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CY1117575T1 - Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων - Google Patents

Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων

Info

Publication number
CY1117575T1
CY1117575T1 CY20161100126T CY161100126T CY1117575T1 CY 1117575 T1 CY1117575 T1 CY 1117575T1 CY 20161100126 T CY20161100126 T CY 20161100126T CY 161100126 T CY161100126 T CY 161100126T CY 1117575 T1 CY1117575 T1 CY 1117575T1
Authority
CY
Cyprus
Prior art keywords
aav
reduced
isosomatia
immunoactivity
reduced immunoreactivity
Prior art date
Application number
CY20161100126T
Other languages
English (en)
Inventor
Alejandra Elena Arbetman
Peter Colosi
Michael A Lochrie
Richard T Surosky
Original Assignee
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of CY1117575T1 publication Critical patent/CY1117575T1/el

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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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Abstract

Περιγράφονται μέθοδοι κατασκευής και χρήσης ιοσωματίων ανασυνδυασμένου AAV με μειωμένη ανοσοαντιδραστικότητα. Τα ιοσωμάτια ανασυνδυασμένου AAV περιλαμβάνουν μεταλλαγμένες καψιδιακές πρωτεΐνες ή προέρχονται από ορότυπους AAV μη πρωτεύοντος θηλαστικού και προϊόντα απομόνωσης τα οποία εμφανίζουν μειωμένη ανοσοαντιδραστικότητα σε σχέση με τον AAV-2.
CY20161100126T 2003-06-19 2016-02-16 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων CY1117575T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48039503P 2003-06-19 2003-06-19
US56731004P 2004-04-30 2004-04-30
US57650104P 2004-06-03 2004-06-03
EP04755800.2A EP1633772B1 (en) 2003-06-19 2004-06-21 Aav virions with decreased immunoreactivity and uses therefor

Publications (1)

Publication Number Publication Date
CY1117575T1 true CY1117575T1 (el) 2017-04-26

Family

ID=33545345

Family Applications (5)

Application Number Title Priority Date Filing Date
CY20161100126T CY1117575T1 (el) 2003-06-19 2016-02-16 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100603T CY1119222T1 (el) 2003-06-19 2017-06-08 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100649T CY1119279T1 (el) 2003-06-19 2017-06-21 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100650T CY1119241T1 (el) 2003-06-19 2017-06-21 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20211100317T CY1124371T1 (el) 2003-06-19 2021-04-13 Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων

Family Applications After (4)

Application Number Title Priority Date Filing Date
CY20171100603T CY1119222T1 (el) 2003-06-19 2017-06-08 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100649T CY1119279T1 (el) 2003-06-19 2017-06-21 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100650T CY1119241T1 (el) 2003-06-19 2017-06-21 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20211100317T CY1124371T1 (el) 2003-06-19 2021-04-13 Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων

Country Status (11)

Country Link
US (6) US7259151B2 (el)
EP (5) EP3235827B1 (el)
JP (7) JP2007524386A (el)
CY (5) CY1117575T1 (el)
DK (5) DK2657248T3 (el)
ES (5) ES2563064T3 (el)
HU (5) HUE054046T2 (el)
PL (5) PL3235827T3 (el)
PT (5) PT2657248T (el)
SI (5) SI3235827T1 (el)
WO (1) WO2004112727A2 (el)

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JP4969002B2 (ja) 1999-06-08 2012-07-04 ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン ｒＡＡＶ形質導入を増加するための化合物および方法
NZ618298A (en) 2001-11-13 2015-04-24 Univ Pennsylvania A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
US7419817B2 (en) 2002-05-17 2008-09-02 The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
CA2520028A1 (en) 2003-03-31 2004-10-21 University Of Iowa Research Foundation Compounds and methods to enhance raav transduction
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PT2657248T (pt) 2003-06-19 2017-06-26 Genzyme Corp Viriões aav com imunorreatividade diminuída e seus usos
US9233131B2 (en) * 2003-06-30 2016-01-12 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
US9441244B2 (en) 2003-06-30 2016-09-13 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
WO2005056807A2 (en) 2003-12-04 2005-06-23 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health Bovine adeno-associated viral (baav) vector and uses thereof
WO2006029196A1 (en) * 2004-09-08 2006-03-16 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of H Ealth Transcytosis of adeno-associated viruses
EP1828390B1 (en) * 2004-12-15 2012-06-13 The University Of North Carolina At Chapel Hill Chimeric vectors
EP2359865B1 (en) * 2005-04-07 2013-10-02 The Trustees of The University of Pennsylvania Method of increasing the function of an AAV vector
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