[go: up one dir, main page]

CY1119400T1 - Μεθοδος παρασκευης σωματιδιων για χρηση σε φαρμακευτικη συνθεση - Google Patents

Μεθοδος παρασκευης σωματιδιων για χρηση σε φαρμακευτικη συνθεση

Info

Publication number
CY1119400T1
CY1119400T1 CY20171101010T CY171101010T CY1119400T1 CY 1119400 T1 CY1119400 T1 CY 1119400T1 CY 20171101010 T CY20171101010 T CY 20171101010T CY 171101010 T CY171101010 T CY 171101010T CY 1119400 T1 CY1119400 T1 CY 1119400T1
Authority
CY
Cyprus
Prior art keywords
particles
pharmaceutical composition
preparation
relates
active
Prior art date
Application number
CY20171101010T
Other languages
English (en)
Inventor
John Nicholas Staniforth
Matthew Michael James Green
David Alexander Vodden Morton
Original Assignee
Vectura Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447911&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119400(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0029261A external-priority patent/GB0029261D0/en
Priority claimed from GB0030946A external-priority patent/GB0030946D0/en
Priority claimed from PCT/GB2001/001606 external-priority patent/WO2001076575A2/en
Priority claimed from GB0124010A external-priority patent/GB0124010D0/en
Application filed by Vectura Limited filed Critical Vectura Limited
Publication of CY1119400T1 publication Critical patent/CY1119400T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση σχετίζεται με μία μέθοδο παρασκευής σύνθετων δραστικών σωματιδίων για χρήση σε μια φαρμακευτική σύνθεση για πνευμονική χορήγηση, με τη μέθοδο να περιλαμβάνει ένα στάδιο άλεσης στο οποίο σωματίδια δραστικού υλικού αλέθονται παρουσία σωματιδίων ενός πρόσθετου υλικού το οποίο είναι κατάλληλο για την προαγωγή της διασποράς των σύνθετων δραστικών σωματιδίων κατά την ενεργοποίηση ενός εισπνευστήρα. Η εφεύρεση επίσης σχετίζεται με συνθέσεις για εισπνοή παρασκευασμένες με τη μέθοδο.
CY20171101010T 2000-11-30 2017-09-26 Μεθοδος παρασκευης σωματιδιων για χρηση σε φαρμακευτικη συνθεση CY1119400T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0029261A GB0029261D0 (en) 2000-11-30 2000-11-30 Method of making particles for use in a pharmaceutical composition
GB0030946A GB0030946D0 (en) 2000-12-19 2000-12-19 Method of making particles for use in a pharmaceutical composition
PCT/GB2001/001606 WO2001076575A2 (en) 2000-04-07 2001-04-09 The treatment of respiratory diseases
GB0124010A GB0124010D0 (en) 2001-10-05 2001-10-05 Pharmaceutical compositions for inhalation
EP01998328.7A EP1337240B2 (en) 2000-11-30 2001-11-30 Method of making particles for use in a pharmaceutical composition

Publications (1)

Publication Number Publication Date
CY1119400T1 true CY1119400T1 (el) 2018-02-14

Family

ID=27447911

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161100553T CY1117749T1 (el) 2000-11-30 2016-06-21 Μεθοδος παρασκευης σωματιδιων για χρηση σε φαρμακευτικη συνθεση
CY20171101010T CY1119400T1 (el) 2000-11-30 2017-09-26 Μεθοδος παρασκευης σωματιδιων για χρηση σε φαρμακευτικη συνθεση

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20161100553T CY1117749T1 (el) 2000-11-30 2016-06-21 Μεθοδος παρασκευης σωματιδιων για χρηση σε φαρμακευτικη συνθεση

Country Status (10)

