CZ20011796A3 - Use of N-substituted azabicycloalkane derivatives for treating central nervous system disorders - Google Patents
Use of N-substituted azabicycloalkane derivatives for treating central nervous system disorders Download PDFInfo
- Publication number
- CZ20011796A3 CZ20011796A3 CZ20011796A CZ20011796A CZ20011796A3 CZ 20011796 A3 CZ20011796 A3 CZ 20011796A3 CZ 20011796 A CZ20011796 A CZ 20011796A CZ 20011796 A CZ20011796 A CZ 20011796A CZ 20011796 A3 CZ20011796 A3 CZ 20011796A3
- Authority
- CZ
- Czechia
- Prior art keywords
- azabicyclo
- exo
- ethyl
- fluorophenyl
- heptyl
- Prior art date
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- 208000015114 central nervous system disease Diseases 0.000 title description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 8
- 206010012335 Dependence Diseases 0.000 claims abstract description 4
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims description 453
- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 229910052731 fluorine Inorganic materials 0.000 claims description 10
- 239000011737 fluorine Substances 0.000 claims description 10
- 125000001153 fluoro group Chemical group F* 0.000 claims description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 239000000460 chlorine Substances 0.000 claims description 8
- 229910052801 chlorine Inorganic materials 0.000 claims description 8
- 125000001624 naphthyl group Chemical group 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 125000001544 thienyl group Chemical group 0.000 claims description 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- 125000001246 bromo group Chemical group Br* 0.000 claims description 3
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims description 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 229940025084 amphetamine Drugs 0.000 claims description 2
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 2
- 125000001041 indolyl group Chemical group 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 125000005561 phenanthryl group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 125000004434 sulfur atom Chemical group 0.000 claims description 2
- 150000001721 carbon Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 125000005236 alkanoylamino group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 201000006145 cocaine dependence Diseases 0.000 claims 1
- 230000001955 cumulated effect Effects 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 183
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- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 47
- CVIBKISSHDMEKJ-UHFFFAOYSA-N 1-ethylquinazoline-2,4-dione Chemical compound C1=CC=C2C(=O)NC(=O)N(CC)C2=C1 CVIBKISSHDMEKJ-UHFFFAOYSA-N 0.000 description 43
- YJJOJBNUDCBRTM-UHFFFAOYSA-N 5-ethyl-3,6-dimethyl-2-(methylamino)pyrimidin-4-one Chemical compound CCC1=C(C)N=C(NC)N(C)C1=O YJJOJBNUDCBRTM-UHFFFAOYSA-N 0.000 description 28
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 28
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 26
- PCDHSSHKDZYLLI-UHFFFAOYSA-N butan-1-one Chemical compound CCC[C]=O PCDHSSHKDZYLLI-UHFFFAOYSA-N 0.000 description 26
- LETMUHYAZQNEQL-UHFFFAOYSA-N 2-ethyl-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one Chemical compound S1C(CC)=CN2C1=NC(C)=CC2=O LETMUHYAZQNEQL-UHFFFAOYSA-N 0.000 description 22
- IICQZTQZQSBHBY-UHFFFAOYSA-N non-2-ene Chemical compound CCCCCCC=CC IICQZTQZQSBHBY-UHFFFAOYSA-N 0.000 description 21
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 17
- YCBSHDKATAPNIA-UHFFFAOYSA-N non-3-ene Chemical compound CCCCCC=CCC YCBSHDKATAPNIA-UHFFFAOYSA-N 0.000 description 17
- RMHJJUOPOWPRBP-UHFFFAOYSA-N naphthalene-1-carboxamide Chemical compound C1=CC=C2C(C(=O)N)=CC=CC2=C1 RMHJJUOPOWPRBP-UHFFFAOYSA-N 0.000 description 16
- JRZJOMJEPLMPRA-UHFFFAOYSA-N 1-nonene Chemical compound CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 14
- ILPBINAXDRFYPL-UHFFFAOYSA-N 2-octene Chemical compound CCCCCC=CC ILPBINAXDRFYPL-UHFFFAOYSA-N 0.000 description 14
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 13
- VSMXLKGFTKFOSB-UHFFFAOYSA-N 1-ethyl-3h-indol-2-one Chemical compound C1=CC=C2N(CC)C(=O)CC2=C1 VSMXLKGFTKFOSB-UHFFFAOYSA-N 0.000 description 10
- CIGBERQUNYDMHH-UHFFFAOYSA-N 1H-indene-3-carboxamide Chemical compound C1=CC=C2C(C(=O)N)=CCC2=C1 CIGBERQUNYDMHH-UHFFFAOYSA-N 0.000 description 10
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 10
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- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
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- MGDYXRLSFHXKEL-UHFFFAOYSA-N 1-propylquinazoline-2,4-dione Chemical compound C1=CC=C2C(=O)NC(=O)N(CCC)C2=C1 MGDYXRLSFHXKEL-UHFFFAOYSA-N 0.000 description 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 1
- VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1h-indole-2-carboxamide Chemical compound C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 description 1
- JQPYINKVAWEQDQ-UHFFFAOYSA-N 1h-pyrido[2,3-d]pyrimidine-2,4-dione Chemical compound C1=CC=C2C(=O)NC(=O)NC2=N1 JQPYINKVAWEQDQ-UHFFFAOYSA-N 0.000 description 1
- GVYVHZKTSVDMNT-UHFFFAOYSA-N 2,3-dihydro-1,2-benzothiazole 1,1-dioxide Chemical compound C1=CC=C2S(=O)(=O)NCC2=C1 GVYVHZKTSVDMNT-UHFFFAOYSA-N 0.000 description 1
- HMOMINHDSCYPKH-UHFFFAOYSA-N 2,5-dimethyl-1h-pyrimidin-6-one Chemical compound CC1=NC=C(C)C(=O)N1 HMOMINHDSCYPKH-UHFFFAOYSA-N 0.000 description 1
- BKIGMBKKKHQCGW-UHFFFAOYSA-N 2-amino-3,5-diethyl-6-methylpyrimidin-4-one Chemical compound CCC1=C(C)N=C(N)N(CC)C1=O BKIGMBKKKHQCGW-UHFFFAOYSA-N 0.000 description 1
- ZBZFHKRVXVKBOU-UHFFFAOYSA-N 2-amino-3-ethyl-6-methylpyrimidin-4-one Chemical compound CCN1C(N)=NC(C)=CC1=O ZBZFHKRVXVKBOU-UHFFFAOYSA-N 0.000 description 1
- ASSKVPFEZFQQNQ-UHFFFAOYSA-N 2-benzoxazolinone Chemical compound C1=CC=C2OC(O)=NC2=C1 ASSKVPFEZFQQNQ-UHFFFAOYSA-N 0.000 description 1
- QHCCOYAKYCWDOJ-UHFFFAOYSA-N 2-ethyl-1h-benzimidazole Chemical compound C1=CC=C2NC(CC)=NC2=C1 QHCCOYAKYCWDOJ-UHFFFAOYSA-N 0.000 description 1
- BYXQNAWQFGHXDQ-UHFFFAOYSA-N 2-ethyl-7-methyl-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-5-one Chemical compound C(C)C1CN2C(=NC(=CC2=O)C)S1 BYXQNAWQFGHXDQ-UHFFFAOYSA-N 0.000 description 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 description 1
- MPFMDBDLIURSOD-UHFFFAOYSA-N 2-methyl-1h-quinazoline-4-thione Chemical compound C1=CC=C2NC(C)=NC(=S)C2=C1 MPFMDBDLIURSOD-UHFFFAOYSA-N 0.000 description 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 1
- IZTRYCWBEAGXLS-UHFFFAOYSA-N 3,5-diethyl-6-methyl-2-(methylamino)pyrimidin-4-one Chemical compound C(C)C=1C(N(C(=NC=1C)NC)CC)=O IZTRYCWBEAGXLS-UHFFFAOYSA-N 0.000 description 1
- OGFFRHQCFMCVIQ-UHFFFAOYSA-N 3-ethyl-1,6-dimethylpyrimidine-2,4-dione Chemical compound CCN1C(=O)C=C(C)N(C)C1=O OGFFRHQCFMCVIQ-UHFFFAOYSA-N 0.000 description 1
- BPHHIFDIGVENEC-UHFFFAOYSA-N 3-ethyl-1-methylquinazoline-2,4-dione Chemical compound C1=CC=C2C(=O)N(CC)C(=O)N(C)C2=C1 BPHHIFDIGVENEC-UHFFFAOYSA-N 0.000 description 1
- DFNXHNBRQIABNY-UHFFFAOYSA-N 3-ethyl-2,6,8-trimethylpyrido[1,2-a]pyrimidin-4-one Chemical compound C1=C(C)C=C(C)N2C(=O)C(CC)=C(C)N=C21 DFNXHNBRQIABNY-UHFFFAOYSA-N 0.000 description 1
- RCSYPYSJSNRLSK-UHFFFAOYSA-N 3-ethyl-2,6-dimethylpyrido[1,2-a]pyrimidin-4-one Chemical compound C1=CC=C(C)N2C(=O)C(CC)=C(C)N=C21 RCSYPYSJSNRLSK-UHFFFAOYSA-N 0.000 description 1
- AAIZLBJGGDQXFD-UHFFFAOYSA-N 3-ethyl-2,8-dimethylpyrido[1,2-a]pyrimidin-4-one Chemical compound C1=C(C)C=CN2C(=O)C(CC)=C(C)N=C21 AAIZLBJGGDQXFD-UHFFFAOYSA-N 0.000 description 1
- XPADSOPDVUAYGG-UHFFFAOYSA-N 3-ethyl-2-methoxyquinazolin-4-one Chemical compound C(C)N1C(=NC2=CC=CC=C2C1=O)OC XPADSOPDVUAYGG-UHFFFAOYSA-N 0.000 description 1
- GJUCKMAZGUZQMM-UHFFFAOYSA-N 3-ethyl-2-methyl-7,8-dihydro-6h-pyrrolo[1,2-a]pyrimidin-4-one Chemical compound O=C1C(CC)=C(C)N=C2CCCN21 GJUCKMAZGUZQMM-UHFFFAOYSA-N 0.000 description 1
- QZFJPVDLQICTAW-UHFFFAOYSA-N 3-ethyl-2-methylpyrimido[1,2-a]pyrimidin-4-one Chemical compound C(C)C1=C(N=C2N(C1=O)C=CC=N2)C QZFJPVDLQICTAW-UHFFFAOYSA-N 0.000 description 1
- UMQKDYHNDQNEBD-UHFFFAOYSA-N 3-ethyl-2-methylquinazolin-4-one Chemical compound C1=CC=C2C(=O)N(CC)C(C)=NC2=C1 UMQKDYHNDQNEBD-UHFFFAOYSA-N 0.000 description 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
- AYESCWWMKKCHKO-UHFFFAOYSA-N 5-ethyl-1,3,6-trimethylpyrimidine-2,4-dione Chemical compound CCC1=C(C)N(C)C(=O)N(C)C1=O AYESCWWMKKCHKO-UHFFFAOYSA-N 0.000 description 1
- JCSPMARRNGTFMN-UHFFFAOYSA-N 5-ethyl-4-methoxy-N,6-dimethylpyrimidin-2-amine Chemical compound C(C)C=1C(=NC(=NC=1C)NC)OC JCSPMARRNGTFMN-UHFFFAOYSA-N 0.000 description 1
- POHMUYGBYJQDCN-UHFFFAOYSA-N 5-heptan-3-yl-2,4-dimethyl-1H-pyrimidin-6-one Chemical compound CCC(CCCC)C=1C(=NC(=NC=1C)C)O POHMUYGBYJQDCN-UHFFFAOYSA-N 0.000 description 1
- ORGZMSYMWCSDIZ-UHFFFAOYSA-N 6,8-dichloro-1-ethylquinazoline-2,4-dione Chemical compound C1=C(Cl)C=C2C(=O)NC(=O)N(CC)C2=C1Cl ORGZMSYMWCSDIZ-UHFFFAOYSA-N 0.000 description 1
- OSRPAHRCPIGTJZ-UHFFFAOYSA-N 6-amino-1-ethylquinazoline-2,4-dione Chemical compound C1=C(N)C=C2C(=O)NC(=O)N(CC)C2=C1 OSRPAHRCPIGTJZ-UHFFFAOYSA-N 0.000 description 1
- ZXGAVIXWLAXEGE-UHFFFAOYSA-N 6-amino-3-ethyl-1-methylpyrimidine-2,4-dione Chemical compound CCN1C(=O)C=C(N)N(C)C1=O ZXGAVIXWLAXEGE-UHFFFAOYSA-N 0.000 description 1
- KOJIUFIJUGTHDB-UHFFFAOYSA-N 7-amino-1-ethylquinazoline-2,4-dione Chemical compound C(C)N1C(NC(C2=CC=C(C=C12)N)=O)=O KOJIUFIJUGTHDB-UHFFFAOYSA-N 0.000 description 1
- UELASANXXMJSKG-UHFFFAOYSA-N 7-chloro-1-ethylquinazoline-2,4-dione Chemical compound ClC1=CC=C2C(=O)NC(=O)N(CC)C2=C1 UELASANXXMJSKG-UHFFFAOYSA-N 0.000 description 1
- NYBDRQJPWDONJD-UHFFFAOYSA-N 7-chloro-3-ethyl-2-methylpyrimido[1,2-a]pyrimidin-4-one Chemical compound C(C)C1=C(N=C2N(C1=O)C=C(C=N2)Cl)C NYBDRQJPWDONJD-UHFFFAOYSA-N 0.000 description 1
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- IJXWKONOCIMIDP-UHFFFAOYSA-N Cl.Cl.C(C)C1=C(N=C2N(C1=O)C=CC=C2)C Chemical compound Cl.Cl.C(C)C1=C(N=C2N(C1=O)C=CC=C2)C IJXWKONOCIMIDP-UHFFFAOYSA-N 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000004300 GABA-A Receptors Human genes 0.000 description 1
- 108090000839 GABA-A Receptors Proteins 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- QIOZLISABUUKJY-UHFFFAOYSA-N Thiobenzamide Chemical compound NC(=S)C1=CC=CC=C1 QIOZLISABUUKJY-UHFFFAOYSA-N 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- RJTJVVYSTUQWNI-UHFFFAOYSA-N beta-ethyl naphthalene Natural products C1=CC=CC2=CC(CC)=CC=C21 RJTJVVYSTUQWNI-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- XBCXJKGHPABGSD-UHFFFAOYSA-N methyluracil Natural products CN1C=CC(=O)NC1=O XBCXJKGHPABGSD-UHFFFAOYSA-N 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 125000005187 nonenyl group Chemical group C(=CCCCCCCC)* 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical compound CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
- FFRYUAVNPBUEIC-UHFFFAOYSA-N quinoxalin-2-ol Chemical compound C1=CC=CC2=NC(O)=CN=C21 FFRYUAVNPBUEIC-UHFFFAOYSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229960000581 salicylamide Drugs 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- IOHCGRJBQIIEOU-UHFFFAOYSA-N thiazin-6-one Chemical compound O=C1C=CC=NS1 IOHCGRJBQIIEOU-UHFFFAOYSA-N 0.000 description 1
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Použití N-substituovaných azabicykloalkanových derivátů pro léčení poruch centrálního nervového systémuUse of N-substituted azabicycloalkane derivatives for the treatment of central nervous system disorders
Oblast technikyTechnical field
Tento vynález se týká použití N-substituovaných azabicykloalkanových derivátů pro léčení poruch centrálního nervového systému.The present invention relates to the use of N-substituted azabicycloalkane derivatives for the treatment of central nervous system disorders.
