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DE60025744D1 - Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1 - Google Patents

Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1

Info

Publication number
DE60025744D1
DE60025744D1 DE60025744T DE60025744T DE60025744D1 DE 60025744 D1 DE60025744 D1 DE 60025744D1 DE 60025744 T DE60025744 T DE 60025744T DE 60025744 T DE60025744 T DE 60025744T DE 60025744 D1 DE60025744 D1 DE 60025744D1
Authority
DE
Germany
Prior art keywords
dihydrochinolinone
condensed
derivatives
mrp1
inhibiting mrp1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60025744T
Other languages
English (en)
Inventor
Rosanne Bonjouklian
Webb Johnson
Ambrose Lander
Christopher Lohman
Francis Patel
Sreenivasarao Vepachedu
Yongping Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE60025744D1 publication Critical patent/DE60025744D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE60025744T 1999-10-07 2000-09-22 Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1 Expired - Lifetime DE60025744D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15817599P 1999-10-07 1999-10-07
US16978499P 1999-12-09 1999-12-09
PCT/US2000/021980 WO2001027116A2 (en) 1999-10-07 2000-09-22 Condensed dihydroquinolinone derivatives for inhibiting mrp1

Publications (1)

Publication Number Publication Date
DE60025744D1 true DE60025744D1 (de) 2006-04-13

Family

ID=26854809

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60025744T Expired - Lifetime DE60025744D1 (de) 1999-10-07 2000-09-22 Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1

Country Status (7)

Country Link
US (2) US6670373B1 (de)
EP (1) EP1224189B1 (de)
AT (1) ATE316531T1 (de)
AU (1) AU7824900A (de)
DE (1) DE60025744D1 (de)
PE (1) PE20010751A1 (de)
WO (1) WO2001027116A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7430257B1 (en) * 1998-02-12 2008-09-30 Lot 41 Acquisition Foundation, Llc Multicarrier sub-layer for direct sequence channel and multiple-access coding
JP2004529919A (ja) 2001-04-09 2004-09-30 イーライ・リリー・アンド・カンパニー Ｍｒｐ１を阻害するための化合物および方法
CN1281210C (zh) * 2003-11-29 2006-10-25 胡汛 五味子乙素在制备治疗肿瘤药物中的应用
US20060035920A1 (en) * 2004-05-28 2006-02-16 Millennium Pharmaceuticals, Inc. Chk-1 inhibitors
WO2006074207A2 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Inhibitors of checkpoint kinases
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
PT3311666T (pt) 2010-08-18 2021-06-21 Biosplice Therapeutics Inc Dicetonas e hidroxicetonas como ativadores da via de sinalização de catenina
CN110711248A (zh) 2011-01-28 2020-01-21 赛诺菲生物技术公司 包含针对pcsk9的人抗体的药物组合物
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
WO2013059548A1 (en) 2011-10-19 2013-04-25 Sanofi Compositions and methods for treating cancer using jak2 inhibitor
JO3370B1 (ar) 2011-11-10 2019-03-13 Regeneron Pharma طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
SG10201606032VA (en) 2013-02-22 2016-09-29 Samumed Llc Gamma-Diketones As Wnt/Beta -Catenin Signaling Pathway Activators
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
DE202014010499U1 (de) 2013-12-17 2015-10-20 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
WO2015116852A1 (en) 2014-01-29 2015-08-06 Regeneron Pharmaceuticals, Inc. Methods for treating rheumatoid arthritis by administering an il-6r antibody
CN107106549B (zh) 2014-08-20 2020-06-16 萨穆梅德有限公司 用于治疗和预防老化皮肤和皱纹的γ–二酮
US10772956B2 (en) 2015-08-18 2020-09-15 Regeneron Pharmaceuticals, Inc. Methods for reducing or eliminating the need for lipoprotein apheresis in patients with hyperlipidemia by administering alirocumab
EP3495351A1 (de) * 2017-12-08 2019-06-12 Solvay Sa Oxidation einer pyrazolylketon verbindung zur entsprechenden carboxysäure
BR112021003206A2 (pt) 2018-08-29 2021-05-25 Regeneron Pharmaceuticals, Inc. métodos e composições para tratar indivíduos com artrite reumatoide
TWI860325B (zh) 2019-01-31 2024-11-01 法商賽諾菲生物技術公司 用於治療幼年原發性關節炎之組成物及方法
AU2020261431A1 (en) 2019-04-24 2021-12-09 Regeneron Pharmaceuticals, Inc. Methods of diagnosis and treatment of rheumatoid arthritis
JP2022534794A (ja) 2019-06-04 2022-08-03 サノフィ・バイオテクノロジー 関節リウマチを有する対象における疼痛を治療するための組成物および方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity
HRP20000646A2 (en) * 1998-04-08 2001-06-30 Lilly Co Eli Methods for inhibiting mrp1

Also Published As

Publication number Publication date
EP1224189A2 (de) 2002-07-24
WO2001027116A3 (en) 2001-11-22
AU7824900A (en) 2001-04-23
US20040077675A1 (en) 2004-04-22
EP1224189B1 (de) 2006-01-25
PE20010751A1 (es) 2001-07-18
ATE316531T1 (de) 2006-02-15
US6670373B1 (en) 2003-12-30
WO2001027116A2 (en) 2001-04-19

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Legal Events

Date Code Title Description
8332 No legal effect for de