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DE60335676D1 - Spezielles Protein der Pankreatischen Beta-Zellen der Langerhans-Inseln und seine Anwendungen - Google Patents

Spezielles Protein der Pankreatischen Beta-Zellen der Langerhans-Inseln und seine Anwendungen

Info

Publication number
DE60335676D1
DE60335676D1 DE60335676T DE60335676T DE60335676D1 DE 60335676 D1 DE60335676 D1 DE 60335676D1 DE 60335676 T DE60335676 T DE 60335676T DE 60335676 T DE60335676 T DE 60335676T DE 60335676 D1 DE60335676 D1 DE 60335676D1
Authority
DE
Germany
Prior art keywords
cells
sequence
protein
nucleic acid
iia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60335676T
Other languages
English (en)
Inventor
Michel Seve
Alain Favier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Joseph Fourier Grenoble 1
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Universite Joseph Fourier Grenoble 1
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA, Universite Joseph Fourier Grenoble 1, Commissariat a lEnergie Atomique et aux Energies Alternatives CEA filed Critical Commissariat a lEnergie Atomique CEA
Application granted granted Critical
Publication of DE60335676D1 publication Critical patent/DE60335676D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
DE60335676T 2002-11-18 2003-11-18 Spezielles Protein der Pankreatischen Beta-Zellen der Langerhans-Inseln und seine Anwendungen Expired - Lifetime DE60335676D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0214374A FR2847263B1 (fr) 2002-11-18 2002-11-18 Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans

Publications (1)

Publication Number Publication Date
DE60335676D1 true DE60335676D1 (de) 2011-02-17

Family

ID=32187667

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60323664T Expired - Lifetime DE60323664D1 (de) 2002-11-18 2003-11-18 Len der langerhans-inseln, und seine verwendungen
DE60335676T Expired - Lifetime DE60335676D1 (de) 2002-11-18 2003-11-18 Spezielles Protein der Pankreatischen Beta-Zellen der Langerhans-Inseln und seine Anwendungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60323664T Expired - Lifetime DE60323664D1 (de) 2002-11-18 2003-11-18 Len der langerhans-inseln, und seine verwendungen

Country Status (12)

