[go: up one dir, main page]

DE60139705D1 - In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker - Google Patents

In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker

Info

Publication number
DE60139705D1
DE60139705D1 DE60139705T DE60139705T DE60139705D1 DE 60139705 D1 DE60139705 D1 DE 60139705D1 DE 60139705 T DE60139705 T DE 60139705T DE 60139705 T DE60139705 T DE 60139705T DE 60139705 D1 DE60139705 D1 DE 60139705D1
Authority
DE
Germany
Prior art keywords
vivo
biomolecular
concentrations
vivo detection
fluorescent markers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60139705T
Other languages
English (en)
Inventor
Robert D Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sicel Technologies Inc
Original Assignee
Sicel Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicel Technologies Inc filed Critical Sicel Technologies Inc
Application granted granted Critical
Publication of DE60139705D1 publication Critical patent/DE60139705D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60139705T 2000-11-09 2001-11-07 In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker Expired - Lifetime DE60139705D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24757400P 2000-11-09 2000-11-09
PCT/US2001/047373 WO2002039112A2 (en) 2000-11-09 2001-11-07 In vivo detection of biomolecule concentrations using fluorescent tags

Publications (1)

Publication Number Publication Date
DE60139705D1 true DE60139705D1 (de) 2009-10-08

Family

ID=22935419

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60139705T Expired - Lifetime DE60139705D1 (de) 2000-11-09 2001-11-07 In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker

Country Status (8)

Country Link
US (3) US7378056B2 (de)
EP (1) EP1332364B1 (de)
JP (1) JP3981328B2 (de)
AT (1) ATE441110T1 (de)
AU (2) AU3659002A (de)
CA (1) CA2429127A1 (de)
DE (1) DE60139705D1 (de)
WO (1) WO2002039112A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4607859B2 (ja) * 2003-02-19 2011-01-05 サイセル・テクノロジーズ，インコーポレイテッド 蛍光分析物と連動して作動するインビボ蛍光センサ、システム及び関連方法
JP4733918B2 (ja) 2003-10-01 2011-07-27 オリンパス株式会社 カプセル投薬システム
EP1839562B1 (de) * 2004-03-25 2009-05-06 Olympus Corporation Gerätesystem zur In-vivo-Informationserfassung
US20060027756A1 (en) * 2004-08-09 2006-02-09 Ian Thomson Dosimeter having an array of sensors for measuring ionizing radiation, and dosimetry system and method using such a dosimeter
US7415482B2 (en) * 2005-02-11 2008-08-19 Rivet Software, Inc. XBRL enabler for business documents
US20060270919A1 (en) * 2005-05-11 2006-11-30 Mytek, Llc Biomarkers sensing
GB0712109D0 (en) * 2007-06-22 2007-08-01 Edinburgh Instr Fluorescence lifetime and fluorescence assays
ES2369472T3 (es) * 2008-02-26 2011-12-01 Biostems Ltd. Dispositivo de investigación micro-invasiva en vivo que comprende una guía metálica.
ES2715633T3 (es) 2008-05-20 2019-06-05 Univ Health Network Dispositivo y método para formación de imágenes y supervisión por fluorescencia
US20100249550A1 (en) * 2009-03-25 2010-09-30 Neilcor Puritan Bennett LLC Method And Apparatus For Optical Filtering Of A Broadband Emitter In A Medical Sensor
US11861696B1 (en) 2013-02-14 2024-01-02 Capital Confirmation, Inc. Systems and methods for obtaining accountant prepared financial statement confirmation
PL3171765T3 (pl) 2014-07-24 2022-01-03 University Health Network Zbieranie i analiza danych do celów diagnostycznych
US11013436B2 (en) 2017-09-06 2021-05-25 Medtronic, Inc. Marker monitoring via a medical device
WO2019060298A1 (en) 2017-09-19 2019-03-28 Neuroenhancement Lab, LLC METHOD AND APPARATUS FOR NEURO-ACTIVATION
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US12280219B2 (en) 2017-12-31 2025-04-22 NeuroLight, Inc. Method and apparatus for neuroenhancement to enhance emotional response
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
CN113382683A (zh) 2018-09-14 2021-09-10 纽罗因恒思蒙特实验有限责任公司 改善睡眠的系统和方法
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep

