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DE60113300D1 - Piperazinylcarbonylchinoline und isochinoline - Google Patents

Piperazinylcarbonylchinoline und isochinoline

Info

Publication number
DE60113300D1
DE60113300D1 DE60113300T DE60113300T DE60113300D1 DE 60113300 D1 DE60113300 D1 DE 60113300D1 DE 60113300 T DE60113300 T DE 60113300T DE 60113300 T DE60113300 T DE 60113300T DE 60113300 D1 DE60113300 D1 DE 60113300D1
Authority
DE
Germany
Prior art keywords
piperazinylcarbonylchinoline
isochinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60113300T
Other languages
English (en)
Other versions
DE60113300T2 (de
Inventor
Henning Boettcher
Gerd Bartoszyk
Juergen Harting
Amsterdam Christoph Van
Christoph Seyfried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE60113300T priority Critical patent/DE60113300T2/de
Publication of DE60113300D1 publication Critical patent/DE60113300D1/de
Application granted granted Critical
Publication of DE60113300T2 publication Critical patent/DE60113300T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60113300T 2001-01-17 2001-12-24 Piperazinylcarbonylchinoline und isochinoline Expired - Lifetime DE60113300T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE60113300T DE60113300T2 (de) 2001-01-17 2001-12-24 Piperazinylcarbonylchinoline und isochinoline

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10102053 2001-01-17
DE10102053A DE10102053A1 (de) 2001-01-17 2001-01-17 Piperazinylcarbonylchinoline und -isochinoline
PCT/EP2001/015311 WO2002057256A1 (en) 2001-01-17 2001-12-24 Piperazinylcarbonylquinolines and -isoquinolines
DE60113300T DE60113300T2 (de) 2001-01-17 2001-12-24 Piperazinylcarbonylchinoline und isochinoline

Publications (2)

Publication Number Publication Date
DE60113300D1 true DE60113300D1 (de) 2005-10-13
DE60113300T2 DE60113300T2 (de) 2006-06-29

Family

ID=7670921

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10102053A Withdrawn DE10102053A1 (de) 2001-01-17 2001-01-17 Piperazinylcarbonylchinoline und -isochinoline
DE60113300T Expired - Lifetime DE60113300T2 (de) 2001-01-17 2001-12-24 Piperazinylcarbonylchinoline und isochinoline

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10102053A Withdrawn DE10102053A1 (de) 2001-01-17 2001-01-17 Piperazinylcarbonylchinoline und -isochinoline

Country Status (22)

Country Link
US (1) US7329749B2 (de)
EP (1) EP1366039B1 (de)
JP (1) JP4417624B2 (de)
KR (1) KR100854481B1 (de)
CN (1) CN1249055C (de)
AR (1) AR035682A1 (de)
AT (1) ATE304010T1 (de)
BR (1) BR0116774A (de)
CA (1) CA2434773C (de)
CZ (1) CZ304144B6 (de)
DE (2) DE10102053A1 (de)
DK (1) DK1366039T3 (de)
ES (1) ES2248230T3 (de)
HU (1) HU230250B1 (de)
MX (1) MXPA03006360A (de)
MY (1) MY127293A (de)
PL (1) PL212087B1 (de)
RU (1) RU2280034C2 (de)
SI (1) SI1366039T1 (de)
SK (1) SK287333B6 (de)
WO (1) WO2002057256A1 (de)
ZA (1) ZA200306331B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057435A2 (en) * 2001-01-18 2002-07-25 Merck Patent Gmbh Bifunctional fusion proteins with glucocerebrosidase activity
CA2483311A1 (en) * 2002-04-22 2003-10-30 Philip A. Beachy Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2004002965A1 (de) * 2002-06-29 2004-01-08 Zentaris Gmbh Aryl- und heteroarylcarbonylpiperazine und deren verwendung zur behandlung gutartiger und bösartiger tumorerkrankungen
WO2006010515A2 (en) * 2004-07-29 2006-02-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine 2a receptor (5ht2a)
GB2497476B (en) * 2010-09-06 2018-01-10 Guangzhou Inst Biomed & Health Amide Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093341A (en) * 1987-12-17 1992-03-03 Merrell Dow Pharmaceuticals Inc. N-aralkyl piperidine derivatives useful as antithrombolytic agents
US4970714A (en) * 1989-01-05 1990-11-13 International Business Machines Corp. Adaptive data link protocol
KR100538152B1 (ko) * 1997-07-07 2005-12-21 코와 가부시키가이샤 디아민 유도체 및 이를 함유하는 의약
WO2000012074A2 (en) * 1998-08-28 2000-03-09 Scios Inc. Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate

Also Published As

Publication number Publication date
CA2434773A1 (en) 2002-07-25
WO2002057256A9 (en) 2005-12-08
PL361741A1 (en) 2004-10-04
HK1061849A1 (en) 2004-10-08
MXPA03006360A (es) 2003-10-06
CA2434773C (en) 2011-10-04
WO2002057256A1 (en) 2002-07-25
US7329749B2 (en) 2008-02-12
DE60113300T2 (de) 2006-06-29
DE10102053A1 (de) 2002-07-18
HUP0401038A2 (hu) 2004-08-30
EP1366039A1 (de) 2003-12-03
HUP0401038A3 (en) 2011-08-29
ZA200306331B (en) 2005-01-26
EP1366039B1 (de) 2005-09-07
KR100854481B1 (ko) 2008-08-26
CZ20031861A3 (cs) 2003-09-17
ES2248230T3 (es) 2006-03-16
DK1366039T3 (da) 2006-01-02
AR035682A1 (es) 2004-06-23
ATE304010T1 (de) 2005-09-15
PL212087B1 (pl) 2012-08-31
BR0116774A (pt) 2004-01-06
RU2003124077A (ru) 2005-01-10
MY127293A (en) 2006-11-30
RU2280034C2 (ru) 2006-07-20
HU230250B1 (hu) 2015-11-30
US20040077657A1 (en) 2004-04-22
SK287333B6 (sk) 2010-07-07
SI1366039T1 (sl) 2006-02-28
CN1486308A (zh) 2004-03-31
CN1249055C (zh) 2006-04-05
JP2004517145A (ja) 2004-06-10
JP4417624B2 (ja) 2010-02-17
SK8652003A3 (en) 2003-11-04
KR20030068579A (ko) 2003-08-21
CZ304144B6 (cs) 2013-11-20

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