DE20304504U1 - Toothbrush-cleaning composition comprises e.g. cetyl pyridinium chloride and/or chlorhexidine, or cleaning salts, or surfactants, or plant extracts and/or essential oils, or a combination of hydrogen peroxide and catalase - Google Patents

Abstract

Toothbrush-cleaning composition comprises cetyl pyridinium chloride and/or chlorhexidine, or cleaning salts, or surfactants, or plant extracts and/or essential oils, or a combination of hydrogen peroxide and catalase, or an alcohol, or an acid, or tannins.

Description

Strictly speaking, it is a toothbrush not just the electric toothbrush, which with stronger Pressure on the gums acts as the manual toothbrush, and where one more often is more careful than with the manual toothbrush - but also the manual one Toothbrush - more than a commodity, as for example with inflamed tissue can come into contact and, above all, bearers of countless different ones Is microorganisms.

Now the toothbrush is not a medical device but a commodity for which the Cosmetics Regulation and parent the Food and Consumer Goods Act are responsible. In this respect, there are certainly no medical principles here. Yet It can be helpful when dealing with the toothbrush dental expertise is accompanied.

It is problematic to note:

Even a fork or a spoon, too into the oral cavity have a better hygiene status than one toothbrush (so.).

Solutions:

Cetylpyridinium chloride and chlorhexidine are considered the most effective and sustainable antiseptics.

Even at only 0.11 ppm chlorhexidine another bacteriostatic occurs, that is, the bacteria in their movement and increase "lame laying "effect.

An admixed surfactant could e.g. in terms of comprehensive toothbrush hygiene doing for one Cleaning the bristles, the dye serves e.g. as an indicator solution for visual demarcation or similar and the flavorings can can be added in different flavors.

(E.g. peppermint, chamomile, lemon, Strawberry, orange, etc.). Also manufacturing in gel form, foam form, Powder form etc. is conceivable.

A specially made cleaning vessel (e.g. narrower than a normal toothed cup with a marking strip for exact dosing also conceivable, similar applies to a cleaning brush or a cleaning sponge).

application

In this cetyl pyridinium chloride or chlorhexidine surfactant solution / (- Gel) the toothbrush should at least 20 minutes - or also about Night - for disinfection remain.

Then the brush should be under running Rinsed off water be and the solution discarded become. Also rinse and dry the disinfection container. This process should be done at least once or twice a week. With viral Diseases daily. The dosage should be as low as possible respectively.

Other variants (e.g. based on Cleaning salts, tannins, acids, Alcohols, hydrogen peroxide catalase, plant extracts etc.) are included in the protection claims contain.

background

Strictly speaking, it is a toothbrush not just the electric toothbrush, which with stronger Pressure on the gums acts as the manual toothbrush, and where one more often is more careful than with the manual toothbrush - but also the manual one Toothbrush - more than a commodity, as for example with inflamed tissue can come into contact and, above all, bearers of countless different ones Is microorganisms. Even cutlery, which is also in the oral cavity introduced has a better hygiene status than a toothbrush, which occasion should give you food for thought.

Regular use of chemical disinfectants Substances in the general area of toothbrush care is, in contrast to denture cleaners or oral rinsing solutions, not yet given what m. E. is a necessity!

Justification: dental care and toothbrush care

Most people keep the disease, which one the teeth first wiggle, then drop out, after as before for age-related wear on the gums. However, periodontitis is the most common infectious disease after caries of the world.

There are bacteria in the oral cavity not just for that known holes etching in the tooth but also to eat deeper into the gums.

A direct consequence is tooth loss, however, myocardial infarction, diabetes and premature births are also due to the Periodontitis germs.

Scientists are increasingly recognizing which one Influence the microbes in the mouth on the whole human organism to have.

There are bacteria in the oral cavity extremely sociable. Apparently there are far more microorganisms here than one has been able to do so far suspected.