Country Link
EP (2) EP1337240B2 (el)
JP (1) JP4380988B2 (el)
AU (3) AU2002222115B2 (el)
CA (1) CA2429665C (el)
CY (2) CY1117749T1 (el)
DE (1) DE60132239T2 (el)
DK (1) DK2283818T3 (el)
ES (1) ES2296831T3 (el)
NZ (1) NZ526059A (el)
WO (2) WO2002043701A2 (el)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6607784B2 (en) 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20040101483A1 (en) * 2001-03-30 2004-05-27 Rudi Muller-Walz Medical aerosol formulations
GB0208742D0 (en) * 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
WO2003026611A2 (en) 2001-09-26 2003-04-03 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
EP1480691A4 (en) * 2002-03-05 2007-11-28 Univ State Cleveland AGGLOMERATED PARTICLES FOR THE DISPOSAL OF A MEDICINAL PRODUCT IN AEROSOL FORM
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
JP2006522634A (ja) 2003-04-14 2006-10-05 ベクトゥラ・リミテッド 投与効率を向上させるデバイス及び製薬組成
CN102688224A (zh) * 2003-04-14 2012-09-26 维克特拉有限公司 用于提高剂量效率的药物组合物和装置
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
WO2005025550A1 (en) * 2003-09-15 2005-03-24 Vectura Limited Pharmaceutical compositions for treating premature ejaculation by pulmonary inhalation
GB0321607D0 (en) 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
WO2005077339A1 (en) * 2004-02-10 2005-08-25 E.I. Dupont De Nemours And Company Process for preparing stable sol of pharmaceutical ingredients and hydrofluorocarbon comprising milling the said sol, then transfert it into a canister
GB0409703D0 (en) * 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
GB0410399D0 (en) * 2004-05-10 2004-06-16 Arakis Ltd The treatment of respiratory disease
GB0418791D0 (en) * 2004-08-23 2004-09-22 Glaxo Group Ltd Novel process
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0426301D0 (en) * 2004-11-30 2004-12-29 Vectura Ltd Pharmaceutical formulations
WO2006076191A2 (en) * 2005-01-10 2006-07-20 Elc Management Llc Discontinuous surface coating for particles
CN101243130B (zh) * 2005-08-05 2011-12-07 3M创新有限公司 显示具有改善的流动性的组合物
GB0525254D0 (en) 2005-12-12 2006-01-18 Jagotec Ag Powder compositions for inhalation
GB0613161D0 (en) 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
GB0801876D0 (en) * 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations
EP3106149B1 (en) * 2009-05-29 2019-11-20 Pearl Therapeutics, Inc. Compositions for pulmonary delivery of long-acting muscarinic antagonists and long-acting beta-2 adrenergic receptor agonists and associated methods and systems
DE102009049470A1 (de) * 2009-10-15 2011-04-28 Süd-Chemie AG Verfahren zur Herstellung von feinteiligen Lithiumtitan-Spinellen und deren Verwendung
GB0921481D0 (en) 2009-12-08 2010-01-20 Vectura Ltd Process and product
PH12012501064B1 (en) * 2009-12-14 2017-09-27 Chiesi Farm Spa Antibiotic microparticles for inhalation
SG184352A1 (en) * 2010-04-01 2012-10-30 Chiesi Farma Spa Process for preparing carrier particles for dry powders for inhalation
ITUD20100112A1 (it) * 2010-06-09 2011-12-10 Farma Derma S R L Preparazione per uso vaginale e rettale e relativo procedimento di produzione
TW201304822A (zh) 2010-11-15 2013-02-01 Vectura Ltd 組成物及用途
TW201306847A (zh) 2010-11-30 2013-02-16 Vectura Ltd 組成物及用途
CA2869849A1 (en) 2012-04-13 2013-10-17 Glaxosmithkline Intellectual Property Development Limited Aggregate particles comprising nanoparticulate drug particles of umeclidinium bromide, vilanterol trifenatate and fluticasone furoate
PL2919903T3 (pl) 2012-11-14 2020-12-14 W.R. Grace & Co. - Conn. Kompozycje zawierające materiał biologicznie aktywny i nieuporządkowany tlenek nieorganiczny
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
EP2957552B1 (en) 2014-06-16 2020-01-22 Arven Ilac Sanayi Ve Ticaret A.S. Vilanterol formulations
TR201407010A2 (tr) 2014-06-16 2015-12-21 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Vilanterol formülasyonları.
BR112017003888B1 (pt) 2014-09-09 2022-11-16 Vectura Limited Método de fabricação de uma formulação de pó seco
CA2965759C (en) 2014-10-31 2023-12-12 Glaxosmithkline Intellectual Property Development Limited Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials
CN107205909B (zh) * 2014-12-17 2020-09-29 莱雅公司 复合颗粒及其制备
CN106539690B (zh) * 2015-09-18 2020-08-04 天士力医药集团股份有限公司 一种液体冷却滴丸的连续智能制备方法
US12269041B2 (en) 2019-09-19 2025-04-08 New Jersey Institute Of Technology Spherical composite powder
WO2021236570A1 (en) * 2020-05-18 2021-11-25 Anovent Pharmaceutical (U.S.), Llc Pharmaceutical formulation containing remdesivir and its active metabolites for dry powder inhalation
JP2025540142A (ja) 2022-12-02 2025-12-11 キナセット・セラピューティクス・インコーポレイテッド 汎ｊａｋ阻害剤の製剤