Family Cites Families (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS36022343B1 (de) * 1959-12-24 1961-11-18 Univ Tokyo
US3638640A (en) * 1967-11-01 1972-02-01 Robert F Shaw Oximeter and method for in vivo determination of oxygen saturation in blood using three or more different wavelengths
US3972320A (en) 1974-08-12 1976-08-03 Gabor Ujhelyi Kalman Patient monitoring system
US4163380A (en) 1977-10-11 1979-08-07 Lockheed Corporation Forming of preconsolidated metal matrix composites
USRE32361E (en) * 1979-05-14 1987-02-24 Medtronic, Inc. Implantable telemetry transmission system for analog and digital data
US4326535A (en) * 1980-05-13 1982-04-27 Akron City Hospital Circuit and method for the radiotelemetry of esophageal pH in an ECG radiotelemetry system
US4494545A (en) * 1980-05-27 1985-01-22 Cordis Corporation Implant telemetry system
US4361153A (en) 1980-05-27 1982-11-30 Cordis Corporation Implant telemetry system
US4556063A (en) 1980-10-07 1985-12-03 Medtronic, Inc. Telemetry system for a medical device
US4523279A (en) * 1980-11-24 1985-06-11 Oximetrix, Inc. Apparatus for determining oxygen saturation levels in blood
US4397313A (en) 1981-08-03 1983-08-09 Clini-Therm Corporation Multiple microwave applicator system and method for microwave hyperthermia treatment
US4397314A (en) 1981-08-03 1983-08-09 Clini-Therm Corporation Method and apparatus for controlling and optimizing the heating pattern for a hyperthermia system
US4416283A (en) 1981-08-31 1983-11-22 Cordis Corporation Programming and telemetry system for biomedical implantable device
CA1188431A (en) 1981-10-02 1985-06-04 Canadian Astronautics Limited Direct reading dosimeter
US4431004A (en) * 1981-10-27 1984-02-14 Bessman Samuel P Implantable glucose sensor
US5186172A (en) * 1982-03-22 1993-02-16 Mountpelier Investments, S.A. Remote sensing tonometric catheter apparatus
DE3219558C2 (de) 1982-05-25 1986-10-23 Norbert H.L. Dr.-Ing. 5173 Aldenhoven Koster Vorrichtung zur Bestimmung der lokalen Temperatur in lebendem Gewebe
US4571292A (en) * 1982-08-12 1986-02-18 Case Western Reserve University Apparatus for electrochemical measurements
CH658729A5 (de) 1982-09-17 1986-11-28 Lehner Max & Co Ag Vorrichtung zur registrierung der strahlenbelastung von mit strahlung umgehenden personen.
US4571589A (en) * 1982-11-22 1986-02-18 Cordis Corporation Biomedical implant with high speed, low power two-way telemetry
CH673768A5 (de) * 1983-01-21 1990-04-12 Ramm Associates
US4961422A (en) 1983-01-21 1990-10-09 Marchosky J Alexander Method and apparatus for volumetric interstitial conductive hyperthermia
US4575676A (en) * 1983-04-04 1986-03-11 Advanced Research And Applications Corporation Method and apparatus for radiation testing of electron devices
GB2140563B (en) 1983-04-27 1987-03-04 Critikon Inc Method and apparatus for zero calibration of oxygen-sensing polarographic devices
US4543953A (en) 1983-07-18 1985-10-01 Cordis Corporation Analog telemetry system for biomedical implant
US4655880A (en) * 1983-08-01 1987-04-07 Case Western Reserve University Apparatus and method for sensing species, substances and substrates using oxidase
US4519401A (en) * 1983-09-20 1985-05-28 Case Western Reserve University Pressure telemetry implant
FI68734C (fi) 1983-11-11 1985-10-10 Seppo Saeynaejaekangas Foerfarande och anordning foer telemetrisk maetning av hjaertslag och ekg-signal med anvaendande av ett magnetiskt naerfaelt
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4638436A (en) * 1984-09-24 1987-01-20 Labthermics Technologies, Inc. Temperature control and analysis system for hyperthermia treatment
US4681111A (en) * 1985-04-05 1987-07-21 Siemens-Pacesetter, Inc. Analog and digital telemetry system for an implantable device
US4651741A (en) * 1985-05-30 1987-03-24 Baxter Travenol Laboratories, Inc. Method and apparatus for determining oxygen saturation in vivo