Around 500 species are currently identified. But With the most modern gene probes, researchers are getting more and more germs Track. Some of these germs are harmless, some of them pose for the However, teeth are also a danger that should not be underestimated.

In the line of fire of the bacteria is not only the tooth in which they dig holes and thus cause tooth decay, the gums also feel the attacks. Initially unnoticed, the bacteria target the gum's weak point. They colonize the Saumzel len, which adhere directly to the tooth and anchor the tooth in the bony tooth compartment. The bacteria release toxins, which in turn penetrate the lozenge and loosen it. The organism then replies with defense cells. These flow into the tissue and increase its permeability. The toxins are then able to penetrate the connective tissue of the gums. The result is inflammation of the gums (gingivitis).

If not now with the right dental care and if a visit to the dentist is stopped, the gums become increasingly red and swells (periodontitis).

When eating and also when lighter Touch begins the tissue to bleed. There are so-called "pockets" between the tooth and the flesh, which can be easily removed can dig in between six to 30 millimeters deep. leftovers give the bacteria more food so that it almost can multiply explosively.

The gums stay in this Stage then only the withdrawal. The bacteria in the gum pocket activate tissue-degrading collagenases. The tooth loosens and the likelihood of tooth loss increases considerably.

So far it has not succeeded in individual Specify the shrinkage in the mouth exactly. Clinical symptoms such as bleeding or deep pockets correlate well with the presence certain types of bacteria in the plaque, on the other hand they are too in healthy gum areas. So suppose Microbiologists meanwhile that the tissue damage from the combination of Bacteria that live together in a plaque.

However, the scientists were able to identify certain key germs. One of them is Porphyromonas gingivalis. Porphyromonas gingivalis can be detected in 63 percent of all patients. Porphyromonas gingivalis has all kinds of periodontal pathogens the broadest spectrum of tissue-degrading enzymes. The proteases build quickly Collagen, immunoglobulins or complement, taking off the connective tissue of the gums is gradually dismembered. Porphyromonas forms gingivalis membrane vesicles. These are released into the surrounding tissue in large numbers distributed, with the result that the secreted proteases receive become.

Actinobacillus poses another problem actinomycetemcomitans, which affects around 30 percent of patients and for example with urinary tract infections, meningitis or osteomyelitis is associated with.

P. actinomycetemcomitans envelops itself with a capsule and is therefore largely complement and phagocytosis immune. Otherwise still belong Collagenases and fimbriae for his equipment. This consists of one Lipopolysaccharide with extremely strong bone resorbing activity and Ability, not negligibly affect the function of neutrophils.

A. actinomycetemcomitans also forms Membrane vesicles that spread some of these substances in the environment.

Bacteria love the community. The oral bacteria are no exception. Made of polymers Create carbohydrates and protein molecules they share common living space. Any bacteria that clings becomes the docking point for more germs. If the bacteria are not removed daily, they form a tough one Rubber that drives a wedge between the tooth and the flesh. Various Microbe species live together in this biofilm, their different ones eating habits make such communities profitable for everyone involved. The slimy accommodation also offers a certain amount to its residents Protection against adverse environmental influences, about attacks from the immune system or the brush. Even with antibiotics is much more difficult to manage these biotopes than free-living Bacteria.

People with profound periodontitis have an approximately eight by nine centimeter wound area in the mouth, informs the Center for Tooth, Oral and Maxillofacial Surgery of the University of Cologne. This wound area is populated with about 10 ¹¹ microorganisms. Whenever the inflamed periodontal is stressed, for example when eating or brushing teeth, bacteremia occurs. The microbes get through the small wounds into the bloodstream and thus into every corner of the body. And that is the reason why periodontitis does more than just damage the mouth. It is suspected of being able to trigger or fuel systemic diseases. The spectrum ranges from atherosclerosis to premature birth and diabetes.

