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CY1119727T1 - UNITS AND COMPOSITIONS FOR TREATMENT OF PARASITIC DISEASES - Google Patents

UNITS AND COMPOSITIONS FOR TREATMENT OF PARASITIC DISEASES

Info

Publication number
CY1119727T1
CY1119727T1 CY20181100008T CY181100008T CY1119727T1 CY 1119727 T1 CY1119727 T1 CY 1119727T1 CY 20181100008 T CY20181100008 T CY 20181100008T CY 181100008 T CY181100008 T CY 181100008T CY 1119727 T1 CY1119727 T1 CY 1119727T1
Authority
CY
Cyprus
Prior art keywords
treatment
compositions
units
compounds
parasitic diseases
Prior art date
Application number
CY20181100008T
Other languages
Greek (el)
Inventor
Arnab Kumar CHATTERJEE
Advait Suresh NAGLE
Prasuna PARASELLI
Ravinder Reddy Kondreddi
Seh Yong Leong
Pranab Kumar MISHRA
Robert Joseph MOREAU
Jason Thomas ROLAND
Wei Lin Sandra SIM
Oliver Simon
Liying Jocelyn Tan
Bryan Ks Yeung
Bin Zou
Venkatataiah BOLLU
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1119727T1 publication Critical patent/CY1119727T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις του χημικού τύπου I: ή ένα φαρμακευτικά αποδεκτό άλας, ταυτομερές ή στερεοϊσομερές αυτού, όπου οι μεταβλητές είναι όπως ορίστηκαν στο παρόν κείμενο. Η παρούσα εφεύρεση παρέχει περαιτέρω φαρμακευτικές συνθέσεις οι οποίες περιλαμβάνουν τέτοιου είδους ενώσεις και μεθόδους που χρησιμοποιούν αυτές τις ενώσεις για τη θεραπεία, την πρόληψη, την αναστολή, τη βελτίωση, ή την εξάλειψη της παθολογίας και/ ή της συμπτωματολογίας μιας νόσου που προκαλείται από ένα παράσιτο Plasmodium, όπως είναι η ελονοσία.The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods utilizing these compounds for the treatment, prevention, inhibition, improvement, or elimination of the pathology and / or symptomatology of a disease caused by a parasite. Plasmodium, such as malaria.

CY20181100008T 2012-11-19 2018-01-03 UNITS AND COMPOSITIONS FOR TREATMENT OF PARASITIC DISEASES CY1119727T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728018P 2012-11-19 2012-11-19
US201361847860P 2013-07-18 2013-07-18
PCT/US2013/070601 WO2014078802A1 (en) 2012-11-19 2013-11-18 Compounds and compositions for the treatment of parasitic diseases

Publications (1)

Publication Number Publication Date
CY1119727T1 true CY1119727T1 (en) 2018-06-27

Family

ID=49667630

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100008T CY1119727T1 (en) 2012-11-19 2018-01-03 UNITS AND COMPOSITIONS FOR TREATMENT OF PARASITIC DISEASES

Country Status (19)

Country Link
US (3) US9556169B2 (en)
EP (1) EP2925757B1 (en)
JP (1) JP6298472B2 (en)
CN (1) CN105164124B (en)
AR (1) AR093532A1 (en)
CY (1) CY1119727T1 (en)
DK (1) DK2925757T3 (en)
ES (1) ES2655030T3 (en)
HR (1) HRP20171998T1 (en)
HU (1) HUE037600T2 (en)
LT (1) LT2925757T (en)
ME (1) ME03042B (en)
PL (1) PL2925757T3 (en)
PT (1) PT2925757T (en)
RS (1) RS56720B1 (en)
SI (1) SI2925757T1 (en)
TW (1) TWI600654B (en)
UY (1) UY35146A (en)
WO (1) WO2014078802A1 (en)

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