Country Link
US (2) US7851164B2 (de)
EP (3) EP2239272B1 (de)
JP (2) JP4498144B2 (de)
CN (2) CN1738900B (de)
AT (2) ATE494376T1 (de)
AU (1) AU2003295025B2 (de)
CA (1) CA2506331C (de)
DE (2) DE60323664D1 (de)
DK (2) DK1563071T3 (de)
ES (3) ES2454592T3 (de)
FR (1) FR2847263B1 (de)
WO (1) WO2004046355A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065544A2 (en) * 2006-09-11 2008-06-05 Mcgill University Genetic predictors of risk for type 2 diabetes mellitus
CN101646781B (zh) * 2006-12-29 2016-06-22 科罗拉多大学董事会 自身免疫病的诊断和治疗靶标及其用途
WO2008096009A2 (en) * 2007-02-09 2008-08-14 Mellitech Polymorphism in the slc30a8 gene
EP2247717B1 (de) * 2008-02-14 2016-04-13 Université Libre de Bruxelles Plasmamembran-biomarker mit bevorzugter expression in beta-zellen des pankreas und eignung bei der bildgebung von oder dem abzielen auf beta-zellen
EP2334696A1 (de) * 2008-09-30 2011-06-22 Novo Nordisk A/S G6pc2-kodierte betazelloberflächenmarker
US20120070847A1 (en) 2008-11-07 2012-03-22 Jan Jensen Method For Detecting And Purifying Pancreatic Beta Cells
EP2462229B1 (de) * 2009-08-05 2016-05-11 CuRNA, Inc. Behandlung von durch insulingene bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen ein insulingen
EP2537859A1 (de) 2011-06-23 2012-12-26 Université de Mons Moleküle zur spezifischen Bindung pankreatischer Betazellen-Biomarker
ES2684976T3 (es) 2012-04-13 2018-10-05 Diabetomics, Inc. Biomarcadores maternos para diabetes gestacional
CN104098675A (zh) * 2013-04-03 2014-10-15 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
CN104098673A (zh) * 2013-04-03 2014-10-15 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
EP3123169B1 (de) 2014-03-26 2022-05-04 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Flattop (fltp) ist ein neuer biomarker für betazellenreifung
GB201520603D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
US11016085B2 (en) 2016-04-25 2021-05-25 The Johns Hopkins University ZNT8 assays for drug development and pharmaceutical compositions
CN106226526A (zh) * 2016-06-30 2016-12-14 深圳市亚辉龙生物科技股份有限公司 一种锌转运蛋白8抗体化学发光免疫检测试剂盒及其制备方法
US11892457B2 (en) 2017-07-12 2024-02-06 The Johns Hopkins University Proteoliposome-based ZnT8 self-antigen for type 1 diabetes diagnosis
US12103968B2 (en) 2018-08-16 2024-10-01 The Johns Hopkins University Antibodies to human ZnT8
CN109734793B (zh) * 2019-03-14 2022-12-02 深圳市药品检验研究院（深圳市医疗器械检测中心） 一种ZnT8重组蛋白及其制备方法和应用
JP2022544238A (ja) * 2019-08-13 2022-10-17 アムジエン・インコーポレーテツド ＳＬＣ３０Ａ８発現を阻害するためのＲＮＡｉコンストラクト及びその使用方法
US12366570B2 (en) 2019-10-01 2025-07-22 The Johns Hopkins University Cell-based ZNT8 assay
WO2023023607A1 (en) 2021-08-20 2023-02-23 The Johns Hopkins University Cell-surface antibody to a specific biomarker of pancreatic beta-cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
NL9001083A (nl) 1990-05-04 1991-12-02 Rijksuniversiteit Beta-cel antigeen.
ZA97476B (en) * 1996-01-22 1998-07-21 Res Dev Foundation Novel methods for the characterization of compounds which stimulate STF-1 expression in pancreatic islet cells.
US6753153B2 (en) * 1999-12-13 2004-06-22 The Scripps Research Institute Markers for identification and isolation of pancreatic islet α and β progenitors
US20020082207A1 (en) * 2000-06-07 2002-06-27 Hirst Shannon K. Compositions and methods for the therapy and diagnosis of pancreatic cancer
EP1360291A2 (de) * 2000-09-15 2003-11-12 Curagen Corporation Humane polynukleotide und dadurch kodierte polypeptide
US7459539B2 (en) * 2000-12-15 2008-12-02 Agensys, Inc. Antibody that binds zinc transporter protein 108P5H8

Also Published As

Publication number Publication date
EP2239272A3 (de) 2010-12-08
DE60323664D1 (de) 2008-10-30
WO2004046355A3 (fr) 2004-09-30
EP1563071A2 (de) 2005-08-17
FR2847263A1 (fr) 2004-05-21
AU2003295025A1 (en) 2004-06-15
CA2506331C (fr) 2015-02-17
ATE494376T1 (de) 2011-01-15
DK1563071T3 (da) 2009-02-02
US7851164B2 (en) 2010-12-14
CN1738900B (zh) 2011-07-06
US9568482B2 (en) 2017-02-14
WO2004046355A2 (fr) 2004-06-03
JP4498144B2 (ja) 2010-07-07
EP2239272B1 (de) 2014-01-01
JP2010150262A (ja) 2010-07-08
ES2361639T3 (es) 2011-06-20
JP5202550B2 (ja) 2013-06-05
CN102250242A (zh) 2011-11-23
EP2239272A2 (de) 2010-10-13
US20060246442A1 (en) 2006-11-02
AU2003295025B2 (en) 2008-09-18
EP1563071B1 (de) 2008-09-17
US20110027807A1 (en) 2011-02-03
DK1925667T3 (da) 2011-04-26
EP1925667A1 (de) 2008-05-28
ES2314268T3 (es) 2009-03-16
ES2454592T3 (es) 2014-04-11
EP1925667B1 (de) 2011-01-05
ATE408689T1 (de) 2008-10-15
FR2847263B1 (fr) 2006-01-13
CA2506331A1 (fr) 2004-06-03
JP2006506084A (ja) 2006-02-23
CN1738900A (zh) 2006-02-22

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