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DE69528197D1 - NEW 1,3-DIALKYL URINE DERIVATIVES - Google Patents

NEW 1,3-DIALKYL URINE DERIVATIVES

Info

Publication number
DE69528197D1
DE69528197D1 DE69528197T DE69528197T DE69528197D1 DE 69528197 D1 DE69528197 D1 DE 69528197D1 DE 69528197 T DE69528197 T DE 69528197T DE 69528197 T DE69528197 T DE 69528197T DE 69528197 D1 DE69528197 D1 DE 69528197D1
Authority
DE
Germany
Prior art keywords
dialkyl
new
urine derivatives
urine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528197T
Other languages
German (de)
Other versions
DE69528197T2 (en
Inventor
Yoichi Kawashima
Ken-Ichi Fujimura
Hiroshi Suhara
Noriyoshi Yamamoto
Hiromi Matsumoto
Nobuaki Miyawaki
Yuko Fujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69528197D1 publication Critical patent/DE69528197D1/en
Publication of DE69528197T2 publication Critical patent/DE69528197T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69528197T 1994-12-14 1995-12-11 NEW 1,3-DIALKYL URINE DERIVATIVES Expired - Fee Related DE69528197T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31049394 1994-12-14
PCT/JP1995/002539 WO1996018606A1 (en) 1994-12-14 1995-12-11 Novel 1,3-dialkylurea derivatives

Publications (2)

Publication Number Publication Date
DE69528197D1 true DE69528197D1 (en) 2002-10-17
DE69528197T2 DE69528197T2 (en) 2003-06-05

Family

ID=18005896

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528197T Expired - Fee Related DE69528197T2 (en) 1994-12-14 1995-12-11 NEW 1,3-DIALKYL URINE DERIVATIVES

Country Status (4)

Country Link
US (1) US5968980A (en)
EP (1) EP0798291B1 (en)
DE (1) DE69528197T2 (en)
WO (1) WO1996018606A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0933346B1 (en) 1996-07-31 2003-12-10 Shionogi & Co., Ltd. NOVEL p-TERPHENYL COMPOUNDS
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
GB9811159D0 (en) * 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
US20050119237A1 (en) * 1999-06-18 2005-06-02 Ramot University Authority For Applied Research & Industrial Development Ltd. Non-malignant disease treatment with Ras antagonists
WO2001014328A2 (en) * 1999-08-20 2001-03-01 Merck & Co., Inc. Substituted ureas as cell adhesion inhibitors
FR2820136A1 (en) * 2001-01-26 2002-08-02 Aventis Pharma Sa NOVEL UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
MY140707A (en) 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
BR0309719A (en) 2002-04-30 2005-02-09 Ucb Sa A compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, use of the compound, and synthesis intermediates.
US7045653B2 (en) 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
BRPI0409924A (en) * 2003-04-30 2006-04-25 Inst For Pharm Discovery Inc substituted amino carboxylic acids
WO2005063699A1 (en) * 2003-12-31 2005-07-14 Council Of Scientific & Industrial Research N-aryloxypropanolyl-n’-phenethyl-urea
US6962945B2 (en) 2004-03-26 2005-11-08 Council Of Scientific And Industrial Research N-aryloxypropanolyl-N′-phenethyl-urea
JP2008520693A (en) * 2004-11-18 2008-06-19 ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー Substituted amino acids as protein tyrosine phosphatase inhibitors
FR2885129B1 (en) 2005-04-29 2007-06-15 Proskelia Sas NOVEL DERIVATIVES OF UREEE SUBSTITUTED WITH THIAZOLE OR BENZOTHIAZOLE, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THE USE THEREOF
RU2297234C2 (en) * 2005-05-12 2007-04-20 Федеральное государственное учреждение "Российский научный центр восстановительной медицины и курортологии Федерального агентства по здравоохранению и социальному развитию"(ФГУ "РНЦ ВМиК Росздрава") Fukolamine preparation for preventing and treating gastroenteric and endocrine system diseases
NZ563739A (en) 2005-06-09 2009-12-24 Ucb Pharma Sa 2,6 Quinolinyl derivatives, processes for preparing them and their use as medicament
WO2007060026A1 (en) * 2005-11-25 2007-05-31 Galapagos Sas Urea derivatives useful as calcium receptor modulators
GB0613674D0 (en) * 2006-07-10 2006-08-16 Proskelia Sas Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
WO2008033931A1 (en) * 2006-09-13 2008-03-20 The Institutes For Pharmaceutical Discovery, Llc Para-xylylene carboxylic acids and isothiazolones useful as protein tyrosine phosphatases (ptps) in particular ptp-ib
ES2602902T3 (en) 2009-05-28 2017-02-22 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
CN102448928B (en) * 2009-05-28 2014-10-01 诺华股份有限公司 Substituted Aminobutyric Derivatives as Neprilysin Inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
TR201808541T4 (en) 2013-02-14 2018-07-23 Novartis Ag Bisphenyl butanoic phosphonic acid derivatives substituted as nep (neutral endopeptidase) inhibitors.
EP2956445A1 (en) 2013-02-14 2015-12-23 Novartis AG Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
CN105732480B (en) * 2016-04-13 2019-04-05 中国药科大学 2- amino -3- (6- hydroxyl naphthalene -2- base) propanoic derivatives, its preparation method and application

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028401A (en) * 1976-07-01 1977-06-07 Morton-Norwich Products, Inc. (Substituted)ureidoacetohydroxamic acids
EP0054862B1 (en) * 1980-12-18 1985-11-27 Schering Corporation Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
DE3134933A1 (en) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "UREA DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINES THEREOF AND THE USE THEREOF"
JPS6140252A (en) * 1984-08-02 1986-02-26 Kureha Chem Ind Co Ltd N-carbamoylamino acid derivative
FR2568723B1 (en) * 1984-08-03 1987-06-05 Commissariat Energie Atomique INTEGRATED CIRCUIT, IN PARTICULAR OF THE MOS TYPE, AND ITS MANUFACTURING METHOD
US4728670A (en) * 1986-06-04 1988-03-01 E. R. Squibb & Sons, Inc. Biphenyl hydroxamic acids
US5262178A (en) * 1987-01-12 1993-11-16 Genentech, Inc. Therapeutic use of enkephalinase
US5403585A (en) * 1987-01-12 1995-04-04 Genentech, Inc. Therapeutic use of enkephalinase
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5066658A (en) * 1988-11-10 1991-11-19 Ortho Pharmaceutical Corporation Substituted hydroxyureas
EP0456760A4 (en) * 1989-02-01 1992-01-08 Abbott Laboratories Lipoxygenase inhibiting compounds
US5175183A (en) * 1989-02-01 1992-12-29 Abbott Laboratories Lipoxygenase inhibiting compounds
JP2775690B2 (en) * 1989-08-22 1998-07-16 昭和シェル石油株式会社 Slip layer sheet
JPH0672985A (en) * 1992-08-28 1994-03-15 Ono Pharmaceut Co Ltd @(3754/24)thio)urea derivative
JP3118738B2 (en) * 1992-12-22 2000-12-18 小野薬品工業株式会社 (Thio) urea derivatives

Also Published As

Publication number Publication date
EP0798291A1 (en) 1997-10-01
DE69528197T2 (en) 2003-06-05
EP0798291B1 (en) 2002-09-11
WO1996018606A1 (en) 1996-06-20
US5968980A (en) 1999-10-19
EP0798291A4 (en) 1999-06-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee