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DE60116106D1 - Benzofuran derivate und ihre verwendung als antibakterielle wirkstoffe - Google Patents

Benzofuran derivate und ihre verwendung als antibakterielle wirkstoffe

Info

Publication number
DE60116106D1
DE60116106D1 DE60116106T DE60116106T DE60116106D1 DE 60116106 D1 DE60116106 D1 DE 60116106D1 DE 60116106 T DE60116106 T DE 60116106T DE 60116106 T DE60116106 T DE 60116106T DE 60116106 D1 DE60116106 D1 DE 60116106D1
Authority
DE
Germany
Prior art keywords
benzofuran derivatives
active substances
antibacterial active
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60116106T
Other languages
English (en)
Other versions
DE60116106T2 (de
Inventor
Kaspar Burri
Dieter Gillessen
Sorana Greiveldinger-Poenaru
Khalid Islam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arpida AG
Original Assignee
Arpida AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arpida AG filed Critical Arpida AG
Publication of DE60116106D1 publication Critical patent/DE60116106D1/de
Application granted granted Critical
Publication of DE60116106T2 publication Critical patent/DE60116106T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60116106T 2000-07-29 2001-07-20 Benzofuran derivate und ihre verwendung als antibakterielle wirkstoffe Expired - Fee Related DE60116106T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/EP00/07357 2000-07-29
PCT/EP2000/007357 WO2002010156A1 (en) 2000-07-29 2000-07-29 Benzofuran derivatives and their use as antibacterial agents
PCT/EP2001/008426 WO2002010157A1 (en) 2000-07-29 2001-07-20 Benzofuran derivatives and their use as antibacterial agents

Publications (2)

Publication Number Publication Date
DE60116106D1 true DE60116106D1 (de) 2006-01-26
DE60116106T2 DE60116106T2 (de) 2006-06-29

Family

ID=8164043

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60116106T Expired - Fee Related DE60116106T2 (de) 2000-07-29 2001-07-20 Benzofuran derivate und ihre verwendung als antibakterielle wirkstoffe

Country Status (14)

Country Link
US (1) US7030130B2 (de)
EP (1) EP1307445B1 (de)
JP (1) JP2004505077A (de)
CN (1) CN1317277C (de)
AT (1) ATE313541T1 (de)
AU (1) AU2001289714A1 (de)
CA (1) CA2417401C (de)
DE (1) DE60116106T2 (de)
DK (1) DK1307445T3 (de)
ES (1) ES2250474T3 (de)
MX (1) MXPA03000606A (de)
NO (1) NO325691B1 (de)
TW (1) TWI283674B (de)
WO (2) WO2002010156A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0205829A (pt) * 2001-03-16 2005-03-08 Abbott Lab Novas aminas como ligantes dos receptores de histamina-3 e suas aplicações terapêuticas
US6969730B2 (en) 2001-03-16 2005-11-29 Abbott Laboratories Amines as histamine-3 receptor ligands and their therapeutic applications
CN100443482C (zh) * 2003-07-11 2008-12-17 阿皮德公开股份有限公司 苯并呋喃衍生物及其在制备治疗由细菌引起的感染的药物中的用途
WO2005014586A1 (en) * 2003-08-08 2005-02-17 Arpida Ag Novel process for the preparation of 2h-chromenes
DE10351315A1 (de) * 2003-10-31 2005-06-16 Aventis Pharma Deutschland Gmbh 2-Phenyl-benzofuran-Derivate, Verfahren zur ihrer Herstellung und ihre Verwendung
US7148254B2 (en) 2003-10-31 2006-12-12 Sanofi-Aventis Deutschland Gmbh 2-Phenylbenzofuran derivatives, a process for preparing them, and their use
HUP0700556A2 (en) 2005-01-07 2008-09-29 Arpida Ag Benzofuran derivatines process for their preparation the intermediates and pharmaceuticals containing them
EP1856106A1 (de) * 2005-02-18 2007-11-21 Arpida AG Neue verfahren zur herstellung eines 2h-chromens
US7737157B2 (en) * 2008-08-29 2010-06-15 Hutchison Medipharma Enterprises Limited Pyrimidine compounds
KR101156666B1 (ko) 2010-09-17 2012-06-15 대한민국(농촌진흥청장) 신규한 항생활성 화합물 및 그 화합물을 포함하는 항생 조성물
CN103288805B (zh) * 2013-03-13 2016-09-14 天津药物研究院有限公司 含有苯并呋喃的嘧啶类化合物及其制备方法和用途
RU2657559C2 (ru) * 2015-12-01 2018-06-14 Общество с ограниченной ответственностью "Квантум Фармасьютикалс" Медицинское применение фармацевтических композиций на основе роданиновых производных бензотиофена, ингибиторов белка клеточного деления FtsZ
MX395591B (es) * 2017-11-10 2025-03-25 Jiangsu Hengrui Medicine Co Metodo para preparar derivado de benzofurano
WO2020244607A1 (zh) * 2019-06-06 2020-12-10 北京泰德制药股份有限公司 P2x3和/或p2x2/3受体拮抗剂、包含其的药物组合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB875562A (en) * 1957-02-21 1961-08-23 Wellcome Found Improvements in and relating to pyrimidine derivatives and the preparation thereof
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
DK190983A (da) * 1982-05-01 1983-11-02 Wellcome Found 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
ZA833067B (en) * 1982-05-01 1984-12-24 Wellcome Found Antibacterial compounds
DE69618986T2 (de) * 1995-12-04 2002-06-20 Arpida Ag, Muenchenstein Diaminopyrimidine, diese enthaltende pharmazeutische zusammensetzungen und ihre verwendung als antibakterielle mittel

Also Published As

Publication number Publication date
ATE313541T1 (de) 2006-01-15
TWI283674B (en) 2007-07-11
CA2417401A1 (en) 2002-02-07
CN1440404A (zh) 2003-09-03
NO325691B1 (no) 2008-07-07
NO20030417D0 (no) 2003-01-27
JP2004505077A (ja) 2004-02-19
DK1307445T3 (da) 2006-04-10
ES2250474T3 (es) 2006-04-16
CN1317277C (zh) 2007-05-23
EP1307445A1 (de) 2003-05-07
NO20030417L (no) 2003-01-27
CA2417401C (en) 2009-11-10
MXPA03000606A (es) 2004-04-02
WO2002010157A1 (en) 2002-02-07
US20040034047A1 (en) 2004-02-19
US7030130B2 (en) 2006-04-18
EP1307445B1 (de) 2005-12-21
WO2002010156A1 (en) 2002-02-07
AU2001289714A1 (en) 2002-02-13
DE60116106T2 (de) 2006-06-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: VOSSIUS & PARTNER, 81675 MUENCHEN

8339 Ceased/non-payment of the annual fee