US5012411A (en) * 1985-07-23 1991-04-30 Charles J. Policastro Apparatus for monitoring, storing and transmitting detected physiological information
CA1204885A (en) * 1985-09-18 1986-05-20 Thomson & Nielson Electronics Ltd. Dosimeter
US4703756A (en) 1986-05-06 1987-11-03 The Regents Of The University Of California Complete glucose monitoring system with an implantable, telemetered sensor module
FI872885A7 (fi) * 1986-07-01 1988-01-02 Terumo Corp Anordning foer maetning av biologisk information.
US4976266A (en) 1986-08-29 1990-12-11 United States Department Of Energy Methods of in vivo radiation measurement
DE3700119A1 (de) * 1987-01-03 1988-07-14 Inst Diabetestechnologie Gemei Implantierbarer elektrochemischer sensor
GB8701432D0 (en) * 1987-01-22 1987-02-25 Unilever Plc Assays
US4769547A (en) 1987-01-27 1988-09-06 Medrad, Inc. Personal dosimeter having a volume of gas atop an integrated circuit
US4804847A (en) * 1987-01-27 1989-02-14 Medrad, Inc. Radiation detector with an ionizable gas atop an integrated circuit
US4970391A (en) 1987-01-27 1990-11-13 Medrad, Inc. Radiation detector with an ionizable gas atop an integrated circuit
US4935345A (en) * 1987-04-07 1990-06-19 Arizona Board Of Regents Implantable microelectronic biochemical sensor incorporating thin film thermopile
US4750495A (en) * 1987-06-05 1988-06-14 Medtronic, Inc. Oxygen sensing pacemaker
US4796641A (en) * 1987-07-06 1989-01-10 Data Sciences, Inc. Device and method for chronic in-vivo measurement of internal body pressure
US4847617A (en) * 1987-08-14 1989-07-11 Siemens-Pacesetter, Inc. High speed digital telemetry system for implantable devices
GB8726933D0 (en) 1987-11-18 1987-12-23 Cadell T E Telemetry system
US4989601A (en) * 1988-05-02 1991-02-05 Medical Engineering & Development Institute, Inc. Method, apparatus, and substance for treating tissue having neoplastic cells
US4846191A (en) * 1988-05-27 1989-07-11 Data Sciences, Inc. Device for chronic measurement of internal body pressure
US4900422A (en) * 1988-07-05 1990-02-13 Bryan Avron I System for monitoring and reporting the operability and calibration status of a dissolved oxygen sensor
AU634979B2 (en) 1988-08-26 1993-03-11 Instrumentarium Corporation Remote sensing tonometric catheter apparatus and method
US5098547A (en) * 1988-10-11 1992-03-24 Bryan Avron I Dissolved oxygen sensor calibration, monitoring and reporting system
EP0372122A1 (de) * 1988-12-08 1990-06-13 Koninklijke Philips Electronics N.V. Zahnärztliche Röntgenbildaufnahmevorrichtung
US5354314A (en) 1988-12-23 1994-10-11 Medical Instrumentation And Diagnostics Corporation Three-dimensional beam localization apparatus and microscope for stereotactic diagnoses or surgery mounted on robotic type arm
US5193538A (en) * 1989-02-14 1993-03-16 Siemens Aktiengesellschaft In vivo implantable medical device with battery monitoring circuitry
US5264843A (en) 1989-04-05 1993-11-23 Siemens Pacesetter, Inc. High speed reflected impedance telemetry system for implantable medical device
US5166073A (en) 1989-05-05 1992-11-24 The Dow Chemical Company Miniaturized sensor for ionizing radiation
US4944299A (en) * 1989-08-08 1990-07-31 Siemens-Pacesetter, Inc. High speed digital telemetry system for implantable device
DE3932428A1 (de) 1989-09-28 1991-04-11 Argumens Gmbh Vorrichtung zur drahtlosen messung einer lokalen physikalischen groesse
US5354319A (en) 1990-01-22 1994-10-11 Medtronic, Inc. Telemetry system for an implantable medical device
US5127404A (en) * 1990-01-22 1992-07-07 Medtronic, Inc. Telemetry format for implanted medical device
US5109850A (en) * 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus
US5008546A (en) * 1990-06-18 1991-04-16 The Regents Of The University Of California Intraoperative beta probe and method of using the same