Dosavadní stav technikyBACKGROUND OF THE INVENTION
N-Substituované azabicykloalkanové dervity jsou již známé jako neuroleptika (WO 95/13279, WO 95/15327, WO 96/04272, US patent č. 5 475 105, US patent č. 5 521 209, US patent č. 5 616 705 a US patent č. 5 753 690). Bylo také nalezeno, že tyto substance jsou také vhodné pro potlačování návykových poruch a jiných poruch centrálního nervového systému.N-substituted azabicycloalkane dervites are already known as neuroleptics (WO 95/13279, WO 95/15327, WO 96/04272, US Patent No. 5,475,105, US Patent No. 5,521,209, US Patent No. 5,616,705, and U.S. Patent No. 5,753,690). It has also been found that these substances are also useful for suppressing addictive disorders and other central nervous system disorders.
Podstata vynálezuSUMMARY OF THE INVENTION
Tento vynález skýtá použití N-substituovanýchThe present invention provides the use of N-substituted
3-azabicykloalkanových derivátů obecného vzorce I3-azabicycloalkane derivatives of the general formula I
ve kterém znamená 4-, 5 - nebo 6-členný kruh, který může obsahovat dvojnou vazbu,wherein it is a 4-, 5- or 6-membered ring which may contain a double bond,
R1 je fenylová, naftylová, fenanthrylová nebo thienylová skupina, v každém případě nesubstituovaná nebo mononebo disubstituovaná atomy halogenu, alkylovými skupinami s 1 až 4 atomy uhlíku, trifluormethylovými skupinami, hydroxyskupinami, alkoxyskupinami s 1 až 4 atomy uhlíku, aminoskupinami, monomethylaminoskupinami, dimethylaminoskupinami, kyanoskupinami nebo nitroskupinami, n je číslo 0, 1, 2, 3 nebo 4 aR 1 is phenyl, naphthyl, phenanthryl or thienyl, in each case unsubstituted or mono- or disubstituted with halogen atoms, C 1 -C 4 alkyl, trifluoromethyl, hydroxy, C 1 -C 4 alkoxy, amino, monomethylamino, dimethylamino n is 0, 1, 2, 3 or 4; and cyano or nitro;
R2 je naftylová skupina, která je nesubstituovaná nebo substituovaná jedním nebo dvěma atomy halogenu, nebo jedním z následujících zbytkůR 2 is naphthyl which is unsubstituted or substituted by one or two halogen atoms, or one of the following radicals
kde r3 je atom vodíku, hydroxyskupina nebo fenylová skupina, která je nesubstituovaná nebo substituovaná atomem fluoru, chloru nebo bromu,wherein r 3 is a hydrogen atom, a hydroxy group or a phenyl group which is unsubstituted or substituted by a fluorine, chlorine or bromine atom,
R4 je atom vodíku neboR 4 is hydrogen or
R3 a R4 tvoří dohromady atom kyslíku,R 3 and R 4 together form an oxygen atom,
R5 je fenylová, naftylová nebo thienylová skupina, každá z nich je nesubstituovaná nebo mono- nebo disubstituovaná atomy fluoru, chloru nebo bromu, nebo hydroxyskupinami, nitroskupinami, aminoskupinami, alkanoylaminoskupinami s 1 až 4 atomy uhlíku, alkylaminoskupinami s 1 až 4 atomy uhlíku, alkylovými skupinami s 1 až 4 atomy uhlíku nebo methoxyskupinami,R 5 is phenyl, naphthyl or thienyl, each of which is unsubstituted or mono- or disubstituted by fluorine, chlorine or bromine atoms, or by hydroxy, nitro, amino, C 1 -C 4 alkanoylamino, C 1 -C 4 alkylamino, (C 1 -C 4) alkyl or methoxy
R6 je atom vodíku nebo methylová skupina,R 6 is a hydrogen atom or a methyl group,
R7 je fenylová, naftylová, benzofurylová, benzo • · thienylová, thienylová, indolylová, N-methylindolylová nebo indenylová skupina, v každém případě nesubstituovaná nebo mono- nebo disubstituovaná atomy fluoru, chloru nebo bromu, nebo alkylovými skupinami s 1 až 4 atomy uhlíku, hydroxyskupinami, methoxyskupinami, nitroskupinami, kyanoskupinami, trifluormethylovými skupinami, aminoskupinami, dialkylaminoskupinami s 1 až 4 atomy uhlíku v každé alkylové části, nebo je cykloalkylová skupina se 3 až 7 atomy uhlíku,R 7 is phenyl, naphthyl, benzofuryl, benzothienyl, thienyl, thienyl, indolyl, N-methylindolyl or indenyl, in each case unsubstituted or mono- or disubstituted with fluorine, chlorine or bromine atoms or C 1 -C 4 alkyl groups , hydroxy, methoxy, nitro, cyano, trifluoromethyl, amino, dialkylamino of 1 to 4 carbon atoms in each alkyl moiety, or is cycloalkyl of 3 to 7 carbon atoms,
R8 je atom vodíku, atom fluoru nebo atom chloru, alkylová skupina s 1 až 4 atomy uhlíku, methoxyskupina nebo aminoskupina,R 8 is hydrogen, fluoro or chloro, C 1 -C 4 alkyl, methoxy or amino,
R9 je atom vodíku nebo methylová skupina aR 9 is hydrogen or methyl and
R10 je atom vodíku nebo methylová skupina nebo r9 a R10 dohromady s atomem uhlíku kruhu tvoří spirocyklopropanový kruh,R 10 is a hydrogen atom or a methyl group, or R 9 and R 10 together with the ring carbon atom form a spirocyclopropane ring,
R11 je atom vodíku, hydroxyskupina, alkylová skupina s 1 až 4 atomy uhlíku nebo alkoxyskupina s 1 až 4 atomy uhlíku, nebo dohromady se sousedícím atomem uhlíku tvoří skupinu vzorce C=0- nebo skupinu vzorce C=S-,R ( 11) is hydrogen, hydroxy, (C1-C4) -alkyl or (C1-C4) alkoxy, or together with an adjacent carbon atom forms a group of formula C = O- or a group of formula C = S-,
X a Y jsou atomy uhlíku, skupiny vzorce CH, CH2, NH nebo alkyl-N-skupina s 1 až 4 atomy uhlíku nebo atomy dusíku,X and Y are carbon atoms, CH, CH 2 , NH or C 1-4 alkyl or N-alkyl,
Z je přímá vazba, skupina vzorce CO, skupina vzorce • 9Z is a direct bond, a group of formula CO, a group of formula • 9
CS, skupina vzorce CH nebo skupina vzorce CH2, kde atom vodíku může být nahrazen hydroxyskupinou, aminoskupinou, alkoxyskupinou s 1 až 4 atomy uhlíku nebo atomem halogenu, aCS, CH or CH 2 , wherein the hydrogen atom may be replaced by hydroxy, amino, C 1 -C 4 alkoxy or halogen, and
A je atom vodíku, hydroxyskupina, aminoskupina, merkaptoskupina, alkylaminoskupina s 1 až 4 atomy uhlíku, dialkylaminoskupina s 1 až 4 atomy uhlíku v každé alkylové části, alkylthioskupina s 1 až 4 atomy uhlíku nebo alkoxyskupina s 1 až 4 atomy uhlíku, nebo dohromady se sousedícím atomem uhlíku tvoří skupinu vzorce C=0, neboA is hydrogen, hydroxy, amino, mercapto, C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino in each alkyl moiety, C 1 -C 4 alkylthio or C 1 -C 4 alkoxy, or together an adjacent carbon atom forms a group of formula C = O, or
A je na Y-vázaná alkylenová skupina se 3 nebo 4 atomy uhlíku, která může obsahovat jednu nebo dvě nekumulované dvojné vazby a kde jedna ze skupin CH nebo CH2 může být nahrazena atomem dusíku nebo atomem síry nebo skupinou NH nebo skupinou N-CH3 a kde kruh je bud' monosubstituován atomem fluoru, chloru nebo methylovou skupinou, methoxyskupinou, nitroskupinou nebo aminoskupinou, nebo v případě benzenového kruhu, tento kruh může být mono-, di- nebo trisubstituován atomy fluoru nebo chloru nebo methylovými skupinami, trifluormethylovými skupinami, nitroskupinami, hydroxyskupinami, methoxyskupinami, aminoskupinami, monomethylovými skupinami nebo dimethylaminoskupinami, a kde kruh obsahující X, Y a Z na atomu dusíku v poloze 1 může nést alkylovou skupinu s 1 až 4 atomy uhlíku, allylovou skupinu nebo benzylovou skupinu a může obsahovat 1 až 3 nekumulované dvojné vazby,A is a Y-linked alkylene group having 3 or 4 carbon atoms, which may contain one or two non-accumulated double bonds and wherein one of the CH or CH 2 groups may be replaced by a nitrogen or sulfur atom or an NH group or an N-CH 3 group and wherein the ring is either monosubstituted by fluorine, chlorine or methyl, methoxy, nitro or amino, or in the case of a benzene ring, the ring may be mono-, di- or trisubstituted by fluorine or chlorine atoms or methyl, trifluoromethyl, nitro , hydroxy, methoxy, amino, monomethyl or dimethylamino groups, and wherein the ring containing X, Y and Z at the 1-position nitrogen atom may carry an alkyl group having 1 to 4 carbon atoms, an allyl group or a benzyl group and may contain 1 to 3 double bonds,
a jejich solí s fyziologicky přijatelnými kyselinami, pro výrobu léčiva pro potlačování návyku, pro léčení poruch koncentrace (poruchy nedostatku pozornosti), hyperaktivity u dětí (poruchy nedostatku pozornosti v důsledku hyperaktivity) , učení a ochablosti paměti (poškození kognitivní funkce).and their salts with physiologically acceptable acids, for the manufacture of a medicament for suppressing addiction, for treating concentration disorders (attention deficit disorders), hyperactivity in children (attention deficit hyperactivity disorders), learning and memory weakness (cognitive impairment).
Použití podle tohoto vynálezu se týká všech návykových poruch, pokud jsou způsobeny odejmutím substance nebo jiných návykových poruch, jako například závislosti na hrách. Substancemi vytvářejícími návyk mohou být:The use according to the invention relates to all addictive disorders as far as they are caused by the withdrawal of a substance or other addictive disorders, such as addiction to games. Addictive substances can be:
opioidy, například morfin nebo heroin, nikotin, alkohol, substance, které vzájemně reagují s komplexem benzodiazepinového receptoru, sedativy nebo transkvilizéry, například benzodiazepiny.opioids, for example morphine or heroin, nicotine, alcohol, substances that interact with a benzodiazepine receptor complex, sedatives or transquillizers, for example benzodiazepines.
