DE1810845B2 - Liquid, pasty or solid, disinfecting and caries-preventing dental care product that is gentle on enamel - Google Patents

Description

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such a compound must be in the context of the 1 g of sodium fluoride contained in 50 ml of water Maintain the required pH values. The law of lyo- der in the dentifrice according to the invention detrope Rows would be applied accordingly and the retained addition using a mixing behavior influencing of the saliva for the above-mentioned foresight of both solutions of 1: 1 (volume basis) to use aisles. In particular, the Rhoda- 5 would have been preserved. The obtained Cerrhodamd will, as vorriidffekt of saliva and the related standing already indicated by the addition of the Fingers in the tissue that has been destroyed by caries or caries calcium chloride is stabilized and can endanger the patient Exploiting tissue. fluoride solution are introduced, whereby a stable

The object of the invention is therefore to create a complex formation and stabilization between cerium liquids, pasty or solid enamel stoves - 10 rhodanide, calcium chloride and sodium fluoride stoves, disinfecting and preventing tooth decay. Care product with a superior effect. This consists of solution I and solution II

The solution of this object is achieved according to the Erfiii- mixture is liquid manure registered for in the usual bases by a liquid, pasty or solid dental pasty or solid dentifrice, melting gentle, disinfecting and kariesver- i contain ₅ and foam-forming substances may hütendes dentifrice , characterized by the content of a sodium lauryl sulfoacetate stabilized with complex formation such as fatty alcohol sulfonate, triethanolamine lauryl sulfate, with a soluble calcium compound, in particular mixtures of alkyl sulfates and alkyl sulfonates calcium chloride, with O-AminoathyiaiKonoi cerrhodanids, which was carried into a sulfonated potassium salt is. 20 Lauric acid or fatty acid condensation products.

According to a particular embodiment, the preparation of the complex compound contains:

the dentifrice according to the invention foam level 1

Forming substances, in particular fatty alcohol sulfonates. _inn ,

S. Triethanolamine Lauryl Sulphate. a) 3.7 g cerium chloride (anhydrous) were, n 100 m

It can be seen that the dentifrice is dissolved in the warmth according to 35 distilled water de «Invention In addition to the usual components of solution, 2.3 g of ammonium thiocyanate were added one stabilized with formation of a complex with calcium chloride. The water was evaporated and the obtained Constant cerium oxide, which converts crystals of alcohol into a sodium fluoride solution and removes them contains. the. The resulting colorless fern-like crystals

_{About 100} moles of the cerium-thodanide complex were washed with ether and rinsed with 30 moles. It was dissolved in 100 ecm of water and contained in the end product. obtained a yield of about 4 g.

The cerrhodanide can be obtained, for example, by Um- b) 3.7 g cerium chloride (anhydrous) in 100 ml

Dissolution of Cerlll-Chlorid with Anrnioniumrhodanid hot distilled water. Then, according to Bender's equation, Z ^ S ^^ iSS ^ L ^ Z ^ l

CeCl, + 3 NH ₁ SCN = Ce (SCN) ₃ + 3 NH ₄ Cl «£ t 3 deposited. The crystals were made with

getting produced. Washed and rinsed from 372.6 g of ether are obtained. The yield was

CeCl ₃ · 7 H ₈ O and 228.6 g ammonium thiocyanate 314 g about 3.8 g.

Cerrhodanid. Instead of ammonium rhodanide, level 2

Potassium rhodanide can also be used: 40 "have _a connection

This gives 372.6 g of CeCl ₃ · 7 H ₂ O and 3.8 g of the after stage 1 a) or ^e '} *> f ^ * ^{en V} ™

001 4 _e Potassium Rhodanide 314 g Cerrhodanid. manure were in 100 ml ^ ¹¹¹ ? * ™ J ^ f '«? ° £

"With regard to d-conversion of rhodanides and 0.3 g calcium chloride added to this. This

Solution in harmless and absorbent compounds is referred to as solution I,

with the aid of the body's own catalytic precautions 45 B e i s ρ i e 1 1

The above connection was chosen, ♦ „„ „„ τ s _tlim> T were

about catalytic processes which are attributed to cerium S n.1 mer nachSufe 2 ^ «^ J ^ SSj ^

can be exploited (cf. publication on 5 ml of an ix-ungll by I

ηαΙίΑ6Γ, »L5 _S u ,, s _Tr 80 ecm

ZT, ' SlI ₀ BB de "Cerrhodanidkomplexes is a foam solution d" ^^ S "" erhaneje Cerrhcdan * in the L ₅ "u" _g an en *, A in ^ gea zu

da »» erhaneje Cerrhcdan * in the L ₅ »u„ _g an en *, A in ^ gea to de «ha, .J» M - = - ■