US5117113A (en) 1990-07-06 1992-05-26 Thompson And Nielson Electronics Ltd. Direct reading dosimeter
US5137022A (en) 1990-07-13 1992-08-11 Cook Pacemaker Corporation Synchronous telemetry system and method for an implantable medical device
US5252962A (en) * 1990-08-03 1993-10-12 Bio Medic Data Systems System monitoring programmable implantable transponder
US5163380A (en) 1990-08-09 1992-11-17 United States Of America Method and apparatus for assessing metabolic behavioral and physiological status of animals
US5438989A (en) * 1990-08-10 1995-08-08 Hochman; Darryl Solid tumor, cortical function, and nerve tissue imaging methods and device
KR930002824B1 (ko) * 1990-08-21 1993-04-10 손병기 감이온 전계효과 트랜지스터를 이용한 바이오 센서용 측정회로
US5117824A (en) * 1990-11-14 1992-06-02 Medtronic, Inc. Apparatus for monitoring electrical physiologic signals
JP2646848B2 (ja) * 1990-11-30 1997-08-27 日本電気株式会社 グルコースセンサの測定方法
FR2671405B1 (fr) * 1991-01-04 1994-07-08 Inst Nat Sante Rech Med Dispositif de mesure du ph d'une cible, procede d'utilisation dudit dispositif et ses applications.
US5205294A (en) * 1991-02-19 1993-04-27 Pacific Communications, Inc. Apparatus and methodology for digital telemetry of biomedical signals
US5377676A (en) * 1991-04-03 1995-01-03 Cedars-Sinai Medical Center Method for determining the biodistribution of substances using fluorescence spectroscopy
US5318023A (en) * 1991-04-03 1994-06-07 Cedars-Sinai Medical Center Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle
US5159262A (en) 1991-07-09 1992-10-27 Cascade Microtech, Inc. Method for measuring the electrical and optical performance of on-wafer microwave devices
US5264103A (en) 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
DE4139122C1 (de) * 1991-11-28 1993-04-08 Fenzlein, Paul-Gerhard, 8500 Nuernberg, De
GB9200569D0 (en) 1992-01-11 1992-03-11 Atomic Energy Authority Uk Semiconductor dosimeter
NL9200207A (nl) 1992-02-05 1993-09-01 Nedap Nv Implanteerbare biomedische sensorinrichting, in het bijzonder voor meting van de glucoseconcentratie.
US6217869B1 (en) * 1992-06-09 2001-04-17 Neorx Corporation Pretargeting methods and compounds
US5444254A (en) 1992-06-12 1995-08-22 Thomson And Nielsen Electronics Ltd. Flexible radiation probe
US5355880A (en) * 1992-07-06 1994-10-18 Sandia Corporation Reliable noninvasive measurement of blood gases
US5676651A (en) * 1992-08-06 1997-10-14 Electric Boat Corporation Surgically implantable pump arrangement and method for pumping body fluids
US5330634A (en) * 1992-08-28 1994-07-19 Via Medical Corporation Calibration solutions useful for analyses of biological fluids and methods employing same
AU683434B2 (en) 1992-11-09 1997-11-13 Ilife Systems, Inc. Apparatus and method for remote monitoring of physiological parameters
US5620479A (en) * 1992-11-13 1997-04-15 The Regents Of The University Of California Method and apparatus for thermal therapy of tumors
US5383909A (en) * 1993-01-29 1995-01-24 Medtronic, Inc. Diagnostic telemetry system for an apparatus for detection and treatment of tachycardia and fibrillation
US5383912A (en) * 1993-05-05 1995-01-24 Intermedics, Inc. Apparatus for high speed data communication between an external medical device and an implantable medical device
US5431171A (en) * 1993-06-25 1995-07-11 The Regents Of The University Of California Monitoring fetal characteristics by radiotelemetric transmission
US5324315A (en) * 1993-08-12 1994-06-28 Medtronic, Inc. Closed-loop downlink telemetry and method for implantable medical device
US5791344A (en) 1993-11-19 1998-08-11 Alfred E. Mann Foundation For Scientific Research Patient monitoring system
US5497772A (en) * 1993-11-19 1996-03-12 Alfred E. Mann Foundation For Scientific Research Glucose monitoring system
DE4341903A1 (de) 1993-12-09 1995-06-14 Josef Prof Dr Rer Nat Binder Implantierbares telemetrisches Endosystem