Apparently, the settlers in the plaque are able to release various inflammation mediators, which means that more cholesterol adheres to the walls of the vessels and stimulates platelet aggregation. Studies by another working group suggest that they mislead blood clotting. For example, bring Streptococcus sanguis blood to clump. The researchers found that streptococcal protein is similar to human collagen, which plays a role in wound healing. The bacteria appear to be faking a wound on the immune system. The coagulation cascade is started and the blood vessel constricted. The bacteria prefer to settle on prostheses such as artificial heart valves or hip joints because they find conditions as good as those on teeth.

A quarter of premature babies in the United States cannot be explained by known triggers such as smoking, alcohol, or multiple pregnancies. It is known from animal experiments that bacterial toxins can cause premature birth. It is therefore reasonable to assume that even pregnant women with periodontitis are more likely to give birth to premature babies. Endotoxins are able to stimulate the production of labor-producing prostaglandins via cytokines. who had premature birth, higher blood levels of prostaglandin E2.Taking all studies together increases the risk of premature birth in pregnant women with periodontitis by a factor of seven.

There are still uncertainties regarding the relationship between periodontitis and diabetes. What is certain is that both type 1 and type 2 diabetes roughly double the risk of developing periodontitis. Conversely, periodontitis as an infectious disease seems to have an unfavorable effect on the diabetic's blood sugar control. How the two diseases actually influence has not yet been clarified. Lipopolysaccharides, which are produced by the periodontitis germs, probably cause the metabolic setting to falter.

There exist on this topic Many small sporadic examinations, but none of them general rules of conduct can be derived. At least they put one Near:

Diabetics should take care of their teeth have special attention and an inflammation of the gums immediately Seek medical.

Capturing the bacteria requires not a big one Carelessness. The caries trigger number one, Streptococcus mutans, is transmitted from mouth to mouth via saliva.

And so the germ between siblings and partners easily passed on. Studies from Finland and the USA has shown that up to sixty percent of children A. Get actinomycetemcomitans from her parents.

In principle, this applies to all people Prevention. After all, periodontitis after caries is probably that common chronic infectious disease in the world ( so.). Already a quarter of the kindergarten children have a person in need of treatment Caries.

According to the Society for Periodontology the gums are inflamed in around 80 to 90 percent of Germans, and In about a third of them, the bacteria have already done so dug deep into the gums that periodontitis manifests itself Has.

Oral and dental hygiene

Dental diseases are not fate. you did it with brush and mouthwash in the truest sense of the word itself in the hand, whether tooth decay, gingivitis and periodontitis have a chance.

With the right oral hygiene supplemented by half-yearly dental Care Dental diseases can be avoided 90 percent.

How does it look, however dental care, with the care of the toothbrush?

Now the toothbrush is not a medical device but a commodity for which the Cosmetics Regulation and parent the Food and Consumer Goods Act are responsible. In this respect, there are certainly no medical principles here. Yet It can be helpful when dealing with the toothbrush dental expertise is accompanied.

In fact, the toothbrush is named Lich more than a commodity, since it can come into contact with inflamed tissue, for example, and is above all the carrier of countless different microorganisms. Even a fork or spoon that is also placed in the oral cavity has a better hygiene status than a toothbrush (see above).

Of course, a clean toothbrush alone is not a "panacea". But a contaminated one Toothbrush is certainly not beneficial to health. Poor hygiene accelerates the onset of periodontitis.

"The be-all and end-all of dental health is to keep the number of germs in your mouth low right from the start to hold, "says e.g. Jörn Muehlenbeck, resident dentist in Hamburg.