Možné substance vytvářející návyk podle tohoto vynálezu jsou zvláště kokain nebo amfetamin a substance podobné amfetaminu.Possible addictive substances according to the invention are in particular cocaine or amphetamine and amphetamine-like substances.
Sloučeniny obecného vzorce I se mohou používat jak ve formě svých racemátů, tak svých optických isomerů.The compounds of the formula I can be used in the form of both their racemates and their optical isomers.
Pro nové indikace se sloučeniny mohou podávat obvyklým způsobem orálně nebo parenterálně, intravenózně nebo intramuskulárně.For new indications, the compounds may be administered orally or parenterally, intravenously or intramuscularly in the usual manner.
Dávka závisí na věku, stavu a hmotnosti pacienta a na typu podávání. Obecně denní dávka aktivní sloučeniny je mezi • · asi 1 a 100 mg/kg tělesné hmotnosti v případě orálního podávání a mezi 0,1 a 10 mg/kg tělesné hmotnosti v případě parenterálního podávání.The dose depends on the age, condition and weight of the patient and the type of administration. Generally, the daily dose of active compound is between about 1 and 100 mg / kg body weight for oral administration and between 0.1 and 10 mg / kg body weight for parenteral administration.
Sloučeniny se mohou používat ve formách obvyklých pro farmaceutické podání, v pevné nebo kapalné formě, například jako tablety, tablety povlečené filmem, kapsle, prášky, granule, tablety povlečné cukrem, čípky, roztoky, masti, krémy a spreje. Ty se vyrábějí obvyklým způsobem. K tomuto účelu se aktivní sloučeniny mohou zpracovávat s obvyklými farmaceutickými pomocnými látkami, jako jsou pojivá tablet, plniva, konzervační látky, látky napomáhající rozpadu tablet, regulátory toku, plastifikátory, zvlhčovači látky, dispergátory, emulgátory, rozpouštědla, látky zpomalující uvolňování, antioxidanty a/nebo propelenty (srovnej H. Sucker a kol., Pharmazeutische Technologie, Thieme-Verlag, Stuttgart (1978)). Výsledné formy pro podávání obvykle obsahují aktivní sloučeninu v množství od 1 do 99 % hmotnostních.The compounds may be used in forms customary for pharmaceutical administration, in solid or liquid form, for example, as tablets, film-coated tablets, capsules, powders, granules, sugar-coated tablets, suppositories, solutions, ointments, creams and sprays. These are produced in the usual manner. For this purpose, the active compounds can be formulated with conventional pharmaceutical auxiliaries such as binding tablets, fillers, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, release retardants, antioxidants and / or or propellants (cf. H. Sucker et al., Pharmazeutische Technologie, Thieme-Verlag, Stuttgart (1978)). The resulting administration forms usually contain the active compound in an amount of from 1 to 99% by weight.
Příklady provedení vynálezuDETAILED DESCRIPTION OF THE INVENTION
Následující sloučeniny se mohou uvést jako příklady sloučenin obecného vzorce I.The following compounds may be exemplified as compounds of formula I.
1. 1-(4-fluorfenyl)-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-1. 1- (4-Fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] -
-(3-heptyl)]butan-l-on,- (3-heptyl)] butan-1-one,
2. 1-fenyl-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-hepty1) ] butan-1-on,2. 1-phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
3. 1-(4-fluorfenyl)-4-[exo-6,7-difenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,3. 1- (4-Fluorophenyl) -4- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
. 1-(4-fluorfenyl)-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan,. 1- (4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butane,
5. l-fenyl-2-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethan-l-on,5. 1-phenyl-2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethan-1-one;
6. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-3-azabicyklo- [3,2,0]-(3-hepty1)]butan,6. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butane;
7. l-(4-fluorfenyl)-4-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,7. 1- (4-Fluorophenyl) -4- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;
8. l-(4-fluorfenyl)-4-[exo-6-o-fluorfenyl-3-azabicyklo- [3,2,0]-(3-heptyl)]butan-l-on,8. 1- (4-Fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;
9. 1-(4-fluorfenyl)-4-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,9. 1- (4-Fluorophenyl) -4- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
10. 1-(4-fluorfenyl)-4-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,10. 1- (4-Fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
11. 1-(4-fluorfenyl)-4-[exo-6-p-methoxyfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,11. 1- (4-Fluorophenyl) -4- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
12. l-(4-fluorfenyl)-4-[exo-6-m,p-dichlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,12. 1- (4-Fluorophenyl) -4- [exo-6-m, p-dichlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
13. l-(4-fluorfenyl)-4-[exo-6-m,p-dimethoxyfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]butan-l-on,13. 1- (4-Fluorophenyl) -4- [exo-6-m, p-dimethoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
14. l-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on, • ·14. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
15. 1-fenyl-4~[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]butan-l-on,15. 1-phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
16. l-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-3-azabicyklo- [3,2,0]-(3-hepty1)]butan,16. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butane;
17. l-(4-fluorfenyl)-4-[exo-6-p-nitrofenyl-3-azabicyklo[3,2,0]-(3-hepty1)]butan-l-on,17. 1- (4-Fluorophenyl) -4- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
18. 1-(4-fluorfenyl)-4-[exo-6-m-nitrofenyl-3-azabicyklo- [3,2,0]-(3-heptyl)]butan-l-on,18. 1- (4-Fluorophenyl) -4- [exo-6-m-nitrophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;
19. 1-(4-fluorfenyl)-4-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,19. 1- (4-Fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
20. 1-(4-fluorfenyl)-4-[exo-6-p-kyanfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,20. 1- (4-Fluorophenyl) -4- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;
21. 1-(4-fluorfenyl)-4-[exo-6-(3-thienyl)-3-azabicyklo— [3,2,0]-(3-heptyl)]butan-l-on,21. 1- (4-Fluorophenyl) -4- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;
22. l-(4-fluorfenyl)-4-[exo-6-(3-pyridyl)-3-azabicyklo- [3,2,0]-(3-heptyl)]butan-l-on,22. 1- (4-Fluorophenyl) -4- [exo-6- (3-pyridyl) -3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;
23. 1-(4-fluorfenyl)-3-[exo-6-p-fluorfenyl-3-azabicyklo- [3,2,0]-(3-heptyl)]propan-l-on,23. 1- (4-Fluorophenyl) -3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] propan-1-one;
24. 1-(bis-4-fluorfenyl)-4-[exo-6-p-f luorf enyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan,24. 1- (bis-4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butane;
25. 1-(bis-4-fluorfenyl)-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-hepty1)]butan,25. 1- (bis-4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butane;
26. 1-(4-fluorfenyl)-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,26. 1- (4-Fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;
27. l-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,27. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;
28. 1- (4-fluorfenyl)-4-[exo-6,7-difenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,28. 1- (4-Fluorophenyl) -4- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;
29. l-fenyl-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,29. 1-phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;
30. l-fenyl-4-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,30. 1-phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;
31. 1-(4-fluorfenyl)-4-[exo-6-o-fluorfenyl-3-azabicyklo- [3,2,0]-(3-heptyl)]butan-l-ol,31. 1- (4-Fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-ol;
32. 1-(4-fluorfenyl)-4-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,32. 1- (4-Fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-ol;
33. 1-(4-fluorfenyl)-4-[exo-6-p-trifluormethylfenyl-3azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,33. 1- (4-Fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-ol;
34. l-(4-fluorfenyl)-4-[exo-6-p-aminofenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,34. 1- (4-Fluorophenyl) -4- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;
35. N-[3-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]propyl]-4-fluorbenzamid,35. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -4-fluorobenzamide;
36. N-[3-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]propyl]benzamid,36. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] propyl] benzamide;
37. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl)-4-fluorbenzamid,37. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl) -4-fluorobenzamide;
38. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl)benzamid,38. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl) benzamide,
39. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-N-methyl-4-fluorbenzamid,39. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -N-methyl-4-fluorobenzamide,
40. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-N-methylbenzamid,40. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -N-methylbenzamide,
41. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl)-N-methyl-4-isopropylbenzamid,41. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -N-methyl-4-isopropylbenzamide,
42. N-[3-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl]-4-chlorbenzamid,42. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -4-chlorobenzamide,
43. N-[2-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-43. N- [2- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3,2,0] -
-(3-heptyl)]ethyl)-4-chlorbenzamid,- (3-heptyl) ethyl) -4-chlorobenzamide,
44. N-[3-[exo-6—fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl]-3-methoxybenzamid,44. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -3-methoxybenzamide;
45. N-[3-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]propylJ-3-nitrobenzamid,45. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -3-nitrobenzamide,
46. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl)-4-fluorbenzamid,46. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] propyl] -4-fluorobenzamide,
47. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))propyl]benzamid,47. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) propyl] benzamide,
48. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-4-fluorbenzamid,48. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -4-fluorobenzamide,
49. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl]benzamid,49. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] benzamide,
50. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-N-methyl-4-fluorbenzamid,50. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -N-methyl-4-fluorobenzamide,
51. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-N-methylbenzamid,51. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -N-methylbenzamide;
52. N—[2 —[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl]-N-methyl-4-isopropylbenzamid,52. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -N-methyl-4-isopropylbenzamide,
53. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl]-4-chlorbenzamid,53. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -4-chlorobenzamide,
54. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]propyl]-3-methoxybenzamid,54. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -3-methoxybenzamide,
55. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))propyl]-3-nitrobenzamid,55. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) propyl] -3-nitrobenzamide,
56. N-[2-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl]-4-chlorbenzamid,56. N- [2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -4-chlorobenzamide;
57. N-[2-(exo-6-o-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-4-chlorbenzamid,57. N- [2- (exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)) ethyl] -4-chlorobenzamide,
58. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-2-hydroxybenzamid,58. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2-hydroxybenzamide;
• ·• ·
59. N-[2-[exo-6-m-hydroxyfenyl-3-azabicyklo[3,2,0]—(3— -hepty1)]ethyl]-4-chlorbenzamid,59. N- [2- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-chlorobenzamide,
60. exo-3-n-butyl-6-fenyl-3-azabicyklo[3,2,0]heptan,60. exo-3-n-butyl-6-phenyl-3-azabicyclo [3.2.0] heptane,
61. exo-3-methyl-6-fenyl-3-azabicyklo[3,2,0]heptan,61. exo-3-methyl-6-phenyl-3-azabicyclo [3.2.0] heptane;
2. exo-3-methyl-6-p-fluorfenyl-3-azabicyklo[3,2,0]heptan,2. Exo-3-methyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane;
63. exo-3-n-propyl-6-p-fluorfenyl-3-azabicyklo[3,2,0]heptan,63. exo-3-n-propyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane;
64. exo-3-methyl-6,7-difenyl-3-azabicyklo[3,2,0]heptan ,64. exo-3-methyl-6,7-diphenyl-3-azabicyclo [3.2.0] heptane;
65. exo-3-n-propyl-6-m-hydroxyfenyl-3-azabicyklo[3,2,0]heptan,65. exo-3-n-propyl-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptane;
66. exo-3-allyl-6-m-methoxyfenyl-3-azabicyklo[3,2,0]heptan,66. exo-3-allyl-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptane;
67. exo-3-(3,4-dimethoxy)fenethyl-6-fenyl-3-azabicyklo[3,2,0]heptan,67. exo-3- (3,4-dimethoxy) phenethyl-6-phenyl-3-azabicyclo [3.2.0] heptane;
68. exo-3-(3,4-dimethoxy)fenethyl-6-p-fluorfenyl-3-azabicyklo[3,2,0]heptan,68. exo-3- (3,4-dimethoxy) phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane;
69. exo-3-(3,4-dihydroxy)fenethy1-3-azabicyklo[3,2,0]heptan,69. exo-3- (3,4-dihydroxy) phenethyl-3-azabicyclo [3.2.0] heptane;
70. exo-3-fenethyl-6-p-fluorfenyl-3-azabicyklo[3,2,0]heptan,70. exo-3-phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane;
71. 6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ] ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,71. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,
• ·• ·
72. ( + ) —6—β—[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)-3-yl]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-οη,72. (+) -6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl) -3-yl] ethyl-7-methyl-5H-thiazolo [ 3,2-a] pyrimidin-5-one,
73. (-)-6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3, 2,0]-(3-heptyl)-3-yl]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-οη,73. (-) - 6-β- [Exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) -3-yl] ethyl-7-methyl-5H-thiazolo [ 3,2-a] pyrimidin-5-one,
74. 6-β-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,74. 6-β- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- he,
75. 6-β-[exo-6,7-difenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,75. 6-β- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,
76. 6-β-[exo-6,7-bis-(p-fluorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)-3-yl]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,76. 6-β- [exo-6,7-bis- (p-fluorophenyl) -3-azabicyclo [3.2.0] - (3-heptyl) -3-yl] ethyl-7-methyl-5H- thiazolo [3,2-a] pyrimidin-5-one,
77. 6-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,77. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,
78. 6-β-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0]-(3-78. 6-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one;
79. 6-β-[exo-6-m-hydroxyfenyl-3-azabicyklo[3, 2,0]-(3-79. 6-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one;
80. 6—β—[2—[exo-6-p-aminofenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,80. 6-β- [2- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,