DE4444577B4 (de) 1993-12-15 2005-02-10 Bridgestone Corp. Verfahren zur Herstellung eines Lichtwellenleiters
US5476488A (en) 1993-12-15 1995-12-19 Pacesetter, Inc. Telemetry system power control for implantable medical devices
IES66403B2 (en) 1993-12-31 1995-12-27 Rodney Arthur Stafford Electronic animal identification device
SE9400622D0 (sv) 1994-02-23 1994-02-23 Siemens Elema Ab Medicinskt implantat
NL9400534A (nl) * 1994-04-05 1995-11-01 Rijksuniversiteit Systeem voor het bepalen van een samenstelling van radionucliden.
US5507786A (en) * 1994-04-14 1996-04-16 Pacesetter, Inc. System and method for measuring and storing parametric data pertaining to operating characteristics of an implantable medical device
US5549654A (en) 1994-04-15 1996-08-27 Medtronic, Inc. Interactive interpretation of event markers in body-implantable medical device
SE9401402D0 (sv) * 1994-04-25 1994-04-25 Siemens Elema Ab Medicinskt implantat
US5470345A (en) 1994-06-16 1995-11-28 Medtronic, Inc. Implantable medical device with multi-layered ceramic enclosure
US6093381A (en) * 1994-07-13 2000-07-25 Neoprobe Corporation Modulation of the sensitivity of tumor cells to chemotherapeutics
US5466246A (en) 1994-07-29 1995-11-14 Pacesetter, Inc. Telemetry receiver for implantable device, incorporating digital signal processing
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5571148A (en) 1994-08-10 1996-11-05 Loeb; Gerald E. Implantable multichannel stimulator
US5572996A (en) 1994-09-19 1996-11-12 Pdt Systems, Inc. In vivo pharmacokinetics of photosensitive drugs and method
US5626630A (en) * 1994-10-13 1997-05-06 Ael Industries, Inc. Medical telemetry system using an implanted passive transponder
US5591217A (en) * 1995-01-04 1997-01-07 Plexus, Inc. Implantable stimulator with replenishable, high value capacitive power source and method therefor
US5606163A (en) * 1995-01-11 1997-02-25 The United States Of America As Represented By The Secretary Of The Navy All-optical, rapid readout, fiber-coupled thermoluminescent dosimeter system
US5620472A (en) * 1995-01-12 1997-04-15 Pacesetter, Inc. Apparatus and method for dynamically interpreting and displaying a real-time telemetry link
US5562713A (en) 1995-01-18 1996-10-08 Pacesetter, Inc. Bidirectional telemetry apparatus and method for implantable device
US5593430A (en) * 1995-01-27 1997-01-14 Pacesetter, Inc. Bus system for interconnecting an implantable medical device with a plurality of sensors
EP0724859B1 (de) * 1995-02-04 1997-11-12 Baumann & Haldi S.A. Einzelne Anordnung zur Messung, Verarbeitung und Übertragung von im wesentlichen physiologischen Parametern
US5596199A (en) * 1995-02-06 1997-01-21 Clemson University Passive solid state microdosimeter with electronic readout
US5517313A (en) * 1995-02-21 1996-05-14 Colvin, Jr.; Arthur E. Fluorescent optical sensor
US5556421A (en) 1995-02-22 1996-09-17 Intermedics, Inc. Implantable medical device with enclosed physiological parameter sensors or telemetry link
US5564434A (en) 1995-02-27 1996-10-15 Medtronic, Inc. Implantable capacitive absolute pressure and temperature sensor
US5535752A (en) * 1995-02-27 1996-07-16 Medtronic, Inc. Implantable capacitive absolute pressure and temperature monitor system
US5633161A (en) * 1995-03-29 1997-05-27 Millennium Pharmaceuticals, Inc. Murine gene fomy030 coding for tumor progression inhibitor
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5840148A (en) 1995-06-30 1998-11-24 Bio Medic Data Systems, Inc. Method of assembly of implantable transponder
US5759199A (en) * 1995-08-02 1998-06-02 Pacesetter, Inc. System and method for ambulatory monitoring and programming of an implantable medical device
US5720771A (en) * 1995-08-02 1998-02-24 Pacesetter, Inc. Method and apparatus for monitoring physiological data from an implantable medical device