The complex is then added to a solution of sodium dentifrice. fluoride entered, whereby an improvement in the B e i s ρ i e 1 2

NND see ™ d zeig.e, "f ch as" d, ebe, de "Verbmdungen and ge '^^^ _a" f _chli Ellend 10gdestillier- ^ lÜSSSL proved look, fes water is added, the Ge _{S. mlm} tight «thoroughly

^ XSälÜSSSLtoM. proved s

based on the amount of about 4 g of Cerrhodanids, ™ ^Γ ™ ° Γ; _{di M was} homogeneous, outside

2 £: <S \

Paraffin oil added. A dentifrice was added received in the form of a toothpaste.

The dental care products according to the invention result in an improved absorption capacity of the fluoride compounds. The use of the ceric rhodanide complex also activates the PAodanase ferment. By the according to the invention Dental care products containing additives are swelling processes in the organism and in the gums which result in tissue friendliness and resorption capacity. The use of foaming Synthetic substances also results in an improvement in the cleaning effect without a Destruction of the tooth enamel is caused.

Comparative example

To demonstrate the technical superiority of the dentifrice according to the invention, the following was made Comparative experiment carried out using a known dentifrice according to British patent specification 6 54 472 was used for comparison.

In the practical implementation of the comparative experiment, the procedure of Example 2 was the Description of the invention repeated. In addition, this was exemplified in the aforementioned British patent 1 dentifrice described with the modification that this composition additionally 5 g a 2% sodium fluoride solution were added, used for the experiment.

1. Dentifrice according to the invention (Example 2):

5 g tragacanth solution (5%)
in addition were given
10 g of distilled water
15 g glycerin

Then 5 g complex solution according to stage 2 (invention)

5 g sodium fluoride solution (2%) 10 g distilled water

The following were then stirred in: 40 g of precipitated lime

6 g calcium phosphate
2 g medicinal soap
0.3 g saccharin

5 g peppermint oil
5 g paraffin oil

2. Dental care products according to British patent specification 6 54 472 (example 1):

45 g calcium sulfate
25 g tragacanth gel (3%)

5 g of the sodium salt of sulfonic acid of the condensation product of benzene and a chlorinated kerosene fraction, predominantly with a chain length of 12 carbon atoms, 5 g of sodium fluoride (2% solution), 9 g of glycerol
0.3 g saccharin
1.5 g peppermint oil
1.5 g of cerium nitrate [Ce (NO _a ) ₂ · 6 H ₂ O] water balance brought to 100 g.

A series of tests was carried out in which 10 teeth were placed in 10 test tubes became. The toothpaste to be examined was then placed in these test tubes and mixed with distilled Slurried water. The series of experiments with the dentifrice according to the invention (II) and the series of tests with the dentifrice according to British patent specification (I) were carried out under the same Conditions subjected to a period of observation, with 5 of the teeth introduced from the Test series I and II were removed after a period of 6 days, while the remaining 5 teeth were taken after an observation period of 14 days. The teeth from both experimental groups were checked for changes. The following results were obtained:

Test series f (according to British patent)

After an observation period of 6 days, there was slight crater formation on the plaques or on the tartar to be observed, but this did not lead to softening.

Test series II (according to the invention)

After an observation time of 6 days, the crater formation was deeper than in test series I. An den “5 surfaces of the plaques and the tartar were softened by a spatula were easily removable.

Test series I (according to British patent)

After an observation period of 14 days it was found that, although softening of the plaques and of the tartar were present but no decomposition had occurred.

Test series II (according to the invention)

After an observation period of 14 days, plaques and tartar were completely softened, decomposed and could easily be lifted off the tooth with a spatula. Subsequent investigations of the enamel and of the dentin canals produced the surprising finding that the penetrated cerrhodanide as Iron rhodanide can be detected in the typical red coloration in the enamel up to and including the dentinal canals was.

The above test results show that the dentifrice according to the present Invention over the dentifrice known from British patent specification 6 54 472 is substantially superior.

The test results are shown in the table below.