81. 6-β-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,81. 6-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,
92. 6-β-[exo-6-(3,4-dihydroxyfenyl)-3-azabicyklo[3,2,0]-92. 6-β- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] -
-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-aJpyrimidin-5-on,- (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,
93. 6-β-[exo-6-(o-fluorfenyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,93. 6-β- [exo-6- (o-fluorophenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,
94. 6-β-[exo-6-(3-thienyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a)pyrimidin-5-on,94. 6-β- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a) pyrimidin-5-one,
95. 6-β-[exo-6-(5-chlor-(2-thienyl))-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,95. 6-β- [exo-6- (5-chloro- (2-thienyl)) - 3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [ 3,2-a] pyrimidin-5-one,
96. 6-β - [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-on,96. 6-β - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-2,3-dihydro-5H-thiazolo [3, 2-a] pyrimidin-5-one,
97. 6-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-aJpyrimidin-5-on,97. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-2,3-dihydro-5H-thiazolo [3, 2-pyrimidin-5-one,
98. 6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,3,7-trimethyl-5H-thiazolo[3,2-a] j)yrimidin-5-on,98. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,3,7-trimethyl-5H-thiazolo [3,2- (a) (j) yrimidin-5-one;
99. 6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-5H-thiazolo[3,2-a]pyrimidin-5-on,99. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-5H-thiazolo [3,2-a] pyrimidin-5-one,
100. 6^-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-5H-thiazolo[3,2-a]pyrimidin-5-on,100. 6- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-5H-thiazolo [3,2-a] pyrimidin-5-one,
101. 7-β—[exo-6—p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,101. 7-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,
102. 7-β-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,102. 7-β- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1] 3] thiazin-6-one,
103. 7”p-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,103. 7 'p- [Exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,
104. 7-β-[exo-6-p-chlorfenyl-3-azabicyklo[ 3,2,0 ] - (3-heptyl)]ethy1-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,104. 7-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,
105. 7-3-[exo-6-p-methoxyfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,105. 7-3- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,
106. 7-β-[exo-6-m-hydroxyfenyl-3-azabicyklo[3,2/0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,106. 7-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,
107. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,107. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
108. (+)-3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethy1-2,4-(1H,3H)chinazolindion,108. (+) - 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
109. (-)-3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl-2,4-(1H,3H)chinazolindion,109. (-) - 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
110. 3-β-(exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)] ethyl-2,4-(1H,3H)chinazolindion,110. 3-β- (exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
111. 3-β-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethy1-2,4-(1H,3H)chinazolindion,111. 3-β- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
112. 3-β-[exo-6-p-kyanfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ] 18 ethyl-2,4-(1H,3H)chinazolindion,112. 3-β- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] 18 ethyl-2,4- (1H, 3H) quinazolinedione,
113. 3-p-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,113. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
114. 3-p-[exo-6-p-hydroxyfenyl-3-azabicyklo[3,2,O]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,114. 3-β- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
115. 3-β-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,115. 3-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
116. 3“3-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0]-(3-116. 3 '3- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
117. 3-β- [exo-6-p-nitrofenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,117. 3-β- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
118. 3-β-[endo-6-p-nitrofenyl-3-azabicyklo[3,2,0]-(3-118. 3-β- [endo-6-p-nitrophenyl-3-azabicyclo [3.2.0] - (3-
-hepty1)]ethyl-2,4-(1H,3H)chinazolindion,-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
119. 3-β-[exo-6—m-hydroxyfenyl-3-azabicyklo[3,2,0]-(3-119. 3-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
120. 3-β-[exo-6-p-aminofenyl-3-azabicyklo[ 3,2,0 ] - (3-heptyl) ]ethyl-2,4-(1H,3H)chinazolindion,120. 3-β- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
121. 3^-[exo-6-p-jodfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-2,4-(1H,3H)chinazolindion,121. 3- [exo-6-p-iodophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
122. 3-β-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-122. 3-β- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] -
-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
123. 3-β-[βχο-6-(3,4-dichlorfenyl)-3-azabicyklo[3,2,0]19123. 3-β- [βχο-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] 19
-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
124. 3-β-[exo-6-(3,4-dihydroxyfenyl)-3-azabicyklo[3,2,0]-124. 3-β- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] -
-(3-heptyl)]ethyl-2,4-(lH,3H)chinazolindion,- (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
125. 3-β-[exo-6-(3,5-dichlorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,125. 3-β- [exo-6- (3,5-dichlorophenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
126. 3-β-[θΧθ-6-ο-ίluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,126. 3-β- [θΧ-6-ο-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
127. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2,4-(1H,3H)chinazolindion,127. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2,4- (1H, 3H) quinazolinedione,
128. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-chlor-2,4-(1H,3H)chinazolindion,128. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-chloro-2,4- (1H, 3H) quinazolinedione,
129. 3-β - [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-fluor-2,4-(1H,3H)chinazolindion,129. 3-β - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-fluoro-2,4- (1H, 3H) quinazolinedione,
130. 3-β-[exo-6—p-fluorfenyl-3—azabicyklo[3,2,0]-(3-heptyl)]ethyl-5-chlor-2,4-(1H,3H)chinazolindion,130. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-5-chloro-2,4- (1H, 3H) quinazolinedione,
131. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6-fluor-2,4-(1H,3H)chinazolindion,131. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-fluoro-2,4- (1H, 3H) quinazolinedione,
2. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-6-methyl-2,4-(1H,3H)chinazolindion,2. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-methyl-2,4- (1H, 3H) quinazolinedione,
133. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-8-methoxy-2,4-(lH,3H)chinazolindion,133. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methoxy-2,4- (1H, 3H) quinazolinedione,
134. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]- ethyl-6-trifluormethyl-2,4-(1H,3H)chinazolindion,134. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-trifluoromethyl-2,4- (1H, 3H) quinazolinedione,
135. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl-7-nitro-2,4-(1H,3H)chinazolindion,135. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-nitro-2,4- (1H, 3H) quinazolinedione,
136. 3-β - [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6-nitro-2,4-(lH,3H)chinazolindion,136. 3-β - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-nitro-2,4- (1H, 3H) quinazolinedione,
137. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-amino-2,4-(1H,3H)chinazolindion,137. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-amino-2,4- (1H, 3H) quinazolinedione,
138. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6-amino-2,4-(1H,3H)chinazolindion,138. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-amino-2,4- (1H, 3H) quinazolinedione,
139. 3-β-[exo—6-p-fluorfenyl-3—azabicyklo[3,2,0]-(3-heptyl)]ethyl-6-hydroxy-2,4-(1H,3H)chinazolindion,139. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-hydroxy-2,4- (1H, 3H) quinazolinedione,
140. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-5-chlor-2,4-(1H,3H)chinazolindion,140. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-5-chloro-2,4- (1H, 3H) quinazolinedione,
141. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6,7-dimethoxy-2,4-(1H,3H)chinazolindion,141. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6,7-dimethoxy-2,4- (1H, 3H) quinazolinedione ,
142. 3^-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6,8-dichlor-2,4-(1H,3H)chinazolindion,142. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-6,8-dichloro-2,4- (1H, 3H) quinazolinedione,
143. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6,7,8-trimethoxy-2,4-(1H,3H)chinazolindion,143. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6,7,8-trimethoxy-2,4- (1H, 3H) ) quinazolindione,
144. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3, 2,0 ] - (3-heptyl)]ethyl-1-methy1-2,4-(1H,3H)chinazolindion,144. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-1-methyl-2,4- (1H, 3H) quinazolinedione,
5. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]21 ethyl-1-ethy1-2,4-(1H,3H)chinazolindion,5. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] 21 ethyl-1-ethyl-2,4- (1H, 3H) quinazolinedione,
·· » * φ · • ♦ · · • · · · · • · · · ··· ·· ·«··· • •
146. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-l-allyl-2,4-(1H,3H)chinazolindion,146. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1-allyl-2,4- (1H, 3H) quinazolinedione,
147. 3-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-l-benzyl-2,4-(1H,3H)chinazolindion,147. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1-benzyl-2,4- (1H, 3H) quinazolinedione,
148. 3-gamma-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl-2,4-(1H,3H)chinazolindion,148. 3-gamma- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl-2,4- (1H, 3H) quinazolinedione,
149. 3-S-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butyl-2,4-(1H,3H)chinazolindion,149. 3-S- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butyl-2,4- (1H, 3H) quinazolinedione,
150. 3-β-[exo-6-(2-thienyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,150. 3-β- [exo-6- (2-thienyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
151. 3-β - [exo-6-(5-chlor-2-thienyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,151. 3-β - [exo-6- (5-chloro-2-thienyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione ,
152. 3-β-[exo-6-(3-thienyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,152. 3-β- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
153. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-lH-thieno[3,2-d]pyrimidin-2,4-dion,153. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1H-thieno [3,2-d] pyrimidine-2,4- dion,
154. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-lH-thieno[2,3-d]pyrimidin-2,4-dion,154. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1H-thieno [2,3-d] pyrimidine-2,4- dion,
155. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-lH-thieno[3,4-d]pyrimidin-2,4-dion,155. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1H-thieno [3,4-d] pyrimidine-2,4- dion,
156. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]22156. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] 22
ethyl-l-methyl-ΙΗ,3H-pyrido[2,3-d]pyrimidin-2,4-dion,ethyl-1-methyl-ΙΗ, 3H-pyrido [2,3-d] pyrimidine-2,4-dione,
157. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methyl-3H-chinazolin-4-on,157. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-3H-quinazolin-4-one,
158. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methoxy-3H-chinazolin-4-on,158. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methoxy-3H-quinazolin-4-one,
159. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on-dihydrochlorid,159. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidine- 4-on-dihydrochloride,
160. 3^-[exo-6-fenyl-3-azabicyklo[ 3,2,0]-(3-heptyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,160. 3- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one ,
161. 3-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl- 2-methyl-4H-pyrido [ 1,2-a ] pyriinidin-4-on,161. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidine- 4-on,
162. 3-β-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,162. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidine- 4-on,
163. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,163. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,6-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one,
164. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-164. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl-2,7-dimethyl-4H-pyrido[l,2-a]pyrimidin-4-on,-heptyl)] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one;
165. 3^-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-165. 3 R - [Exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on, • ·. · ·· · · ·9·-heptyl)] ethyl-2,8-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one; · ·· · · · · ·
9 9 9 9 9 9 9 · 999 9 9 9 9 9 9 · 99
9 9 9 9 9 9 9 9· • 9999999 9 9 99 999 9 9 9 9 9 9 9 • 9999999 9 9 99 99
9 99 999 99999 9. 9 99 999 99999 9
166. 3-β- [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]—(3—166. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,-heptyl)] ethyl-2,9-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one;
167. 3-8-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl-2,6,8-trimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,167. 3-8- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,6,8-trimethyl-4H-pyrido [1,2- a] pyrimidin-4-one,
168. 3-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,168. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one,
169. 3-β-[exo-6-o-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,169. 3-β- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one,
170. 3-β-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)Jethyl-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,170. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl) ethyl-2,8-dimethyl-4H-pyrido [1,2-a] pyrimidin-4 -he,
171. 3-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,171. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,9-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one,
172. 3-8-[exo-6-(5-chlor-(2-thienyl))-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,172. 3-8- [exo-6- (5-chloro- (2-thienyl)) - 3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrido [ 1,2-a] pyrimidin-4-one,
173. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,173. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6,7,8,9-tetrahydro-2-methyl-4H- pyrido [1,2-a] pyrimidin-4-one,
174. 3—β — [exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl) ] ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a] pyrimidin-4-on,174. 3-β - [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6,7,8,9-tetrahydro-2-methyl-4H- pyrido [1,2-a] pyrimidin-4-one,
175. 3-β-[exo—6-p—methoxyfenyl-3-azabícyklo[3,2,0]-(3-heptyl)]ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,175. 3-β- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-6,7,8,9-tetrahydro-2-methyl-4H- pyrido [1,2-a] pyrimidin-4-one,