US5732704A (en) * 1995-10-13 1998-03-31 Neoprobe Corporation Radiation based method locating and differentiating sentinel nodes
US5857463A (en) * 1995-10-13 1999-01-12 Neoprobe Corporation Remotely controlled apparatus and system for tracking and locating a source of photoemissions
US5656815A (en) 1996-02-08 1997-08-12 The United States Of America As Represented By The Secretary Of The Navy Thermoluminescence radiation dosimetry using transparent glass containing nanocrystalline phosphor
US5811814A (en) 1996-02-12 1998-09-22 Cordis Corporation Radiation measuring catheter apparatus and method
JP3796635B2 (ja) * 1996-03-06 2006-07-12 富士写真フイルム株式会社 蛍光検出装置
US5833603A (en) * 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
US5744805A (en) * 1996-05-07 1998-04-28 University Of Michigan Solid state beta-sensitive surgical probe
US6076009A (en) * 1997-05-05 2000-06-13 The University Of Michigan Solid state beta-sensitive surgical probe
US5932879A (en) 1996-05-07 1999-08-03 Regents Of The University Of Michigan Solid state beta-sensitive surgical probe
JP3896176B2 (ja) * 1996-05-21 2007-03-22 浜松ホトニクス株式会社 近赤外線蛍光トレーサーおよび蛍光イメージング方法
DE19621996C2 (de) * 1996-05-31 1998-04-09 Siemens Ag Verfahren zur Herstellung einer Kombination eines Drucksensors und eines elektrochemischen Sensors
US5682888A (en) 1996-06-13 1997-11-04 Neoprobe Corporation Apparatus and system for detecting and locating photon emissions with remote switch control
EP0944414B1 (de) 1996-07-11 2005-11-09 Medtronic, Inc. Minimalinvasive implantierbare vorrichtung zur überwachung physiologischer vorgänge
US6119031A (en) * 1996-11-21 2000-09-12 Boston Scientific Corporation Miniature spectrometer
AU5446098A (en) * 1996-11-21 1998-06-10 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors
US5814089A (en) 1996-12-18 1998-09-29 Medtronic, Inc. Leadless multisite implantable stimulus and diagnostic system
USD424453S (en) * 1997-03-18 2000-05-09 Neoprobe Corporation Detector unit for radiation detecting probe
USD423377S (en) * 1997-03-18 2000-04-25 Neoprobe Corporation Radiation detecting probe
AU6942198A (en) 1997-03-27 1998-10-22 Advanced Bionics, Inc. System of implantable devices for monitoring and/or affecting body para meters
EP0990151A2 (de) 1997-06-16 2000-04-05 ELAN CORPORATION, Plc Verfahren zum kalibrieren und testen eines sensors für in vivo messung eines analytes, und vorrichtungen zum gebrauch dergleichen verfahren
CA2215369C (en) * 1997-09-12 2008-11-18 Nicholas Garry Tarr Method of monitoring radiation using a floating gate field effect transistor dosimeter, and dosimeter for use therein
US5928150A (en) * 1997-10-04 1999-07-27 Neoprobe Corporation System for locating and detecting a source of photon emissions
US5987350A (en) 1997-10-10 1999-11-16 Neoprobe Corporation Surgical probe apparatus and system
US5916167A (en) * 1997-10-10 1999-06-29 Neoprobe Corporation Surgical probe apparatus and system
US6240312B1 (en) * 1997-10-23 2001-05-29 Robert R. Alfano Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
US5891179A (en) * 1997-11-20 1999-04-06 Paceseter, Inc. Method and apparatus for monitoring and displaying lead impedance in real-time for an implantable medical device
US6239724B1 (en) * 1997-12-30 2001-05-29 Remon Medical Technologies, Ltd. System and method for telemetrically providing intrabody spatial position
AU2652599A (en) 1998-01-06 1999-07-26 University Of Virginia Patent Foundation Nuclear scintigraphic assessment of mucosal function
US6289229B1 (en) * 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6087666A (en) * 1998-02-18 2000-07-11 The United States Of America As Represented By The Secretary Of The Navy Optically stimulated luminescent fiber optic radiation dosimeter
