[go: up one dir, main page]

DE60002733D1 - Diester prodrugs von decahydroischinoline-3-carbonsäure - Google Patents

Diester prodrugs von decahydroischinoline-3-carbonsäure

Info

Publication number
DE60002733D1
DE60002733D1 DE60002733T DE60002733T DE60002733D1 DE 60002733 D1 DE60002733 D1 DE 60002733D1 DE 60002733 T DE60002733 T DE 60002733T DE 60002733 T DE60002733 T DE 60002733T DE 60002733 D1 DE60002733 D1 DE 60002733D1
Authority
DE
Germany
Prior art keywords
decahydroischinoline
prodrugs
carbonic acid
prodrug forms
decahydroisoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60002733T
Other languages
English (en)
Other versions
DE60002733T2 (de
Inventor
John Bleisch
Louis Mattiuz
Leslie Ornstein
Eugene Stratford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE60002733D1 publication Critical patent/DE60002733D1/de
Application granted granted Critical
Publication of DE60002733T2 publication Critical patent/DE60002733T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60002733T 1999-07-06 2000-06-13 Diester prodrugs von decahydroischinoline-3-carbonsäure Expired - Fee Related DE60002733T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14248499P 1999-07-06 1999-07-06
US142484P 1999-07-06
PCT/US2000/015030 WO2001002367A2 (en) 1999-07-06 2000-06-13 Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid

Publications (2)

Publication Number Publication Date
DE60002733D1 true DE60002733D1 (de) 2003-06-18
DE60002733T2 DE60002733T2 (de) 2004-03-18

Family

ID=22500022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60002733T Expired - Fee Related DE60002733T2 (de) 1999-07-06 2000-06-13 Diester prodrugs von decahydroischinoline-3-carbonsäure

Country Status (7)

Country Link
US (1) US6486175B1 (de)
EP (1) EP1208087B1 (de)
AT (1) ATE240299T1 (de)
AU (1) AU5591900A (de)
DE (1) DE60002733T2 (de)
ES (1) ES2198323T3 (de)
WO (1) WO2001002367A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL146697A0 (en) 1999-07-06 2002-07-25 Lilly Co Eli SELECTIVE iGluR5 RECEPTOR FOR THE TREATMENT OF MIGRAINE
WO2001046173A1 (en) 1999-12-22 2001-06-28 Eli Lilly And Company SELECTIVE iGLUR5 RECEPTOR ANTAGONISTS
US6924294B2 (en) 2001-01-05 2005-08-02 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO2002053556A2 (en) 2001-01-05 2002-07-11 Eli Lilly And Company Pyrrolidinylmethyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists
US6953805B2 (en) 2001-01-05 2005-10-11 Eli Lilly And Company Excitatory amino acid receptor antagonists
US7205313B2 (en) 2001-01-05 2007-04-17 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO2002058691A1 (en) * 2001-01-23 2002-08-01 Neurosearch A/S Use of non-competitive and selective glur5 antagonists as glutamate receptor modulating compounds
NZ535245A (en) 2002-04-26 2007-11-30 Lilly Co Eli Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgesics
WO2008066750A1 (en) 2006-11-22 2008-06-05 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism
WO2011109398A2 (en) 2010-03-02 2011-09-09 President And Fellows Of Harvard College Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110294879A1 (en) 2010-05-28 2011-12-01 Xenoport, Inc. Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders
US20120016021A1 (en) 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
WO2012054724A1 (en) 2010-10-21 2012-04-26 Massachusetts Institute Of Technology Methods of treating seizure disorders
JP7653184B2 (ja) 2020-07-02 2025-03-28 シー ファーマシューティカルズ エルエルシー ６‐（２‐（２ｈ‐テトラゾール‐５‐イル）エチル）‐６‐フルオロデカヒドロイソキノリン‐３‐カルボキシル酸及びそのエステル誘導体の医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2252381B (en) 1990-12-14 1995-08-09 Charles Bickford Improved fixing
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5446051A (en) * 1994-05-31 1995-08-29 Eli Lilly And Company Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
EP0980358A4 (de) * 1997-04-07 2001-02-07 Lilly Co Eli Pharmakolgisch aktive mittel

Also Published As

Publication number Publication date
WO2001002367A2 (en) 2001-01-11
US6486175B1 (en) 2002-11-26
ES2198323T3 (es) 2004-02-01
EP1208087B1 (de) 2003-05-14
EP1208087A2 (de) 2002-05-29
DE60002733T2 (de) 2004-03-18
AU5591900A (en) 2001-01-22
WO2001002367A3 (en) 2001-03-08
ATE240299T1 (de) 2003-05-15

Similar Documents

Publication Publication Date Title
FI970246A7 (fi) Dihydrobentsofuraanit
DE60131160D1 (de) Caspase-inhibitoren und ihre verwendungen
BR9900443A (pt) Esteres de ácido aril acrìlico.
ATE232873T1 (de) Phosphonsaürederivate als ptp-1b-inhibitoren
EA199900373A2 (ru) Фармацевтические композиции
DK1140918T3 (da) Thrombininhibitorer
IS4695A (is) (Metýlsúlfónýl)fenýl-2-(5H)-fúranón sem sýklóoxýgenasa-2 tálmar
TR200001435T2 (tr) Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları
DE69915004D1 (de) 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate
FI924311A0 (fi) Nya 2-substituerade indan-2 -merkaptoacetylamidderivat anvaendbara som inhibitorer av enkefalinas och ace.
MEP24608A (en) Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same
ZA200309887B (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
DE60002733D1 (de) Diester prodrugs von decahydroischinoline-3-carbonsäure
IL94915A0 (en) Substituted quinazolinones and pharmaceutical compositions containing them
DE69732571D1 (de) Beta-sulfonyl-hydroxamsäuren als matrix-metalloproteinaseinhibitoren
DE60334773D1 (de) Formulierungen zur oralen verabreichung von wirkstoffen
TR199901765T2 (xx) S�lfomid-metalloproteaz inhibit�rleri
EA200100516A1 (ru) Производные 3,3-биарилпиперидина и 2,2-биарилморфолина
ATE223376T1 (de) Bisarylcyclobutenderivate als cyclooxygenasehemmer
BR0212899A (pt) Compostos orgânicos
ES2147973T3 (es) Estirenos alquilatados como profarmacos de inhibidores de cox-2.
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
TR200200494T2 (tr) Yağlı asit sintazı inhibitörleri.
GR3017348T3 (en) Novel isoindolinone derivative, preparation thereof, and pharmaceutical compositions containing same.
ES2183500T3 (es) Nuevos compuestos y composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee