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CY1119031T1 - Βακτηριακως λαμβανομενα, ανεπαφα μινικυτταρα που συμπεριλαμβανουν ρυθμιστικο rna - Google Patents

Βακτηριακως λαμβανομενα, ανεπαφα μινικυτταρα που συμπεριλαμβανουν ρυθμιστικο rna

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Publication number
CY1119031T1
CY1119031T1 CY20171100476T CY171100476T CY1119031T1 CY 1119031 T1 CY1119031 T1 CY 1119031T1 CY 20171100476 T CY20171100476 T CY 20171100476T CY 171100476 T CY171100476 T CY 171100476T CY 1119031 T1 CY1119031 T1 CY 1119031T1
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CY
Cyprus
Prior art keywords
minicators
bacterius
shutting
continuous
including regulatory
Prior art date
Application number
CY20171100476T
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English (en)
Inventor
Himanshu Brahmbatt
Jennifer Macdiarmid
Toby Hulf
Original Assignee
Engeneic Molecular Delivery Pty Ltd
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Publication date
Application filed by Engeneic Molecular Delivery Pty Ltd filed Critical Engeneic Molecular Delivery Pty Ltd
Publication of CY1119031T1 publication Critical patent/CY1119031T1/el

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Abstract

Ανέπαφα, βακτηριακώς-λαμβανόμενα μινικύτταρα μπορεί ασφαλώς να εισάγουν θεραπευτικώς αποτελεσματικές ποσότητες λειτουργικού νουκλεϊνικού οξέος άνευ πλασμιδίου σε κύτταρα θηλαστικού στόχους. Προς τούτο, λειτουργικό νουκλεϊνικό οξύ μπορεί να είναι συσκευασμένο εντός ανέπαφων μινικυττάρων απευθείας, χωρίς προσφυγή σε κατασκευάσματα έκφρασης, το μηχανισμό έκφρασης του κυττάρου ξενιστή, σκληρά χημικά ή ηλεκτροπόρωση.
CY20171100476T 2007-03-30 2017-05-02 Βακτηριακως λαμβανομενα, ανεπαφα μινικυτταρα που συμπεριλαμβανουν ρυθμιστικο rna CY1119031T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90907407P 2007-03-30 2007-03-30
EP08828079.7A EP2145002B1 (en) 2007-03-30 2008-03-26 Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells

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CY1119031T1 true CY1119031T1 (el) 2018-01-10

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EP (5) EP3564372A1 (el)
JP (1) JP5167338B2 (el)
CN (2) CN105854029B (el)
AU (1) AU2008291833B2 (el)
CA (3) CA2933978C (el)
CY (1) CY1119031T1 (el)
DK (2) DK2145002T3 (el)
ES (2) ES2534435T3 (el)
HR (2) HRP20150328T1 (el)
LT (1) LT2865755T (el)
MX (1) MX2009010411A (el)
NZ (1) NZ580487A (el)
PL (2) PL2865755T3 (el)
PT (2) PT2865755T (el)
SG (2) SG10201507969PA (el)
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WO (1) WO2009027830A2 (el)

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AU2008291833A1 (en) 2009-03-05
SI2865755T1 (sl) 2017-06-30
DK2865755T3 (en) 2017-05-15
CA2933978C (en) 2018-08-21
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JP5167338B2 (ja) 2013-03-21
HK1209786A1 (en) 2016-04-08
WO2009027830A2 (en) 2009-03-05
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CA2682704C (en) 2014-07-08
ES2534435T3 (es) 2015-04-22
EP2532746A2 (en) 2012-12-12
CN101715489A (zh) 2010-05-26
EP2145002A2 (en) 2010-01-20
PT2865755T (pt) 2017-05-26
JP2010523487A (ja) 2010-07-15
WO2009027830A3 (en) 2009-05-14
CN105854029A (zh) 2016-08-17
EP3564372A1 (en) 2019-11-06
AU2008291833B2 (en) 2012-11-08
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EP2865755A2 (en) 2015-04-29
EP3205724B1 (en) 2019-05-08
SI2145002T1 (sl) 2015-05-29
SG10201804257RA (en) 2018-06-28
CN105854029B (zh) 2019-10-18
HK1138326A1 (en) 2010-08-20
DK2145002T3 (en) 2015-04-20
EP2865755A3 (en) 2015-05-06
EP2145002B1 (en) 2015-01-07
LT2865755T (lt) 2017-07-25
HRP20170662T1 (hr) 2017-07-14
EP2532746A3 (en) 2013-08-14
CN101715489B (zh) 2016-05-25
MX2009010411A (es) 2009-11-23
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HRP20150328T1 (hr) 2015-05-22
CA2682704A1 (en) 2009-03-05
PL2865755T3 (pl) 2017-08-31
CA2844647A1 (en) 2009-03-05
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