176. 3-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl-2-methyl-4H-pyrimido[1,2-a]pyrimidin-4-on,176. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrimido [1,2-a] pyrimidine- 4-on,
177. 3~3~[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methyl-7-chlor-4H-pyrimido[1,2-a]pyrimidin-4-on,177. 3- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-7-chloro-4H-pyrimido [1,2- a] pyrimidin-4-one,
178. 6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-lH,5H-imidazo[l,2-a]pyrimidin-5-on,178. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-1H, 5H-imidazo [1,2-a] pyrimidin-5-one,
179. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methy1-7,8-dihydro-4H,6H-pyrrolo[1,2-a]pyrimidin-4-on,179. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-7,8-dihydro-4H, 6H-pyrrolo [ 1,2-a] pyrimidin-4-one,
180. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]methylbenzimidazol,180. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methylbenzimidazole,
181. l-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethylbenzimidazol,181. 1- [beta] - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethylbenzimidazole,
182. l-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,3-dihydrobenzimidazol-2-on,182. 1- [beta] - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,3-dihydrobenzimidazol-2-one;
3. 2-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ] methylbenzimidazol,3. 2- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methylbenzimidazole;
184. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethylindol, teplota tání 193 až 195 °C (hydrochlorid) ,184. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethylindole, m.p. 193-195 ° C (hydrochloride),
185. 3-β - [2-(exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]—(3— -heptyl))ethylindol,185. 3-β - [2- (exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)) ethylindole,
186. 3-β-[exo-6-fenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethylindol , teplota tání 104 až 105 °C (hydrochlorid),186. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethylindole, m.p. 104-105 ° C (hydrochloride),
187. 3-β-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethylindol,187. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethylindole,
188. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]methyl-3,4-dihydrochinazolin-4-on,188. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-3,4-dihydroquinazolin-4-one,
189. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]methyl-3,4-dihydrochinazolin-4-thion,189. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-3,4-dihydroquinazoline-4-thione,
190. 2-[exo-6-fenyl-3-azabicyklo(3,2,0]-(3-heptyl)Jmethyl-3,4-dihydrochinazolin-4-on,190. 2- [exo-6-phenyl-3-azabicyclo (3.2.0) - (3-heptyl)] methyl-3,4-dihydroquinazolin-4-one,
191. 2-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]methyl-3,4-dihydrochinazolin-4-on,191. 2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-3,4-dihydroquinazolin-4-one,
192. 2-[exo-6-o-methoxyfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]methyl-3,4-dihydrochinazolin-4-on,192. 2- [exo-6-o-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-3,4-dihydroquinazolin-4-one,
193. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))methyl-4-hydroxy-6-methylpyrimidin,193. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) methyl-4-hydroxy-6-methylpyrimidine,
194. 6- [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]methyl-2-methyl-4-hydroxypyrimidin,194. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-2-methyl-4-hydroxypyrimidine,
5. 6-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl) ]methyluracil, * ·5. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyluracil;
196. 6-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)Jmethyluracil,196. 6- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl) -methyluracil,
197. 6-[exo-6-p-fluorfenyl-3-azabicyklo[3, 2,0 ] - (3-heptyl)]-1,2,3,4-tetrahydro-l,3-dimethyl-2,4-dioxopyrimidin,197. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] -1,2,3,4-tetrahydro-1,3-dimethyl-2,4 -dioxopyrimidine,
198. 5-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-6-methyl-2,4-dioxopyrimidin,198. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1,2,3,4-tetrahydro-6-methyl-2; 4-dioxopyrimidine,
199. 5-β—[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-l,6-dimethyl-2,4-dioxopyrimidin,199. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-1,2,3,4-tetrahydro-1,6-dimethyl- 2,4-dioxopyrimidine,
200. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-3,6-dimethyl-2,4-dioxopyrimidin,200. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1,2,3,4-tetrahydro-3,6-dimethyl- 2,4-dioxopyrimidine,
201. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-3,6-dimethyl-2,4-dithiopyrimidin,201. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1,2,3,4-tetrahydro-3,6-dimethyl- 2,4-dithiopyrimidine,
202. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0}—(3-heptyl)]ethyl-1,2,3,4-tetrahydro-l,3,6-trimethyl-2,4-dioxopyrimidin,202. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0} - (3-heptyl)] ethyl-1,2,3,4-tetrahydro-1,3,6- trimethyl-2,4-dioxopyrimidine,
203. 5-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-6-amino-l-methyl-2,4-dioxopyrimidin,203. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-1,2,3,4-tetrahydro-6-amino-1- methyl-2,4-dioxopyrimidine,
204. 5-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-2-amino-6-methyl-4(3H)pyrimidinon, • · * · · ♦ «· ·· « ♦ « ·♦·«- · · 9 · • · · · >·· · · · • · ···· · · « » · · « · ·· · · · *·· · · ··· ·204. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-amino-6-methyl-4 (3H) pyrimidinone; * · - 9 - - - - 9 9 •>> 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 ·· · · ··· ·
5. 5—β-Cexo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-amino-3,6-dimethyl-4(3H)pyrimidinon,5. 5-β-Cexo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-amino-3,6-dimethyl-4 (3H) pyrimidinone;
206. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethy1-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,206. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
207. 5-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3-ethyl-6-methyl-4(3H)pyrimidinon,207. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3-ethyl-6-methyl-4 (3H) pyrimidinone,
208. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-amino-3-ethyl-6-methyl-4(3H)pyrimidinon,208. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-amino-3-ethyl-6-methyl-4 (3H) pyrimidinone,
209. 5-β- [exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,209. 5-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
210. 5^-[exo-6-m-chlorfenyl-3-azabicyklo[3, 2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,210. 5 '- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
211. 5-β-[exo-6-o-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,211. 5-β- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
212. 5^-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H ) pyrimidinon,212. 5 '- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
213. 5^-[exo-6-p-kyanfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon ,213. 5 '- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
214. 5-β-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,214. 5-β- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
215. 5^-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]28 ethyl-2-methylamino-4-methoxy-6-methylpyrimidin,215. 5 - [[exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] 28 ethyl-2-methylamino-4-methoxy-6-methylpyrimidine,
216. 3-3-(exo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,O]-(3-oktyl)]ethyl-2,4-(1H,3H)chinazolindion,216. 3-3- (exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2,4- (1H) (3H) quinazolinedione,
217. 3-β-[endo-6-fenyl-7-methyl-1,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl-2,4-(lH,3H)chinazolindion,217. 3-β- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2,4- (1H) (3H) quinazolinedione,
218. 3-β-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl))ethyl-2,4-(1H,3H)chinazolindion,218. 3-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl) ethyl-2,4- (1H, 3H) quinazolinedione,
219. 3-β-[exo-6-p-trifluormethylfenyl-7-methyl-l,5-cis-3,7diazabicyklo[3,3,0)-(3-oktyl)]ethyl-6-fluor-2,4-(1H,3H)chinazolindion,219. 3-β- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-6-fluoro-2, 4- (1H, 3H) quinazolinedione,
220. 3-β-[exo-6-m-chlorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl))ethyl-2,4-(1H,3H)chinazolindion,220. 3-β- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl) ethyl-2,4- (1H, 3H) quinazolinedione,
221. 3-β-[exo-6-p-methoxyfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl-6-methyl-2,4-(1H,3H)chinazolindion,221. 3-β- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-6-methyl- 2,4- (1H, 3H) quinazolinedione,
222. 5-β-[exo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl))ethyl-2-methylamino-3,6-dimethyl-4(3H)-pyrimidinon,222. 5-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl)) ethyl-2-methylamino-3, 6-Dimethyl-4 (3H) -pyrimidinone
223. 5-β-[exo-6-p-fluorfenyl-7-methyl-1,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dinethyl-4(3H)pyrimidinon,223. 5-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2-methylamino- 3,6-Dinethyl-4 (3H) pyrimidinone
224. 1-β-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl))ethyl-2(3H)benzimidazolon,224. 1-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)) ethyl-2 (3H) benzimidazolone,
225. 5-β-[exo-6-p-nitrofenyl-7-methyl-l,5-cis-3,7-diazabicyklo £3,3,0j — (3-oktyl)]ethyl-2-methylamino-3,6-dimethyl -4(3H)pyrimidinon,225. 5-β- [exo-6-p-nitrophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] -3- (3-octyl)] ethyl-2-methylamino-3 6-dimethyl-4 (3H) pyrimidinone
226. 5-β-[exo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)-pyrimidinon,226. 5-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2-methylamino-3, 6-Dimethyl-4 (3H) -pyrimidinone
227. 5-p-[endo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)-pyrimidinon,227. 5-β- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2-methylamino-3, 6-Dimethyl-4 (3H) -pyrimidinone
228. 3-β-[exo-6-p-fluorfenyl-7-methyl-l,5-CÍS-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,228. 3-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2-methyl- 4H-pyrido [1,2-a] pyrimidin-4-one,
229. ΐ-β-[exo-6-p-fluorfenyl-7-methyl-l,5-CÍS-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethylindolin-2-on,229. ΐ-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethylindolin-2-one,
230. 6-β-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-7-methyl-5H-thiazolo- [3,2-a]pyrimidin-5-on,230. 6-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-7-methyl- 5H-thiazolo- [3,2-a] pyrimidin-5-one,
231. l-p-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl-2(lH)chinolon,231. 1- [beta] - [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2 (1H) quinolone,
232. 3-β-[7-fenyl-1,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)] ethyl-2,4-(lH,3H)chinazolindion,232. 3-β- [7-phenyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
233. 3-3-[7-p-fluorfenyl-l,5-cis-3,7-diazabicyklo[3,3,0]-233. 3-3- [7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo [3.3.0] -
-(3-oktyl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-octyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
234. 5-β-[7-p-fluorfenyl-1,5-cis-3,7-diazabicyklo[3,3,0]-234. 5-β- [7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo [3.3.0] -
Φ · · · · φ· *Φ · · · φ · *
Φ · · '* ♦ · ·· • · · » · · a · ·· • »····»> · · ♦ ·· · • > · φφφφ·· φφ φ φφ μφ φφ φφφφA · * ♦ a a a a a a a a · φ · · · · · · · · ·
- 30 -(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3Η)pyrimidinon,- 30- (3-octyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3 ') pyrimidinone,
235. 3^-[exo-6-p-fluorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl-2,4-(1H,3H)chinazolindion,235. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
236. 3-β-[exo-6-fenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl-2,4-(1H,3H)chinazolindion,236. 3-β- [exo-6-phenyl-3-azabicyclo [3.1.0] - (3-hexyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
237. 3-β-[6,6-difenyl-3-azabicyklo[3,1,0]-(3-hexyl)Jethyl-2,4-(1H,3H)chinazolindion,237. 3-β- [6,6-diphenyl-3-azabicyclo [3.1.0] - (3-hexyl) ethyl-2,4- (1H, 3H) quinazolinedione,
238. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,238. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] - (3-hexyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
239. 6-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,239. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] - (3-hexyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,
240. 3-p-[6-p-fluorfenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-(6-okten)y1)]ethyl-2,4-(1H,3H)chinazolindion,240. 3-p- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octenyl))] ethyl-2,4- (1H, 3H) quinazolinedione,
241. 5-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-(6-okten)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H) pyrimidinon,241. 5-β- [6-p-Fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone
242. 6-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-(6okten)y1)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,242. 6-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octenyl))] ethyl-7-methyl-5H-thiazolo [3] , 2-a] pyrimidin-5-one,
3 . 1—β— [ 6-fenyl-1,5-cis-3-azabicyklo[ 3,3,0 ] - (3-( 6-ok-ten)yl)]ethyl-2(3H)benzimidazolon,3. 1-β- [6-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-oc-ten) yl)] ethyl-2 (3H) benzimidazolone,
244. l-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-(631244. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (631)
-okten)y1)]ethylindolin-2-on,ethyl-indolin-2-one,
245. 1—β — [6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-(6-okten)yl)]ethyl-2(lH)chinolon,245. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-2 (1H) quinolone,
246. 3-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)- (3-oktyl))ethyl-2,4-(1H,3H)chinazolindion,246. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] (3-octyl) ethyl-2,4- (1H, 3H) quinazolinedione ,
247. 5-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,247. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl-2-methylamino-3,6-dimethyl- 4 (3H) pyrimidinone
248. 6^-[exo-6-fenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,248. 6- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] (3-octyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,
249. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)-249. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl)]ethylindolin-2-on,- (3-octyl)] ethylindolin-2-one,
250. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-250. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl)]ethyl-2(lH)chinolon,- (3-octyl)] ethyl-2 (1H) quinolone,
251. 3-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-251. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl))ethyl-2,4-(1H,3H)chinazolindion,- (3-octyl) ethyl-2,4- (1H, 3H) quinazolinedione,
252. 5-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo(3,3,0]-252. 5-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo (3.3.0) -
-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,- (3-octyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
53. 6-β-[endo-fenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-oktyl) ]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,53. 6-β- [endo-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,
