DE60036395D1 - Enzyme des auf die lysosomen gerichteten weges - Google Patents
Enzyme des auf die lysosomen gerichteten wegesInfo
- Publication number
- DE60036395D1 DE60036395D1 DE60036395T DE60036395T DE60036395D1 DE 60036395 D1 DE60036395 D1 DE 60036395D1 DE 60036395 T DE60036395 T DE 60036395T DE 60036395 T DE60036395 T DE 60036395T DE 60036395 D1 DE60036395 D1 DE 60036395D1
- Authority
- DE
- Germany
- Prior art keywords
- lysosomes
- enzymes
- path taken
- methods
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 210000003712 lysosome Anatomy 0.000 title 1
- 230000002132 lysosomal effect Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1223—Phosphotransferases with a nitrogenous group as acceptor (2.7.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04045—N-Acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (3.1.4.45)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15383199P | 1999-09-14 | 1999-09-14 | |
| US153831P | 1999-09-14 | ||
| PCT/US2000/021970 WO2001019955A2 (en) | 1999-09-14 | 2000-09-14 | Lysosomal targeting pathway enzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60036395D1 true DE60036395D1 (de) | 2007-10-25 |
| DE60036395T2 DE60036395T2 (de) | 2008-06-12 |
Family
ID=22548927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60036395T Expired - Lifetime DE60036395T2 (de) | 1999-09-14 | 2000-09-14 | Enzyme des auf die lysosomen gerichteten weges |
Country Status (10)
| Country | Link |
|---|---|
| US (8) | US6534300B1 (de) |
| EP (1) | EP1224266B1 (de) |
| JP (1) | JP2003509043A (de) |
| AT (1) | ATE373086T1 (de) |
| AU (1) | AU783224B2 (de) |
| BR (1) | BR0014514A (de) |
| CA (1) | CA2383217C (de) |
| DE (1) | DE60036395T2 (de) |
| MX (1) | MXPA02002901A (de) |
| WO (1) | WO2001019955A2 (de) |
Families Citing this family (152)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
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| WO2001056596A1 (en) | 2000-02-04 | 2001-08-09 | Children's Hospital Research Foundation | Use of lysosomal acid lipase for treating atherosclerosis and related diseases |
| ES2523024T3 (es) | 2000-07-18 | 2014-11-20 | Duke University | Tratamiento de glucogenosis de tipo II |
| EP1782825B1 (de) * | 2000-07-18 | 2014-09-10 | Duke University | Behandlung der Glykogenspeicherkrankheit typ II |
| US7138262B1 (en) * | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
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| US7001994B2 (en) * | 2001-01-18 | 2006-02-21 | Genzyme Corporation | Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
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| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
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| US5928928A (en) | 1995-06-07 | 1999-07-27 | Universiteit Van Amsterdam | Human chitinase, its recombinant production, its use for decomposing chitin, its use in therapy or prophylaxis against infection diseases |
| US6118045A (en) | 1995-08-02 | 2000-09-12 | Pharming B.V. | Lysosomal proteins produced in the milk of transgenic animals |
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| US5916911A (en) | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
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-
2000
- 2000-08-10 US US09/635,872 patent/US6534300B1/en not_active Expired - Lifetime
- 2000-08-10 US US09/636,060 patent/US6642038B1/en not_active Expired - Lifetime
- 2000-08-10 US US09/636,077 patent/US6537785B1/en not_active Expired - Lifetime
- 2000-09-14 AT AT00961335T patent/ATE373086T1/de not_active IP Right Cessation
- 2000-09-14 CA CA2383217A patent/CA2383217C/en not_active Expired - Lifetime
- 2000-09-14 WO PCT/US2000/021970 patent/WO2001019955A2/en not_active Ceased
- 2000-09-14 AU AU73303/00A patent/AU783224B2/en not_active Expired
- 2000-09-14 BR BR0014514-9A patent/BR0014514A/pt not_active IP Right Cessation
- 2000-09-14 EP EP00961335A patent/EP1224266B1/de not_active Expired - Lifetime
- 2000-09-14 DE DE60036395T patent/DE60036395T2/de not_active Expired - Lifetime
- 2000-09-14 JP JP2001523727A patent/JP2003509043A/ja active Pending
- 2000-09-14 MX MXPA02002901A patent/MXPA02002901A/es unknown
-
2001
- 2001-07-02 US US09/895,072 patent/US6861242B2/en not_active Expired - Lifetime
- 2001-11-09 US US09/986,552 patent/US6670165B2/en not_active Expired - Lifetime
-
2003
- 2003-09-09 US US10/657,280 patent/US7067127B2/en not_active Expired - Lifetime
-
2005
- 2005-08-09 US US11/199,233 patent/US7371366B2/en not_active Expired - Lifetime
-
2008
- 2008-02-27 US US12/038,018 patent/US20080176285A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060073498A1 (en) | 2006-04-06 |
| US6537785B1 (en) | 2003-03-25 |
| US6642038B1 (en) | 2003-11-04 |
| US20080176285A1 (en) | 2008-07-24 |
| US7371366B2 (en) | 2008-05-13 |
| EP1224266A2 (de) | 2002-07-24 |
| AU783224B2 (en) | 2005-10-06 |
| CA2383217A1 (en) | 2001-03-22 |
| DE60036395T2 (de) | 2008-06-12 |
| US20020025550A1 (en) | 2002-02-28 |
| US7067127B2 (en) | 2006-06-27 |
| WO2001019955A3 (en) | 2001-10-04 |
| ATE373086T1 (de) | 2007-09-15 |
| AU7330300A (en) | 2001-04-17 |
| US6534300B1 (en) | 2003-03-18 |
| WO2001019955A2 (en) | 2001-03-22 |
| CA2383217C (en) | 2013-11-19 |
| EP1224266A4 (de) | 2003-05-28 |
| BR0014514A (pt) | 2002-07-23 |
| US6861242B2 (en) | 2005-03-01 |
| EP1224266B1 (de) | 2007-09-12 |
| MXPA02002901A (es) | 2003-10-14 |
| US20020150981A1 (en) | 2002-10-17 |
| US6670165B2 (en) | 2003-12-30 |
| JP2003509043A (ja) | 2003-03-11 |
| US20050089869A1 (en) | 2005-04-28 |
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