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1204826B (it) † 1986-03-04 1989-03-10 Chiesi Farma Spa Composizioni farmaceutiche per inalazione
US5506203C1 (en) * 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
DE4323636A1 (de) * 1993-07-15 1995-01-19 Hoechst Ag Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung
JP4155594B2 (ja) * 1994-12-22 2008-09-24 アストラゼネカ・アクチエボラーグ エアゾール製剤
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
GB9501841D0 (en) † 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
GB9515182D0 (en) * 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
HUP0101608A2 (hu) † 1998-04-18 2002-03-28 Glaxo Group Limited Aeroszol formájú gyógyszerkészítmény és eljárás előállítására
US7521068B2 (en) * 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
RU2221552C2 (ru) † 1998-11-13 2004-01-20 Джаго Рисерч Аг Сухой порошок для ингаляции
GB9827145D0 (en) † 1998-12-09 1999-02-03 Co Ordinated Drug Dev Improvements in or relating to powders
WO2000053157A1 (en) † 1999-03-05 2000-09-14 Chiesi Farmaceutici S.P.A. Improved powdery pharmaceutical compositions for inhalation
PE20011227A1 (es) † 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
US8580306B2 (en) † 2000-11-30 2013-11-12 Vectura Limited Particles for use in a pharmaceutical composition

Also Published As

Publication number Publication date
AU2002222115B2 (en) 2006-09-28
CY1117749T1 (el) 2017-05-17
JP4380988B2 (ja) 2009-12-09
EP1337241A2 (en) 2003-08-27
NZ526059A (en) 2005-05-27
CA2429665A1 (en) 2002-06-06
WO2002043702A2 (en) 2002-06-06
CA2429665C (en) 2013-10-22
AU2211502A (en) 2002-06-11
EP1337240A2 (en) 2003-08-27
EP1337240B2 (en) 2014-09-24
DE60132239D1 (de) 2008-02-14
AU2002222118A1 (en) 2002-06-11
WO2002043701A3 (en) 2002-10-17
DE60132239T2 (de) 2008-05-08
EP1337240B1 (en) 2011-07-27
WO2002043701A2 (en) 2002-06-06
JP2004514504A (ja) 2004-05-20
WO2002043702A3 (en) 2002-10-17
ES2296831T3 (es) 2008-05-01
EP1337241B1 (en) 2008-01-02
DK2283818T3 (en) 2017-10-16

Similar Documents

Publication Publication Date Title
CY1119400T1 (el) Μεθοδος παρασκευης σωματιδιων για χρηση σε φαρμακευτικη συνθεση
CY1112338T1 (el) Μεθοδος παρασκευης σωματιδιων για χρηση σε φαρμακευτικη συνθεση
CY1123152T1 (el) Τροποποιημενες πρωτεϊνες rsv f και μεθοδοι χρησης τους
CY1120799T1 (el) Ενα προϊον στοματικης χορηγησης νικοτινης που περιεχει μια σκονη κλεισμενη σε ενα υδατοαδιαλυτο φακελακι οπου η εν λογω σκονη περιλαμβανει νικοτινη και μια συνθεση τσιχλας
CY1124720T1 (el) Απο του στοματος σκευασματα αναλογων κυτιδινης και μεθοδοι χρησης αυτων
CY1123945T1 (el) Στοματικα σκευασματα αμεσης απελευθερωσης για υποκατεστημενες κιναζολινονες
CY1120230T1 (el) Προϊον χορηγησης απο του στοματος
CY1109142T1 (el) Χαρακτηρισμος: σπειροκυκλικα παραγωγα κυκλοεξανιου
CY1119216T1 (el) Φαρμακευτικη συνθεση για εισπνοη
CY1111705T1 (el) Παραγωγα 2-αζα-δικυκλο[3.1.0]εξανιου ως ανταγωνιστες του υποδοχεα ορεξινης
CY1114616T1 (el) Σπειροκυκλικα παραγωγα κυκλοεξανιου
CY1115526T1 (el) Φαρμακευτικη συνθεση η οποια περιλαμβανει πιμοβενδανη
CY1112879T1 (el) Συνθεση εμβολιου
CY1112453T1 (el) Αντιϊικες ενωσεις
PT1119543E (pt) N-aralquilaminotetralinas como ligandos para o receptor y5 do neuropeptido y
CY1119252T1 (el) Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40
CY1107426T1 (el) Νεα παραγωγα φθοριογλυκοσιδιων απο πυραζολες, φαρμακευτικα προϊοντα που περιεχουν τις εν λογω ενωσεις και η χρηση αυτων
CY1113533T1 (el) Ετεροαρυλο-υποκατεστημενα παραγωγα κυκλοεξυλο-1,4-διαμινης
CY1108529T1 (el) Νεα αζαδικυκλικα παραγωγα, μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τα περιεχουν
EA201070162A1 (ru) Лекарственное средство в виде сухого порошка
BRPI0313764A2 (pt) método de preparação de composições de inalação de pó seco
CY1105866T1 (el) Αναλογα ταμανταρινης και διδεμνινης και μεθοδοι παρασκευης και χρησης αυτων
BR112014017756A8 (pt) Sistema de administração transmucosa para um medicamento
CY1108770T1 (el) Νεα παραγωγα του ινδολιου και χρηση τους ως φαρμακων
BRPI0407433A (pt) Método para produzir uma partìcula semelhante a virossoma, partìcula semelhante a virossoma, uso da mesma , e, composição farmacêutica