54. l-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3 y 0)-54. L-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3 y 0) -
-(3-oktyl)]ethylindolin-2-on,- (3-octyl)] ethylindolin-2-one,
255. l-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-255. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl)]ethyl-2(1H)chinoIon,- (3-octyl)] ethyl-2 (1H) quinone,
256. 3-β—[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-256. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl)]ethy1-2,4-(1H,3H)chinazolindion,- (3-octyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
257. 5-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-257. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,- (3-octyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
258. 6-β-[exo-7-fenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,258. 6-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl-7-methyl-5H-thiazolo [3,2- (a) pyrimidin-5-one,
259. l-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-259. 1- [beta] - [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl)]ethylindolin-2-on,- (3-octyl)] ethylindolin-2-one,
260. l-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-260. 1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl)]ethyl-2(lH)chinolon,- (3-octyl)] ethyl-2 (1H) quinolone,
261. 3-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-261. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nonyl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
262. 5^-[endo-6-p-fluorfenyl-l,5-cis-3-azabicyklo[4,3,0]-262. 5 - [- endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4,3,0] -
-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,- (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
263. 3-β-[endo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-263. 3-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-
-nonyl)]ethyl-2,4-(lH,3H)chinazolindion,-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
264. 5-β-[endo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,264. 5-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-4 ( 3H) pyrimidinone,
265. 3-β-[endo-6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo- [4,3,Ο]-(3-nonyl)]ethyl-2,4-(1Η,3Η)chinazolindion,265. 3-β- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.1] - (3-nonyl)] ethyl-2,4- (1Η, 3Η) quinazolindione,
266. 5-β-[endo-6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo[4,3,0]—(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-266. 5-β- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-
-4(3H)pyrimidinon,-4 (3H) pyrimidinone
267. 3-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,267. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2,4- ( 1H, 3H) quinazolinedione,
268. 5-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-268. 5-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-(7-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,- (3- (7-Nonen) yl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
269. l-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2(3H)benzimidazolon,269. 1- [beta] - [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2 (3H) benzimidazolone ,
270. 1-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethylindolin-2-on,270. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethylindolin-2-one,
271. 3-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)yl)]ethyl-2, 4-(1H,3H)chinazolindion,271. 3-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolinedione,
272. 5-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-272. 5-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-(6-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl—4(3H)pyrimidinon,- (3- (6-nonen) yl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
3. 3-β-[6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)yl)]ethyl-2,4-(1Η,3H)chinazolindion,3. 3-β- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolindione,
274. 5—β—[6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)- yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon, ·· » ·· * φφ φφ • · · φ φ φ φ · φ · φ • · φ · · φ · ·· · • · φ··· φ φ φ · · · · · φ φ φ φ φ φ φ · φ φφ · ·· φφφ φφ φφφφ274. 5-β- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) -yl)] ethyl-2-methylamino-3,6- dimethyl-4 (3H) pyrimidinone, · φ • · · · · • • • • • · • • • • • · · · Φ · · · · · · · · · ·
275. 3-β-[6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo[4,3,0]—(3—(6-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,275. 3-β- [6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolinedione,
276. 5-β-[6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,276. 5-β- [6-p-Trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone
277. 1—β— [6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-277. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-(6-nonen)yl)]ethyl-2(3H)benzimidazolon,- (3- (6-nonen) yl)] ethyl-2 (3H) benzimidazolone,
278. l-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)yl)]ethylindolin-2-on,278. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethylindolin-2-one,
279. l-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-279. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-(6-nonen)yl)]ethyl-2(lH)chinolon,- (3- (6-nonen) yl)] ethyl-2 (1H) quinolone,
280. 3-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2,4-(1H,3H)chinazolidon,280. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2,4- ( 1H, 3H) quinazolidone,
281. 5-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H) pyrimidinon,281. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2-methylamino-3 6-dimethyl-4 (3H) pyrimidinone
282. 3-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2-methyl-4H-pyrido[l,2-a]pyrimidin-4-on,282. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2-methyl-4H -pyrido [1,2-a] pyrimidin-4-one,
283. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2(lH)chinolon,283. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2 (1H) quinolone ,
284. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-284. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-(7-nonen)yl)]ethyl-2(3H)benzimidazolon,- (3- (7-nonen) yl)] ethyl-2 (3H) benzimidazolone,
285. 1-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-285. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-(7-nonen)yl)]ethylindolin-2-on,- (3- (7-Nonen) yl)] ethylindolin-2-one,
286. 3-β-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)y1)]ethyl-2,4-(1H,3H)chinazolindion,286. 3-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolinedione,
287. 5-β-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)y1)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,287. 5-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonenyl))] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone
288. 3-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-288. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nony1)]ethyl-2,4-(1H,3H)chinazolindion,- (3-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
289. 5-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,289. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl- 4 (3H) pyrimidinone
290. 3-β-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2,4-(1H,3H)chinazolindion,290. 3-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione,
291. 5-β-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,291. 5-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-4 ( 3H) pyrimidinone,
292. 6—β—[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-292. 6-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nonyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,- (3-Nonyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,
293. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2(3H)benzimidazolon,293. 1- [beta] - [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2 (3H) benzimidazolone,
294. 1-β-[βχο-6-ρ-ίluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-294. 1-β- [βχο-6-β-fluorophenyl-1,5-cis-3-azabicyclo [4,3,0] -
-(3-nonyl)]ethylindolin-2-on, ·· · *9 · ··9* • · 9 9 9 9 99**9 * 9 · · ··· ··· · 9 · · · 9 9 · 9 ·· 9· ··· *··*9* ·· · ·» ··· ♦♦ ··*·- (3-nonyl)] ethylindolin-2-one, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9 · 9 ··· 9 · ··· * ·· * 9 * ·· · »··· ♦♦ ·· * ·
295. 1—β —[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-295. 1-β - [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nonyl)]ethyl-2(lH)chinolon, .296. 3-β-(exo-7-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-nonyl)] ethyl-2 (1H) quinolone, 296. 3-β- (exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolindione,
297. 5-β-[exo-7-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,297. 5-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone
298. 3-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,298. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl-2,4- ( 1H, 3H) quinazolinedione,
299. 5-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H) pyrimidinon,299. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl-2-methylamino-3 6-dimethyl-4 (3H) pyrimidinone
300. 3-β-[7-p-fluorfenyl-3-azabicyklo[4,3,0]-(3-(1-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,300. 3-β- [7-p-fluorophenyl-3-azabicyclo [4.3.0] - (3- (1-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolinedione,
301. 5-β-[7-fenyl-3-azabicyklo[4,3,0]-(3-(1-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,301. 5-β- [7-phenyl-3-azabicyclo [4.3.0] - (3- (1-nonen) yl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone ,
302. 5-β-[7-p-fluorfenyl-3-azabicyklo[4,3,0]]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,302. 5-β- [7-p-fluorophenyl-3-azabicyclo [4.3.0]] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
303. 3-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2,4-(1H,3H)chinazolindion,303. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione ,
304. 5-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-304. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)— pyrimidinon,- (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) -pyrimidinone,
305. l-β- [exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2(3H)benzimidazolon,305. 1- [beta] - [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2 (3H) benzimidazolone,
306. l-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethylindolin-2-on,306. 1- [beta] - [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethylindolin-2-one,
307. l-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2(lH)chinolon,307. 1- [beta] - [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2 (1H) quinolone,
308. 3—β—[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]—(3—(6-okten)yl)]ethyl-2,4-(1H,3H)chinazolindion,308. 3-β- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-2 4- (1H, 3H) quinazolinedione,
309. 5-β-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]—(3—(6-okten)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,309. 5-β- [6-p-Fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-2 - methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
310. 3-β-[exo/endo-6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0 ] (3-oktyl)]ethyl-2,4-(1H,3H)chinazolindion,310. 3-β- [Exo / endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] (3-octyl)] ethyl-2,4 - (1H, 3H) quinazolinedione,
311. 5-β-[exo/endo-6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,311. 5-β- [Exo / endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2- methylamino-3,6-dimethyl-4 (3H) pyrimidinone,
312. l-β-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]—(3—(6-okten)yl)]ethylindolin-2-on,312. 1- [beta] - [6-p-Fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethylindolin-2 -he,
313. 6-β-[6-fenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-(3-(6-okten)yl)]ethyl-7-methyl-5H-thiazolo[3,2-a ] pyrimidin-5-on, • ·313. 6-β- [6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-7-methyl -5H-thiazolo [3,2-a] pyrimidin-5-one;
314. N-[2-[exo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]-4-fluorbenzamid,314. N- [2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl)] ethyl] -4-fluorobenzamide,
315. N-[2-[endo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]-4-fluorbenzamid,315. N- [2- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] -4-fluorobenzamide,
316. N-[2-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]-4-fluorbenzamid,316. N- [2- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] -4- fluorobenzamide,
317. N-[2-[exo—6—p—trifluormethylfenyl-7—methyl-1,5-cis—3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]benzamid,317. N- [2- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] benzamide,
318. N-2-[exo-6-m-chlorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]benzamid,318. N-2- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] benzamide,
319. N-[2-[exo-6-p-methoxyfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl]-4-chlorbenzamid,319. N- [2- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl)] ethyl] -4- chlorobenzamide,
320. N-[2-[exo-6-fenyl-7-methyl-1,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen-l-karboxamid,320. N- [2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene-1-carboxamide ,
321. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]butan-l-on,321. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] butan-1-one,
322. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-7-methyl-1,5—cis—3,7-diazabicyklo[3,3,0]-(3-oktyl)]butan-l-ol,322. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] butan-1-ol,
323. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]benzamid,323. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] benzamide,
324. l-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-324. 1- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nonyl)]ethyl]naftalen, . .1 • ·- (3-nonyl)] ethyl] naphthalene,. .1 • ·
iand
325. 1- (4-fluorfenyl)-4-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-on,325. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-one,
326. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-ol,326. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-ol,
327. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]- ( 3-nony 1) ] ethyl ] -2- (N-methy1) aminobenzamid,327. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] -2- (N-methyl) aminobenzamide,
328. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]-5-chlor-(2-thienyl)karboxamid,328. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] -5-chloro- (2-thienyl) ) Carboxamide
329. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]inden-3-karboxamid,329. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] indene-3-carboxamide,
330. N-[2-[exo-6-fenyl-l,5-cis-3-azabicyklo(4,3,0]-(3-nonyl)]ethyl]-4-fluorbenzamid,330. N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] (3-nonyl)] ethyl] -4-fluorobenzamide,
331. N-[2-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]naftalen-l-karboxamid,331. N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] (3-nonyl)] ethyl] naphthalene-1-carboxamide,
332. 1-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]naftalen,332. 1- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] naphthalene,
333. l-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]butan-l-on,333. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] butane -l-he,
334. N-[2-[exo-6-p-fluorfenyl-l,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]benzamid,334. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] benzamide,
335. N-[2-[exo-6-p-fluorfenyl-l,5-cis-3-azabicyklo[4,3 ,0]-(3-(7-nonen)yl)]ethyl]inden-3-karboxamid, • ·335. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] indene-3- carboxamide, •
.J { ..J {.
346. N-[2-[6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo-346. N- [2- [6-p-Trifluoromethylphenyl-1,5-cis-3-azabicyclo-
[4,3,0)-(3-(6-nonen)yl)]ethyl]naftalen-l-karboxamid,[4,3,0] - (3- (6-nonen) yl)] ethyl] naphthalene-1-carboxamide,
347. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]ethyl]inden-3-karbonimid,347. N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl] indene-3-carbonimide,
348. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]ethyl]naftalen-l-karboxamid,348. N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl] naphthalene-1-carboxamide,
349. 1-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-nonyl)]ethylJnaftalen,349. 1- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] naphthalene,
350. 1-(4-fluorfenyl)-4-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-on,350. 1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-one,
351. 1-(4-fluorfenyl)-4-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-nonyl))butan-l-ol,351. 1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)) butan-1-ol,
352. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]-2-(N-methyl)aminobenzamid,352. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] - 2- (N-methyl) aminobenzamide,
353. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethylJbenzamid,353. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] benzamide,
354. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-354. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nonyl)]ethyl]-5-chlor-(2-thienyl)karboxamid,- (3-nonyl)] ethyl] -5-chloro- (2-thienyl) carboxamide,
355. N-[2-[endo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-nonyl)]ethyl]-4-fluorbenzamid,355. N- [2- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] -4-fluorobenzamide,
356. N-[2—[endo-6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl))ethyl]inden-3-karboxamid,356. N- [2- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] (3-nonyl) ethyl] indene-3-carboxamide,
357. 2-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]42 • · : :357. 2- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] 42
• 9• 9
V ♦ • » t ί·· · • · · ·· · ϊ .: t.· • fc ·· « · 9 9 9 ····♦ ♦ t t:: t t t t t t t t t t t t t t t t t
-(3-(7-nonen) yl) ]ethyl]naftalen,- (3- (7-Nonen) yl)] ethyl] naphthalene,
358. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]benzamid,358. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] benzamide,
359. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]-2-(N-methyl)aminobenzamid,359. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] -2- ( N-methyl) aminobenzamide,
360. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]naftalen-l-karboxamid,360. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] naphthalene-1- carboxamide,
361. 1-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]naftalen,361. 1- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] naphthalene,
362. 1-(4-fluorfenyl)-4-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]butan-l-on,362. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] butane -l-he,
363. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]benzamid,363. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] benzamide,
364. N-[2-[exo-7-p-fluorfenyl—1,5-cis—3—azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]-5-chlor-(2-thienyl)karboxamid,364. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] -5-chloro - (2-thienyl) carboxamide,
365. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]-3-chlor-l-benzo-(2-thienyl )karboxamid,365. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] -3-chloro -1-benzo- (2-thienyl) carboxamide,
366. N-[2-[exo-7-fenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(8-nonen)y1)]ethyl]inden-3-karboxamid,366. N- [2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonene) yl] ethyl] indene-3-carboxamide,
367. N-[2-[exo-7-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]naftalen-l-karboxamid, »· · · · • t I · · • ·····*· · • · » · · «· * ··367. N- [2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] naphthalene-1-carboxamide, · I I I I I I I I I I I I I I I I I I
368. 1-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]naftalen,368. 1- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] naphthalene,
369. 1-(4-fluorfenyl)-4-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-on,369. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-one,
370. 1-(4-fluorfenyl)-4-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-ol, ♦370. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-ol; ♦
371. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-371. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nonyl)]ethyl]-2-(N-methyl)aminobenzamid,- (3-nonyl)] ethyl] -2- (N-methyl) aminobenzamide,
372. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]benzamid,372. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] benzamide,
373. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]-5-chlor-(2-thienyl)karboxamid,373. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] -5-chloro- (2-thienyl) ) Carboxamide
374. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-374. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -
-(3-nonyl)]ethyl]naftalen-l-karboxamid,- (3-nonyl)] ethyl] naphthalene-1-carboxamide,
375. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]inden-3-karboxamid,375. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] indene-3-carboxamide,
376. l-[2-[6-p-fluorfenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-(6-okten)yl)]ethyl]naftalen,376. 1- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl] naphthalene,
77. 1-(4-fluorfenyl)-4-[6-p-fluorfenyl-1,5-cis-3-azabi cyklo[3,3,O]-(3-(6-okten)yl)]butan-l-on,77. 1- (4-Fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] butane- l-he,
378. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-(6-okten)y1)]ethyl]benzamid,378. N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octenyl)] - ethyl] benzamide,
379. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-(6-okten)yl)]ethyl]naftalen-l-karboxamid,379. N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl] naphthalene-1-carboxamide,
380. l-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen,380. 1- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene,
381. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]butan-l-ol,381. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] butan-1-ol,
382. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl)benzamid,382. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl) benzamide,
383..N-[2-[exo-6—fenyl—1,5—cis-3-azabicyklo[3,3,0)-(3-oktyl)]ethyl]naftalen-l-karboxamid,383..N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene-1-carboxamide,
384. N-[2-[exo-6-fenyl-l,5-cis-3-azabicyklo[3,3,0)-(3-oktyl)]ethyl]inden-3-karboxamid,384. N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] indene-3-carboxamide,
385. 1-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen,385. 1- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene,
386. l-(4-fluorfenyl)-4-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-oktyl)]butan-l-on,386. 1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] butan-1-one,
387. N-[2-[endo-6-p-fluorfenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]benzamid,387. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] benzamide,
388. N-[2-[endo-6-fenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-oktyl)]ethyl]naftalen-l-karboxamid,388. N- [2- [endo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene-1-carboxamide,
389. l-[2-[exo-7-p-fluorfenyl-l,5-cis-3-azabicyklo[3,3,0]-389. 1- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -
-(3-oktyl)]ethyl)naftalen, ·- (3-octyl)] ethyl) naphthalene,
· · • · *· ·
• ♦ 1 • i ·• ♦ 1 • i ·
390. 1-(4-fluorfenyl)-4-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]butan-l-on,390. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] butan-1-one,
391. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]benzamid,391. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] benzamide,
392. N-[2-[exo-7-fenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen-l-karboxamid,392. N- [2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] (3-octyl)] ethyl] naphthalene-1-carboxamide,
393. N-[2-[exo-7-fenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]inden-3-karboxamid,393. N- [2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] indene-3-carboxamide,
394. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl]-4-fluorbenzamid,394. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] -4-fluorobenzamide,
395. N-[2-[exo-6—fenyl-3-azabicyklo[3,l,0]-(3-hexyl)]ethyl]-5-chlor-(2-thienyl)karboxamid,395. N- [2- [exo-6-phenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] -5-chloro (2-thienyl) carboxamide,
396. N-[2-[6 ,6-difenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl]-(1-naftyl)karboxamid,396. N- [2- [6,6-Diphenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] - (1-naphthyl) carboxamide,
397. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl]-3-chlor-l-benzo-(2-thienyl)karboxamid,397. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] -3-chloro-1-benzo (2-thienyl) carboxamide ,
398. N-[2-[exo-6-m-chlorfenyl-3-azabicyklo[3,1,0]-(3-hexyl) ]ethyl]-4-chlorbenzamid,398. N- [2- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] -4-chlorobenzamide,
399. l-[2-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicykLo[3,3,0]-(3-(6-okten)yl)jethylnaftalen,399. 1- [2- [6-p-Fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl) ethylnaphthalene,
400. N-[2-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicykLo- [3,3,0]-(3-(6-okten)yl)]ethyl]benzamid,400. N- [2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl ] benzamide,
401. N-[2—[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo- [3,3,0]-(3-(6-okten)yl)]ethyl]naftalen-l-karboxamid,401. N- [2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl ] Naphthalene-1-carboxamide
402. N-[2-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0)-(3-(6-okten)yl)]ethyl]inden-3-karboxamid,402. N- [2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl] indene-3-carboxamide,
403. 1-[2-[exo/endo-6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen,403. 1- [2- [Exo-endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene ,
404. N-[2-[exo/endo-6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo [ 3 ,3,0]-(3-oktyl)]ethylJbenzamid,404. N- [2- [exo-endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] (3-octyl)] ethyl] benzamide,
405. l-[2-[6-fenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-405. 1- [2- [6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] -
-(3-(6-okten)yl)]ethyl]naftalen,- (3- (6-octenyl)) ethyl] naphthalene,
406. N-[2-[6-fenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-(3-(6-okten)yl)]ethylJbenzamid,406. N- [2- [6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl] benzamide,
407. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]benzosulfonamid,407. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzosulfonamide,
408. N-[2-[exo-6-fenyl-3-azabicyklo[ 3,2,0 J - (3-heptyl)]ethyl]benzosulfonamid,408. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzosulfonamide,
409. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]-N-methylbenzosulfonamid,409. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -N-methylbenzosulfonamide,
410. N-[2-[exo-6-(5-chlor-(2-thienyl))-3-azabicyklo[3,2,0]-410. N- [2- [exo-6- (5-chloro-2-thienyl)] - 3-azabicyclo [3.2.0] -
-(3-heptyl)]ethyl]-4-fluorbenzosulfonamid,- (3-heptyl)] ethyl] -4-fluorobenzosulfonamide,
411. 3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-1fenoxypropan,411. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] - 1-phenoxypropane,
412. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]-l-p-fluorfenoxyethan,412. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] -1-p-fluorophenoxyethane,
413. 3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-l-(l-naftyloxy)propan,413. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] - 1- (1-naphthyloxy) propane,
414. 3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]-l-p-terc.-butylfenoxypropan,414. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] - 1-p-tert-butylphenoxypropane,
415. 3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-415. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] -
-1-p-fluorfenoxypropan,-1-p-fluorophenoxypropane
416. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-416. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-
-hepty1)]ethyl]thiobenzamid,-heptyl) ethyl] thiobenzamide,
417. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-4-fluorthiobenzamid,417. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-fluorothiobenzamide,
418. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-418. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl]-4-chlorthiobenzamid,-heptyl) ethyl] -4-chlorothiobenzamide,
419. O-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]benzoát,419. O- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] benzoate,
420. O-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-4-fluorbenzoát,420. O- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-fluorobenzoate,
421. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-ΙΗ-benzo[ c, d ]indol-2-on,421. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-benzo [c, d] indol-2-one,
422. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-422. N- [2- [exo-6-p-chloro-phenyl-3-azabicyclo [3.2.0] - (3-
-heptyl)]ethyl]-ΙΗ-benzo[c,d]indol-2-on, • *-heptyl) ethyl] -ΙΗ-benzo [c, d] indol-2-one;
423. N-[2-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-ΙΗ-benzo[c,d]indol-2-on,423. N- [2- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-benzo [c, d] indol-2-one,
424. N-[2-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]-ΙΗ-benzo[ c, d ]indol-2-on,424. N- [2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-benzo [c, d] indol-2-one,
425. 3,3-dimethyl-l-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]indolin-2-on,425. 3,3-dimethyl-1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,
426. 3,3-dimethyl-l-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indolin-2-on,426. 3,3-dimethyl-1- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,
427. 3,3-dimethyl-l-[2-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indolin-2-on,427. 3,3-dimethyl-1- [2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,
428. 1-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-3,3,5-trimethylindolin-2-on,428. 1- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3,3,5-trimethylindolin-2-one,
429. 3,4-dichlor-N-[2-[exo-6-p-nitrofenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]benzamid,429. 3,4-dichloro-N- [2- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,
430. 2,5-difluor-N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]benzamid,430. 2,5-difluoro-N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] benzamide,
431. 2-amino-N-[2-[exo-6-p-fluorfenyl-3-azabicyklo- [3,2,0]-(3-hepty1)]ethyl]benzamid,431. 2-amino-N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,
432. 2-amino-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]benzamid,432. 2-amino-N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,
433. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-2-methylaminobenzamid,433. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2-methylaminobenzamide,
434. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-2-methylaminobenzamid,434. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -2-methylaminobenzamide,
435. 3-amino-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl]benzamid,435. 3-amino-N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,
436. 4-amino-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl]benzamid,436. 4-amino-N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,
437. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]thiofen-2-karboxamid,437. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] thiophene-2-carboxamide,
438. 5-chlor-N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl)thiofen-2-karboxamid,438. 5-chloro-N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] thiophene-2-carboxamide,
439. 5-chlor-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-439. 5-chloro-N- [2- [exo-6-p-chloro-phenyl-3-azabicyclo [3.2.0] -
-(3-heptyl)]ethyl)thiofen-2-karboxamid,- (3-heptyl) ethyl) thiophene-2-carboxamide,
440. 5-chlor-N-[2-[exo-6-(5-chlor-(2-thienyl))-3-azabicyklo- [3,2,0)-(3-heptyl)]ethyl)thiofen-2-karboxamid,440. 5-chloro-N- [2- [exo-6- (5-chloro- (2-thienyl)) - 3-azabicyclo [3.2.0] (3-heptyl)] ethyl) thiophene- 2-carboxamide,
441. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl)benzo[b)furan-2-karboxamid,441. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] benzo [b] furan-2-carboxamide,
442. 3-chlor-N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-442. 3-chloro-N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0]