GLASS and LARE (1986) pointed to toothbrushes other than the usual Oral cavity germs pathogenic and opportunistic microorganisms that not only can cause oral diseases but also in connection with special organ infections become. (However, it must be emphasized that the proof a potentially pathogenic type of germ does not come into being a specific disease). On experimental contaminated toothbrushes were survival rates oral bacteria species studied. BUNETEL et al. (2000) demonstrated that cultures of Porphyromonas gingivalis, Streptococcus mutans and Candida albicans to 0.2 to two percent after 24 hours their initial number of germs were reduced, the toothbrush type some impact on survival possessed. Herpes simplex viruses were still from GLASS and JENSEN (1988) seven days in active form. Starting from your own Experience in the chemistry laboratory, where word has long since got around that used toothbrushes for breeding of bacterial cultures, (Petri dishes with agar agar and nutrient solution e.g. with prints "inoculated" with used toothbrushes) my husband advised me Mr. Dipl.-Chem. Patrick Schmidt, currently a PhD student in the field of biological Chemistry / biochemistry at the University of Konstanz, but my toothbrush just go through regularly Boil out, clean with denture tablets or with ethanol. I have been doing this since then but have been asking why the m. E. obvious Need for proper oral hygiene, toothbrush hygiene so neglected. These solutions also appeared to me only as the second best choice, since it seemed more sensible to me, a concrete one To develop toothbrush cleaning product instead of resorting to emergency remedies. The denture cleaners are e.g. B. overdosed and it's difficult to break through in the middle. That too Boiling has disadvantages. This is how it deforms on some models Toothbrushes so that they are no longer usable.

General objections to separate toothbrush hygiene

Now one may object that some ingredients in toothpastes have an antimicrobial effectiveness have. In this way, all the surfactants common in toothpastes could be inhibited the growth of oral germs can be assigned (GERCKENS et al. 1992), also the combination of sodium laurysulfate with sodium monofluorophosphate or with sodium fluoride, the best inhibitory amine fluoride (BENTHIN et al. 1994). It seems to be superior to all active ingredients Combination of amine and tin fluoride. (SAXER, 1991).

Still, it was still, too with the use of these products, possible without any problems, from your home toothbrush Breeding colonies of bacteria, so that it seems obvious to me, here - not only in a private context - remedy to accomplish. All of the above options did not appear to me optimal Which) means could so be more suitable than the above Aids? What about other markets?

Which approaches exist it in the innovative markets? (U.S.A. and Japan)

Various toothbrush disinfectors are on the market in the U.S.A. Market:

The "self-sanitizing toothbrush", a self cleaning elaborate System, has not been very successful so far. Is on the market, however also a device in the toothbrush to be disinfected with ultraviolet light. Both the "self-sanitizing toothbrush" and the devices for disinfection are Products that have to be purchased and operated. In Japan are similar Products in the development phase. However, they do one costly and cumbersome Impression, so these options too appeared to me as not optimal. So I continued to search for suitable ones Alternatives.

Suitable alternatives

Cetylpyridinium chloride and chlorhexidine are considered the most effective and sustainable antiseptics to use in the mouth and throat with oral inflammation.

Chlorhexidine belongs to the chemical group of Until biguandine. It proves to be effective against a wide range pathogenic germs.

In high concentrations, 100 ppm, destroys chlorhexidine the cell membrane of the bacteria and thus has a bactericidal effect. A bacteriostatic, So the bacteria in their movement and multiplication "paralyzing" effect still occurs at only 0.11 ppm chlorhexidine. (Experiments are still running).

It is also of high substantivity and favors the length of its effect through electro static bonds and interactions with the proteins and glycoproteins of the saliva stored in the toothbrush and the plaque or the enamel hydroxyapatite.

Even at only 0.11 ppm chlorhexidine another bacteriostatic occurs, that is, the bacteria in their movement and increase "lame laying "effect.

An added surfactant could now in terms of comprehensive toothbrush hygiene doing for one Cleaning the bristles, the dye serves e.g. as an indicator solution for visual demarcation or similar and the flavorings can can be added in different flavors.

(E.g. peppermint, chamomile, lemon, Strawberry, orange, etc.). Manufacturing in gel form is also conceivable.