Dentifrices

Changes in plaques and tartar
6 days 14 days

According to
invention

According to
GB-PS

severe cratering and softening

slight crater formation, none
softening

complete softening, complete decomposition, easy to lift off

Crater formation, some softening, none
decomposition

Claims (2)

lenhydrates, consist. Furthermore, the tooth enamel contains patent claims: still small amounts of chemically bound fluorine calcium carbonate, magnesium phosphate and others 1. Liquid, paste or solid enamel salts. gentle, disinfecting and preventing caries 5 One kilogram of teeth contains around 1.8 g fluorine. Of the Dental care products characterized by the enamel of healthy teeth contains average the content of one with a soluble calcium 0.011%, the enamel of carious teeth on the other hand only compound, especially calcium chloride, below 0.0069% fluorine. Complex formation stabilized Cerrhodanids, which has been fixed in numerous research reports a sodium fluoride solution was entered. posed that fluorine has a much more favorable 2. Dentifrice according to claim 1, marked flussung on the tooth enamel and thus on the characterized by the content of foam-forming substances that has caries prevention when the fluorine compound is in in particular fatty alcohol sulfonates or trietha form of absorbable compounds or in easily nolamine laurylsuliaten. absorbable compounds or attachment compounds 15 fertilize is transferred. From other recently published publications results in the following: In the pathological In the genesis of dental caries, the composition of the saliva is of fundamental importance. It could The invention relates to a liquid, pasty or 20 can be demonstrated through experiments that Solid, disinfectant and in-vitro saliva that is gentle on the enamel, it is treated with acid-treated, anti-caries Dentifrices. brought together mineralized enamel, capable To clean and beautify the teeth, decalcified tissue must be remineralized. Because of are mainly toothpaste today, toothpastes based on this finding, it is likely that and tooth powder used, which mostly the following * 5 initial stage of caries of the saliva a certain amount Ingredients included: causes rebuilding of tooth enamel. It comes then 1. Abrasive and abrasive agents that are used to smooth ^the dental caries in the early onset of healing. The teeth are said to contribute to the remineralizing properties of saliva 2. Consistency means that give the toothpaste a soft one likely individually different. To give such a quality, ³ ° meralization could e.g. B. by adding fluorine Thickeners can be used, again being advised 4 *. antiseptic additives, it must be ensured that these fluorine additives are absorbed from Flavorings baren specific fluorine compounds exist have to. as well as special additives that the dentifrice 35 It is also known that rhodanide compounds give a certain desired effect. Are significant for dentistry insofar as Games for special such additions are: as the constant presence of these compounds in Turkish red oil normal saliva is important for the maintenance of teeth Emser or Karlsbader salt ^{and that caries has} been shown to contain rhodanide Pancreatin ⁴ ° reduces ^{neither 'm} saliva or does not exist Äiiimininminl-tatp (compare? Z. Ö. Dr. Arthui Speier. Zahnheil- / MununiumiaKiaie j ~ ™, *. «··«. · * Η * /> \ t ~ '■. 1 Magnesium salts künde, Zahntechnik, Berlin 1930). It is also known Lactic acid ^ ^ate * ^m saliva existing ferment rhodanese Means against Raue ^ erbelap such. B. _iK ' ^ie _f conversion of rhodanides into compatible and Benzyl alcohol 'receptive compounds with HiUe catalytic Vitaminzuvize enables processes. It was also found that Sodium perborate ^the saliva l ^ ch ingestion of opiates and nicotine Tannin is decreased. There is a ferment in saliva Myrrh ptyalin, which regulates the carbon dioxide metabolism. Alkali metal salts ⁵ ° Physiologically, the rhodium content of saliva is 10 mg%, which is sufficient under normal conditions Toothpastes with fluorine compounds are known. is (see textbook of pharmacology, Dr. med. Such toothpastes with a content of cerium Fritz E i c h h o 1 z, 1947). Salts and rhodanides are already known. In the testing of inorganic salts, the role in which the anions and cations act, in which the anions and cations act on, with such cerium compounds play an essential role in the testing of inorganic salts Effect Reason for their effect to be increased in a certain order by fluorides. It is sufficiently known that fluorine compounds have the effect of swelling or dissolving the formation of caries within the area of the teeth using gelatin, ie peptization. These hinder or restrict. Chemical additives to the peptization are also used therapeutically, today's toothpastes or dentifrices are used because it is possible to use easily accessible mucus with a view to the fact that the tooth enamel dissolves firmly adhering, viscous mucus and is a hard surface layer that represents a hardness of trapped germs a disinfectant M o hs of 7 has to make 96 to 97% of hydroxylic agents available,
apatite and small amounts, about 3.5%, of It is therefore necessary to improve the organic substances incorporated, whereby the fluorine compounds build up these to absorb the latter from structural proteins such as keratin and carbon-capable compounds. The overall structure