-(3-heptyl)]ethyl]benzo[b]thiofen-2-karboxamid,- (3-heptyl)] ethyl] benzo [b] thiophene-2-carboxamide,
443. 3-chlor-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-443. 3-chloro-N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] < / RTI >
-(3-heptyl))ethyl]benzo[b]thiofen-2-karboxamid,- (3-heptyl) ethyl] benzo [b] thiophene-2-carboxamide,
444. 3-chlor-N-[2-[exo-6-p-nitrofenyl-3-azabicyklo[3,2,0]-444. 3-chloro-N- [2- [exo-6-p-nitrophenyl-3-azabicyclo [3,2.0] -
-(3-heptyl)]ethyl)benzo[b]thiofen-2-karboxamid,- (3-heptyl)] ethyl) benzo [b] thiophene-2-carboxamide,
445. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]inden-3-karboxamid,445. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indene-3-carboxamide,
446. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]inden-3-karboxamid,446. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indene-3-carboxamide,
447. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]cyklopropankarboxamid,447. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] cyclopropanecarboxamide,
448. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]cyklopentankarboxamid,448. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] cyclopentanecarboxamide,
449. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3, 2,0]-(3-hepty1)]ethyl]cyklopentankarboxamid,449. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3,2.0] - (3-heptyl)] ethyl] cyclopentanecarboxamide,
450. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]cyklohexankarboxamid,450. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] cyclohexanecarboxamide,
451. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl)cyklohexankarboxamid,451. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] cyclohexanecarboxamide,
452. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]naftalen-l-karboxamid,452. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] naphthalene-1-carboxamide,
453. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indol-2-karboxamid,453. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] indole-2-carboxamide,
454. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3, 2,0]-(3-heptyl)]ethyl]indol-3-karboxamid,454. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] indole-3-carboxamide,
455. exo-6-p-fluorfenyl-3-[2-(1-naftyl)ethyl] -3-azabicyklo[3,2,0]heptan,455. exo-6-p-fluorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane,
456. exo-6-p-chlorfenyl-3-[2-(1-naftyl)ethyl] -3-azabicyklo[3,2,O]heptan,456. exo-6-p-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane,
457. exo-6-m-chlorfenyl-3-[2-(l-naftyl)ethyl]-3-azabicyklo[3,2,0 Jheptan,457. exo-6-m-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane,
458· exo-6-(5-chlor-(2-thienyl))-3-[2-(1-naftyl)ethyl)-3-azabicyklo[3,2,0Jheptan,458 · exo-6- (5-chloro- (2-thienyl)) - 3- [2- (1-naphthyl) ethyl) -3-azabicyclo [3.2.0] heptane,
459. exo-6-p-fluorfenyl-3-[2-(2-naftyl)ethyl]-3-azabicyklo[3,2,0]heptan,459. exo-6-p-fluorophenyl-3- [2- (2-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane,
460. exo-6-p-fluorfenyl-3-[l-naftylmethyl]-3-azabicyklo[3,2,0]heptan,460. exo-6-p-fluorophenyl-3- [1-naphthylmethyl] -3-azabicyclo [3.2.0] heptane,
461. exo-6-p-fluorfenyl-3-[2-naftylmethyl]-3-azabicyklo- [3,2,0Jheptan,461. exo-6-p-fluorophenyl-3- [2-naphthylmethyl] -3-azabicyclo [3.2.0] heptane,
462. 4-[6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-1-(2-thienyl)butan-l-on,462. 4- [6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] - 1- (2-thienyl) butan-1-one,
463. 4-[6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-l- (2-thienyl)butan-l-on,463. 4- [6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] -1- (2-thienyl) butan-1-one,
464. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-4-fenylpyrrolidin-2-on,464. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-phenylpyrrolidin-2-one,
465. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]benzoxazolin-2-on,465. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzoxazolin-2-one,
66. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0J-(3-hepty1)]ethyl]isoindolinon,66. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0- (3-heptyl)] ethyl] isoindolinone,
4 4 ·· · 4 4 4 » 4 4 4 4 · φ · · 4 4 4 a 4 4 • 4 4 4 · • 4 4 ··4 4 ·· 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
467. 1-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indazol,467. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indazole,
468. 1-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-1,8-naftalensultam,468. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1,8-naphthalenesultam,
469. 4-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-l,4-benzoxazin-3-on,469. 4- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1,4-benzoxazin-3-one,
470. 1-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]chinoxalin-2(1H)-on,470. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] quinoxalin-2 (1H) -one,
471. 1—[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indolin-2-on,471. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,
472. l-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]spiro[cyklopropan-1',3-indolin-2-on],472. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] spiro [cyclopropan-1 ', 3-indolin-2-one] ,
473. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-3H-pyrimidin-4-on,473. 3,6-dimethyl-2-methylamino-5- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3H- pyrimidin-4-one,
474. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-3H-pyrimidin-4-on,474. 3,6-dimethyl-2-methylamino-5- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -3H- pyrimidin-4-one,
475. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(5-chlor-1-naftyl)-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl]-3H-pyrimidin-4-on,475. 3,6-dimethyl-2-methylamino-5- [2- [exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl -3H-pyrimidin-4-one
476. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(6-chlor-2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-3H-pyrimidin-4-on,476. 3,6-dimethyl-2-methylamino-5- [2- [exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl -3H-pyrimidin-4-one
477. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(9-fenanthryl)-3-477. 3,6-Dimethyl-2-methylamino-5- [2- [exo-6- (9-phenanthryl) -3-
-azabicyklo[3,2,0]—(3-heptyl)]ethyl]-3H-pyrimidin-4-on,-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3H-pyrimidin-4-one,
478. 7-methyl-6-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]—(3— -heptyl)]ethyl]-5H-thiazolo[3,2-a]pyrimidin-5-on,478. 7-Methyl-6- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -5H-thiazolo [3,2] -a] pyrimidin-5-one,
479. 3-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-1H,3H-chinazolin-2,4-dion,479. 3- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H, 3H-quinazoline-2,4-dione,
480. 3-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-1H,3H-chinazolin-2,4-dion,480. 3- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H, 3H-quinazoline-2,4-dione,
481. 6-fluor-3-[2-(exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]-1H,3H-chinazolin-2,4-dion,481. 6-fluoro-3- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H, 3H-quinazoline-2, 4-dione,
482. 3-[2-[exo-6-(5-chlor-2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-lH,3H-chinazolin-2,4-dion,482. 3- [2- [exo-6- (5-chloro-2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H, 3H-quinazoline-2, 4-dione,
483. 3-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,483. 3- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -2-methyl-4H-pyrido [1,2- a] pyrimidin-4-one,
484. 1-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-2(1H)chinolon,484. 1- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2 (1H) quinolone,
485. 1—[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indolin-2-on,485. 1- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,
86. 1-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl]-2(3H)benzimidazolon,86. 1- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2 (3H) benzimidazolone,
487. 1-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl) ] ethyl]-3-methyl-2(3H)benzimidazolon,487. 1- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -3-methyl-2 (3H) benzimidazolone,
488. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl) ] - 54 - ethyl]benzamid,488. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] - 54-ethyl] benzamide,
489. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,O]-(3-heptyl)]ethyl]benzamid,489. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,
490. N- [2-[exo-6-(5-chlor-1-naftyl)-3-azabicyklo[3,2,0]-490. N- [2- [exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3,2,0] -
-(3-heptyl)]ethyl]benzamid,- (3-heptyl)] ethyl] benzamide,
491. 3-[2-(1-naftyl)ethyl]-exo-6-(1-naftyl)-3-azabicyklo[3,2,0]heptan,491. 3- [2- (1-naphthyl) ethyl] -exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptane,
492. 3-[2-(1-naftyl)ethyl]-exo-6-(2-naftyl)-3-azabicyklo[3,2,O]heptan,492. 3- [2- (1-naphthyl) ethyl] -exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptane,
493. 1-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,O]-(3-heptyl)]ethyl]-ΙΗ-benzo[c,d]indol-2-on,493. 1- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-benzo [c, d] indole-2- he,
494. 1-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,O]-(3-heptyl)]ethyl]-lH-benzo[c,d]indol-2-on,494. 1- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H-benzo [c, d] indole-2- he,
495. 3,3-dimethyl-l-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-l,3-dihydroindol-2-on,495. 3,3-dimethyl-1- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -1,3-dihydroindole- 2-on,
496. 3,3-dimethyl-l-[2-[exo-6-(2-naftyl)-3-azabicyklo- [3,2,O]-(3-heptyl)]ethyl]-l,3-dihydroindol-2-on,496. 3,3-dimethyl-1- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -1,3-dihydroindole -2-on,
497. 3,3-dimethyl-l-[2-[exo-6-(6-chlor-2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-l,3-dihydroindol-2—on,497. 3,3-dimethyl-1- [2- [exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -1, 3-dihydroindol-2-one,
498. 5-chlor-N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-498. 5-chloro-N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3,2,0] -
-(3-heptyl)]ethyl]-2-thiofenkarboxamid,- (3-heptyl)] ethyl] -2-thiophenecarboxamide,
499. 5-chlor-N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]• 9 9499. 5-chloro-N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] • 9 9
- 55 -(3-heptyl)]ethyl]-2-thiofenkarboxamid,- 55 - (3-heptyl)] ethyl] -2-thiophenecarboxamide,
500. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-4-fluorbenzamid,500. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-fluorobenzamide,
501. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-4-nitrobenzamid,501. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-nitrobenzamide,
502. N-[2-[exo-6-(6-chlor-2-naftyl)-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl]benzamid,502. N- [2- [exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,
503. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-4-methoxybenzamid,503. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-methoxybenzamide,
504. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-4-hydroxybenzamid,504. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-hydroxybenzamide,
505. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethylJ-3,4-dichlorbenzamid,505. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3,4-dichlorobenzamide,
506. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]naftalen-l-karboxamid,506. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] naphthalene-1-carboxamide,
507. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]naftalen-l-karboxamid,507. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] naphthalene-1-carboxamide,
508. N-[2-[exo-6-(9-fenanthryl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]benzamid,508. N- [2- [exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,
509. 1-[2-[exo-6-(6-chlor-2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl))ethyl)-lH-benzo[c,d]indol-2-on,509. 1- [2- [exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl) ethyl] -1H-benzo [c, d] indol-2-one,
510. 1-[2-[exo-6-(9-fenanthryl)-3-azabicyklo[3,2,0]- 56 -(3-hepty1)]ethyl]-ΙΗ-benzo[c,d]indol-2-on,510. 1- [2- [exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] -5- (3-heptyl)] ethyl] -4-benzo [c, d] indole- 2-on,
511. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[ 3,2,0 ] - (3-heptyl)]ethyl]isoindolinon,511. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] isoindolinone,
512. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]isoindolinon,512. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] isoindolinone,
513. (+)-(1S,5R,6S)exo-1-[2-[6-(4-chlorfenyl)-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl]-3-methyl-2H-l,3-dihydrobenzimidazol-2-on,513. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3 - methyl-2H-1,3-dihydrobenzimidazol-2-one,
514. (+)-(lS,5R,6S)exo-l-[2-[6-(4-chlorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)Jethyl]-3-ethyl-2H-l,3-dihydrobenzimidazol-2-on,514. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl) -ethyl] -3- ethyl-2H-1,3-dihydrobenzimidazol-2-one,
515. (+)-(1S,5R,6S)exo-1-[2-[6-(4-chlorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-3-n-propyl-2H-l,3-dihydrobenzimidazol-2-on,515. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3 -n-propyl-2H-1,3-dihydrobenzimidazol-2-one,
516. (+)-(1S,5R,6S)exo-2-[2-[6-(4-chlorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-3,3-dimethyl-2,3-dihydro-l, 2benzisothiazol-1,1-dioxid,516. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3 3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide,
517. (+)-(lS,5R,6S)exo-2-[2-[6-(4-chlorfenyl) -3-azabicyklo[3,2,0]—(3-heptyl)]ethyl]-2,3-dihydro-l,2-benzisothiazol-1,1-dioxid,517. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2 3-dihydro-1,2-benzisothiazole-1,1-dioxide,
518. (+)-(lS,5R,6S)exo-2-[2-[6-(4-fluorfenyl)-3-azabicyklo- [3,2,0]-(3-heptyl)]ethyl]-3,3-dimethyl-2,3-dihydro-l, 2benzisothiazol-1,1-dioxid,518. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] - 3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide,
519. (+)-(1S,5R,6S)exo-2-[2-[6-(4-fluorfenyl)-3-azabicyklo• · • 9 • 9· • 999519. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo] -9-9-9999
999·· ·9 [3,2,0)-(3-heptyl)]ethyl)-3,3-diethyl-2,3-dihydro-l,2benzisothiazol-1,1-dioxid a999 ··· 9 [3,2,0) - (3-heptyl)] ethyl) -3,3-diethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide and
520. (+)-(1S,5R,6S)exo-2-[2-[6-(4-fluorfenyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl)-2,3-dihydro-l,2-benzisothiazol-1,1-dioxid.520. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl) -2 1,3-dihydro-1,2-benzisothiazole-1,1-dioxide.
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| DE19854147A DE19854147A1 (en) | 1998-11-24 | 1998-11-24 | Control of cocaine addiction comprises administration of N-substituted azabicycloalkane derivative |
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| BR (1) | BR9915589A (en) |
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| CZ (1) | CZ20011796A3 (en) |
| DE (1) | DE19854147A1 (en) |
| HK (1) | HK1040933A1 (en) |
| HR (1) | HRP20010472A2 (en) |
| HU (1) | HUP0104416A3 (en) |
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| DE4427648A1 (en) * | 1994-08-04 | 1996-02-08 | Basf Ag | N-Stubstituted 3-azabicyclo [3,2,0,] heptane derivatives, their preparation and use |
| DE4341403A1 (en) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituted 3-azabicycloalkane derivatives, their preparation and use |
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-
1998
- 1998-11-24 DE DE19854147A patent/DE19854147A1/en not_active Withdrawn
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1999
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- 1999-11-12 WO PCT/EP1999/008734 patent/WO2000030639A1/en not_active Ceased
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2001
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- 2001-05-23 NO NO20012538A patent/NO20012538L/en not_active Application Discontinuation
- 2001-05-30 BG BG105549A patent/BG105549A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL348758A1 (en) | 2002-06-03 |
| CA2352526A1 (en) | 2000-06-02 |
| AR021502A1 (en) | 2002-07-24 |
| SK7112001A3 (en) | 2001-12-03 |
| BG105549A (en) | 2001-12-29 |
| EP1133293A1 (en) | 2001-09-19 |
| CN1328455A (en) | 2001-12-26 |
| NO20012538L (en) | 2001-07-04 |
| JP2002530333A (en) | 2002-09-17 |
| IL143181A0 (en) | 2002-04-21 |
| HRP20010472A2 (en) | 2003-04-30 |
| DE19854147A1 (en) | 2000-05-25 |
| HUP0104416A2 (en) | 2002-04-29 |
| HK1040933A1 (en) | 2002-06-28 |
| TR200101476T2 (en) | 2001-10-22 |
| NO20012538D0 (en) | 2001-05-23 |
| HUP0104416A3 (en) | 2002-11-28 |
| ZA200103976B (en) | 2002-05-16 |
| AU1775300A (en) | 2000-06-13 |
| WO2000030639A1 (en) | 2000-06-02 |
| KR20010080535A (en) | 2001-08-22 |
| BR9915589A (en) | 2001-08-07 |
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