DE60325874D1 - Neuartige endothelzellen, gegen die zellen gerichtete antikörper und verwendung davon - Google Patents
Neuartige endothelzellen, gegen die zellen gerichtete antikörper und verwendung davonInfo
- Publication number
- DE60325874D1 DE60325874D1 DE60325874T DE60325874T DE60325874D1 DE 60325874 D1 DE60325874 D1 DE 60325874D1 DE 60325874 T DE60325874 T DE 60325874T DE 60325874 T DE60325874 T DE 60325874T DE 60325874 D1 DE60325874 D1 DE 60325874D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- endothelial cells
- phenotype
- angiogenic phenotype
- targeted against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000002889 endothelial cell Anatomy 0.000 title abstract 6
- 210000004027 cell Anatomy 0.000 title abstract 2
- 230000002491 angiogenic effect Effects 0.000 abstract 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 210000000709 aorta Anatomy 0.000 abstract 1
- 229960005309 estradiol Drugs 0.000 abstract 1
- 229930182833 estradiol Natural products 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000002135 phase contrast microscopy Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C12N2501/392—Sexual steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0212606A FR2845691B1 (fr) | 2002-10-10 | 2002-10-10 | Nouvelles cellules endotheliales, anticorps diriges contre ces cellules et leur utilisation, notamment pour le criblage de substances inhibant l'angiogenese |
| PCT/FR2003/002996 WO2004033674A1 (fr) | 2002-10-10 | 2003-10-10 | Nouvelles cellules endotheliales, anticorps diriges contre ces cellules et leur utilisation, notamment pour le criblage de substances inhibant l'angiogenese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60325874D1 true DE60325874D1 (de) | 2009-03-05 |
Family
ID=32039615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60325874T Expired - Lifetime DE60325874D1 (de) | 2002-10-10 | 2003-10-10 | Neuartige endothelzellen, gegen die zellen gerichtete antikörper und verwendung davon |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060263827A1 (de) |
| EP (1) | EP1549741B1 (de) |
| AT (1) | ATE420948T1 (de) |
| AU (1) | AU2003300487A1 (de) |
| DE (1) | DE60325874D1 (de) |
| ES (1) | ES2321508T3 (de) |
| FR (1) | FR2845691B1 (de) |
| WO (1) | WO2004033674A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006262682B2 (en) * | 2005-06-21 | 2012-07-05 | Shire Regenerative Medicine, Inc. | Methods and compositions for enhancing vascular access |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPM425294A0 (en) * | 1994-03-04 | 1994-03-31 | Australian National University, The | In-vitro angiogenesis assay |
| WO1997030173A1 (en) * | 1996-02-15 | 1997-08-21 | Chugai Seiyaku Kabushiki Kaisha | Monoclonal antibody that recognizes antigens present on the surface of endothelial cell of tumor vessel |
| EP1144594A1 (de) * | 1998-11-24 | 2001-10-17 | Regents Of The University Of Minnesota | Transgenische zirkulierende endothelzellen |
| FR2796073B1 (fr) * | 1999-07-07 | 2003-08-29 | Centre Nat Rech Scient | Anticorps anti-idiotypiques des facteurs de croissance des fibroblastes et leur utilisation comme medicaments |
-
2002
- 2002-10-10 FR FR0212606A patent/FR2845691B1/fr not_active Expired - Fee Related
-
2003
- 2003-10-10 ES ES03807892T patent/ES2321508T3/es not_active Expired - Lifetime
- 2003-10-10 WO PCT/FR2003/002996 patent/WO2004033674A1/fr not_active Ceased
- 2003-10-10 AU AU2003300487A patent/AU2003300487A1/en not_active Abandoned
- 2003-10-10 DE DE60325874T patent/DE60325874D1/de not_active Expired - Lifetime
- 2003-10-10 US US10/530,893 patent/US20060263827A1/en not_active Abandoned
- 2003-10-10 AT AT03807892T patent/ATE420948T1/de not_active IP Right Cessation
- 2003-10-10 EP EP03807892A patent/EP1549741B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2321508T3 (es) | 2009-06-08 |
| FR2845691B1 (fr) | 2004-12-10 |
| FR2845691A1 (fr) | 2004-04-16 |
| EP1549741A1 (de) | 2005-07-06 |
| ATE420948T1 (de) | 2009-01-15 |
| WO2004033674A1 (fr) | 2004-04-22 |
| AU2003300487A1 (en) | 2004-05-04 |
| US20060263827A1 (en) | 2006-11-23 |
| EP1549741B1 (de) | 2009-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |