CY1118572T1 - Παραγωγο κυκλοαλκανιου - Google Patents
Παραγωγο κυκλοαλκανιουInfo
- Publication number
- CY1118572T1 CY1118572T1 CY20171100142T CY171100142T CY1118572T1 CY 1118572 T1 CY1118572 T1 CY 1118572T1 CY 20171100142 T CY20171100142 T CY 20171100142T CY 171100142 T CY171100142 T CY 171100142T CY 1118572 T1 CY1118572 T1 CY 1118572T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- alkyl group
- alkoxy
- hydroxy
- alkyl
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 abstract 1
- 108010052164 Sodium Channels Proteins 0.000 abstract 1
- 102000018674 Sodium Channels Human genes 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Παρεχόμενο είναι ένα φάρμακο για τη θεραπεία ή/και πρόληψη του πόνου ή ένα φάρμακο για τη θεραπεία και πρόληψη προκαλούμενων από δίαυλο νατρίου ασθενειών. Μία ένωση που αντιπροσωπεύεται από τον τύπο (I) ή φαρμακευτικώς αποδεκτό άλας αυτής: Ar1, Ar2: ετεροαρύλ ομάδα, αρύλ ομάδα· R1, R2, R3: άτομο υδρογόνου, άτομο αλογόνου, C1-C6 αλκύλ ομάδα, αλογονωμένη C1-C6 αλκύλ ομάδα, υδρόξυ C1-C6 αλκύλ ομάδα, C1-C6 αλκόξυ C1-C6 αλκύλ ομάδα ή C3-C7 κυκλοαλκύλ ομάδα, κύανο ομάδα· R4 και R5: άτομο υδρογόνου, άτομο αλογόνου, C1-C6 αλκύλ ομάδα, αλογονωμένη C1-C6 αλκύλ ομάδα, υδροξύλ ομάδα, υδρόξυ C1-C6 αλκύλ ομάδα, C1-C6 αλκόξυ C1-C6 αλκύλ ομάδα, C3-C7 κυκλοαλκύλ ομάδα, C1-C6 αλκόξυ ομάδα· n: ακέραιος από 1 έως 3· η ετεροαρύλ ομάδα και η αρύλ ομάδα μπορεί να έχουν μία ή δύο ομάδες επιλεγόμενες ανεξαρτήτως από άτομο αλογόνου, C1-C6 αλκύλ ομάδα, αλογονωμένη C1-C6 αλκύλ ομάδα, υδρόξυ ομάδα, υδρόξυ C1-C6 αλκύλ ομάδα, C1-C6 αλκόξυ C1-C6 αλκύλ ομάδα, C3-C7 κυκλοαλκύλ ομάδα, καρβόξυλ ομάδα, κύανο ομάδα, άμινο ομάδα, C1-C3 αλκυλάμινο ομάδα και δι-C1-C3 αλκυλάμινο ομάδα· στη δε περίπτωση των δύο, οι δύο μπορεί να είναι οι ίδιες ή διαφορετικές.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012025754 | 2012-02-09 | ||
| JP2012259122 | 2012-11-27 | ||
| PCT/JP2013/052985 WO2013118854A1 (ja) | 2012-02-09 | 2013-02-08 | シクロアルカン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118572T1 true CY1118572T1 (el) | 2017-07-12 |
Family
ID=48947609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100142T CY1118572T1 (el) | 2012-02-09 | 2017-01-31 | Παραγωγο κυκλοαλκανιου |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8889741B2 (el) |
| EP (2) | EP2813491B1 (el) |
| JP (2) | JP5997710B2 (el) |
| KR (1) | KR20140127238A (el) |
| CN (1) | CN104185629B (el) |
| AU (1) | AU2013218592B2 (el) |
| BR (1) | BR112014019478A2 (el) |
| CA (1) | CA2864222C (el) |
| CO (1) | CO7151511A2 (el) |
| CY (1) | CY1118572T1 (el) |
| DK (1) | DK2813491T3 (el) |
| ES (2) | ES2613078T3 (el) |
| HR (1) | HRP20161713T1 (el) |
| HU (2) | HUE037048T2 (el) |
| IL (1) | IL234014A (el) |
| IN (1) | IN2014MN01577A (el) |
| LT (1) | LT2813491T (el) |
| MX (1) | MX349354B (el) |
| NZ (1) | NZ628096A (el) |
| PH (2) | PH12014501804B1 (el) |
| PL (1) | PL2813491T3 (el) |
| PT (1) | PT2813491T (el) |
| RS (1) | RS55671B1 (el) |
| RU (1) | RU2635354C2 (el) |
| SG (1) | SG11201404707VA (el) |
| SI (1) | SI2813491T1 (el) |
| SM (2) | SMT201700053T1 (el) |
| TW (1) | TWI612042B (el) |
| WO (1) | WO2013118854A1 (el) |
| ZA (1) | ZA201405801B (el) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853439A1 (en) * | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| CA2855019A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
| US8889741B2 (en) * | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
| WO2013177224A1 (en) | 2012-05-22 | 2013-11-28 | Genentech, Inc. | N-substituted benzamides and their use in the treatment of pain |
| BR112015000187A2 (pt) | 2012-07-06 | 2017-06-27 | Genentech Inc | benzamidas substituídas com n e métodos de uso das mesmas |
| ES2663798T3 (es) * | 2013-03-14 | 2018-04-17 | Daiichi Sankyo Company, Limited | Fármaco para enfermedades respiratorias |
| BR112015022488A2 (pt) | 2013-03-14 | 2017-07-18 | Genentech Inc | triazolopiridinas substituídas e métodos de uso das mesmas |
| EP2970156B1 (en) | 2013-03-15 | 2018-07-25 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
| JP6383418B2 (ja) | 2013-11-27 | 2018-08-29 | ジェネンテック， インコーポレイテッド | 置換ベンズアミド及びその使用方法 |
| EP3166939B1 (en) | 2014-07-07 | 2019-06-05 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| CR20170591A (es) | 2015-05-22 | 2018-05-07 | Genentech Inc | Benzamidas sustituidas y métodos para utilizarlas |
| EP3341353A1 (en) | 2015-08-27 | 2018-07-04 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| PE20181003A1 (es) | 2015-09-28 | 2018-06-26 | Genentech Inc | Compuestos terapeuticos y sus metodos de uso |
| CA3002920A1 (en) | 2015-11-06 | 2017-05-11 | Daiichi Sankyo Company, Limited | Method for removing dimethoxybenzyl group |
| WO2017091592A1 (en) | 2015-11-25 | 2017-06-01 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| EP3436432B1 (en) | 2016-03-30 | 2021-01-27 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| AU2017268006B2 (en) * | 2016-05-20 | 2021-03-11 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| MA46546A (fr) * | 2016-10-17 | 2021-05-05 | Genentech Inc | Composés thérapeutiques et leurs procédés d'utilisation |
| CN110088093B (zh) * | 2016-10-27 | 2023-06-13 | 百时美施贵宝公司 | 酰基磺酰胺NaV1.7抑制剂 |
| RU2760303C2 (ru) | 2016-12-09 | 2021-11-23 | Ксенон Фармасьютикалз Инк. | Соединения бензолсульфонамидов и их использование в качестве терапевтических средств |
| EP3601273B1 (en) | 2017-03-24 | 2021-12-01 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| WO2019060611A1 (en) | 2017-09-20 | 2019-03-28 | Abm Therapeutics, Inc. | CYCLIC IMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF KINASES |
| WO2019165290A1 (en) * | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
| CN111936494A (zh) | 2018-03-30 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 作为钠通道抑制剂的取代的氢-吡啶并-吖嗪 |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| JP7371029B2 (ja) | 2018-06-13 | 2023-10-30 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ベンゼンスルホンアミド化合物および治療剤としてのその使用 |
| JP7383012B2 (ja) | 2018-08-31 | 2023-11-17 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヘテロアリール置換スルホンアミド化合物、およびナトリウムチャネル阻害剤としてのその使用 |
| EA202190395A1 (ru) | 2018-08-31 | 2021-06-15 | Ксенон Фармасьютикалз Инк. | Замещенные гетероарилом сульфонамидные соединения и их применение в качестве терапевтических средств |
| JP2022515630A (ja) * | 2018-12-26 | 2022-02-21 | ラクオリア創薬株式会社 | Ｎａｖ１．７およびＮａｖ１．８遮断薬としての複素環誘導体 |
| US20240241265A1 (en) * | 2023-01-18 | 2024-07-18 | Qualcomm Incorporated | Virtual positioning signal measurements |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6222048B1 (en) | 1995-12-18 | 2001-04-24 | Merck Frosst Canada & Co. | Diaryl-2-(5H)-furanones as Cox-2 inhibitors |
| WO2006038594A1 (ja) | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
| CN101218226A (zh) * | 2005-05-16 | 2008-07-09 | 沃泰克斯药物股份有限公司 | 作为离子通道调控剂的二环衍生物 |
| CA2693588C (en) | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Sodium channel inhibitors |
| WO2010035166A1 (en) | 2008-09-23 | 2010-04-01 | Pfizer Limited | Benzamide derivatives |
| NZ593473A (en) * | 2009-01-12 | 2013-02-22 | Pfizer Ltd | Sulfonamide derivatives |
| CA2803118C (en) | 2010-07-09 | 2015-11-03 | Pfizer Limited | Sulfonamide derivatives as nav 1.7 inhibitors |
| EP2590951B1 (en) * | 2010-07-09 | 2015-01-07 | Pfizer Limited | Benzenesulfonamides useful as sodium channel inhibitors |
| JP5872552B2 (ja) * | 2010-07-09 | 2016-03-01 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | 化学化合物 |
| CA2853439A1 (en) * | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| US8889741B2 (en) * | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
-
2013
- 2013-01-31 US US13/756,173 patent/US8889741B2/en active Active
- 2013-02-07 TW TW102104725A patent/TWI612042B/zh not_active IP Right Cessation
- 2013-02-08 ES ES13746373.3T patent/ES2613078T3/es active Active
- 2013-02-08 PL PL13746373T patent/PL2813491T3/pl unknown
- 2013-02-08 AU AU2013218592A patent/AU2013218592B2/en not_active Ceased
- 2013-02-08 PT PT137463733T patent/PT2813491T/pt unknown
- 2013-02-08 IN IN1577MUN2014 patent/IN2014MN01577A/en unknown
- 2013-02-08 HU HUE16193142A patent/HUE037048T2/hu unknown
- 2013-02-08 EP EP13746373.3A patent/EP2813491B1/en active Active
- 2013-02-08 KR KR1020147021798A patent/KR20140127238A/ko not_active Abandoned
- 2013-02-08 NZ NZ628096A patent/NZ628096A/en not_active IP Right Cessation
- 2013-02-08 HR HRP20161713TT patent/HRP20161713T1/hr unknown
- 2013-02-08 DK DK13746373.3T patent/DK2813491T3/en active
- 2013-02-08 SM SM20170053T patent/SMT201700053T1/it unknown
- 2013-02-08 RU RU2014136463A patent/RU2635354C2/ru not_active IP Right Cessation
- 2013-02-08 WO PCT/JP2013/052985 patent/WO2013118854A1/ja not_active Ceased
- 2013-02-08 CN CN201380017715.1A patent/CN104185629B/zh not_active Expired - Fee Related
- 2013-02-08 RS RS20170101A patent/RS55671B1/sr unknown
- 2013-02-08 BR BR112014019478A patent/BR112014019478A2/pt not_active Application Discontinuation
- 2013-02-08 SI SI201330423A patent/SI2813491T1/sl unknown
- 2013-02-08 JP JP2013557586A patent/JP5997710B2/ja not_active Expired - Fee Related
- 2013-02-08 ES ES16193142.3T patent/ES2659434T3/es active Active
- 2013-02-08 HU HUE13746373A patent/HUE031450T2/en unknown
- 2013-02-08 LT LTEP13746373.3T patent/LT2813491T/lt unknown
- 2013-02-08 SG SG11201404707VA patent/SG11201404707VA/en unknown
- 2013-02-08 MX MX2014009637A patent/MX349354B/es active IP Right Grant
- 2013-02-08 EP EP16193142.3A patent/EP3144300B1/en not_active Not-in-force
