪唑类化合物的新方法
EP3083589B1 (en) * 2013-12-20 2019-12-18 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
CN104725363B (zh) * 2013-12-20 2019-03-01 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
US10316025B2 (en) * 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
CN109467554B (zh) * 2017-09-07 2022-05-10 上海医药工业研究院 吲哚-芳杂环哌嗪(啶)类衍生物及其在抗抑郁症中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
US5468767A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
DE19512639A1 (de) * 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitrile und -fluoride

Also Published As

Publication number Publication date
CZ20012444A3 (cs) 2002-02-13
IL143979A0 (en) 2002-04-21
ES2219302T3 (es) 2004-12-01
CN1166636C (zh) 2004-09-15
PT1147083E (pt) 2004-09-30
KR20010086163A (ko) 2001-09-08
DE60011570T2 (de) 2004-11-25
HUP0200309A2 (en) 2002-06-29
JP2002534411A (ja) 2002-10-15
EP1147083A1 (en) 2001-10-24
ZA200105190B (en) 2002-09-23
HUP0200309A3 (en) 2003-05-28
AU2490900A (en) 2000-07-24
CA2355342A1 (en) 2000-07-13
DE60011570D1 (de) 2004-07-22
DK1147083T3 (da) 2004-08-16
CN1336916A (zh) 2002-02-20
ATE269303T1 (de) 2004-07-15
EP1147083B1 (en) 2004-06-16
WO2000040554A1 (en) 2000-07-13
AR028810A1 (es) 2003-05-28
BR0007424A (pt) 2001-10-09
NO20013369D0 (no) 2001-07-06

Similar Documents

Publication Publication Date Title
NO20013369L (no) Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon
SG128491A1 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
ATE334975T1 (de) Sulfonamidderivate, ihre herstellung und verwendung
MY127066A (en) Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors.
NO20025118D0 (no) Dipeptylpeptidase IV-inhibitorer
DK1569901T3 (da) Aryl-, aryloxy- og alkoxysubstituerede 1H-indol-3-yl-glyoxylsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1)
NO20044501L (no) [1,4] diazenino [6,7,1-IJ] kinolin-derivater som antipsykotis og antifedme-midler
NZ510097A (en) Pyrroloindoles, pyridoindoles and azepinoindoles useful as 5-HT2C agonists
IL165262A (en) Kinase inhibitors and pharmaceutical compositions containing them
EP1527049B8 (en) Fused heterocyclic compounds as peptidase inhibitors
EA200001172A1 (ru) Терапевтические диарильные производные
DE60107435D1 (de) 2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission
MY157949A (en) Thioxanthine derivatives as myeloperoxidase inhibitors
DK78995A (da) Anvendelse af visse substituerede arylalkylaminer til fremstilling af et lægemiddel med neurobeskyttende virkning
DE69414112D1 (de) Pyridazinon derivate mit pharmazeutischer wirkung
DK1068184T3 (da) N-aryloxyethylaminderivater til behandling af despression
EP1144393A3 (en) Heterocyclic derivatives and their use as integrin inhibitor
EP0761666A3 (en) Antidepressant 1-arylalkyl-4-(alkoxypyridinyl)- or 4-(alkoxypyrimidinyl)piperazine derivatives
MX9709465A (es) Derivados de bencimidazol 2-sustituidos como inhibidores de la proliferacion de celulas del musculo liso.
IL179029A0 (en) New piperazine derivatives of dialkyl oxindoles
AU2002244985A1 (en) Thiazolidinedione derivatives and pharmaceutical composition comprising the same
ATE552003T1 (de) Chinoxalinderivate
ES2182775T3 (es) Derivados de ciclohexano 1,4-disustituidos para el tratamiento de la depresion.
NO981689L (no) Naftylpiperasinderivater
MX9704299A (es) Derivados de bencimidazol.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application