GB9805896D0 (en) 1998-03-20 1998-05-13 Eglise David Remote analysis system
WO2002039917A1 (en) 1998-05-14 2002-05-23 Calypso Medical, Inc. Systems and methods for locating and defining a target location within a human body
US6363940B1 (en) * 1998-05-14 2002-04-02 Calypso Medical Technologies, Inc. System and method for bracketing and removing tissue
EP2289423A1 (de) 1998-05-14 2011-03-02 David N. Krag System zum Klammern von Gewebe
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6047214A (en) * 1998-06-09 2000-04-04 North Carolina State University System and method for powering, controlling, and communicating with multiple inductively-powered devices
US6015390A (en) * 1998-06-12 2000-01-18 D. Krag Llc System and method for stabilizing and removing tissue
DE19828840C1 (de) * 1998-06-27 1999-10-28 Sartorius Gmbh Mehrfachfiltergehäuse mit Verriegelungseinrichtung für Filterelemente
US6295680B1 (en) 1998-07-05 2001-10-02 The Regents Of The University Of Michigan Method for detecting early atherosclerosis and vascular damage using radioactive tracers and intravascular radiation detection devices
US6304766B1 (en) 1998-08-26 2001-10-16 Sensors For Medicine And Science Optical-based sensing devices, especially for in-situ sensing in humans
DK1956365T3 (da) * 1998-08-26 2013-03-11 Senseonics Inc Optisk-baserede sensor-indretninger
WO2000018294A1 (en) 1998-09-30 2000-04-06 Sicel Medical Group Methods, systems, and associated implantable devices for dynamic monitoring of tumors
US6076666A (en) * 1998-10-08 2000-06-20 Santa-Maria; Toni M. Garment bag
US6259095B1 (en) 1998-10-23 2001-07-10 Neoprobe Corporation System and apparatus for detecting and locating sources of radiation
US6242741B1 (en) * 1998-10-23 2001-06-05 United States Surgical Corporation Radiation detection apparatus
US6272373B1 (en) 1998-10-23 2001-08-07 Neoprobe Corporation Scanning system and method for locating sources of radiation emission
US6274159B1 (en) 1998-10-28 2001-08-14 University Of Florida Surface modified silicone drug depot
US6113795A (en) 1998-11-17 2000-09-05 The University Of Kansas Process and apparatus for size selective separation of micro- and nano-particles
WO2000033065A1 (en) 1998-12-02 2000-06-08 Ut-Battelle, Llc In vivo biosensor apparatus and method of use
US6398710B1 (en) 1999-01-06 2002-06-04 Ball Semiconductor, Inc. Radiation dosimetry system
US8636648B2 (en) * 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6444475B1 (en) 1999-08-02 2002-09-03 Alltech Associates, Inc. Ion chromatography apparatus and method for removing gas prior to sample detection
EP1690527B1 (de) * 1999-11-17 2015-01-07 Boston Scientific Limited Miniaturisierte Vorrichtungen zur Abgabe von Molekülen in einer Trägerflüssigkeit
ATE499988T1 (de) * 2000-03-02 2011-03-15 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
US6614025B2 (en) 2000-03-28 2003-09-02 Thomson & Nielsen Electronics Ltd. Radiation sensor and dosimeter incorporating same
US6717154B2 (en) 2000-08-02 2004-04-06 Sicel Technologies, Inc. Evaluation of irradiated foods and other items with telemetric dosimeters and associated methods
US7226442B2 (en) * 2000-10-10 2007-06-05 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
CA2324048A1 (en) 2000-10-20 2002-04-20 Wei Ding Computer assisted radiotherapy dosimeter system and software therefor
US20020193685A1 (en) 2001-06-08 2002-12-19 Calypso Medical, Inc. Guided Radiation Therapy System
US7515953B2 (en) * 2002-08-01 2009-04-07 The Johns Hopkins University Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence
JP4436258B2 (ja) * 2002-08-16 2010-03-24 マイクロチップス・インコーポレーテッド 制御された放出デバイスおよび方法
US8738106B2 (en) * 2005-01-31 2014-05-27 Given Imaging, Ltd Device, system and method for in vivo analysis
US7616111B2 (en) * 2005-06-20 2009-11-10 Carestream Health, Inc. System to monitor the ingestion of medicines