- 2013-02-08 CA CA2864222A patent/CA2864222C/en not_active Expired - Fee Related
-
2014
- 2014-08-06 ZA ZA2014/05801A patent/ZA201405801B/en unknown
- 2014-08-07 IL IL234014A patent/IL234014A/en not_active IP Right Cessation
- 2014-08-11 PH PH12014501804A patent/PH12014501804B1/en unknown
- 2014-09-05 CO CO14195847A patent/CO7151511A2/es unknown
- 2014-09-30 US US14/502,708 patent/US9493448B2/en not_active Expired - Fee Related
-
2015
- 2015-11-27 PH PH12015502675A patent/PH12015502675A1/en unknown
-
2016
- 2016-08-26 JP JP2016165515A patent/JP6154052B2/ja not_active Expired - Fee Related
- 2016-09-19 US US15/269,485 patent/US9845313B2/en not_active Expired - Fee Related
-
2017
- 2017-01-24 SM SM201700053T patent/SMT201700053B/it unknown
- 2017-01-31 CY CY20171100142T patent/CY1118572T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1118572T1 (el) | Παραγωγο κυκλοαλκανιου | |
| IN2014DN03063A (el) | ||
| CY1124117T1 (el) | Ετεροκυκλικες αλκυνυλοβενζολικες ενωσεις και ιατρικες συνθεσεις και χρησεις αυτων | |
| CY1123627T1 (el) | Παραγωγα διυδροϊμιδαζοπυραζινονης χρησιμα στη θεραπευτικη αντιμετωπιση του καρκινου | |
| CY1121231T1 (el) | Παραγωγο τετραϋδροϊμιδαζο[1,5-d][1,4]οξαζεπινης | |
| CY1120248T1 (el) | Ενωσεις ιμιδαζο[4,5-c]κινολιν-2-ονης και η χρηση τους στη θεραπευτικη αντιμετωπιση του καρκινου | |
| CY1119727T1 (el) | Ενωσεις και συνθεσεις για τη θεραπεια παρασιτικων νοσων | |
| CY1121804T1 (el) | Καινοτομες ενωσεις πυριμιδινης και πυριδινης και η χρηση τους | |
| EA201690019A1 (ru) | Производное аминотриазина и содержащая его фармацевтическая композиция | |
| MX2020007265A (es) | Derivados de rapamicina. | |
| ECSP16025201A (es) | Profármacos de amidas de piridona útiles como moduladores de canales de sodio | |
| CY1117719T1 (el) | Παραγωγα αμινοπυριμιδινης ως διαμορφωτες της lrrk2 | |
| MX2010006421A (es) | Compuestos organicos. | |
| CY1117776T1 (el) | Εναντιομερη ενωσεων σπειρο-οξινδολιου και οι χρησεις τους ως θεραπευτικοι παραγοντες | |
| MX379300B (es) | Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales. | |
| CY1123154T1 (el) | Παραγοντας ενισχυσης της επιδρασης αποκαταστασης μετα απο νευρικη βλαβη που περιλαμβανει ενα παραγωγο αλκυλαιθερα ή ενα αλας αυτου | |
| CY1119296T1 (el) | Ενωση δικαρβοξυλικου οξεος | |
| CY1121677T1 (el) | Ενωσεις διμεθυλοβενζοϊκου οξεος | |
| JO3261B1 (ar) | مشتق بيريدين أحادي الحلقة | |
| EA201200471A1 (ru) | Простые эфирные производные бициклических гетероарилов | |
| MD20150075A2 (ro) | Compuşi tetraciclici heterociclu-substituiţi şi metode de utilizare a acestora pentru tratamentul bolilor virale | |
| EA201600337A1 (ru) | 2,6-замещенные пуриновые производные и их применение в лечении пролиферативных заболеваний | |
| CY1121060T1 (el) | Παραγωγα [1,2,4] τριαζολο[1,5-α] πυριμιδινης ως αναστολεις πρωτεασωματος πρωτοζωων για τη θεραπεια παρασιτικων νοσηματων οπως η λεϊσμανιαση | |
| EA201590074A1 (ru) | Производное бензодиоксола, способ его получения и его применение | |
| CY1117026T1 (el) | Ετεροκυκλικες ενωσεις για αντιμετωπιση ή προληψη διαταραχων που προκαλουνται απο μειωμενη νευροδιαβιβαση σεροτονινης, νορεπινεφρινης ή ντοπαμινης |