A specially made cleaning vessel (e.g. narrower than a normal toothed cup with a marking strip for exact dosing conceivable).

application

In this cetyl pyridinium chloride or chlorhexidine surfactant solution / (- Gel) the toothbrush should at least 20 minutes - or also about Night - for disinfection remain.

Then the brush should be under running Rinsed off water be and the solution discarded become.

Also rinse and dry the disinfection container.

This process should at least up to twice a week. Daily for viral diseases.

As a variant, I could see a development of Toothbrush cleaner tablets on the basis of denture cleaner tablets, which contain cleaning salts work, introduce.

This could be especially true for those allergic to chlorhexidine to be useful.

The exact dosage and Size of tablets still to be explored.

Why is there such a thing? Toothbrush cleaner Product not yet?

I can also be economical reasons imagine. possibly it's the fear of economic Losses. (Decline buying new toothbrushes). But this argument can be countered that disinfection a toothbrush does not help against bristle material wear.

economic Conclusion

So this is in a meaningful way to counter the development of a much more expensive and cumbersome "toothbrush cleaner station" (see above). Such a device as I have outlined will change a lot easier to sell to a wide audience. Toothbrush cleaner drops / gel (or for chlorhexidine allergy sufferers: toothbrush cleaner tabs based on on denture cleaning tabs in a different dosage size and another, "more youthful" presentation, see above) to make essentials more practical, more precise and cheaper to acquire.

Medical conclusion

"The A and 0 of dental health is to keep the number of germs in your mouth low right from the start to hold ". (see above)

In fact, the toothbrush is more than a commodity, as for example with inflamed tissue can come into contact and, above all, bearers of countless different ones Is microorganisms.

Cetylpyridinium chloride and chlorhexidine are considered the most effective and sustainable antiseptics.

This gave me the Idea for and the development of the toothbrush cleaning product outlined above.

Bibliography

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Claims (20)

Chemical toothbrush cleaning product, characterized in that it is produced on the basis of a cetylpyridinium chloride and or chlorhexidine mixture (derivatives included) optionally with dye and variable flavoring agents (eg E 124) and / or plant extracts. Chemical toothbrush cleaning product, thereby characterized that it is based on cleaning salts (e.g. based on sodium bicarbonate, sodium gluconate) optionally with dye and variable flavors and / or plant extracts (e.g. sage, Peppermint, mutton, menthol, tea tree). Chemical toothbrush cleaning product, thereby characterized that it is based on surfactants (including derivatives), (e.g. based on Igeponen, Mersolat, Gardinal, Tergitol optionally with Color and variable flavors and / or plant extracts is made. Chemical toothbrush cleaning product, thereby characterized that it is made on the basis of plant extracts / essential oils is. Chemical toothbrush cleaning product, thereby characterized that it is based on a hydrogen peroxide-catalase combination is made. Chemical toothbrush cleaning product, thereby characterized that it is based on alcohols (e.g. on ethyl alcohol) (including derivatives). Chemical toothbrush cleaning product, thereby characterized that it is based on acids (e.g. based on citric acid, salicylic acid) (derivatives included). Chemical toothbrush cleaning product, thereby characterized that it is made on the basis of tannins is. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is in the form of a cleaning gel. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is in the form of a soluble cleaning tablet. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is present as a cleaning drop. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is present as a cleaning solution. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is present as a cleaning foam. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is present as a soluble cleaning powder. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is used as cleaning granules is present. Chemical toothbrush cleaning product according to at least one of claims 1 to 8, because characterized by that it is available as a cleaning spray. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is present as a cleaning paste. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is a combined cleaning set together with a tooth cup with a radius of approx. 2 cm. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is a combined cleaning set together with a cleaning sponge. Chemical toothbrush cleaning product after at least one of the claims 1 to 8, characterized in that it is a combined cleaning set together with a cleaning brush in size one toothbrush is present.