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CY1124117T1 - Ετεροκυκλικες αλκυνυλοβενζολικες ενωσεις και ιατρικες συνθεσεις και χρησεις αυτων - Google Patents

Ετεροκυκλικες αλκυνυλοβενζολικες ενωσεις και ιατρικες συνθεσεις και χρησεις αυτων

Info

Publication number
CY1124117T1
CY1124117T1 CY20201100897T CY201100897T CY1124117T1 CY 1124117 T1 CY1124117 T1 CY 1124117T1 CY 20201100897 T CY20201100897 T CY 20201100897T CY 201100897 T CY201100897 T CY 201100897T CY 1124117 T1 CY1124117 T1 CY 1124117T1
Authority
CY
Cyprus
Prior art keywords
compounds
heterocyclic
alkynylbenzole
medicinal compositions
alkynylbenzene
Prior art date
Application number
CY20201100897T
Other languages
English (en)
Inventor
Ke Ding
Duanqing Pei
Zhang Zhang
Mengjie Shen
Kun LUO
Yubing Feng
Deping Wang
Original Assignee
Guangzhou Healthquest Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Healthquest Pharma Co., Ltd. filed Critical Guangzhou Healthquest Pharma Co., Ltd.
Publication of CY1124117T1 publication Critical patent/CY1124117T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Οι ετεροκυκλικές αλκυνυλοβενζολικές ενώσεις του τύπου (Ι), τα φαρμακευτικώς αποδεκτά άλατα και τα στερεοϊσομερή αυτών, όπως και η εφαρμογή στην παρασκευή φαρμάκων για την πρόληψη ή θεραπευτική αντιμετώπιση όγκων. Οι ενώσεις μπορούν να αντιμετωπίσουν την κλινικά επαγόμενη ανθεκτικότητα έναντι του Gleevec.
CY20201100897T 2010-07-01 2020-09-23 Ετεροκυκλικες αλκυνυλοβενζολικες ενωσεις και ιατρικες συνθεσεις και χρησεις αυτων CY1124117T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010102166037A CN101885722B (zh) 2010-07-01 2010-07-01 杂环炔苯类化合物及其药用组合物和应用
PCT/CN2011/000935 WO2012000304A1 (zh) 2010-07-01 2011-06-03 杂环炔苯类化合物及其药用组合物和应用

Publications (1)

Publication Number Publication Date
CY1124117T1 true CY1124117T1 (el) 2022-03-24

Family

ID=43071837

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100897T CY1124117T1 (el) 2010-07-01 2020-09-23 Ετεροκυκλικες αλκυνυλοβενζολικες ενωσεις και ιατρικες συνθεσεις και χρησεις αυτων

Country Status (16)

Country Link
EP (2) EP2594567B1 (el)
JP (1) JP5756518B2 (el)
KR (1) KR101570456B1 (el)
CN (2) CN101885722B (el)
AU (1) AU2011274192B2 (el)
CA (1) CA2804347C (el)
CY (1) CY1124117T1 (el)
DK (1) DK2594567T3 (el)
ES (1) ES2816382T3 (el)
HU (1) HUE051346T2 (el)
IL (1) IL223983A (el)
LT (1) LT2594567T (el)
PL (1) PL2594567T3 (el)
PT (1) PT2594567T (el)
SI (1) SI2594567T1 (el)
WO (1) WO2012000304A1 (el)

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CN103214480B (zh) * 2012-01-19 2015-12-16 中国科学院广州生物医药与健康研究院 吡唑并吡啶炔苯类化合物及其药用组合物和应用
US8859553B2 (en) * 2012-07-30 2014-10-14 Astar Biotech Llc Protein kinase inhibitors
CN103848829B (zh) * 2012-11-28 2017-04-12 南京圣和药业股份有限公司 杂芳基炔烃化合物及其应用
CN103965195B (zh) * 2013-02-01 2016-09-28 中国科学院广州生物医药与健康研究院 用于盘状结构域受体小分子抑制剂的化合物及其应用
CN104211639A (zh) * 2013-06-05 2014-12-17 中国科学院上海药物研究所 一类炔基杂环类化合物及其应用
ES2829504T3 (es) 2013-12-24 2021-06-01 Oncotartis Inc Compuestos de benzamida y nicotinamida y métodos de uso de los mismos
CN104490889B (zh) * 2014-12-30 2016-04-20 中国人民解放军第四军医大学 一种 ddr2 小分子抑制剂抗肺纤维化应用
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RU2652992C2 (ru) * 2016-04-18 2018-05-04 Общество С Ограниченной Ответственностью "Фьюжн Фарма" Новая кристаллическая солевая форма 3-(1,2,4-триазоло[4,3-а]пиридин-3-илэтинил)-4-метил-n-(4-((4-метилпиперазин-1-ил)метил)-3-трифторметилфенил)бензамида для медицинского применения
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CN111035641B (zh) * 2018-10-11 2022-04-12 暨南大学 Gzd824及其药学上可接受的盐在治疗疾病中的新应用
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
CN111249282B (zh) * 2018-12-03 2023-08-29 苏州亚盛药业有限公司 癌症疗法
EP3986559A1 (en) * 2019-06-24 2022-04-27 BenevolentAI Bio Limited New compounds and methods
TW202116301A (zh) * 2019-07-19 2021-05-01 大陸商蘇州亞盛藥業有限公司 藥物組合及其用途
CN110372705A (zh) * 2019-08-05 2019-10-25 辽宁大学 新型取代苯甲酰胺类化合物及其药学上可接受的盐及制备方法和应用
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CN110917157B (zh) * 2020-01-21 2020-06-16 上海亚盛医药科技有限公司 含炔基化合物的药物组合物、其制备方法及应用
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CN111732586B (zh) * 2020-07-02 2021-03-12 广州顺健生物医药科技有限公司 含炔基化合物盐的晶型、制备方法及应用
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CN115947693B (zh) * 2022-12-18 2024-11-05 重庆医科大学 一种fgfr4抑制剂及其制备与应用
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CN101885722B (zh) * 2010-07-01 2013-07-24 中国科学院广州生物医药与健康研究院 杂环炔苯类化合物及其药用组合物和应用

Also Published As

Publication number Publication date
LT2594567T (lt) 2020-12-28
EP2594567A4 (en) 2015-03-11
PL2594567T3 (pl) 2021-04-06
KR101570456B1 (ko) 2015-12-01
JP5756518B2 (ja) 2015-07-29
EP2594567A1 (en) 2013-05-22
EP3741751A1 (en) 2020-11-25
EP2594567B1 (en) 2020-07-29
AU2011274192B2 (en) 2014-11-06
SI2594567T1 (sl) 2021-01-29
ES2816382T3 (es) 2021-04-05
AU2011274192A8 (en) 2013-03-07
CN103124730A (zh) 2013-05-29
JP2013529652A (ja) 2013-07-22
KR20130043175A (ko) 2013-04-29
CN101885722B (zh) 2013-07-24
WO2012000304A1 (zh) 2012-01-05
IL223983A (en) 2017-11-30
CN101885722A (zh) 2010-11-17
HUE051346T2 (hu) 2021-03-01
DK2594567T3 (da) 2020-09-28
CN103124730B (zh) 2014-12-10
CA2804347C (en) 2016-07-05
PT2594567T (pt) 2020-09-07
CA2804347A1 (en) 2012-01-05
AU2011274192A1 (en) 2013-02-07

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