Also Published As

Publication number Publication date
EP1332364B1 (de) 2009-08-26
EP1332364A2 (de) 2003-08-06
WO2002039112A2 (en) 2002-05-16
US7378056B2 (en) 2008-05-27
US20080228049A1 (en) 2008-09-18
CA2429127A1 (en) 2002-05-16
US20110237909A1 (en) 2011-09-29
JP3981328B2 (ja) 2007-09-26
ATE441110T1 (de) 2009-09-15
WO2002039112A3 (en) 2003-02-06
AU3659002A (en) 2002-05-21
US20020102212A1 (en) 2002-08-01
AU2002236590B2 (en) 2006-05-25
JP2004523257A (ja) 2004-08-05

Similar Documents

Publication Publication Date Title
DE60139705D1 (de) In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker
ATE383440T1 (de) Funktionalisierte eingekapselte fluoreszierende nanokristalle
ATE279720T1 (de) Verfahren und vorrichtung zur bestimmung temperaturabhängiger parameter und/oder der gleichgewichtskonstante von komplexen, die zumindest zwei komponenten umfassen
WO2005030030A3 (en) Method and apparatus for ratio fluorometry
DE69833378D1 (de) Fluoreszierende polarisation
CY1112666T1 (el) Φυσιγγα βιοδιαχωρισμου πολλαπλων διαυλων
WO2005008212A3 (en) Modulated excitation fluorescence analysis
NO20011338L (no) Kontrastmiddel som fluorescerer i et område n¶r det infraröde område og fluorescensavbildning
JP2008510965A5 (de)
WO2008134811A8 (en) A portable device for reading a fluorescent-labelled, membrane based assay
DE69840146D1 (de) Fluoreszenzprotein-sensoren zur erkennung von analyten
DE60038127D1 (de) Methoden und syteme zur überwachung intrazellulärer bindereaktionen
DK0834074T4 (da) Detektering af transmembranpotentialer ved optiske metoder
ATE320605T1 (de) Dotierte nanoteilchen als biolabel
Chaicham et al. Highly effective discrimination of catecholamine derivatives via FRET-on/off processes induced by the intermolecular assembly with two fluorescence sensors
AU2002221848A1 (en) Dye pair for fluorescence resonance energy transfer (fret) measurements
MXPA02005806A (es) Agente de contraste fluorescente cercano al infrarrojo y formacion de imagen fluorescente.
JP2004523257A5 (de)
WO2008108074A1 (ja) 蛍光プローブ
Ai et al. In situ labeling and imaging of cellular protein via a bi-functional anticancer aptamer and its fluorescent ligand
DE60031965D1 (de) Hochsensitiver nachweis von biomolekülen mittels "phage display"
Santos et al. An investigation on the analytical potential of polymerized liposomes bound to lanthanide ions for protein analysis
AR024540A1 (es) Uso de resonancia magnetica nuclear 13 c para detectar la union con moleculas blanco
RU99110898A (ru) Экспресс-метод оценки степени тяжести состояния больных
CN101387637A (zh) 生物快速检测系统

Legal Events

Date Code Title Description
8364 No opposition during term of opposition